検索結果 - 岡山大学学術成果リポジトリ

薬物代謝酵素の発現情報を活用した腎がん治療の個別適正化

タイトル（別表記）	Precision Medicine for Patients with Renal Cell Carcinoma Based on Drug-metabolizing Enzyme Expression Levels
フルテキストURL	fulltext.pdf
著者	松本准\|
キーワード	renal cell carcinoma (RCC) kidney CYP uridine diphosphate glucose (UDP)-glucuronosyltransferase metabolism
発行日	2025-01-01
出版物タイトル	YAKUGAKU ZASSHI
巻	145巻
号	1号
出版者	Pharmaceutical Society of Japan
開始ページ	7
終了ページ	14
ISSN	0031-6903
NCID	AN00284903
資料タイプ	学術雑誌論文
言語	日本語
OAI-PMH Set	岡山大学
著作権者	© 2025 公益社団法人日本薬学会
論文のバージョン	publisher
PubMed ID	39756928
DOI	10.1248/yakushi.24-00166
Web of Science KeyUT	001392549800002
関連URL	isVersionOf https://doi.org/10.1248/yakushi.24-00166

Association Between Change in Prognostic Nutritional Index During Neoadjuvant Therapy and Dental Occlusal Support in Patients with Esophageal Cancer Under Neoadjuvant Therapy: A Retrospective Longitudinal Pilot Study

フルテキストURL	fulltext.pdf
著者	Yamanaka-Kohno, Reiko\| Shirakawa, Yasuhiro\| Inoue-Minakuchi, Mami\| Yokoi, Aya\| Noma, Kazuhiro\| Tanabe, Shunsuke\| Maeda, Naoaki\| Fujiwara, Toshiyoshi\| Morita, Manabu\| Ekuni, Daisuke\|
キーワード	esophageal cancer prognostic factors nutrition neoadjuvant therapy dental occlusion
発行日	2024-11-26
出版物タイトル	Nutrients
巻	16巻
号	24号
出版者	MDPI
開始ページ	4383
ISSN	2072-6643
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	39771004
DOI	10.3390/nu16244383
Web of Science KeyUT	001385589500001
関連URL	isVersionOf https://doi.org/10.3390/nu16244383

Endoscopic and Histological Gastritis in University Students with Helicobacter pylori Infection

フルテキストURL	fulltext.pdf
著者	Okanoue, Shotaro\| Sakae, Hiroyuki\| Yokota, Kenji\| Tanaka, Takehiro\| Obayashi, Yuka\| Abe, Makoto\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Iwamuro, Masaya\| Kawano, Seiji\| Kawahara, Yoshiro\| Yanai, Hiroyuki\| Okada, Hiroyuki\|
キーワード	atrophic gastritis gastric cancer Helicobacter pylori young adults eradication
発行日	2024-11-01
出版物タイトル	Internal Medicine
巻	63巻
号	21号
出版者	Japanese Society of Internal Medicine
開始ページ	2875
終了ページ	2884
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Ⓒ 2024 The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	38432971
DOI	10.2169/internalmedicine.1851-23
Web of Science KeyUT	001361033600001
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.1851-23

Clinical and microbiological characteristics of high-level daptomycin-resistant Corynebacterium species: A systematic scoping review

著者	Fukushima, Shinnosuke\| Hagiya, Hideharu\| Gotoh, Kazuyoshi\| Tsuji, Shuma\| Iio, Koji\| Akazawa, Hidemasa\| Matsushita, Osamu\| Otsuka, Fumio\|
キーワード	Antimicrobial resistance Corynebacterium Daptomycin High-level daptomycin resistance pgsA2
備考	© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jan. 2026.\|
発行日	2024-12-03
出版物タイトル	Journal of Infection and Chemotherapy
巻	31巻
号	2号
出版者	Elsevier
開始ページ	102575
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
論文のバージョン	author
PubMed ID	39638285
DOI	10.1016/j.jiac.2024.12.004
Web of Science KeyUT	001416617600001
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2024.12.004

Human Papillomavirus vaccination awareness and uptake among healthcare students in Japan

著者	Shimbe, Madoka\| Otsuka, Yuki\| Hagiya, Hideharu\| Yamada, Yoichi\| Otsuka, Fumio\|
キーワード	Cervical cancer Human Papillomavirus Immunization Vaccine literacy
備考	© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jan. 2026.\|
発行日	2024-11-05
出版物タイトル	Journal of Infection and Chemotherapy
巻	31巻
号	2号
出版者	Elsevier
開始ページ	102554
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
論文のバージョン	author
PubMed ID	39510445
DOI	10.1016/j.jiac.2024.11.004
Web of Science KeyUT	001416618400001
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2024.11.004

Loss of Nr4a1 ameliorates endothelial cell injury and vascular leakage in lung transplantation from circulatory-death donor

フルテキストURL	fulltext.pdf
著者	Kawana, Shinichi\| Okazaki, Mikio\| Sakaue, Tomohisa\| Hashimoto, Kohei\| Nakata, Kentaro\| Choshi, Haruki\| Tanaka, Shin\| Miyoshi, Kentaroh\| Ohtani, Shinji\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Matsukawa, Akihiro\| Toyooka, Shinichi\|
キーワード	lung transplantation ischemia-reperfusion injury donation after circulatory death nuclear receptor subfamily 4 group A member 1 endothelial cell
発行日	2024-10-05
出版物タイトル	The Journal of Heart and Lung Transplantation
巻	44巻
号	2号
出版者	Elsevier
開始ページ	249
終了ページ	260
ISSN	1053-2498
NCID	AA10796579
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Authors.
論文のバージョン	publisher
PubMed ID	39369968
DOI	10.1016/j.healun.2024.09.028
Web of Science KeyUT	001416964100001
関連URL	isVersionOf https://doi.org/10.1016/j.healun.2024.09.028

Cryptococcal prostatitis in an immunocompromised patient with tocilizumab and glucocorticoid therapy: A case report

著者	Oguni, Kohei\| Fukushima, Shinnosuke\| Hagiya, Hideharu\| Kato, Atsushi\| Suyama, Atsuhito\| Iwata, Takehiro\| Miyawaki, Yoshia\| Ono, Sawako\| Iio, Koji\| Otsuka, Fumio\|
キーワード	Cryptococcosis Fluconazole Glucocorticoids Prostatitis Tocilizumab
備考	© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jan. 2026.\|
発行日	2025-01
出版物タイトル	Journal of Infection and Chemotherapy
巻	31巻
号	1号
出版者	Elsevier
開始ページ	102494
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
論文のバージョン	author
PubMed ID	39152054
DOI	10.1016/j.jiac.2024.08.009
Web of Science KeyUT	001419817400001
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2024.08.009

A nationwide longitudinal survey of infantile injury and its recurrence in Japan

フルテキストURL	fulltext.pdf
著者	Hiraoka, Tomohiro\| Obara, Takafumi\| Matsumoto, Naomi\| Tsukahara, Kohei\| Hongo, Takashi\| Nojima, Tsuyoshi\| Hisamura, Masaki\| Yumoto, Tetsuya\| Nakao, Atsunori\| Yorifuji, Takashi\| Naito, Hiromichi\|
キーワード	Retrospective cohort study Injury recurrence Injury prevention
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-76403-z\|
発行日	2024-10-21
出版物タイトル	Scientific Reports
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	24716
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	39433855
DOI	10.1038/s41598-024-76403-z
Web of Science KeyUT	001339991400047
関連URL	isVersionOf https://doi.org/10.1038/s41598-024-76403-z

Perioperative gum-chewing training prevents a decrease in tongue pressure after esophagectomy in thoracic esophageal cancer patients: a nonrandomized trial

フルテキストURL	fulltext.pdf
著者	Yamanaka-Kohno, Reiko\| Shirakawa, Yasuhiro\| Yokoi, Aya\| Maeda, Naoaki\| Tanabe, Shunsuke\| Noma, Kazuhiro\| Shimizu, Kazuyoshi\| Mituhashi, Toshiharu\| Nakamura, Yoshihide\| Nanba, Souto\| Uchida, Yurika\| Maruyama, Takayuki\| Morita, Manabu\| Ekuni, Daisuke\|
キーワード	Esophageal cancer Esophagectomy Gum-chewing training Tongue pressure Historical control Propensity score matching analysis
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-74090-4\|
発行日	2024-10-12
出版物タイトル	Scientific Reports
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	23886
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	39396079
DOI	10.1038/s41598-024-74090-4
Web of Science KeyUT	001336579100027
関連URL	isVersionOf https://doi.org/10.1038/s41598-024-74090-4

Rates and risk factors of bleeding after gastric endoscopic submucosal dissection with continuous warfarin or 1‐day withdrawal of direct oral anticoagulants

フルテキストURL	fulltext.pdf
著者	Hirata, Shoichiro\| Hamada, Kenta\| Iwamuro, Masaya\| Mouri, Hirokazu\| Miyahara, Koji\| Tsuzuki, Takao\| Yamauchi, Kenji\| Kobayashi, Sayo\| Takahashi, Sakuma\| Takenaka, Ryuta\| Hori, Shinichiro\| Inoue, Masafumi\| Toyokawa, Tatsuya\| Nishimura, Mamoru\| Ishiyama, Shuhei\| Miyaike, Jiro\| Kato, Ryo\| Matsubara, Minoru\| Yunoki, Naoko\| Kanzaki, Hiromitsu\| Kawahara, Yoshiro\| Okada, Hiroyuki\| Ishikawa, Hideki\| Otsuka, Motoyuki\| Okayama Gut Study Group\|
キーワード	direct oral anticoagulants endoscopic submucosal dissection gastric cancer postprocedural bleeding warfarin
発行日	2024-10-03
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	39巻
号	12号
出版者	Wiley
開始ページ	2760
終了ページ	2766
ISSN	0815-9319
NCID	AA10727383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Author(s).
論文のバージョン	publisher
PubMed ID	39363400
DOI	10.1111/jgh.16757
Web of Science KeyUT	001328472100001
関連URL	isVersionOf https://doi.org/10.1111/jgh.16757

Endoscopic Transpterygoid Repair of Sphenoid Sinus Meningocele: A Comprehensive Case Report and Literature Review

フルテキストURL	fulltext20240925-01.pdf table20240925-01.pdf fig1_20240925-01.pdf fig2_20240925-01.pdf fig3_20240925-01.pdf
著者	Shimizu, Aiko\| Makihara, Seiichiro\| Imoto, Ryoji\| Hirashita, Koji\| Ando, Mizuo\|
キーワード	Cerebrospinal fluid leakage Meningocele Transpterygoid approach Ipsilateral nasoseptal flap Bath-plug technique
備考	© 2024 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Aug. 2025.\|
発行日	2024-10
出版物タイトル	Auris Nasus Larynx
巻	51巻
号	5号
出版者	Elsevier BV
開始ページ	875
終了ページ	879
ISSN	0385-8146
NCID	AA00061157
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc.
論文のバージョン	author
PubMed ID	39163824
DOI	10.1016/j.anl.2024.08.003
Web of Science KeyUT	001313505100001
関連URL	isVersionOf https://doi.org/10.1016/j.anl.2024.08.003

Surface Pre-Reacted Glass-Ionomer Eluate Suppresses Osteoclastogenesis through Downregulation of the MAPK Signaling Pathway

フルテキストURL	fulltext.pdf
著者	Chandra, Janaki\| Nakamura, Shin\| Shindo, Satoru\| Leon, Elizabeth\| Castellon, Maria\| Pastore, Maria Rita\| Heidari, Alireza\| Witek, Lukasz\| Coelho, Paulo G.\| Nakatsuka, Toshiyuki\| Kawai, Toshihisa\|
キーワード	S-PRG osteoclast hydroxyapatite TRAP staining bioactive filler
発行日	2024-08-12
出版物タイトル	Biomedicines
巻	12巻
号	8号
出版者	MDPI
開始ページ	1835
ISSN	2227-9059
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	39200299
DOI	10.3390/biomedicines12081835
Web of Science KeyUT	001305892200001
関連URL	isVersionOf https://doi.org/10.3390/biomedicines12081835

Insomnia among patients with chronic pain A retrospective study

フルテキストURL	fulltext.pdf
著者	Ueda, Masataka\| Tetsunaga, Tomoko\| Tetsunaga, Tomonori\| Nishida, Keiichiro\| Takatori, Ryo\| Shitozawa, Hisakazu\| Uotani, Koji\| Shinohara, Kennsuke\| Oda, Yoshiaki\| Ozaki, Toshifumi\|
キーワード	AIS cognitive-behavioral therapy EQ5D HADS insomnia pain-liaison outpatient clinic sleep disorders
発行日	2024-08-09
出版物タイトル	Medicine
巻	103巻
号	32号
出版者	Lippincott, Williams & Wilkins
開始ページ	e39113
ISSN	0025-7974
NCID	AA00728867
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 the Author(s).
論文のバージョン	publisher
PubMed ID	39121265
DOI	10.1097/MD.0000000000039113
Web of Science KeyUT	001287977800045
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000039113

Long-term follow-up of a patient with Parkinson's disease under nursing care after replacement of fixed implant-supported prostheses with an implant overdenture: a case report

フルテキストURL	fulltext.pdf
著者	Tokumoto, Kana\| Mino, Takuya\| Tosa, Ikue\| Omori, Ko\| Yamamoto, Michiyo\| Takaoka, Kazuki\| Maekawa, Kenji\| Kuboki, Takuo\| Kishimoto, Hiromitsu\|
キーワード	Parkinson's disease Older people Implant overdenture Nursing homes Implant-related troubles Peri-implantitis
備考	The version of record of this article, first published in International Journal of Implant Dentistry, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40729-024-00557-8\|
発行日	2024-07-29
出版物タイトル	International Journal of Implant Dentistry
巻	10巻
号	1号
出版者	Springer
開始ページ	37
ISSN	2198-4034
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024.
論文のバージョン	publisher
PubMed ID	39073725
DOI	10.1186/s40729-024-00557-8
Web of Science KeyUT	001279622000001
関連URL	isVersionOf https://doi.org/10.1186/s40729-024-00557-8

Factors Associated with Differences in Physicians’ Attitudes toward Percutaneous Endoscopic Gastrostomy Feeding in Older Adults Receiving End-of-Life Care in Japan: A Cross-Sectional Study

フルテキストURL	fulltext.pdf
著者	Sakamoto, Yoko\| Mitsuhashi, Toshiharu\| Hotta, Katsuyuki\|
キーワード	attitude end-of-life care older persons decision making percutaneous endoscopic gastrostomy tube feeding
発行日	2024-07-08
出版物タイトル	Palliative Medicine Reports
巻	5巻
号	1号
出版者	Mary Ann Liebert
開始ページ	206
終了ページ	214
ISSN	2689-2820
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Yoko Sakamoto et al., 2024
論文のバージョン	publisher
DOI	10.1089/pmr.2023.0088
Web of Science KeyUT	001264185700001
関連URL	isVersionOf https://doi.org/10.1089/pmr.2023.0088

Thoughts on and Proposal for the Education, Training, and Recruitment of Infectious Disease Specialists

JaLCDOI	10.18926/AMO/67195
フルテキストURL	78_3_205.pdf
著者	Hagiya, Hideharu\|
抄録	The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists.
キーワード	antimicrobial resistance emerging infectious diseases infection prevention and control medical education silent pandemic
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	205
終了ページ	213
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902208
Web of Science KeyUT	001267351000001

The effectiveness of palliative middle meningeal artery embolization prior to craniotomy for large acute epidural hematoma: A case report

フルテキストURL	fulltext.pdf
著者	Hirata, Yuichi\| Takahashi, Yu\| Kuramoto, Satoshi\| Nishihiro, Shingo\| Ono, Yasuhiro\| Ichikawa, Tomotsugu\|
キーワード	Acute epidural hematoma Middle meningeal artery embolization Transcatheter arterial embolization
発行日	2024-05
出版物タイトル	International Journal of Surgery Case Reports
巻	118巻
出版者	Elsevier
開始ページ	109704
ISSN	2210-2612
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 The Author(s).
論文のバージョン	publisher
PubMed ID	38669807
DOI	10.1016/j.ijscr.2024.109704
Web of Science KeyUT	001235165400001
関連URL	isVersionOf https://doi.org/10.1016/j.ijscr.2024.109704

Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells

フルテキストURL	fulltext.pdf
著者	Gohara, Yuma\| Tomonobu, Nahoko\| Kinoshita, Rie\| Futami, Junichiro\| Audebert, Léna\| Chen, Youyi\| Komalasari, Ni Luh Gede Yoni\| Jiang, Fan\| Yoshizawa, Chikako\| Murata, Hitoshi\| Yamamoto, Ken-ichi\| Watanabe, Masami\| Kumon, Hiromi\| Sakaguchi, Masakiyo\|
キーワード	Breast cancer REIC/Dkk-3 PD-L1 Immune checkpoint Cancer therapy
備考	The version of record of this article, first published in Journal of Molecular Medicine, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00109-023-02292-w\|
発行日	2023-03-04
出版物タイトル	Journal of Molecular Medicine
巻	101巻
号	4号
出版者	Springer Science and Business Media LLC
開始ページ	431
終了ページ	447
ISSN	0946-2716
NCID	AA11034065
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	36869893
DOI	10.1007/s00109-023-02292-w
Web of Science KeyUT	000943221900001
関連URL	isVersionOf https://doi.org/10.1007/s00109-023-02292-w

Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study

JaLCDOI	10.18926/AMO/66927
フルテキストURL	78_2_185.pdf
著者	Takahashi, Hiroko\| Eguchi, Jun\| Watanabe, Mayu\| Nakayama, Masanori\| Wada, Jun\|
抄録	The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
キーワード	obesity type 2 diabetes COVID-19 vaccination
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	185
終了ページ	191
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688836
Web of Science KeyUT	001227932200002

p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression

JaLCDOI	10.18926/AMO/66924
フルテキストURL	78_2_151.pdf
著者	Komatsubara, Tadashi\| Tazawa, Hiroshi\| Hasei, Joe\| Omori, Toshinori\| Sugiu, Kazuhisa\| Mochizuki, Yusuke\| Demiya, Koji\| Yoshida, Aki\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
抄録	Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
キーワード	soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	151
終了ページ	161
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688833
Web of Science KeyUT	001229151800007