検索結果 18224 件
| JaLCDOI | 10.18926/bgeou/56527 |
|---|---|
| タイトル（別表記） | A Case Study Considering “Food-Related Education” in Combination with Environment to Foster Ordinary Food Habits of Children (2) : Situations about the Practice of Food-Related Education in China, and Possibilities of Focusing on the Concept “Culture” |
| フルテキストURL | bgeou_170_005_013.pdf |
| 著者 | 佐藤 園| 出野 誉大| 陳 北辰| 山本 郁子| |
| 抄録 | 学校教育における今日的課題として，学校・家庭・地域相互の連携を目指した，子どもの食習慣を確立させるための食教育実践の充実が求められている。先んじて，第Ⅰ報では，これまでの食教育実践に関する先行研究の現状を，子どもの食教育に関する基本的価値認識の観点から明らかにしていった。それに続く第Ⅱ報では，食教育の比較教育学研究を試みるため，第Ⅰ報での研究視点・研究方法を援用しながら，中国における食教育実践に関する先行研究の現状について検討し，日中両国の食教育の類似点・相違点を明らかにしていくことで，「文化」概念を中核に据えた就学前・初等教育における食教育実践の検討可能性を理論的に示唆することを試みていく。 |
| キーワード | 食教育の基本的価値 中国の食教育実践 文化概念 拡張的側面としての価値認識 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2019-02-22 |
| 巻 | 170巻 |
| 開始ページ | 5 |
| 終了ページ | 13 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006583685 |
| JaLCDOI | 10.18926/56520 |
|---|---|
| タイトル（別表記） | Laugh for Laugh and Conversation with Inner Otherness : Reading Nathaniel Hawthorne's Three Short Stories and a Japanese Novel |
| フルテキストURL | scs_018_027_051.pdf |
| 著者 | 中谷 ひとみ| |
| 出版物タイトル | 文化共生学研究 |
| 発行日 | 2019-03-15 |
| 巻 | 18巻 |
| 開始ページ | 27 |
| 終了ページ | 51 |
| ISSN | 1880-9162 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2019 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/56513 |
|---|---|
| フルテキストURL | hss_047_209_229.pdf |
| 著者 | エイ タンダー アウン| |
| 抄録 | This paper deals mainly with the relations between Myanmar and Japan. In this study, a prominent figure from Myanmar politics who visited Japan and his endeavor to develop the relations between the two countries will be presented. At the beginning of the 20th century, the cordial relations between Myanmar and Japan did not exist. In 1907 Sayadaw U Ottama’s visit to Japan that the Myanmar began to take an interest in Japan. After Japan appeared as a modernized nation, the reform movements and achievements of Japanese was emulated by Myanmar. Likewise, it is assured that Myanmar nationals such as political leaders and entrepreneurs from all sectors have the desires to achieve as an Asian country like Japan. Therefore, how did the prominent figures from Myanmar nationals at that time study and observe about the achievements of Japan will be discussed in this paper. Moreover, the advantages of the Japanese developed achievement under observation and the some disadvantages of Myanmar under British administration and the necessary factors to make reforms will be researched. By conducting this research, it aimed to know not only the efforts to develop the Japan – Myanmar relations at present but also efforts to develop the relations in the past and it also aimed to observe costumes and traditions of both countries. The primary and secondary sources to write this paper was obtained from the National Library of Myanmar, Universities’Central Library, University of Yangon Library, University of Maubin Library and Internet Archive. |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2019-03-22 |
| 巻 | 47巻 |
| 開始ページ | 209 |
| 終了ページ | 229 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2019 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120006583677 |
| JaLCDOI | 10.18926/56505 |
|---|---|
| タイトル（別表記） | A Study of the Japanese Particle No at the Early Phase of First Language Acquisition: Focusing on its Conversational Functions and Change in Use |
| フルテキストURL | hss_047_051_069.pdf |
| 著者 | 富岡 史子| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2019-03-22 |
| 巻 | 47巻 |
| 開始ページ | 51 |
| 終了ページ | 69 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2019 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120006583669 |
| JaLCDOI | 10.18926/OER/56486 |
|---|---|
| フルテキストURL | oer_050_3_039_050.pdf |
| 著者 | Ozeki Miki| |
| 抄録 | Group norms are often revised or changed, although consistency and stability are desired when considering group management. The current study aimed to explore the process of group norm change by analyzing the minutes of meetings. Meeting minutes were coded by a psychologist and two graduate students of psychology. A total of 12 categories were identified: “Express determination in changing constitution”, “Ideal constitution,” “Informing current situation” “Changes from the past,” “Questions,”“Resolution of question by explanation,” “Statements for improvements” “Personal opinions,” “Understanding/agreements,” “Consents” “Conclusions,” and “Suspensions.” The results of the current study demonstrated that 1) central group members’ perceptions of the gap between their ideals and the current situation led to a change in group norms in order to realize their ideals, and 2) group members changed the group norms taking into consideration the norms that had been passed down by former members and those that they would hand over to future members. |
| キーワード | Group norm change process group |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2019-03-15 |
| 巻 | 50巻 |
| 号 | 3号 |
| 開始ページ | 39 |
| 終了ページ | 50 |
| ISSN | 2433-4146 |
| 言語 | 英語 |
| 著作権者 | Copyright © 2019 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120006583661 |
| フルテキストURL | K0005859_abstract_review.pdf K0005859_summary.pdf K0005859_fulltext.pdf |
|---|---|
| 著者 | 大橋 敬司| |
| 発行日 | 2018-12-27 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5859号 |
| 学位授与年月日 | 2018-12-27 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005858_abstract_review.pdf K0005858_summary.pdf K0005858_fulltext.pdf |
|---|---|
| 著者 | 榮 浩行| |
| 発行日 | 2018-12-27 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5858号 |
| 学位授与年月日 | 2018-12-27 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005856_abstract_review.pdf K0005856_summary.pdf K0005856_fulltext.pdf |
|---|---|
| 著者 | 和田 望| |
| 発行日 | 2018-12-27 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5856号 |
| 学位授与年月日 | 2018-12-27 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005853_abstract_review.pdf K0005853_summary.pdf K0005853_fulltext.pdf |
|---|---|
| 著者 | 益田 加奈| |
| 発行日 | 2018-12-27 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5853号 |
| 学位授与年月日 | 2018-12-27 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/56466 |
|---|---|
| フルテキストURL | 73_1_93.pdf |
| Amo Type | Errata |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 93 |
| 終了ページ | 93 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/56465 |
|---|---|
| フルテキストURL | 73_1_91.pdf |
| 抄録 | In the article by Takase K et al. entitled “High-dose Dexamethasone Therapy as the Initial Treatment for Idiopathic Thrombocytopenic Purpura: Protocol for a Multicenter, Open-label, Single Arm Trial”, which appeared in the December 2018 issue, Vol.72, No.2, pp197-201, regarding the authors’ information in the first page, following corrections should be added as below. |
| Amo Type | Errata |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 91 |
| 終了ページ | 91 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/56464 |
|---|---|
| フルテキストURL | 73_1_85.pdf |
| 著者 | Abe, Yoshiyuki| Fujibayashi, Kazutoshi| Nishizaki, Yuji| Yanagisawa, Naotake| Nojiri, Shuko| Nakano, Soichiro| Tada, Kurisu| Yamaji, Ken| Tamura, Naoto| |
| 抄録 | Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. |
| キーワード | pneumocystis pneumonia prophylaxis systemic rheumatic disease sulfamethoxazole-trimethoprim conventional-dose versus half-dose |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 89 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820060 |
| JaLCDOI | 10.18926/AMO/56463 |
|---|---|
| フルテキストURL | 73_1_81.pdf |
| 著者 | Sugihara, Yuusaku| Harada, Keita| Oka, Shohei| Yasutomi, Eriko| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Hiraoka, Sakiko| Otsuka, Fumio| Okada, Hiroyuki| |
| 抄録 | Endoscopic submucosal dissection (ESD) is reportedly one of the standard treatment strategies for large superficial colorectal neoplasms in Japan because of its high en bloc resection rate. A few technical issues regarding ESD should be considered, one of which is the selection of the Endo-cut I mode versus the Swift-coagulation mode as the electrosurgical unit mode setting during submucosal dissection. We seek to determine which of these two modes is more suitable for submucosal dissections of colorectal tumors with regard to procedure time and safety. |
| キーワード | endoscopic submucosal dissection electrosurgical mode colorectal tumor |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 81 |
| 終了ページ | 84 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820059 |
| JaLCDOI | 10.18926/AMO/56462 |
|---|---|
| フルテキストURL | 73_1_77.pdf |
| 著者 | Morita, Mio| Matsumoto, Hiroshi| Shirakawa, Yasuhiro| Noma, Kazuhiro| Tanabe, Shunsuke| Kimata, Yoshihiro| |
| 抄録 | Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications. |
| キーワード | anterior cervical plate fixation esophageal perforation reconstruction pectoralis major flap jejunal free flap |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 77 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820058 |
| JaLCDOI | 10.18926/AMO/56461 |
|---|---|
| フルテキストURL | 73_1_71.pdf |
| 著者 | Takahashi-Arimasa, Keiko| Kohno-Yamanaka, Reiko| Soga, Yoshihiko| Miura, Rumi| Morita, Manabu| |
| 抄録 | Preoperative oral care is helpful to prevent postoperative complications in patients who are undergoing esophagectomy. Here, we report the case of an 81-year-old Japanese man with an upper limb disability caused by post-polio syndrome who was receiving neoadjuvant chemotherapy for esophageal cancer. He had poor oral health status and developed oral complications as a side effect of chemotherapy. He could not brush his teeth by himself. However, infection control by oral care provided by an interprofessional collaboration successfully improved his oral hygiene, and his follow-up involved no severe complications. Interprofessional collaboration is useful especially for patients with upper limb disability. |
| キーワード | esophageal cancer preoperative oral care post-polio syndrome neoadjuvant chemotherapy oral mucositis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820057 |
| JaLCDOI | 10.18926/AMO/56460 |
|---|---|
| フルテキストURL | 73_1_67.pdf |
| 著者 | Kono, Reika| Shimizu, Takehiro| Ohtsuki, Hiroshi| Hamasaki, Ichiro| Shibata, Kiyo| Kishimoto, Fumiko| Morizane, Yuki| Shiraga, Fumio| |
| 抄録 | We report a case of congenital multiple ocular motor nerve palsy combined with splitting of the lateral rectus muscle (LR). A 59-year-old Japanese female was investigated for worsening esotropia after corrective surgery. She presented with left hypertropia (35Δ) and esotropia (45-50Δ). Orbital magnetic resonance imaging (MRI) showed reduced belly sizes in the superior rectus, inferior rectus, and superior oblique muscles and splitting of the LR, extending from the origin to the belly, in the left eye. Splitting of the LR belly was detected on MRI in a case of congenital multiple ocular motor nerve palsy. |
| キーワード | multiple ocular motor nerve palsy congenital cranial dysinnervation disorder lateral rectus muscle splitting orbital connective tissue magnetic resonance imaging |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 67 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820056 |
| JaLCDOI | 10.18926/AMO/56459 |
|---|---|
| フルテキストURL | 73_1_61.pdf |
| 著者 | Tamefusa, Kosuke| Ishida, Hisashi| Washio, Kana| Ishida, Toshiaki| Morita, Hirosuke| Shimada, Akira| |
| 抄録 | Patients with multi-system (MS)-type langerhans cell histiocytosis (LCH) show poor outcomes, especially congenital MS LCH cases were shown in high mortality rate. We experienced a congenital case of MS LCH with high risk organs, who needed intensive respiratory support after birth. Even though intensive chemotherapy was discontinued, this patient’s lung LCH lesions gradually became reduced and his respiratory condition recovered; therefore, we restarted and completed maintenance chemotherapy. The patient maintained complete remission for more than 4 years after the end of chemotherapy. Our case suggests that congenital MS LCH even with severe organ involvement can be treated successfully with chemotherapy. |
| キーワード | Langerhans-cell histiocytosis congenital multisystem type |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 61 |
| 終了ページ | 65 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820055 |
| レファレンス | Morimoto A, Oh Y, Shioda Y, Kudo K and Imamura T: Recent advances in Langerhans cell histiocytosis. Pediatr Int (2014) 56: 451-461.| Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, Astigarraga I, Braier J, Donadieu J, Henter JI, Janka-Schaub G, McClain KL, Weitzman S, Windebank K and Ladisch S: Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood (2013) 121: 5006-5014.| Morimoto A, Shioda Y, Imamura T, Kudo K, Kawaguchi H, Sakashita K, Yasui M, Koga Y, Kobayashi R, Ishii E, Fujimoto J, Horibe K, Bessho F, Tsunematsu Y and Imashuku S: Intensified and prolonged therapy comprising cytarabine, vincristine and prednisolone improves outcome in patients with multisystem Langerhans histiocytosis: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study. Int J Hematol (2016) 104: 99-109.| Nakashima T, Onoe Y, Tashiro A and Yamashita H: Congenital self-healing LCH: A case with lung lesions and review of the literature. Pediatr Int (2010) 52: 224-226.| Yu J De, Rubin AI, Castelo-Soccio L and Perman MJ: Congenital Self-Healing Langerhans Cell Histiocytosis. J Pediatr (2017) 184: 232-232.| Inoue M, Tomita Y, Egawa T, Ioroi T, Kugo M and Imashuku S: A Fatal Case of Congenital Langerhans Cell Histiocytosis with Disseminated Cutaneous Lesions in a Premature Neonate. Case Rep Pediatr (2016) 2016: 4972180.| Lucioni M, Beluffi G, Bandiera L, Zecca M, Inzani F, Fiandrino G, Viglio A, Stronati M, Necchi V, Riboni R, Locatelli F and Paulli M: Congenital aggressive variant of Langerhans cells histiocytosis with CD56+/E-Cadherin- phenotype. Pediatr Blood Cancer (2009) 53: 1107-1110.| Goñi-Orayen C, Ruiz-Cano R, Pérez-Martínez A, Escario-Travesedo E, Atienzar-Tobarra M and Martínez-Gutiérrez A: A fatal case of congenital disseminated Langerhans cell histiocytosis. J Perinat Med (1999) 27: 228-230.| Henter JI, Horne A, Aricò M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J and Janka G: HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer (2007) 48: 124-131| Vassallo R, Harari S and Tazi A: Current understanding and management of pulmonary Langerhans cell histiocytosis. Thorax (2017) 72: 937-945.| Héritier S, Emile JF, Barkaoui MA, Thomas C, Fraitag S, Boudjemaa S, Renaud F, Moreau A, Peuchmaur M, Chassagne- Clément C, Dijoud F, Rigau V, Moshous D, Lambilliotte A, Mazingue F, Kebaili K, Miron J, Jeziorski E, Plat G, Aladjidi N, Ferster A, Pacquement H, Galambrun C, Brugières L, Leverger G, Mansuy L, Paillard C, Deville A, Armari-Alla C, Lutun A, Gillibert- Yvert M, Stephan JL, Cohen-Aubart F, Haroche J, Pellier I, Millot F, Lescoeur B, Gandemer V, Bodemer C, Lacave R, Hélias- Rodzewicz Z, Taly V, Geissmann F and Donadieu J: BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy. J Clin Oncol (2016) 34: 3023-3030.| Kansal R, Quintanilla-Martinez L, Datta V, Lopategui J, Garshfield G and Nathwani BN: Identification of the V600D mutation in Exon 15 of the BRAF oncogene in congenital, benign langerhans cell histiocytosis. Genes Chromosomes Cancer (2013) 52: 99-106.| |
| JaLCDOI | 10.18926/AMO/56458 |
|---|---|
| フルテキストURL | 73_1_51.pdf |
| 著者 | Fujii, Masakuni| Fujimoto, Kenji| Yabe, Syuntaro| Nasu, Junichiro| Miyaike, Jiro| Yoshioka, Masao| Shiode, Junji| Yamamoto, Kazuhide| Matsuda, Shinya| |
| 抄録 | We investigated the relationship between body mass index (BMI) and postoperative outcomes in 450 gallbladder cancer patients in Japan. We collected patient information, including sex, age, underlying disease, BMI, stage, surgery method, postoperative time to discharge, and postoperative Medicare fees, from the Japanese administrative database associated with the Diagnosis Procedure Combination system. We classified patient BMIs as underweight (BMI<18.5 kg/m2), normal (BMI≥18.5 kg/m2 and <25 kg/m2) or overweight/obese (BMI≥25 kg/m2), then investigated the relationship between these categories and two postoperative outcomes: time to discharge and postoperative Medicare fees. The median postoperative time to discharge was 12 days in all patients, and 12 days in each of the three weight groups (p=0.62, n.s.). The median postoperative Medicare fees from surgery until discharge were (USD): all patients, $5,002; underweight, $5,875; normal weight, $4,797; and overweight/obese, $5,179 (p=0.146, n.s.). A multivariate analysis with adjustment for competing risk factors revealed that BMI was not associated with increased risk of longer postoperative time to discharge (normal weight: HR 1.17, p=0.29; overweight/obese: HR 1.17, p=0.37) or higher postoperative Medicare fees (OR 0.99, p=0.86, n.s.). Thus, high BMI was not found to be a factor for poor postoperative outcomes in Japanese patients with gallbladder cancer. |
| キーワード | body mass index gallbladder cancer surgery obesity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 51 |
| 終了ページ | 59 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820054 |
| JaLCDOI | 10.18926/AMO/56457 |
|---|---|
| フルテキストURL | 73_1_43.pdf |
| 著者 | Ikeda, Ailee| Takaki, Akinobu| Yasunaka, Tetsuya| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Yoshida, Kazuhiro| Kuise, Takashi| Nobuoka, Daisuke| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| Okada, Hiroyuki| |
| 抄録 | Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses. |
| キーワード | acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 41 |
| 終了ページ | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820053 |
| レファレンス | Ishigami M, Ogura Y, Hirooka Y and Goto H: Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation. World J Gastroenterol (2015) 21: 10290-10298.| Kennedy M and Alexopoulos SP: Hepatitis B virus infection and liver transplantation. Curr Opin Organ Transplant (2010) 15: 310-315.| Takaki A, Yagi T, Iwasaki Y, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Miyake Y, Terada R, Kobashi H, Sakaguchi K, Tanaka N and Shiratori Y: Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation. Transplantation (2007) 83: 231-233.| Takaki A, Yagi T and Yamamoto K: Safe and cost-effective control of post-transplantation recurrence of hepatitis B. Hepatol Res (2015) 45: 38-47.| Holmberg SD, Suryaprasad A and Ward W: Updated CDC recommendations for the management of hepatitis B virus-infected health-care providers and students. 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Dig Liver Dis (2018) 50: 944-953.| Schumann A, Lindemann M, Valentin-Gamazo C, Lu M, Elmaagacli A, Dahmen U, Knop D, Broelsch CE, Grosse-Wilde H, Roggendorf M and Fiedler M: Adoptive immune transfer of hepatitis B virus specific immunity from immunized living liver donors to liver recipients. Transplantation (2009) 87: 103-111.| Hu X, Ma S, Huang X, Jiang X, Zhu X, Gao H, Xu M, Sun J, Abbott WG and Hou J: Interleukin-21 is upregulated in hepatitis B-related acute-on-chronic liver failure and associated with severity of liver disease. J Viral Hepat (2011) 18: 458-467.| Li Y, Tang L and Hou J: Role of interleukin-21 in HBV infection: friend or foe? Cell Mol Immunol (2015) 12: 303-308.| Soejima Y, Ikegami T, Taketomi A, Yoshizumi T, Uchiyama H, Harada N, Yamashita Y and Maehara Y: Hepatitis B vaccination after living donor liver transplantation. Liver Int (2007) 27: 977–982.| Chang SH, Suh KS, Yi NJ, Choi SH, Lee HJ, Seo JK and Lee KU: Active immunization against de novo hepatitis B virus infection in pediatric patients after liver transplantation. Hepatology (2003) 37: 1329-1334.| Kwon CH, Suh KS, Yi NJ, Chang SH, Cho YB, Cho JY, Lee HJ, Seo JK and Lee KU: Long-term protection against hepatitis B in pediatric liver recipients can be achieved effectively with vaccination after transplantation. Pediatr Transplant (2006) 10: 479-486.| Lee S, Kim JM, Choi GS, Park JB, Kwon CH, Choe YH, Joh JW and Lee SK: De novo hepatitis b prophylaxis with hepatitis B virus vaccine and hepatitis B immunoglobulin in pediatric recipients of core antibody-positive livers. Liver Transpl (2016) 22: 247-251.| Lin CC, Chen CL, Concejero A, Wang CC, Wang SH, Liu YW, Yang CH, Yong CC, Lin TS, Jawan B, Cheng YF and Eng HL: Active immunization to prevent de novo hepatitis B virus infection in pediatric live donor liver recipients. Am J Transplant (2007) 7: 195-200.| Yoshizawa A, Yamashiki N, Ueda Y, Kaido T, Okajima H, Marusawa H, Chiba T and Uemoto S: Long-term efficacy of hepatitis B vaccination as post-transplant prophylaxis in hepatitis B surface antigen (HBsAg) positive recipients and HBsAg negative recipients of anti-hepatitis B core positive grafts. Hepatol Res (2016) 46: 541-551.| Ota MO, Vekemans J, Schlegel-Haueter SE, Fielding K, Whittle H, Lambert PH, McAdam KP, Siegrist CA and Marchant A: Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. Vaccine (2004) 22: 511-519.| Tuaillon E, Tabaa YA, Petitjean G, Huguet MF, Pajeaux G, Fondere JM, Ponseille B, Ducos J, Blanc P and Vendrell JP: Detection of memory B lymphocytes specific to hepatitis B virus (HBV) surface antigen (HBsAg) from HBsAg-vaccinated or HBVimmunized subjects by ELISPOT assay. J Immunol Methods (2006) 315: 144-152.| Bauer T, Gunther M, Bienzle U, Neuhaus R and Jilg W: Vaccination against hepatitis B in liver transplant recipients: pilot analysis of cellular immune response shows evidence of HBsAg-specific regulatory T cells. Liver Transpl (2007) 13: 434-442.| Rosenau J, Hooman N, Rifai K, Solga T, Tillmann HL, Grzegowski E, Nashan B, Klempnauer J, Strassburg CP, Wedemeyer H and Manns MP: Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: failure of humoral and cellular immune response. Transpl Int (2006) 19: 828-833.| Di Paolo D, Lenci I, Cerocchi C, Tariciotti L, Monaco A, Brega A, Lotti L, Tisone G and Angelico M: One-year vaccination against hepatitis B virus with a MPL-vaccine in liver transplant patients for HBV-related cirrhosis. Transpl Int (2010) 23: 1105-1112.| Sintusek P, Posuwan N, Wanawongsawad P, Jitraruch S, Poovorawan Y and Chongsrisawat V: High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation. World J Gastroenterol (2018) 24: 752-762.| |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| フルテキストURL | 73_1_29.pdf |
| 著者 | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| 抄録 | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| キーワード | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 29 |
| 終了ページ | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820052 |