ID | 56075 |
JaLCDOI | |
FullText URL | |
Author |
Kitajima, Kazuhiro
Division of Nuclear Medicine and PET Center, Hyogo College of Medicine
Yamamoto, Shingo
Department of Urology, Hyogo College of Medicine
Odawara, Soichi
Division of Nuclear Medicine and PET Center, Hyogo College of Medicine
Kobayashi, Kaoru
Department of Radiology, Hyogo College of Medicine
Fujiwara, Masayuki
Department of Radiology, Hyogo College of Medicine
Kamikonya, Norihiko
Department of Radiology, Hyogo College of Medicine
Fukushima, Kazuhito
Department of Nuclear Medicine, University Hospital Wuerzburg
Nakanishi, Yukako
Department of Urology, Hyogo College of Medicine
Hashimoto, Takahiko
Department of Urology, Hyogo College of Medicine
Yamada, Yusuke
Department of Urology, Hyogo College of Medicine
Suzuki, Toru
Department of Urology, Hyogo College of Medicine
Kanematsu, Akihiro
Department of Urology, Hyogo College of Medicine
Nojima, Michio
Department of Urology, Hyogo College of Medicine
Yamakado, Koichiro
Department of Radiology, Hyogo College of Medicine
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Abstract | We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55.0%), 9 (45.0%), and 13 (65.0%), respectively. The patient-based sensitivity/specificity/accuracy/area under the receiver-operating-characteristic curve (AUC) values for 11C-choline-PET/CT for diagnosing local lesions were 90.9% /100%/ 95.0% / 1.0, whereas those for FDG-PET/CT were 45.5% /100%/ 75.0% / 0.773. Those for 11C-choline-PET/CT for node metastasis were 88.9% /100%/ 95.0% / 0.944, and those for FDG-PET/CT were 44.4%/100%/75.0%/0.722. Those for 11C-choline-PET/CT for bone metastasis were 84.6%/100%/90.0%/0.951, and those for FDG-PET/CT were 76.9% /100%/ 85.0% / 0.962. The AUCs for local lesion and node metastasis differed significantly (p=0.0039, p=0.011, respectively). The lesion-based detection rates of 11C-choline compared to FDG PET/CT for local lesion, and node and bone metastases were 91.7% vs. 41.7%, 92.0% vs. 32.0%, and 94.8% vs. 83.0% (p=0.041, p=0.0030, p<0.0001), respectively. 11C-choline-PET/CT is more useful for the staging and restaging of prostate cancer than FDG-PET/CT in Japanese men.
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Keywords | prostate cancer
PET
choline
FDG
Japanese
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2018-06
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Volume | volume72
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Issue | issue3
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Publisher | Okayama University Medical School
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Start Page | 289
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End Page | 296
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID |