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ID 13761
Eprint ID
13761
FullText URL
107_205.pdf 3.53 MB
Title Alternative
Possible protective effects of zine on halothane-induced liver injury in rats
Author
Koyama, Yusuke
Abstract
In a rat model, halothane causes liver injury by interaction with microsomal cytohrome P450 (P450) under a hypoxic condition. Rats that were pretreated with phenobarbital and exposed to halothane under reduced oxygen tension for 2 hours developed hepatic centrilobular necrosis with marked elevation of serum alanine aminotransferase (ALT) 24h after exposure. The elevation of ALT was significantly suppressed in the rats pretreated with a 10mg/kg dose of zinc (Zn) 24h prior to the exposure in comparison with the rats pretreated with saline (control rats). The region of necrosis was also significantly reduced in Zn-pretreated rats. The P450 content of the hepatic microsomes was slightly decreased before the exposure in Zn-pretreated rats in comparison with that in the control rats. It was noteworthy that the aminopyrine demethylation (AD) activity of hepatic microsomal after the exposure in Zn-pretreated rats. These findings indicate that Zn-pratreatment has some protective effect against halothane-induced liver injury and suggest that this protective effect of Zn involcves not only the decrease of P450 before exposure but also the preservation of AD activity during exposure, which result in reduced interaction between P450 and halothane in the microsomes.
Keywords
ハロタン
肝障害
亜鉛
チトクロームP450
Note
原著
Published Date
1995-10-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume107
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
205
End Page
217
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/107/9-10/107_9-10_205/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma