ID | 54808 |
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Author |
Tanino, Masaaki
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kobayashi, Motomu
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Sasaki, Toshihiro
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takata, Ken
Department of Anesthesiology and Intensive Care Medicine, Kawasaki Medical School
Takeda, Yoshimasa
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Mizobuchi, Satoshi
Division of Anesthesiology, Department of Surgery Related, Kobe University Graduate School of Medicine
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Morita, Kiyoshi
Okayama University
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Nagai, Taku
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine
Morimatsu, Hiroshi
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
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Keywords | postoperative cognitive dysfunction
isoflurane
spatial working memory
retention
delayed spatial win-shift task
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2016-12
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Volume | volume70
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Issue | issue6
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Publisher | Okayama University Medical School
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Start Page | 455
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End Page | 460
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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