ID | 10616 |
Eprint ID | 10616
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FullText URL | |
Title Alternative | 一過性脳虚血後におけるT1強調MR画像の臨床的意義
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Author |
Aoe, Hisami
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Abstract | To try to determine the cause of hyperintensity of T1-weighted MR images that occurred on and after day 7 following transient cerebral ischemia, dynamic changes in T1-weighted images and histology of rats subjected to 20 min of 4-vessel occlusion were observed. T1-weighted images showed no remarkable alteration on days 1 and 3, although high signal intensity in the striatal region, in which the T1 value was significantly lower than the values on days 1 and 3, was observed on day 7. High signal intensity in T1-weighted images indicates low T1 values. Histological observation revealed accumulation of microglia in the striatal region on day 7 by lectin staining. There was a tight correlation between T1 values and number of lectin-positive cells. Microglia had stout processes and hypertrophic cell bodies on day 7, resembling lipid-laden phagocytes. Sudan black B staining showed the presence of many fatty droplets in the striatal region on day 7. Furthermore, double staining with lectin and Sudan black B revealed the presence of fatty droplets in bodies of lectin-positive cells on day 7. These results suggest that hyperintensity of T1-weighted images on day 7 following transient ischemia and reperfusion indicates accumulation and phagocytic activation of microglia. T1-weighted images seem to represent the progression of non-reversible tissue injury after transient ischemia and reperfusion.
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Keywords | Cerebral ischemia
Cardiopulmonary resuscitation
Magnetic resonance imaging
T1-weighted images
Basal ganglia
Microglia
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Note | http://dx.doi.org/10.1016/j.jns.2005.10.013
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Published Date | 2006-03-24
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Publication Title | |
Content Type |
Thesis or Dissertation
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Grant Number | 乙第4089号
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Granted Date | 2006-03-24
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Thesis Type |
Doctor of Philosophy in Medical Science
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Grantor | 岡山大学
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Official Url | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16386758&dopt=Abstract
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language |
Japanese
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File Version | none
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Refereed |
Unknown
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