検索結果 199 件
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| フルテキストURL | 76_4_479.pdf |
| 著者 | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| 抄録 | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| キーワード | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 479 |
| 終了ページ | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63903 |
|---|---|
| フルテキストURL | 76_4_439.pdf |
| 著者 | Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi| |
| 抄録 | This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex. |
| キーワード | social capital post-traumatic stress disorder disaster flooding |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 446 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123159 |
| Web of Science KeyUT | 000882167300010 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Maruyama, Takayuki| Ekuni, Daisuke| Higuchi, Masakazu| Takayama, Eiji| Tokuno, Shinichi| Morita, Manabu| |
| キーワード | periodontitis psychological stress voice analysis prospective cohort study |
| 発行日 | 2022-08-02 |
| 出版物タイトル | International Journal Of Environmental Research |
| 巻 | 19巻 |
| 号 | 15号 |
| 出版者 | MDPI |
| 開始ページ | 9489 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35954845 |
| DOI | 10.3390/ijerph19159489 |
| Web of Science KeyUT | 000838914100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph19159489 |
| JaLCDOI | 10.18926/AMO/63745 |
|---|---|
| フルテキストURL | 76_3_339.pdf |
| 著者 | Yano, Akihiko| Sada, Ken-ei| Sawada, Tsutomu| Ito, Hideki| Yano, Hiroko| Ikeda, Tatsuya| |
| 抄録 | A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to papillary thyroid cancer ten years prior. Laboratory findings were as follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration and electrolyte supplementation with discontinuation of PPI. After discontinuing PPI, the patient’s serum magnesium, potassium, and calcium levels normalised with oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative complication of thyroidectomy. Careful monitoring of electrolyte levels is required in patients with long-term PPI treatment, especially in post-thyroidectomy cases. |
| キーワード | hypocalcaemia thyroidectomy proton pump inhibitors hypomagnesemia rhabdomyolysis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 339 |
| 終了ページ | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790366 |
| Web of Science KeyUT | 000823568300014 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Muzembo, Basilua Andre| Ntontolo, Ngangu Patrick| Ngatu, Nlandu Roger| Khatiwada, Januka| Suzuki, Tomoko| Wada, Koji| Kitahara, Kei| Ikeda, Shunya| Miyoshi, Shin-Ichi| |
| キーワード | Ebola knowledge attitudes practices beliefs misperceptions rumors sub-Saharan Africa |
| 発行日 | 2022-04-13 |
| 出版物タイトル | International Journal Of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 8号 |
| 出版者 | MDPI |
| 開始ページ | 4714 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35457585 |
| DOI | 10.3390/ijerph19084714 |
| Web of Science KeyUT | 000785094500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph19084714 |
| JaLCDOI | 10.18926/AMO/63414 |
|---|---|
| フルテキストURL | 76_2_195.pdf |
| 著者 | Inoue, Shinichiro| Maeda, Isseki| Ogawa, Asao| Yoshiuchi, Kazuhiro| Terada, Seishi| Yamada, Norihito| |
| 抄録 | The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event. |
| キーワード | delirium cancer perospirone risperidone |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 195 |
| 終了ページ | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503448 |
| Web of Science KeyUT | 000792291900002 |
| JaLCDOI | 10.18926/AMO/63407 |
|---|---|
| フルテキストURL | 76_2_137.pdf |
| 著者 | Tsukahara, Masaru| So, Ryuhei| Yada, Yuji| Kodama, Masafumi| Kishi, Yoshiki| Yamada, Norihito| |
| 抄録 | Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients. |
| キーワード | Asian clozapine schizophrenia smoking |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 143 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503441 |
| Web of Science KeyUT | 000792374900005 |
| JaLCDOI | 10.18926/AMO/63405 |
|---|---|
| フルテキストURL | 76_2_121.pdf |
| 著者 | Okazaki, Yuki| Furumatsu, Takayuki| Hiranaka, Takaaki| Kamatsuki, Yusuke| Nakata, Eiji| Tetsunaga, Tomonori| Yamane, Kentaro| Ozaki, Toshifumi| |
| 抄録 | Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK. |
| キーワード | medial meniscus posterior root tear subchondral insufficiency fracture bone marrow edema meniscus extrusion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 121 |
| 終了ページ | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503439 |
| Web of Science KeyUT | 000792374900003 |
| フルテキストURL | fulltext20220413-8.pdf figure20220413-8.pdf |
|---|---|
| 著者 | Bian, Zhihong| Liu, Xia| Feng, Tian| Yu, Haibo| Hu, Xiao| Hu, Xinran| Bian, Yuting| Sun, Hongming| Tadokoro, Koh| Takemoto, Mami| Yunoki, Taijun| Nakano, Yumiko| Fukui, Yusuke| Morihara, Ryuta| Abe, Koji| Yamashita, Toru| |
| キーワード | Alzheimer’s disease cerebral amyloid angiopathy chronic cerebral hypoperfusion rivaroxaban warfarin |
| 備考 | This is an Accepted Manuscript of an article published by IOS Press. available online: https://doi.org/10.3233/jad-215318| |
| 発行日 | 2022-3-8 |
| 出版物タイトル | Journal of Alzheimer's Disease |
| 巻 | 86巻 |
| 号 | 1号 |
| 出版者 | IOS Press |
| 開始ページ | 111 |
| 終了ページ | 123 |
| ISSN | 1387-2877 |
| NCID | AA11545428 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright ©2022 IOS Press All rights reserved. |
| 論文のバージョン | author |
| PubMed ID | 35001892 |
| DOI | 10.3233/jad-215318 |
| Web of Science KeyUT | 000768536700003 |
| 関連URL | isVersionOf https://doi.org/10.3233/jad-215318 |
| フルテキストURL | fulltext20220316-1.pdf table20220316-1.pdf figure1_20220316-1.pdf figure2_20220316-1.pdf |
|---|---|
| 著者 | Maruyama, Takayuki| Kobayashi, Terumasa| Sugiura, Yoshio| Yoneda, Toshiki| Ekuni, Daisuke| Morita, Manabu| |
| キーワード | experimental animal model microRNA mRNA obesity periodontitis |
| 備考 | This is the peer reviewed version of the following article: [Maruyama, T, Kobayashi, T, Sugiura, Y, Yoneda, T, Ekuni, D, Morita, M. Association between serum miRNAs and gingival gene expression in an obese rat model. J Periodont Res. 2022; 00: 1– 8. doi:10.1111/jre.12979], which has been published in final form at https://doi.org/10.1111/jre.12979. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext is available in Mar. 2023.| |
| 発行日 | 2022-3-2 |
| 出版物タイトル | Journal of Periodontal Research |
| 巻 | 57巻 |
| 号 | 3号 |
| 出版者 | Wiley |
| 開始ページ | 502 |
| 終了ページ | 509 |
| ISSN | 0022-3484 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| 論文のバージョン | author |
| PubMed ID | 35234284 |
| DOI | 10.1111/jre.12979 |
| Web of Science KeyUT | 000762837900001 |
| 関連URL | isVersionOf https://doi.org/10.1111/jre.12979 |
| タイトル（別表記） | HIV infection diagnosed from delayed wound healing after tonsillectomy : A case report |
|---|---|
| フルテキストURL | fulltext20220131-1.pdf |
| 著者 | 假谷 彰文| 石原 久司| 秋定 直樹| 藤澤 郁| 藤 さやか| 赤木 成子| 竹内 彩子| |
| キーワード | HIV（human immunodeficiency virus） 創傷治癒遅延 口蓋扁桃摘出術 手術合併症 性感染症 |
| 発行日 | 2021-01-20 |
| 出版物タイトル | 耳鼻と臨床 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | 耳鼻と臨床会 |
| 開始ページ | 26 |
| 終了ページ | 30 |
| ISSN | 04477227 |
| NCID | AN00107114 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| Web of Science KeyUT | 10.11334/jibi.67.1_26 |
| 関連URL | isVersionOf https://doi.org/10.11334/jibi.67.1_26 |
| フルテキストURL | fulltext20220106-3.pdf Int_Orthop_Figure P.pdf Fig2.pdf Fig3.pdf Tables20220106-3.pdf |
|---|---|
| 著者 | Hiranaka, Takaaki| Furumatsu, Takayuki| Masuda, Shin| Okazaki, Yoshiki| Okazaki, Yuki| Kodama, Yuya| Kamatsuki, Yusuke| Kajiki, Yuya| Zhang, Ximing| Ozaki, Toshifumi| |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00590-020-02647-w| This is an Accepted Manuscript published by Springer.| |
| 発行日 | 2020-3-10 |
| 出版物タイトル | European Journal of Orthopaedic Surgery & Traumatology |
| 巻 | 30巻 |
| 号 | 5号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 901 |
| 終了ページ | 908 |
| ISSN | 1633-8065 |
| NCID | AA11622799 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Springer-Verlag France SAS, part of Springer Nature 2020 |
| 論文のバージョン | author |
| PubMed ID | 32157399 |
| DOI | 10.1007/s00590-020-02647-w |
| Web of Science KeyUT | 000729760300019 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00590-020-02647-w |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanabe, Katsuyuki| Matsuoka-Uchiyama, Natsumi| Mifune, Tomoyo| Kawakita, Chieko| Sugiyama, Hitoshi| Wada, Jun| |
| キーワード | corticosteroid drug-induced interstitial nephritis eosinophils mycophenolate mofetil polypharmacy |
| 発行日 | 2021-12-17 |
| 出版物タイトル | Medicine |
| 巻 | 100巻 |
| 号 | 50号 |
| 出版者 | Lippincott Williams ＆ Wilkins |
| 開始ページ | e28252 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 34918693 |
| DOI | 10.1097/MD.0000000000028252 |
| Web of Science KeyUT | 000731129100044 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000028252 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishimura, Yoshito| Miyoshi, Tomoko| Sato, Asuka| Hasegawa, Kou| Hagiya, Hideharu| Kosaki, Yoshinori| Otsuka, Fumio| |
| キーワード | coronavirus disease 2019 (COVID-19) pandemic burnout prevention intention to leave |
| 発行日 | 2021-11-04 |
| 出版物タイトル | International Journal of Environmental Research and Public Health |
| 巻 | 18巻 |
| 号 | 21号 |
| 出版者 | MDPI |
| 開始ページ | 11581 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34770095 |
| DOI | 10.3390/ijerph182111581 |
| Web of Science KeyUT | 000719055900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph182111581 |
| JaLCDOI | 10.18926/AMO/62820 |
|---|---|
| フルテキストURL | 75_6_763.pdf |
| 著者 | Iwata, Takehiro| Sadahira, Takuya| Maruyama, Yuki| Sekito, Takanori| Yoshinaga, Kasumi| Watari, Shogo| Nagao, Kentaro| Kawada, Tatsushi| Tominaga, Yusuke| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Ishii, Ayano| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| Wada, Koichiro| |
| 抄録 | The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants. |
| キーワード | genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 763 |
| 終了ページ | 766 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955548 |
| Web of Science KeyUT | 000735319800006 |
| NAID | 120007180272 |
| JaLCDOI | 10.18926/AMO/62816 |
|---|---|
| フルテキストURL | 75_6_745.pdf |
| 著者 | Hayata, Kei| Mishima, Sakurako| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Ogawa, Chikako| Masuyama, Hisashi| |
| 抄録 | NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results. |
| キーワード | NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 745 |
| 終了ページ | 750 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955544 |
| Web of Science KeyUT | 000735319800002 |
| NAID | 120007180276 |
| JaLCDOI | 10.18926/AMO/62805 |
|---|---|
| フルテキストURL | 75_6_671.pdf |
| 著者 | Gao, Shangze| Nishibori, Masahiro| |
| 抄録 | Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many verte-brates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant and well-characterized protein having a multidomain structure that enable it to interact with many ligands, func-tion as an adaptor molecule, and participate in numerous physiological and pathological processes. As a plasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis and angiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plas-minogen) and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets). This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogen-esis in various pathological conditions. |
| キーワード | histidine-rich glycoprotein vascular biology coagulation angiogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 671 |
| 終了ページ | 675 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955533 |
| Web of Science KeyUT | 000735297900001 |
| NAID | 120007180287 |
| JaLCDOI | 10.18926/AMO/62782 |
|---|---|
| フルテキストURL | 75_5_663.pdf |
| 著者 | Sadahira, Takuya| Maruyama, Yuki| Hiyama, Yoshiki| Kitano, Hiroyuki| Yamada, Hiroki| Goto, Takayuki| Kondo, Tsubasa| Shigemura, Katsumi| Mitsui, Yosuke| Iwata, Takehiro| Edamura, Kohei| Araki, Motoo| Watanabe, Masami| Takenaka, Tadasu| Teishima, Jun| Miyata, Yasuyoshi| Ishikawa, Kiyohito| Takaoka, Ei-Ichiro| Miyazaki, Jun| Takahashi, Satoshi| Masumori, Naoya| Kiyota, Hiroshi| Fujisawa, Masato| Yamamoto, Shingo| Sakuma, Takafumi| Kusumi, Norihiro| Ichikawa, Takaharu| Watanabe, Toyohiko| Nasu, Yoshitsugu| Tsugawa, Masaya| Nasu, Yasutomo| Wada, Koichiro| |
| 抄録 | The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. |
| キーワード | antibiotic prophylaxis selective culture media prostate biopsy fluoroquinolone-resistant extended- spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 663 |
| 終了ページ | 667 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703052 |
| Web of Science KeyUT | 000711568400007 |
| NAID | 120007166667 |
| JaLCDOI | 10.18926/AMO/62775 |
|---|---|
| フルテキストURL | 75_5_625.pdf |
| 著者 | Iwamuro, Masaya| Yamasaki, Yasushi| Tanaka, Takehiro| Asada, Noboru| Matsuoka, Ken-ichi| Hiraoka, Sakiko| Kawahara, Yoshiro| Okada, Hiroyuki| |
| 抄録 | A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases. |
| キーワード | colorectal lymphoma follicular lymphoma diffuse large B-cell lymphoma histologic transformation |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 625 |
| 終了ページ | 629 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703045 |
| Web of Science KeyUT | 000711561300001 |
| NAID | 120007166675 |
| JaLCDOI | 10.18926/AMO/62405 |
|---|---|
| フルテキストURL | 75_4_517.pdf |
| 著者 | Ochi, Masahiko| Iida, Atsuyoshi| Takahashi, Yuka| Tanaka, Masamichi| Saito, Hironori| Naito, Hiromichi| Mikane, Takeshi| Fuke, Soichiro| |
| 抄録 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically mediated cardiomyopathy charac-terized by progressive myocardial loss of the right ventricle and its replacement by fibrofatty tissue, causing dyskinesia, aneurysm, and/or arrhythmia. The prevalence of ARVC is estimated to be 1 in 2,000-5,000, with the condition accounting for up to 20% of sudden cardiac deaths in individuals < 35 years old. This report describes the case of 61-year-old Japanese who was diagnosed with ARVC after cardiac arrest (CA) and successful resusci-tation. After the sudden CA, the restoration of spontaneous circulation was achieved with appropriate resusci-tation, followed by the introduction of target temperature management in the intensive care unit. He was diag-nosed with ARVC based on angiography and histology results. An ICD (implantable cardioverter-defibrillator) was implanted, and he was discharged without neurological sequelae 1 month post-CA. ARVC is an important cause of sudden CA, and successfully resuscitated patients with right ventricular dilation should undergo testing to rule out ARVC. |
| キーワード | inverted T-wave right ventricular dilatation sudden cardiac arrest sudden cardiac death |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 517 |
| 終了ページ | 521 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511620 |
| Web of Science KeyUT | 000709282300006 |
| NAID | 120007146031 |