検索結果 47501 件
| タイトル（別表記） | “Investment Treaties Network” and its Influence on Investment Treaties Reforms ‒ An Analysis of Swissbourgh v. Lesotho |
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| フルテキストURL | olj_69_1_(70_45).pdf |
| 著者 | 二杉 健斗| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2019-08-30 |
| 巻 | 69巻 |
| 号 | 1号 |
| 開始ページ | 70 |
| 終了ページ | 45 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006716051 |
| タイトル（別表記） | A Note on Asbestos Litigation: Focusing on Causatioin |
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| フルテキストURL | olj_69_1_(82_72).pdf |
| 著者 | 辻 博明| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2019-08-30 |
| 巻 | 69巻 |
| 号 | 1号 |
| 開始ページ | 82 |
| 終了ページ | 72 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006716050 |
| タイトル（別表記） | Die Rechtstheorie von der landwirtschaftlicher Genossenschaft in Japan |
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| フルテキストURL | olj_69_1_(112_83).pdf |
| 著者 | 田代 滉貴| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2019-08-30 |
| 巻 | 69巻 |
| 号 | 1号 |
| 開始ページ | 112 |
| 終了ページ | 83 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006716049 |
| タイトル（別表記） | Regelungsdichte und Verhältnismäßigkeit 1. Teil |
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| フルテキストURL | olj_69_1_(160_114).pdf |
| 著者 | 山田 哲史| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2019-08-30 |
| 巻 | 69巻 |
| 号 | 1号 |
| 開始ページ | 160 |
| 終了ページ | 114 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006716048 |
| フルテキストURL | olj_69_1_contents.pdf |
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| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2019-08-30 |
| 巻 | 69巻 |
| 号 | 1号 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | Front_Sociol_201900016.pdf |
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| 著者 | Aoo, Ken| Abe, Noriko| Kano, Mitsunobu R.| |
| キーワード | social innovation local community older people welfare society social service |
| 発行日 | 2019-03-12 |
| 出版物タイトル | Frontiers in Sociology |
| 巻 | 4巻 |
| 開始ページ | 16 |
| ISSN | 2297-7775 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.3389/fsoc.2019.00016 |
| 関連URL | isVersionOf https://doi.org/10.3389/fsoc.2019.00016 |
| フルテキストURL | PLoSONE_0050082.PDF |
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| 著者 | Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko| |
| 発行日 | 2012-11-26 |
| 出版物タイトル | PLoS ONE |
| 巻 | 7巻 |
| 号 | 11号 |
| 出版者 | Public Library of Science |
| 開始ページ | e50082 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 23189181 |
| DOI | 10.1371/journal.pone.0050082 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0050082 |
| フルテキストURL | NeurobiolDis_50_209.pdf |
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| 著者 | Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Mori, Akiko| Michiue, Hiroyuki| Nishiki, Teiichi| Ohtsuka, Yoko| Matsui, Hideki| |
| 備考 | CACNA1A variants contribute to severity of seizures in Dravet syndrome| |
| 発行日 | 2013-02 |
| 出版物タイトル | Neurobiology of disease |
| 巻 | 50巻 |
| 出版者 | Academic Press |
| 開始ページ | 209 |
| 終了ページ | 217 |
| ISSN | 09699961 |
| NCID | AA11645502 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 23103419 |
| DOI | 10.1016/j.nbd.2012.10.016 |
| Web of Science KeyUT | 000313758100023 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.nbd.2012.10.016 |
| タイトル（別表記） | Difficulties in school life can be seen from the medical records of patients with gender dysphoria |
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| フルテキストURL | hyky_20_39.pdf |
| 著者 | 天野 佑美| 佐々木 新| 松本 洋輔| 大守 伊織| |
| 抄録 | A school should be a place where every child can feel comfortable and safe. We aimed to shed light upon difficulties in school life in children with gender dysphoria (GD) and find a way to support them. We extracted the episodes in school life from the medical records of 59 patients with GD. They suffered from using gender segregated bookbags, school uniforms, swimming wears, and bathrooms. Sex education was not enough for them to understand GD. Children with male-to-female GD were bullied at school more often than those with female-to-male GD. Teachers should take note of children with GD, and should provide necessary supports in their school life, including the facilities and their relationships with their peers. |
| キーワード | gender dysphoria gender identity disorder school education gender and sexual diversity difficulties |
| 出版物タイトル | 教育実践学論集 |
| 発行日 | 2019-03 |
| 号 | 20号 |
| 開始ページ | 39 |
| 終了ページ | 48 |
| ISSN | 2433-1791 |
| 関連URL | isVersionOf http://hdl.handle.net/10132/17792 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Development of teaching materials on water color using a plastic pipe as a long path cell ： their applications to elementary science lessons |
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| フルテキストURL | hyky_19_191.pdf |
| 著者 | 宮﨑 唯| 安心院 翼| 喜多 雅一| |
| 抄録 | Water is an essential substance for living things. Topic on water are at grades 3-6 in elementary science. The roles and functions of water (erosion, accumulation, transportation), germination and growth of plants, etc. On the other hand, the properties of water are not treated except physical change like boiling, evaporation, freezing, etc. The color, taste, and smell of water are not discussed in elementary science. This research proposes that the color of water because an excellent theme for inquire based leaning. We have developed a suitable and low cost teaching material for the water color. Furthermore, we have conducted a few lessons with the teaching materials to examine the appropriateness. |
| キーワード | Transmission excited vibrational state of molecule Long light path cell Absorption of light |
| 出版物タイトル | 教育実践学論集 |
| 発行日 | 2018-03 |
| 号 | 19号 |
| 開始ページ | 191 |
| 終了ページ | 196 |
| ISSN | 2433-1791 |
| 関連URL | isVersionOf http://hdl.handle.net/10132/17608 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120006455118 |
| JaLCDOI | 10.18926/AMO/56941 |
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| フルテキストURL | 73_4_373.pdf |
| 著者 | Oda, Yoshiaki| Yamauchi, Tarou| Tanaka, Masato| |
| 抄録 | A minimally invasive surgical (MIS) procedure is an ideal surgical procedure. Many MIS techniques have been reported in spinal surgery. In clinical practice, we often encounter two-level canal stenosis cases, in which one level shows instability and the other does not. In such a case, fusion surgery for one level and decompression surgery for the other level is ideal. LLIF/OLIF approached from the lateral side has been reported effective. MIS decompression techniques in the lateral decubitus position have never been reported. We devised a surgical method that can accomplish both fixation and decompression in a consistent lateral decubitus position. |
| キーワード | microendoscopic surgery lateral position navigation minimally invasive surgery image free |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 373 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439962 |
| JaLCDOI | 10.18926/AMO/56940 |
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| フルテキストURL | 73_4_367.pdf |
| 著者 | Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun| |
| 抄録 | Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored. |
| キーワード | autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 367 |
| 終了ページ | 372 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439961 |
| JaLCDOI | 10.18926/AMO/56939 |
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| フルテキストURL | 73_4_361.pdf |
| 著者 | Watanabe, Ayako| Kadowaki, Yoshihiko| Hattori, Kenji| Ohmori, Mika| Tsukayama, Hiroyuki| Kubota, Nobuhito| Okumoto, Tatsuo| Ishido, Nobuhiro| Okino, Takeshi| |
| 抄録 | A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis. |
| キーワード | phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 361 |
| 終了ページ | 365 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439960 |
| JaLCDOI | 10.18926/AMO/56938 |
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| フルテキストURL | 73_4_357.pdf |
| 著者 | Maeda, Naoto| Kodama, Naoki| Manda, Yosuke| Kawakami, Shigehisa| Oki, Kazuhiro| Minagi, Shogo| |
| 抄録 | We investigated the characteristics of grouped discharge (GD) waveforms obtained from long-term masseter electromyogram (EMG) recording in 6 female temporomandibular disorder (TMD) patients with myofascial pain and 6 healthy females. The EMG measurement was performed from the morning of the experiment day until the subject woke up the next day. We observed a significantly larger number of GD waveforms in the TMD group compared to the control group (p=0.002). Our results indicate that the existence of GD waveforms in masseter EMGs might be a predictor of future TMD with myofascial pain. |
| キーワード | temporomandibular disorder grouped discharge masseter muscle electromyography |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 357 |
| 終了ページ | 360 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439959 |
| JaLCDOI | 10.18926/AMO/56937 |
|---|---|
| フルテキストURL | 73_4_349.pdf |
| 著者 | Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro| |
| 抄録 | To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS. |
| キーワード | ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 356 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439958 |
| JaLCDOI | 10.18926/AMO/56936 |
|---|---|
| フルテキストURL | 73_4_341.pdf |
| 著者 | Kitajima, Kazuhiro| Yamamoto, Shingo| Nakanishi, Yukako| Yamada, Yusuke| Hashimoto, Takahiko| Suzuki, Toru| Go, Shuken| Kanematsu, Akihiro| Nojima, Michio| Fujiwara, Masayuki| Kaida, Hayato| Tsurusaki, Masakatsu| Kanda, Tomonori| Tamaki, Yukihisa | Yamakado, Koichiro| |
| 抄録 | We investigated the effectiveness of 11C-choline-positron emission tomography/computed tomography (PET/CT) for evaluating treatment response in patients with prostate cancer or renal cell carcinoma. We performed 34 11C-choline PET/CT scans before/after a combined total of 17 courses of treatment in 6 patients with prostate cancer and 2 with renal cell carcinoma. The 17 treatments including hormonal therapy, radiotherapy, chemotherapy, radium-223, molecular target therapy, radiofrequency ablation, transcatheter arterial embolization, and cancer immunotherapy yielded 1 (5.9%) complete metabolic response (CMR), 3 (17.6%) partial metabolic responses (PMRs), 2 (11.8%) stable metabolic diseases (SMDs), and 11 (64.7%) progressive metabolic diseases (PMDs). Target lesions were observed in bone (n=14), lymph nodes (n=5), lung (n=2), prostate (n=2), and pleura (n=1), with CMR in 4, PMR in 10, SMD in 8 and PMD in 2 lesions. SUVmax values of the target lesions before and after treatment were 7.87±2.67 and 5.29±3.98, respectively, for a mean reduction of −35.4±43.6%. The response for the 8 prostate cancer-treatment courses was PMD, which correlated well with changes in serum prostatic specific antigen (PSA) (7 of 8 cases showed increased PSA). 11C-choline-PET/CT may be an effective tool for detecting viable residual tumors and evaluating treatment response in prostate cancer and renal cell carcinoma patients. |
| キーワード | treatment response 11C-choline PET/CT prostate cancer renal cell carcinoma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 341 |
| 終了ページ | 347 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439957 |
| JaLCDOI | 10.18926/AMO/56935 |
|---|---|
| フルテキストURL | 73_4_333.pdf |
| 著者 | Kuwaki, Kenji| Nouso, Kazuhiro| Miyashita, Manabi| Makino, Yasuhiro| Hagihara, Hiroaki| Moriya, Akio| Adachi, Takuya| Wada, Nozomu| Yasunaka, Yuki| Yasunaka, Tetsuya| Takeuchi, Yasuto| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki| |
| 抄録 | Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC. |
| キーワード | antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 339 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439956 |
| JaLCDOI | 10.18926/AMO/56934 |
|---|---|
| フルテキストURL | 73_4_325.pdf |
| 著者 | Ueno, Tsuyoshi| Maki, Yuho| Sugimoto, Ryujiro| Suehisa, Hiroshi| Yamashita, Motohiro| Harada, Daijiro| Kozuki, Toshiyuki| Nogami, Naoyuki| |
| 抄録 | Therapeutic approaches to bronchopleural fistula (BPF) closure after lung resection are surgical or endoscopic interventions. We evaluated therapeutic outcomes to determine the optimal approach. We reviewed 15 patients who had developed BPF after lung resection for thoracic malignant diseases at our institution in the 10 years since 2008. The patients were 11 men and 4 women (mean age 68 years). We performed one pneumonectomy, 6 lobectomies, 7 segmentectomies, and one partial resection for malignant diseases. The median interval from lung resection to the BPF diagnosis was 46 days. The BPF-associated mortality rate was 26.7% (4/15). The rate of successful BPF closure was 66.6% (10/15). The endoscopic and surgical intervention success rates were 14.2% (1/7) and 69.2% (9/13), respectively (p<0.01). Of 5 patients who had failed BPF treatments, 4 died, and one transferred out without BPF closure. The therapeutic outcomes were related to preoperative comorbidities, performance status at the BPF diagnosis, time intervals from lung resection to BPF diagnosis, and presence of active pneumonia. The difference between endoscopic and surgical outcomes was nonsignificant, although the surgical intervention success rate was somewhat higher. The selection of endoscopic or surgical intervention for BPF does not significantly affect therapeutic outcomes. |
| キーワード | bronchopleural fistula endoscopic intervention surgical intervention |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 325 |
| 終了ページ | 331 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439955 |
| JaLCDOI | 10.18926/AMO/56933 |
|---|---|
| フルテキストURL | 73_4_315.pdf |
| 著者 | Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya| |
| 抄録 | The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains. |
| キーワード | periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 315 |
| 終了ページ | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439954 |
| JaLCDOI | 10.18926/AMO/56932 |
|---|---|
| フルテキストURL | 73_4_307.pdf |
| 著者 | Takahashi, Sho| Akagi, Teiji| Toh, Norihisa| Takaya, Yoichi| Nakagawa, Koji| Nishii, Nobuhiro| Ito, Hiroshi| |
| 抄録 | The follow-up of patients with adult congenital heart disease (ACHD) at a specialized medical unit is necessary for the patients’ appropriate medical care. However, limited information is available about cardiovascular events among ACHD patients. Here we investigated the type and frequency of cardiovascular events in ACHD patients in relation to disease complexity. We retrospectively analyzed the cases of 535 patients (median age 35 years) referred to our ACHD center between 2014 and 2017. We divided the patients into 3 groups based on their disease complexity. To evaluate the relationship between disease complexity and cardiovascular events, we performed univariate and multivariate survival analyses. The Simple, moderate, and complex disease groups accounted for 62%, 19%, and 19% of the patients, respectively. Apart from events related to atrial septal defect (ASD) trans-catheter treatment, the frequency of cardiovascular events was dependent on the disease complexity (event-free survival rates at 3 years were 85%, 65%, and 58%, respectively). The hazard ratios were 4.0 and 5.1 in the moderate and complex groups, respectively. With the exception of scheduled transcatheter intervention, cardiovascular events were strongly related to the disease complexity of original heart disease. However, cardiovascular events were not rare even in the simple ACHD group. |
| キーワード | congenital heart defect congenital in adults hospitalization cardiovascular event |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 313 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439953 |