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ID 17445
Eprint ID
17445
FullText URL
Thumnail 90_1111.pdf 257 KB
Title Alternative
Influence of bucolome on non-bilirubin fraction showing positive diazo-reaction in the bile
Author
Kondo, Tadasuke
Yonei, Jiro
Ishikawa, Yasusuke
Abstract
Influence of bucolome on non-bilirubin fraction showing positive diazo-reaction (non-bilirubin fraction, dipyrril substances) was studied using heterozygous Gunn rats. Two hundred mg of bucolome per kg of rat body weight was injected intramuscularly once a day for four days. The bile collection by the bile duct canulation was started 24 hours after the final drug loading and continued for 22 hours. The following results were obtained: 1) Amount of non-bilirubin in the rat bile increased significantly in bucolome loading group than in the control group. 2) Radioactivity in non-bilirubin fraction in the bile after bucolome and (3)H-bilirubin loading was not increased significantly than in the control. 3) In bucolome loading group, bile volume increased significantly but the excreted amount of bilirubin did not increased. According to these results, bucolome did not catabolize bilirubin directly but increased non-bilirubin fraction, dipyrril substances, in the bile.
Published Date
1978-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1111
End Page
1116
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/9-10/90_9-10_1111/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma