ID | 11761 |
Eprint ID | 11761
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FullText URL | |
Title Alternative | 潰瘍性大腸炎患者における大腸切除となる危険因子と適応は,患者背景により異なる
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Author |
Kuriyama, Motoaki
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Abstract | PURPOSE: Despite progress in medical treatment for ulcerative colitis, a considerable fraction of ulcerative colitis patients undergo colectomy. We analyzed the clinical variables of ulcerative colitis patients and determined the risk factors and indications for colectomy. METHODS: The clinical records of 981 consecutive Japanese patients with ulcerative colitis were reviewed both retrospectively and prospectively. RESULTS: Of 981 patients with ulcerative colitis, 85 patients underwent colectomy. Multivariate analysis indicated that male gender (risk ratio, 2.16; 95 percent confidence interval, 1.37-3.42), onset year during and after 2000 (risk ratio, 2.85; 95 percent confidence interval, 1.31-6.22), severe disease activity (risk ratio, 2; 95 percent confidence interval, 1.15-3.48), corticosteroid resistance (risk ratio, 7.05; 95 percent confidence interval, 4.29-11.59), and complications because of corticosteroid administration (risk ratio, 3.55; 95 percent confidence interval, 2.08-6.06) were significant risk factors for colectomy. In patients with disease duration of more than five years, only corticosteroid resistance and complications because of corticosteroid were significant risk factors for colectomy. When we stratified indications for colectomy for the 85 cases via patient disease duration, massive hemorrhage was a relatively frequent cause of colectomy in patients with a disease duration of less than five years (P = 0.091). On the other hand, colon dysplasia or cancer was a major cause for colectomy in patients with a disease duration of more than ten years (P = 0.0001). CONCLUSIONS: In ulcerative colitis patients, the risk factors and indications for colectomy were different according to the patient's clinical background. Our findings may help to predict patients with ulcerative colitis who have a high risk for colectomy.
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Keywords | Ulcerative colitis
Inflammatory bowel disease
Colectomy
Risk factor
Indication
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Note | http://dx.doi.org/10.1007/s10350-006-0574-6
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Published Date | 2007-03-23
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Publication Title | |
Content Type |
Thesis or Dissertation
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Grant Number | 甲第3324号
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Granted Date | 2007-03-23
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Thesis Type |
Doctor of Philosophy in Medical Science
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Grantor | 岡山大学
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Official Url | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16741598&dopt=Abstract
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language |
Japanese
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File Version | none
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Refereed |
Unknown
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