検索結果 - 岡山大学学術成果リポジトリ

Preparation of Absorption-Resistant Hard Tissue Using Dental Pulp-Derived Cells and Honeycomb Tricalcium Phosphate

フルテキストURL	fulltext.pdf
著者	Takabatake, Kiyofumi\| Nakano, Keisuke\| Kawai, Hotaka\| Inada, Yasunori\| Sukegawa, Shintaro\| Shan, Qiusheng\| Fushimi, Shigeko\| Tsujigiwa, Hidetsugu\| Nagatsuka, Hitoshi\|
キーワード	dental pulp mesenchymal stem cells honeycomb TCP matrix formation dentin formation osteodentin
発行日	2021-06-20
出版物タイトル	Materials
巻	14巻
号	12号
出版者	MDPI
開始ページ	3409
ISSN	1996-1944
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34202970
DOI	10.3390/ma14123409
Web of Science KeyUT	000666508000001
関連URL	isVersionOf https://doi.org/10.3390/ma14123409

Exosome-Based Molecular Transfer Activity of Macrophage-Like Cells Involves Viability of Oral Carcinoma Cells: Size Exclusion Chromatography and Concentration Filter Method

フルテキストURL	fulltext.pdf
著者	Lu, Yanyin\| Eguchi, Takanori\| Sogawa, Chiharu\| Taha, Eman A.\| Tran, Manh Tien\| Nara, Toshiki\| Wei, Penggong\| Fukuoka, Shiro\| Miyawaki, Takuya\| Okamoto, Kuniaki\|
キーワード	macrophage exosomes extracellular vesicles molecular transfer size exclusion chromatography and concentration filter (SEC-CF) method heat shock proteins oral carcinoma
発行日	2021-05-27
出版物タイトル	Cells
巻	10巻
号	6号
出版者	MDPI
開始ページ	1328
ISSN	2073-4409
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34071980
DOI	10.3390/cells10061328
Web of Science KeyUT	000665278700001
関連URL	isVersionOf https://doi.org/10.3390/cells10061328

The Fungal Metabolite (+)-Terrein Abrogates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-kappa B Ligand-Induced Osteoclastogenesis by Suppressing Protein Kinase-C alpha/beta II Phosphorylation

フルテキストURL	fulltext.pdf
著者	Sakaida, Kyosuke\| Omori, Kazuhiro\| Nakayama, Masaaki\| Mandai, Hiroki\| Nakagawa, Saki\| Sako, Hidefumi\| Kamei, Chiaki\| Yamamoto, Satoshi\| Kobayashi, Hiroya\| Ishii, Satoki\| Ono, Mitsuaki\| Ibaragi, Soichiro\| Yamashiro, Keisuke\| Yamamoto, Tadashi\| Suga, Seiji\| Takashiba, Shogo\|
キーワード	(+)-terrein ovariectomy osteoporosis RANKL PKC
発行日	2021-06-08
出版物タイトル	Frontiers In Pharmacology
巻	12巻
出版者	Frontiers Media SA
開始ページ	674366
ISSN	1663-9812
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Sakaida, Omori, Nakayama, Mandai, Nakagawa, Sako, Kamei, Yamamoto, Kobayashi, Ishii, Ono, Ibaragi, Yamashiro, Yamamoto, Suga and Takashiba.
論文のバージョン	publisher
PubMed ID	34168561
DOI	10.3389/fphar.2021.674366
Web of Science KeyUT	000664090900001
関連URL	isVersionOf https://doi.org/10.3389/fphar.2021.674366

Osteopontin silencing attenuates bleomycin-induced murine pulmonary fibrosis by regulating epithelial-mesenchymal transition

フルテキストURL	fulltext.pdf
著者	Hatipoglu, Omer Faruk\| Uctepe, Eyyup\| Opoku, Gabriel\| Wake, Hidenori\| Ikemura, Kentaro\| Ohtsuki, Takashi\| Inagaki, Junko\| Gunduz, Mehmet\| Gunduz, Esra\| Watanabe, Shogo\| Nishinaka, Takashi\| Takahashi, Hideo\| Hirohata, Satoshi\|
キーワード	Pulmonary fibrosis Osteopontin Epithelial-mesenchymal transition
発行日	2021-07
出版物タイトル	Biomedicine & Pharmacotherapy
巻	139巻
出版者	Elsevier France-Editions Scientifiques Medicales e
開始ページ	111633
ISSN	0753-3322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s).
論文のバージョン	publisher
DOI	10.1016/j.biopha.2021.111633
Web of Science KeyUT	000663683300007
関連URL	isVersionOf https://doi.org/10.1016/j.biopha.2021.111633

Disseminated gonococcal infection in a Japanese man with complement 7 deficiency with compound heterozygous variants A case report

フルテキストURL	fulltext.pdf
著者	Kageyama, Misaki\| Hagiya, Hideharu\| Ueda, Yasutaka\| Ohtani, Katsuki\| Fukumori, Yasuo\| Inoue, Norimitsu\| Wakamiya, Nobutaka\| Yoneda, Nanoka\| Kimura, Keigo\| Nagasawa, Motonori\| Nakagami, Futoshi\| Nishi, Isao\| Sugimoto, Ken\| Rakugi, Hiromi\|
キーワード	complement addition test complement deficiency disseminated gonococcal infection genome analysis Neisseria gonorrhoeae sexually transmitted infection
発行日	2021-04-02
出版物タイトル	Medicine
巻	100巻
号	13号
出版者	LIPPINCOTT WILLIAMS & WILKINS
開始ページ	e25265
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 the Author(s).
論文のバージョン	publisher
PubMed ID	33787610
DOI	10.1097/MD.0000000000025265
NAID	120007098535
Web of Science KeyUT	000658960700045
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000025265

Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress

フルテキストURL	fulltext20210629-1.pdf
著者	Wang, Chen\| Chen, Jian\| Wang, Mengxue\| Naruse, Keiji\| Takahashi, Ken\|
発行日	2021-8-20
出版物タイトル	Biochemical and Biophysical Research Communications
巻	566巻
出版者	Elsevier BV
開始ページ	190
終了ページ	196
ISSN	0006-291X
NCID	AA00564395
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s)
論文のバージョン	publisher
PubMed ID	34144257
DOI	10.1016/j.bbrc.2021.03.077
Web of Science KeyUT	000662063200001
関連URL	isVersionOf https://doi.org/10.1016/j.bbrc.2021.03.077

Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression

フルテキストURL	fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
著者	Sugiu, Kazuhisa\| Tazawa, Hiroshi\| Hasei, Joe\| Yamakawa, Yasuaki\| Omori, Toshinori\| Komatsubara, Tadashi\| Mochizuki, Yusuke\| Kondo, Hiroya\| Osaki, Shuhei\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kunisada, Toshiyuki\| Ueda, Koji\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
キーワード	Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
備考	This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5\|
発行日	2021-6-10
出版物タイトル	Cancer Chemotherapy and Pharmacology
巻	88巻
号	3号
出版者	Springer Science and Business Media LLC
開始ページ	513
終了ページ	524
ISSN	0344-5704
NCID	AA00598397
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	34114067
DOI	10.1007/s00280-021-04310-5
Web of Science KeyUT	000659839700002
関連URL	isVersionOf https://doi.org/10.1007/s00280-021-04310-5

Fibril Growth Behavior of Amyloid beta on Polymer-Based Planar Membranes: Implications for the Entanglement and Hydration of Polymers

フルテキストURL	fulltext.pdf
著者	Shimanouchi, Toshinori\| Iwamura, Miki\| Deguchi, Shintaro\| Kimura, Yukitaka\|
キーワード	biocompatible polymer amyloid fibril amyloid beta nucleation quartz crystal microbalance hydration entanglement hydration
発行日	2021-05-13
出版物タイトル	Applied Sciences-Basel
巻	11巻
号	10号
出版者	MDPI
開始ページ	4408
ISSN	2076-3417
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
DOI	10.3390/app11104408
NAID	120007098537
Web of Science KeyUT	000662593800001
関連URL	isVersionOf https://doi.org/10.3390/app11104408

[18F]FDG-labelled stem cell PET imaging in different route of administrations and multiple animal species

フルテキストURL	fulltext.pdf
著者	Nose, Naoko\| Nogami, Suguru\| Koshino, Kazuhiro\| Chen, Xinyu\| Werner, Rudolf A.\| Kashima, Soki\| Rowe, Steven P.\| Lapa, Constantin\| Fukuchi, Kazuki\| Higuchi, Takahiro\|
発行日	2021-05-25
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	NATURE RESEARCH
開始ページ	10896
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34035416
DOI	10.1038/s41598-021-90383-4
NAID	120007098536
Web of Science KeyUT	000659135700025
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-90383-4

Evaluation of the Water Shielding Performance of a Capillary Barrier System through a Small-Scale Model Test

フルテキストURL	fulltext.pdf
著者	Kim, Byeong-Su\|
キーワード	small-scale capillary barrier lateral no-flow condition diversion length water-shielding water retention characteristics
発行日	2021-06-04
出版物タイトル	Applied Sciences-Basel
巻	11巻
号	11号
出版者	MDPI
開始ページ	5231
ISSN	2076-3417
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the author.
論文のバージョン	publisher
DOI	10.3390/app11115231
NAID	120007089819
Web of Science KeyUT	000659611300001
関連URL	isVersionOf https://doi.org/10.3390/app11115231

The effect of Humanitude care methodology on improving empathy: a six-year longitudinal study of medical students in Japan

フルテキストURL	fulltext.pdf
著者	Fukuyasu, Yusuke\| Kataoka, Hitomi U.\| Honda, Miwako\| Iwase, Toshihide\| Ogawa, Hiroko\| Sato, Masaru\| Watanabe, Mayu\| Fujii, Chikako\| Wada, Jun\| DeSantis, Jennifer\| Hojat, Mohammadreza\| Gonnella, Joseph S.\|
キーワード	Empathy Humanitude Medical education
発行日	2021-06-04
出版物タイトル	BMC Medical Education
巻	21巻
号	1号
出版者	BMC
開始ページ	316
ISSN	1472-6920
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2021
論文のバージョン	publisher
PubMed ID	34088308
DOI	10.1186/s12909-021-02773-x
NAID	120007089818
Web of Science KeyUT	000660873600001
関連URL	isVersionOf https://doi.org/10.1186/s12909-021-02773-x

Leucine-rich alpha-2 glycoprotein as a marker of mucosal healing in inflammatory bowel disease

フルテキストURL	fulltext.pdf
著者	Yasutomi, Eriko\| Inokuchi, Toshihiro\| Hiraoka, Sakiko\| Takei, Kensuke\| Igawa, Shoko\| Yamamoto, Shumpei\| Ohmori, Masayasu\| Oka, Shohei\| Yamasaki, Yasushi\| Kinugasa, Hideaki\| Takahara, Masahiro\| Harada, Keita\| Furukawa, Masaki\| Itoshima, Kouichi\| Okada, Ken\| Otsuka, Fumio\| Tanaka, Takehiro\| Mitsuhashi, Toshiharu\| Kato, Jun\| Okada, Hiroyuki\|
発行日	2021-05-27
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	11086
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34045529
DOI	10.1038/s41598-021-90441-x
NAID	120007089817
Web of Science KeyUT	000658389400001
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-90441-x

Prostate Cancer Detected by Choroidal Tumor and Complete Response to Hormonal Therapy: Case Report and Literature Review of 24 Patients With Choroidal Metastasis From Prostate Cancer

フルテキストURL	fulltext20210625-1.pdf
著者	Matsuo, Toshihiko\| Tanaka, Takehiro\| Nakamura, Aya\| Wada, Koichiro\|
キーワード	prostate cancer choroidal/uveal tumor choroidal/uveal metastasis radiation surgical castration complete remission hormonal therapy literature review prostate-specific antigen PSA positron emission tomography PET
発行日	2021-06-23
出版物タイトル	Journal of Investigative Medicine High Impact Case Reports
巻	8巻
出版者	American Federation for Medical Research
開始ページ	1
終了ページ	8
ISSN	2324-7096
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 American Federation for Medical Research
論文のバージョン	publisher
PubMed ID	34159819
DOI	10.1177/23247096211026471
NAID	120007089816
関連URL	isVersionOf https://doi.org/10.1177/23247096211026471

A Case of Metastatic Fumarate Hydratase-Deficient–like Renal Cell Carcinoma Successfully Managed by Ipilimumab plus Nivolumab

JaLCDOI	10.18926/AMO/62237
フルテキストURL	75_3_397.pdf
著者	Sekito, Takanori\| Takamoto, Atsushi\| Kobayashi, Yasuyuki\| Mitsui, Masao\| Watari, Shogo\| Kubota, Risa\| Sadahira, Takuya\| Iwata, Takehiro\| Nishimura, Shingo\| Edamura, Kohei\| Sako, Tomoko\| Araki, Motoo\| Watanabe, Masami\| Watanabe, Toyohiko\| Shibata, Rei\| Ennishi, Daisuke\| Nasu, Yasutomo\|
抄録	We report a 62-year-old male with metastatic fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) without fumarate hydratase (FH) mutation (FH-deficient–like RCC). The International Metastatic RCC Database Consortium risk score was intermediate, and immunotherapy with nivolumab and ipilimumab (Ipi/ Nivo) was initiated. Four cycles of Ipi/Nivo and 5 cycles of nivolumab resulted in a complete response of the metastases. Hypophysitis occurred as an immune-related adverse event after four cycles of Ipi/Nivo. The prognosis of patients with FH-deficient RCC is generally poor. Few reports of FH-deficient RCC successfully treated with Ipi/Nivo have been published. Ipi/Nivo can be effective for treating FH-deficient RCC.
キーワード	fumarate hydratase fumarate hydratase-deficient renal cell carcinoma renal cell carcinoma ipilimumab nivolumab
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	397
終了ページ	402
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176946
Web of Science KeyUT	000667147700017
NAID	120007089822

Embedding of Epiretinal Proliferation for a Secondary Lamellar Macular Hole 12 Years after Rhegmatogenous Retinal Detachment Repair

JaLCDOI	10.18926/AMO/62236
フルテキストURL	75_3_391.pdf
著者	Fujiwara, Miyuki\| Kimura, Shuhei\| Morizane Hosokawa, Mio\| Shiode, Yusuke\| Doi, Shinichiro\| Takahashi, Kosuke\| Matoba, Ryo\| Kanzaki, Yuki \| Morizane, Yuki\|
抄録	A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair.
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	391
終了ページ	395
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176945
Web of Science KeyUT	000667147700016
NAID	120007089821

Successful Surgical Management of Acute Appendicitis in a Centenarian

JaLCDOI	10.18926/AMO/62235
フルテキストURL	75_3_385.pdf
著者	Okita, Atsushi\| Fujimura, Masaki\| Sato, Isao\| Chino, Yoshihide\| Yuba, Takafumi\| Mizutani, Makoto\| Tabata, Tomotake\| Iida, Minoru\| Kumano, Kimitsuka\|
Amo Type	Case Report
備考	We report an extremely rare case of a centenarian with acute appendicitis that was successfully managed via emergent surgery. A 109-year-old woman was referred to Daiichi Towakai Hospital with a high fever and nausea. She presented with peritoneal irritation, and computed tomography showed a swollen appendix with intraluminal fecolith. She was diagnosed with acute appendicitis and underwent appendectomy, which was performed via an open approach under spinal anesthesia. The patient’s postoperative course was uneventful. As for treatment planning for centenarians, comprehensive and exhaustive discussions with the patient and family members should be encouraged under the principals of narrative medicine.\|
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	385
終了ページ	389
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176944
Web of Science KeyUT	000667147700015
NAID	120007089820

Presence of Microplastics in Four Types of Shellfish Purchased at Fish Markets in Okayama City, Japan

JaLCDOI	10.18926/AMO/62234
フルテキストURL	75_3_381.pdf
著者	Yamamoto, Ken-ichi\| Oshiki, Toshiyuki\| Kagawa, Hiroko\| Namba, Masayoshi\| Sakaguchi, Masakiyo\|
抄録	The worldwide microplastic pollution in our environment is a matter of great concern. Harmful effects of plastics have been reported in various types of organisms including murine animals. We examined the presence of microplastics in four types of shellfish purchased from fish markets in Okayama, Japan and served to the public: short-neck clam (Ruditapes philippinarum, asari in Japanese), hard-shell clam (Meretrix lusoria, hamaguri), brackishwater clam (Cyrenidae, shijimi), and oyster (Crassostrea gigas, kaki). Our analyses demonstrated that approx. 3 pieces of microplastics were present per single shellfish, based on the division of the total number of pieces of microplastic obtained from all 4 types of shellfish by the total number of shellfish examined. Since health problems in humans due to microplastics have not yet been confirmed, further examinations of the effects of ingested microplastics are needed.
キーワード	microplastics, shellfish Japan health effect pollution
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	381
終了ページ	384
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176943
Web of Science KeyUT	000667147700014
NAID	120007089831

Relationships among Bone Metabolic Markers, Body Fat Composition and Carotid Intima–Media Thickness in Premenopausal Obese Women

JaLCDOI	10.18926/AMO/62233
フルテキストURL	75_3_373.pdf
著者	Yaylali, Guzin F.\| Dedeoglu, Ozen \| Topsakal, Senay\| Herek, Duygu\| Senol, Hande\|
抄録	Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=−0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis.
キーワード	body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	373
終了ページ	379
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176942
Web of Science KeyUT	000667147700013
NAID	120007089830

Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia

JaLCDOI	10.18926/AMO/62232
フルテキストURL	75_3_363.pdf
著者	Tanioka, Nohito\| Shimizu, Hiroko\| Omori, Emiko\| Takahashi, Toru\| Yamaoka, Masakazu\| Morimatsu, Hiroshi\|
抄録	Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver.
キーワード	heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	363
終了ページ	372
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176941
Web of Science KeyUT	000667147700012
NAID	120007089829

Optimizing the timing of 3.6 mg Pegfilgrastim Administration for Dose-Dense Chemotherapy in Japanese Patients with Breast Cancer

JaLCDOI	10.18926/AMO/62231
フルテキストURL	75_3_357.pdf
著者	Takabatake, Daisuke\| Kajiwara, Yukiko\| Ohtani, Shoichiro\| Suzuki, Yoko\| Yamamoto, Mari\| Kubo, Shinichiro\| Ikeda, Masahiko\| Takahashi, Mina\| Hara, Fumikata\| Aogi, Kenjiro\| Ohsumi, Shozo\| Ogasawara, Yutaka\| Nishiyama, Yoshitaka\| Hikino, Hajime\| Matsuoka, Kinya\| Shien, Tadahiko\| Taira, Naruto\| Doihara, Hiroyoshi\|
抄録	Perioperative dose-dense chemotherapy (DDCT) with pegfilgrastim (Peg) prophylaxis is a standard treatment for high-risk breast cancer. We explored the optimal timing of administration of 3.6 mg Peg, the dose approved in Japan. In the phase II feasibility study of DDCT (adriamycin+cyclophosphamide or epirubicin+cyclophosphamide followed by paclitaxel) for breast cancer, we investigated the feasibility, safety, neutrophil transition, and optimal timing of Peg treatment by administering Peg at days 2, 3, and 4 post-chemotherapy (P2, P3, and P4 groups, respectively). Among the 52 women enrolled, 13 were aged > 60 years. The anthracycline sequence was administered to P2 (n=33), P3 (n=5), and P4 (n=14) patients, and the taxane sequence to P2 (n=38) and P3 (n=6) patients. Both sequences showed no interaction between Peg administration timing and treatment discontinuation, treatment delay, or dose reduction. However, the relative dose intensity (RDI) was significantly different among the groups. The neutrophil count transition differed significantly among the groups receiving the anthracycline sequence. However, the neutrophil count remained in the appropriate range for both sequences in the P2 group. The timing of Peg administration did not substantially affect the feasibility or safety of DDCT. Postoperative day 2 might be the optimal timing for DDCT.
キーワード	dose-dense chemotherapy breast cancer pegfilgrastim
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	357
終了ページ	362
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176940
Web of Science KeyUT	000667147700011
NAID	120007089828