ID | 16142 |
Eprint ID | 16142
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FullText URL | |
Title Alternative | Effect of cepharanthine on lipid peroxidation
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Author |
Joja, Ikuo
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Abstract | The effect of cepharanthine on radiation- and Fe(2+)-induced lipid peroxidation was examined. Cepharanthine and α-tocopherol inhibited radiation-induced lipid peroxidation of liposomes and Fe(2+)-induced lipid peroxidation of mitochondria. Cepharanthine reduced the velocity of Fe(2+)oxidation in the presence of mitochondria but not in the absence. α-Tocopherol strongly inhibited radiation-induced peroxidation of lipid dissolved in MeOH/CHCl(3)/H(2)O (v/v, 2/1/0.8) and Fe(2+)-induced peroxidation of lipid dissolved in MeOH. Cepharanthine, on the other hand, only weakly inhibited lipid peroxidation in the MeOH/CHCl(3)/H(2)O system, and did not inhibit peroxidation in the MeOH system. The change in the absorption stectrum of α-tocopherol and cepharanthine by free radicals (X irradiation) was measured. The reagents were dissolved in 95% EtOH acidified with 20mM HCl and MeOH/CHCl(3)/H(2)O (v/v, 2/1/0.8). α-Tocopherol exhibited a change in its absorption spectrum in both systems and seemed to be oxidized at a higher rate by radicals. However, cepharanthine did not exhibit a change in its absorption spectrum in acidified 95% EtOH exposed to X irradiation, and slightly exhibited a chang in its absorption spectrum in MeOH/CHCl(3)/H(2)O exposed to X irradiation. From these observations, cepharanthine seemed not to exhibit a radical-trapping ability.
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Keywords | 脂質過酸化反応 (Lipid peroxidation)
X線照射 (X-irradiation)
二価鉄 (Ferrous ion)
セファランチン (Cepharanthine)
α-トコフェロール (α-Tocopherol)
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Published Date | 1985-04-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume97
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Issue | issue3-4
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 235
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End Page | 248
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_235/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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