検索結果 25209 件
| JaLCDOI | 10.18926/okadai-bun-kiyou/56091 |
|---|---|
| タイトル（別表記） | What Are Little Worlds Made of ? : White New York Mandala as Described by Paul Auster |
| フルテキストURL | jfl_069_033_047.pdf |
| 著者 | 中谷 ひとみ| |
| 出版物タイトル | 岡山大学文学部紀要 |
| 発行日 | 2018-06-29 |
| 巻 | 69巻 |
| 開始ページ | 33 |
| 終了ページ | 47 |
| ISSN | 0285-4864 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006486865 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56090 |
|---|---|
| タイトル（別表記） | Report on the Death of Norihide Abe in China |
| フルテキストURL | jfl_069_019_032.pdf |
| 著者 | 姜 克實| |
| 出版物タイトル | 岡山大学文学部紀要 |
| 発行日 | 2018-06-29 |
| 巻 | 69巻 |
| 開始ページ | 19 |
| 終了ページ | 32 |
| ISSN | 0285-4864 |
| 言語 | 中国語 |
| 論文のバージョン | publisher |
| NAID | 120006486864 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/56089 |
|---|---|
| タイトル（別表記） | Revealing the Truth of the YANSUYA and HUANGTULING Records |
| フルテキストURL | jfl_069_001_018.pdf |
| 著者 | 姜 克實| |
| 出版物タイトル | 岡山大学文学部紀要 |
| 発行日 | 2018-06-29 |
| 巻 | 69巻 |
| 開始ページ | 1 |
| 終了ページ | 18 |
| ISSN | 0285-4864 |
| 言語 | 中国語 |
| 論文のバージョン | publisher |
| NAID | 120006486863 |
| フルテキストURL | jfl_069_contents.pdf |
|---|---|
| 著者 | 岡山大学文学部| |
| 出版物タイトル | 岡山大学文学部紀要 |
| 発行日 | 2018-06-29 |
| 巻 | 69巻 |
| ISSN | 0285-4864 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/OER/56086 |
|---|---|
| タイトル（別表記） | Karl Kautsky, Die Krisis in Österreich |
| フルテキストURL | oer_050_1_091_103.pdf |
| 著者 | 太田 仁樹| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2018-07-02 |
| 巻 | 50巻 |
| 号 | 1号 |
| 開始ページ | 91 |
| 終了ページ | 103 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006484392 |
| JaLCDOI | 10.18926/OER/56085 |
|---|---|
| タイトル（別表記） | J. H. Clapham, An Economic History of Modern Britain, vol. 3, Machines and National Rivalries(1887-1914), with an Epilogue(1914-1929), Outline, Chap.5 |
| フルテキストURL | oer_050_1_071_090.pdf |
| 著者 | 一ノ瀬 篤| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2018-07-02 |
| 巻 | 50巻 |
| 号 | 1号 |
| 開始ページ | 71 |
| 終了ページ | 90 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006398877 |
| JaLCDOI | 10.18926/OER/56084 |
|---|---|
| フルテキストURL | oer_050_1_057_070.pdf |
| 著者 | 岡 益巳| 廣田 陽子| 宇塚 万里子| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2018-07-02 |
| 巻 | 50巻 |
| 号 | 1号 |
| 開始ページ | 57 |
| 終了ページ | 70 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006484390 |
| JaLCDOI | 10.18926/OER/56083 |
|---|---|
| タイトル（別表記） | China Go Global : the China Money and Chinese Tourist |
| フルテキストURL | oer_050_1_033_055.pdf |
| 著者 | 滕 鑑| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2018-07-02 |
| 巻 | 50巻 |
| 号 | 1号 |
| 開始ページ | 33 |
| 終了ページ | 55 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006484389 |
| JaLCDOI | 10.18926/OER/56082 |
|---|---|
| タイトル（別表記） | Genealogy of Toyota Production System Evolution : Focusing cost & productivity management |
| フルテキストURL | oer_050_1_001_031.pdf |
| 著者 | 清水 耕一| |
| 抄録 | TPS（ Toyota Production System） is the well-known system which is one of the strong points in Toyota. Nowadays lots of books are published about TPS as thesis and know-how books. It is said in Toyota internal, TPS is the management system and know-how of Kaizen for cost reduction activities based on two pillars such as Autonomy（Jidoka） and“ Just in time”. However I think it is not enough paying attention about on a management system, than the know-how of Kaizen by the ₃rd party. In this paper, focusing particularly on the management system such as wages linked on productivity measurements which Mr. Taichi Ohno, the founder of TPS, developed as well. Also focusing on the evolution, how does this system pursue the circumstance change including Toyota employee interview. Utilizing this wage linked productivity measurement system Mr. Ohno stimulated his coworkers to get good results applying TPS know-how. It is very complicated but well considered system. |
| キーワード | トヨタ生産システム 原価・能率管理 生産手当（生産性給） 歩合制度 歩合会議 生産性評価制度 |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2018-07-02 |
| 巻 | 50巻 |
| 号 | 1号 |
| 開始ページ | 1 |
| 終了ページ | 31 |
| ISSN | 2433-4146 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006484388 |
| JaLCDOI | 10.18926/AMO/56080 |
|---|---|
| フルテキストURL | 72_3_319.pdf |
| 著者 | Makimoto, Go| Ichihara, Eiki| Hotta, Katsuyuki| Ninomiya, Kiichiro| Oze, Isao| Minami, Daisuke| Ninomiya, Takashi| Kubo, Toshio| Ohashi, Kadoaki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| 抄録 | Although cisplatin-based chemotherapy shows a survival advantage compared to carboplatin for treating advanced non-small cell lung cancer, high-volume hydration and a long infusion time are necessary to avoid nephrotoxicity, and cisplatin-based chemotherapy has been difficult to administer in outpatient settings. A low-volume hydration method using mannitol or furosemide as forced diuresis was recently introduced, but there are no clear conclusions regarding which agent should be used. We describe our ongoing randomized phase II trial (the OLCSG1406 Study) evaluating the efficacy of forced diuresis. This study will clarify whether mannitol or furosemide is more suitable in cisplatin-based chemotherapy with low-volume hydration. |
| キーワード | cisplatin mannitol furosemide lung cancer hydration non-small cell lung cancer |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 319 |
| 終了ページ | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926012 |
| JaLCDOI | 10.18926/AMO/56079 |
|---|---|
| フルテキストURL | 72_3_315.pdf |
| 著者 | Miyata, Yasuhiko| Saito M. , Akiko| Yano, Takahiro| Yoshida, Isao| Suehiro, Youko| Harada, Naoki| Nagai, Hirokazu| |
| 抄録 | In very-elderly diffuse large B-cell lymphoma (DLBCL) patients, treatment intensities must be lowered due to the risks of comorbidities and organ function deterioration, and treatment outcomes are worse compared to younger patients. Very-elderly patients are often excluded from DLBCL clinical trials, and optimal treatments and dosages are not established. In this clinical trial, we examined the efficacy and safety of 6 courses of R-mini CHP therapy (cf., CHOP [cyclophosphamide, doxorubicin, vincristine, and prednisone]) in which vincristine is omitted to avoid the peripheral neuropathy that reduces elderly patients’ quality of life, as remission induction therapy in DLBCL patients aged≥80 years. |
| キーワード | rituximab diffuse large B-cell lymphoma open-label single arm trial |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 315 |
| 終了ページ | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926011 |
| JaLCDOI | 10.18926/AMO/56078 |
|---|---|
| フルテキストURL | 72_3_309.pdf |
| 著者 | Katayama, Satoshi| Takenaka, Tadasu| Nakamura, Aya| Sako, Sinichi| Bessho, Akihiro| Ohara, Nobuya| |
| 抄録 | Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal, malignancy-related respiratory complication; we herein report a PTTM case induced by metastatic prostate cancer. An 81-year-old Japanese man developed dyspnea. High-resolution computed tomography (HRCT) revealed ground-glass opacities spread across bilateral lung fields. Pulmonary microvascular aspiration cytology detected prostate cancer cells. As PTTM was highly suspected, docetaxel chemotherapy was performed immediately. His respiratory condition and HRCT findings improved temporarily, but he died approx. 6 weeks after admission. Autopsy showed fibrocellular intimal proliferation of small pulmonary arterioles, which confirmed the diagnosis of PTTM induced by prostate cancer. As in the present case, it is often difficult to confirm the presence of not only tumor embolization but also fibrocellular intimal proliferation before the patient’s death. |
| キーワード | autopsy dyspnea prostate neoplasm metastatic lung cancer thrombotic microangiopathy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 309 |
| 終了ページ | 313 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926010 |
| JaLCDOI | 10.18926/AMO/56077 |
|---|---|
| フルテキストURL | 72_3_301.pdf |
| 著者 | Kakio, Yuki| A. Uchida, Haruhito| Kitagawa, Masashi| Arata, Yuka| Kato, Ayako| Inoue-Torii, Akiko| Hinamoto, Norikazu| Ogawa-Akiyama, Ayu| Sugiyama, Hitoshi| Wada, Jun| |
| 抄録 | Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission. |
| キーワード | IgAN nephropathy Wiskott-Aldrich syndrome X-linked thrombocytopenia galactose-deficient IgA1 |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 301 |
| 終了ページ | 307 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926009 |
| JaLCDOI | 10.18926/AMO/56076 |
|---|---|
| フルテキストURL | 72_3_297.pdf |
| 著者 | Yamamoto, Hirotsugu| Naito, Hiromichi| Osako, Takaaki| Tsukahara, Kohei| Yamada, Taihei| Yumoto, Tetsuya| Iida, Atsuyoshi| Kosaki, Yoshinori| Oka, Makio| Endo, Fumika| Gochi, Akira| Nakao, Atsunori| |
| 抄録 | A healthy 10-year-old boy vomited during sleep and later complained of abdominal pain; he became drowsy and uncommunicative. At the nearby hospital E.R., he deteriorated rapidly, and his respiratory movements were absent with cardiac arrest. He was immediately resuscitated. Brain MRI showed no abnormalities. EEG revealed an abnormal pattern with recurrent multifocal epileptiform activity over the bilateral occipital and frontal regions during sleep. Based on the clinical/radiological findings we diagnosed Panayiotopoulos syndrome (PS), a benign form of early-onset pediatric epilepsy characterized by autonomic symptoms. Lifethreating cardiopulmonary arrest is rare in PS, but long seizure duration of PS may associate with apnea and bradycardia. |
| キーワード | pediatric epilepsy autonomic symptom cardiac arrest afebrile seizure EEG |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 297 |
| 終了ページ | 300 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926008 |
| JaLCDOI | 10.18926/AMO/56075 |
|---|---|
| フルテキストURL | 72_3_289.pdf |
| 著者 | Kitajima, Kazuhiro| Yamamoto, Shingo| Odawara, Soichi| Kobayashi, Kaoru| Fujiwara, Masayuki| Kamikonya, Norihiko| Fukushima, Kazuhito| Nakanishi, Yukako| Hashimoto, Takahiko| Yamada, Yusuke| Suzuki, Toru| Kanematsu, Akihiro| Nojima, Michio| Yamakado, Koichiro| |
| 抄録 | We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55.0%), 9 (45.0%), and 13 (65.0%), respectively. The patient-based sensitivity/specificity/accuracy/area under the receiver-operating-characteristic curve (AUC) values for 11C-choline-PET/CT for diagnosing local lesions were 90.9% /100%/ 95.0% / 1.0, whereas those for FDG-PET/CT were 45.5% /100%/ 75.0% / 0.773. Those for 11C-choline-PET/CT for node metastasis were 88.9% /100%/ 95.0% / 0.944, and those for FDG-PET/CT were 44.4%/100%/75.0%/0.722. Those for 11C-choline-PET/CT for bone metastasis were 84.6%/100%/90.0%/0.951, and those for FDG-PET/CT were 76.9% /100%/ 85.0% / 0.962. The AUCs for local lesion and node metastasis differed significantly (p=0.0039, p=0.011, respectively). The lesion-based detection rates of 11C-choline compared to FDG PET/CT for local lesion, and node and bone metastases were 91.7% vs. 41.7%, 92.0% vs. 32.0%, and 94.8% vs. 83.0% (p=0.041, p=0.0030, p<0.0001), respectively. 11C-choline-PET/CT is more useful for the staging and restaging of prostate cancer than FDG-PET/CT in Japanese men. |
| キーワード | prostate cancer PET choline FDG Japanese |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 289 |
| 終了ページ | 296 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926007 |
| JaLCDOI | 10.18926/AMO/56074 |
|---|---|
| フルテキストURL | 72_3_283.pdf |
| 著者 | Namba, Shihoko| Ikeda, Fusao| Takaguchi, Koichi| Shimomura, Yasuyuki| Yasunaka, Tetsuya| Okada, Hiroyuki| |
| 抄録 | We investigated whether a small amount of blood collected by fingertip blood sampling would be adequate in a mass examination for hepatitis virus infection in Japan. A cross-sectional survey was conducted at health fairs in Kasaoka City and Shodoshima Island, where participants took the hepatitis screening test. A total of 114 consecutive individuals who took the hepatitis screening test were enrolled. Twenty microliters of plasma was successfully obtained from all participants. Among the participants, two had positive results for HBs antigen and two were positive for anti-HCV; all four were > 60 years old and rarely visited the hospital. Thirty-three and 38 patients chronically infected with HBV and HCV, respectively, were examined for confirmatory assays at participating hospitals. All subjects with undetectable serum levels of HBs antigen and anti-HCV had undetectable levels of both markers in fingertip blood, and the levels in serum and fingertip blood were significantly correlated (p<0.01). The lower detection limit of HBs antigen was defined as 0.005 IU/ml, and the cut-off value of anti-HCV was 1.0 by using 10-μl fingertip blood samples. The fingertip blood sampling described herein may be adequate in mass examinations for hepatitis virus testing in Japan. |
| キーワード | fingertip hepatitis test HBV HCV Japan |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 283 |
| 終了ページ | 287 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926006 |
| JaLCDOI | 10.18926/AMO/56073 |
|---|---|
| フルテキストURL | 72_3_275.pdf |
| 著者 | Morizane, Shin| Ouchida, Mamoru| Sunagawa, Ko| Sugimoto, Saeko| Kobashi, Mina| Sugihara, Satoru| Nomura, Hayato| Tsuji, Kazuhide| Sato, Atsushi| Miura, Yoshihiro| Hattori, Hiroaki| Tada, Kotaro| Huh, Wook-Kang| Seno, Akemi| Iwatsuki, Keiji| |
| 抄録 | Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients. |
| キーワード | atopic dermatitis SPINK5 LEKTI serine protease inhibitor epidermal barrier dysfunction |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 275 |
| 終了ページ | 282 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926005 |
| JaLCDOI | 10.18926/AMO/56072 |
|---|---|
| フルテキストURL | 72_3_267.pdf |
| 著者 | Matsuura, Ryutaro| Goto, Sachiko| Sato, Shuhei| Akagi, Noriaki| Tahara, Seiji| |
| 抄録 | We validated a navigator-echo-triggered sequence that drives magnetization before cardiac-gated inversion recovery T1 turbo field echo acquisition, in the sedated free-breathing pediatric population. Cardiac magnetic resonance imaging was performed on sedated infants with single ventricle. We calculated the signal-to-noise ratios and contrast-to-noise ratios of 2 groups of images obtained using respiratory triggering with and without navigator echo. All images were then visually assessed by 2 observers. The signal-to-noise ratio and the contrast-to-noise ratio were significantly higher with than without navigator echo (p<0.01; p<0.05). The visual assessment scores were also consistently better with than without navigator echo (p<0.01). Free-breathing navigator echo was found to have the advantage of decreasing the motion artifact caused by respiration. Cardiacgated inversion recovery T1 turbo field echo sequence for free-breathing navigator-echo-triggered respiration allows for the acquisition, in sedated infants, of diagnostic images whose quality exceeds that of the non-navigator-echo-triggered alternative. |
| キーワード | magnetic resonance imaging navigator echo inversion recovery T1 turbo field echo cardiac infant |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 273 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926004 |
| JaLCDOI | 10.18926/AMO/56071 |
|---|---|
| フルテキストURL | 72_3_257.pdf |
| 著者 | Asano, Keiichi| Edamatsu, Midori| F. Hatipoglu, Omer| Inagaki, Junko| Ono, Mitsuaki| Ohtsuki, Takashi| Oohashi, Toshitaka| Hirohata, Satoshi| |
| 抄録 | Several research groups demonstrated that ‘a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)’-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine Lewis lung carcinoma (LLC) tumors showed marked expressions of Adamts4 and Adamts5. We examined the contributions and distributions of host-derived Adamts4 and Adamts5 on tumor growth, using Adamts4LacZ/LacZ and Adamts5LacZ/LacZ knockout mice. Interestingly, the Adamts4LacZ/LacZ mice showed enhanced tumor growth compared to wild-type mice at 5-, 10- and 12-days post-inoculation, whereas the Adamts5LacZ/LacZ mice did not show significant differences in tumor growth. We next examined LacZ distribution in LLC tumor-bearing Adamts4LacZ/LacZ mice by β-galactosidase (β-gal) staining. We found that the β-gal-positive signals were strictly localized at the interior areas of the tumor at 10 days post-inoculation. Multiple staining demonstrated that most of the β-gal-positive cells were localized at the tumor vasculature in Adamts4LacZ/LacZ mice. Interestingly, β-gal-positive signals were not co-localized with biglycan after 10 days post-inoculation, excluding the biglycan cleavage by host-derived ADAMTS4. Taken together, these findings illustrate that host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. |
| キーワード | ADAMTS metalloproteinase extracellular matrix tumor microenvironment mouse |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 257 |
| 終了ページ | 266 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926003 |
| JaLCDOI | 10.18926/AMO/56070 |
|---|---|
| フルテキストURL | 72_3_249.pdf |
| 著者 | Nakahara, Takako| Suemori, Shin-ichiro| Tsujioka, Takayuki| Kataoka, Mikio| Kataoka, Hiromi| Shibakura, Misako| Tohyama, Kaoru| |
| 抄録 | To investigate megakaryocyte (MK) DNA ploidy in various hematological diseases, fluorescence microscopy imaging system (FMI) can be used to analyze DNA ploidy with cell morphology at the single-cell level by using specialized image-processing software. Here we compared DNA ploidy obtained by FMI measured with that obtained flow cytometry (FCM). With FMI, we could evaluate the DNA ploidy in long-term preserved bone marrow smear samples after staining. We next analyzed the MK DNA ploidy in 42 bone marrow smear samples including 26 myeloid neoplasm cases, and we compared the DNA ploidy and platelet counts in the patients' peripheral blood; the production of platelets was significantly high compared to DNA ploidy in the myeloproliferative neoplasms group. The FMI method revealed that the patients with 5q- syndrome exhibited relatively low DNA ploidy despite high platelet counts, and this result suggested that increased DNA ploidy is not indispensable to abundant platelet production. The FMI method for DNA ploidy will be a useful tool to clarify the relationship between DNA ploidy and platelet production by MKs. |
| キーワード | fluorescence microscopy image analysis DNA ploidy megakaryocytes MDS with isolated del(5q) 5q- syndrome |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 256 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926002 |