検索結果 47501 件
| JaLCDOI | 10.18926/AMO/60808 |
|---|---|
| フルテキストURL | 74_5_455.pdf |
| 著者 | Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Kanetaka, Kengo| Nagayasu, Takeshi| Eguchi, Susumu| |
| 抄録 | Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients’ records until 3 weeks after the fourth docetaxel administration. This study’s results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients. |
| キーワード | breast cancer docetaxel neuropathy compression |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 455 |
| 終了ページ | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106704 |
| Web of Science KeyUT | 000581970100013 |
| NAID | 120006892934 |
| JaLCDOI | 10.18926/AMO/60807 |
|---|---|
| フルテキストURL | 74_5_449.pdf |
| 著者 | Tsuchiya, Junpei| Kondo, Naoki| Fujimoto, Atsushi| Kondo, Rie| Yamada, Masahiko| Kuraishi, Tatsuya| Yoda, Takuya| Abe, Riichiro| Endo, Naoto| |
| 抄録 | We report a case of psoriatic arthritis where oligoarthritis preceded the skin lesions. A 57-year-old man complained of left third-finger pain. Laboratory examinations were negative for anti-cyclic citrullinated peptide antibodies and rheumatoid factor; he was treated for suspected rheumatoid arthritis. Six years later, X-ray revealed enthesitis of his fingers and wrist joint. At 9.5 years after the initial visit, skin lesions appeared in the left auricular region and buttock and dermatopathology findings indicated psoriasis vulgaris. The final diagnosis was psoriatic arthritis. In cases of seronegative oligoarthritis, psoriatic arthritis must be considered because some patients demonstrate osteoarticular lesions preceding skin lesions. |
| キーワード | enthesitis psoriatic arthritis seronegative oligoarthritis classification criteria for psoriatic arthritis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 449 |
| 終了ページ | 453 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106703 |
| Web of Science KeyUT | 000581970100012 |
| NAID | 120006892933 |
| JaLCDOI | 10.18926/AMO/60806 |
|---|---|
| フルテキストURL | 74_5_443.pdf |
| 著者 | Sekito, Takanori| Araki, Motoo| Hiraki, Takao| Uka, Mayu| Komaki, Toshiyuki| Matsui, Yusuke| Iguchi, Toshihiro| Katayama, Satoshi| Yoshinaga, Kasumi| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Kubota, Risa| Sadahira, Takuya| Nishimura, Shingo| Wada, Koichiro| Takamoto, Atsushi| Edamura, Kohei| Sako, Tomoko| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Kanazawa, Susumu| Nasu, Yasutomo| |
| 抄録 | We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. |
| キーワード | laparoscopic cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma von Hippel-Lindau disease |
| Amo Type | Case Report |
| 備考 | Fig. 1B is replaced on Dec. 23, 2020.| |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 443 |
| 終了ページ | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106702 |
| Web of Science KeyUT | 000581970100011 |
| NAID | 120006892932 |
| JaLCDOI | 10.18926/AMO/60805 |
|---|---|
| フルテキストURL | 74_5_435.pdf |
| 著者 | Fujishita, Keigo| Oka, Satoshi| Kamei, Katsuhiko| Tani, Katsuma| Fujisawa, Yuka| Kitamura, Wataru| Machida, Takuya| Imai, Toshi| |
| 抄録 | A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring normal hematopoiesis is important in the treatment of fusariosis, HSCT might be considered for patients with persistent pancytopenia. |
| キーワード | disseminated fusariosis Fusarium fujikuroi species complex allogeneic hematopoietic stem cell transplantation acute myeloid leukemia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 435 |
| 終了ページ | 441 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106701 |
| Web of Science KeyUT | 000581970100010 |
| NAID | 120006892931 |
| JaLCDOI | 10.18926/AMO/60804 |
|---|---|
| フルテキストURL | 74_5_431.pdf |
| 著者 | Miura, Akihiro| Shien, Kazuhiko| Toji, Tomohiro| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi| |
| 抄録 | We encountered a rare case of thymic cyst accompanied by mediastinitis. A 39-year-old Japanese male presented with fever and chest pain. The chest CT revealed a mass composed of a lobular cystic lesion with inflammation, suggesting the onset of mediastinitis. A definitive histological diagnosis was not obtained, and we performed a thymectomy. Pathologically, the thymic cyst was accompanied by multiple cavities, mimicking thymic cysts, caused by the inflammatory abscess. The surrounding adipose tissue showed inflammatory cell infiltrations with chronic fibrosis. These findings indicate that clinicians should be aware that thymic cysts may cause severe mediastinitis. |
| キーワード | thymic cyst multilocular thymic cyst mediastinitis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 431 |
| 終了ページ | 433 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106700 |
| Web of Science KeyUT | 000581970100009 |
| NAID | 120006892930 |
| JaLCDOI | 10.18926/AMO/60803 |
|---|---|
| フルテキストURL | 74_5_427.pdf |
| 著者 | Hiraoka, Tomohiro| Senoo, Haruka| Yamazaki, Yuka| Suenobu, Kosaku| Tsukahara, Hirokazu| |
| 抄録 | Polydactyly is one of the most common foot congenital anomalies. It is often detected immediately after birth, but the diagnosis can sometimes be delayed if the symptoms are less evident. A 2-year-old girl with a complaint of recurrent bleeding from the right toenail was diagnosed with foot polydactyly. She underwent corrective surgery, and her family was satisfied with the outcome. Although the diagnosis of polydactyly may be difficult in cases with minor nail problems, further radiographic evaluation will be needed for the improvement of the patient’s quality of life. |
| キーワード | polydactyly hyperdactyly hexadactyly |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 427 |
| 終了ページ | 429 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106699 |
| Web of Science KeyUT | 000581970100008 |
| NAID | 120006892929 |
| JaLCDOI | 10.18926/AMO/60802 |
|---|---|
| フルテキストURL | 74_5_423.pdf |
| 著者 | Hirabae, Atsuko| Ichihara, Eiki| Sunami, Ryota| Ota, Moeko| Iwamoto, Yoshitaka| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| 抄録 | We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks. |
| キーワード | lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 423 |
| 終了ページ | 425 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106698 |
| Web of Science KeyUT | 000581970100007 |
| NAID | 120006892928 |
| JaLCDOI | 10.18926/AMO/60801 |
|---|---|
| フルテキストURL | 74_5_415.pdf |
| 著者 | Narihiro, Naomasa| Oita, Masataka| Takeda, Yoshihiro| |
| 抄録 | During radiation therapy, incident radiation oblique to the skin surface is high and may cause severe skin damage. Understanding the dose of radiation absorbed by the skin is important for predicting skin damage due to radiation. In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new equation in which the oblique surface dose can be calculated within the error range of −7.7-5.1%. |
| キーワード | optically stimulated luminescent dosimeter radiotherapy oblique surface dose high-energy X-ray therapy angular dependence |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 415 |
| 終了ページ | 422 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106697 |
| Web of Science KeyUT | 000581970100006 |
| NAID | 120006892927 |
| JaLCDOI | 10.18926/AMO/60800 |
|---|---|
| フルテキストURL | 74_5_407.pdf |
| 著者 | Togo, Masaaki| Akazawa, Yuko| Akashi, Taro| Yamashita, Rika| Yoshitomi, Izumi| Ohba, Kazuo| Hashimoto, Satsuki| Iwashita, Hiroko| Kurogi, Tadafumi| Osada, Yukiko| Wada, Noriko| Imamura, Yoshifumi| Hashiguchi, Keiichi| Yamaguchi, Naoyuki| Kondo, Hisayoshi| Nakao, Kazuhiko| |
| 抄録 | Endoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data were available for analysis, 5 (8.3%) experienced pneumonia confirmed either by chest radiography or computed tomography. Although no difference in the rate of pneumonia was found between the control and oral care groups, the post-oral care bacteria count was significantly higher in the saliva of patients who developed pneumonia compared to those without pneumonia. In addition, the presence of vascular brain diseases and the dose of meperidine were also significantly associated with the occurrence of pneumonia. These results suggest that the number of oral bacteria as well as pre-existing vascular brain diseases and high-dose narcotics can affect the incidence of post-ESD pneumonia. |
| キーワード | endoscopy oral bacteria respiratory disease pneumonia sedation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 407 |
| 終了ページ | 413 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106696 |
| Web of Science KeyUT | 000581970100005 |
| NAID | 120006892926 |
| JaLCDOI | 10.18926/AMO/60799 |
|---|---|
| フルテキストURL | 74_5_401.pdf |
| 著者 | Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| |
| 抄録 | Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC. |
| キーワード | differentiated thyroid carcinoma juvenile children |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 401 |
| 終了ページ | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106695 |
| Web of Science KeyUT | 000581970100004 |
| NAID | 120006892925 |
| JaLCDOI | 10.18926/AMO/60798 |
|---|---|
| フルテキストURL | 74_5_391.pdf |
| 著者 | Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakaif, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Shimada, Hayato| Dohmae, Yoichiro| Endo, Naoto| |
| 抄録 | Indexes for objectively evaluating abnormal gait in hip osteoarthritis (OA) patients and determining effective interventions are unclear. We analyzed the abnormal gait of hip OA patients by focusing on movements of the trunk and pelvis to establish an effective evaluation index for each direction of motion. We studied 28 patients with secondary hip OA due to developmental dysplasia of the hip and 16 controls. The trunk and pelvic movements during gait were measured in the medial-lateral (x), vertical (y), and back-and-forth (z) directions by a triaxial angular accelerometer. Gait speed, steps, step length, muscle strength, range of motion, and timed up-and-go (TUG) test performance were measured. We determined the correlations between physical function and the index of abnormal gait in the hip OA patients. Movements other than trunk and pelvic motions in the y-direction indicated abnormal gait in the patients. Significant correlations were found between abnormal gait and range of motions (extension, internal rotation), TUG score, stride length, and steps. The TUG test, stride length and steps were important for evaluating abnormal gait in hip OA patients. Individual interventions for each movement direction are required. |
| キーワード | hip osteoarthritis three-dimensional gait analysis abnormal gait timed up and go test range of motion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 391 |
| 終了ページ | 399 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106694 |
| Web of Science KeyUT | 000581970100003 |
| NAID | 120006892924 |
| JaLCDOI | 10.18926/AMO/60797 |
|---|---|
| フルテキストURL | 74_5_381.pdf |
| 著者 | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
| 抄録 | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
| キーワード | hormones hyperprolactinemia inflammation pituitary prolactin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 381 |
| 終了ページ | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106693 |
| Web of Science KeyUT | 000581970100002 |
| NAID | 120006892923 |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| フルテキストURL | 74_5_371.pdf |
| 著者 | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| 抄録 | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| キーワード | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 371 |
| 終了ページ | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
| フルテキストURL | oer_052_2_contents_eng.pdf |
|---|---|
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2020-11-06 |
| 巻 | 52巻 |
| 号 | 2号 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2020 岡山大学経済学会 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/OER/60794 |
|---|---|
| タイトル（別表記） | Recent Trends in Currency Investment |
| フルテキストURL | oer_052_2_025_032.pdf |
| 著者 | 酒本 隆太| |
| 抄録 | This paper surveys the recent trends in currency investment. In particular, this paper focuses upon strategies which employ cross-sectional information across countries. First, I introduce a carry trade that is the most popular investment strategy. Next, I explain developments of momentum and value strategies. Then, the other strategies are classifi ed into two groups. The former group exploits macroeconomic information such external debts and output growth. The latter group employs information in fi nancial markets such as term spreads and cross-sectional spot exchange rate return correlations. Finally, I describe two future research directions. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2020-11-06 |
| 巻 | 52巻 |
| 号 | 2号 |
| 開始ページ | 25 |
| 終了ページ | 32 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2020 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006892921 |
| JaLCDOI | 10.18926/OER/60793 |
|---|---|
| フルテキストURL | oer_052_2_013_024.pdf |
| 著者 | 津守 貴之| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2020-11-06 |
| 巻 | 52巻 |
| 号 | 2号 |
| 開始ページ | 13 |
| 終了ページ | 24 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2020 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006892920 |
| JaLCDOI | 10.18926/OER/60792 |
|---|---|
| タイトル（別表記） | Input pricing under strategic delegation: Application of Cournot-Ikema curve |
| フルテキストURL | oer_052_2_001_011.pdf |
| 著者 | 大越 裕史| |
| 抄録 | Once a fi rm is vertically integrated, it is well-known that such a firm has an incentive to delegate quantity decision to its downstream affiliate to increase its total profits by manipulating its input price. This kind of analysis has been analytically done but this note applies Ikema's diagrammatic demonstration to the model with a vertically integrated fi rm to show how to derive the market equilibrium in "quantity-price" plane diagrammatically. First, we derive the locus that firms' optimal supplies at any price level, which is called "Cournot-Ikema curve" and derive the equilibrium point which is identifi ed with the intersection of a demand curve and the Cournot-Ikema curve. This paper fi nds that strategic delegation rotates the curve clockwise with a fixed point at a price level equal to marginal cost. Finally, our model is extended to the case that a multinational enterprise manipulates transfer price, and shows that such a tax motivated transfer price further rotates the curve. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2020-11-06 |
| 巻 | 52巻 |
| 号 | 2号 |
| 開始ページ | 1 |
| 終了ページ | 11 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2020 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006892919 |
| フルテキストURL | oer_052_2_contents.pdf |
|---|---|
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2020-11-06 |
| 巻 | 52巻 |
| 号 | 2号 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2020 岡山大学経済学会 |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Adachi, Yuji| Koga, Kenichiro| |
| 備考 | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Yuji Adachi and Kenichiro Koga Structure and phase behavior of highdensity ice from molecular-dynamics simulations with the ReaxFF potential. J. Chem. Phys. 153, 114501 (2020) and may be found at https://doi.org/10.1063/5.0016565.| |
| 発行日 | 2020-09-16 |
| 出版物タイトル | Journal of Chemical Physics |
| 巻 | 153巻 |
| 号 | 11号 |
| 出版者 | American Institute of Physics |
| 開始ページ | 114501 |
| ISSN | 0021-9606 |
| NCID | AA00694991 |
| 資料タイプ | 学術雑誌論文 |
| 著作権者 | © 2020 Author(s) |
| 論文のバージョン | publisher |
| PubMed ID | 32962394 |
| DOI | 10.1063/5.0016565 |
| Web of Science KeyUT | 000574657400001 |
| 関連URL | isVersionOf https://doi.org/10.1063/5.0016565 |
| 著者 | Kodama, Hiroyuki| Okazaki, Shingo| Jiang, Yifan| Yoden, Hiroyuki| Ohashi, Kazuhito| |
|---|---|
| キーワード | Carbon fiber reinforced plastic (CFRP) Grinding Grinding heat Heat-affected layer Heat condition analysis |
| 発行日 | 2020-09 |
| 出版物タイトル | Precision Engineering |
| 巻 | 65巻 |
| 出版者 | Elsevier |
| 開始ページ | 53 |
| 終了ページ | 63 |
| ISSN | 0141-6359 |
| NCID | AA00363145 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.precisioneng.2020.04.005 |
| Web of Science KeyUT | 000573306600006 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.precisioneng.2020.04.005 |