ID | 40623 |
FullText URL | |
Title Alternative | Acetylcholine turnover on the experimental epileptic focus of the rat cerebral cortex
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Author |
Kawakami, Yunosuke
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Abstract | The effect of iron ion injection on acetylcholine (ACh) turnover was studied in the cerebral cortex of male Sprague-Dawley rats. Rats were divided into 3 groups: rats of the Fe-group were injected with 500 nmol of Fe(3+) in the left sensorimotor cortex, rats of the HCl-group were injected with HCl-acidified saline (pH 1.8) in the left sensorimotor cortex, and a shamoperated group acted as a control (Sham-group).
On both sides of the cortex, the choline acetyltransferase (CAT) activity of the HCI- and Fe-groups decreased 30 min after, increased 6h after, and then decreased 24h after the injection compared with the activity of the Sham-group. A no time was there any difference between the CAT activities of the HCl- and Fe-groups. On both sides of the cortex, the ACh content of the HCl- and Fe-groups decreased transiently 24h after injection, but there was no difference in ACh content between the two groups. In the left cortex of the Fe- and HCl-groups, acetylcholinesterase (AChE) activity, which showed no difference between the two groups, decreased 30 min after injection.
These findings suggested that cortical neurons especially AChergic neurons might be irritated by a transient increase in intracranial pressure due to brain edema induced by the injection of acid into the cortex, as no specific effct of Fe(3+)-injection was observed in this study.
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Keywords | acetylcholine turnover
head injury
choline acetyltransferase
cholinesterase
brain edema
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Published Date | 1990-04
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume102
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Issue | issue3-4
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 453
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End Page | 463
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/102/3-4/102_3-4_453/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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