検索結果 1721 件
| フルテキストURL | fulltext20240904-02.pdf |
|---|---|
| 著者 | Asanuma, Masato| Miyazaki, Ikuko| Funada, Masahiko| |
| キーワード | Psychoactive drugs 2,5-Dimethoxy-substituted phenethylamines Neurotoxicity Serotonin-containing neurons Dopamine neurons Reactive oxygen species |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11419-020-00527-w| |
| 発行日 | 2020-02-21 |
| 出版物タイトル | Forensic Toxicology |
| 巻 | 38巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 394 |
| 終了ページ | 408 |
| ISSN | 1860-8965 |
| NCID | AA12435006 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Japanese Association of Forensic Toxicology 2020 |
| 論文のバージョン | author |
| DOI | 10.1007/s11419-020-00527-w |
| Web of Science KeyUT | 000516475700001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s11419-020-00527-w |
| JaLCDOI | 10.18926/AMO/67554 |
|---|---|
| フルテキストURL | 78_4_349.pdf |
| 著者 | Tominaga, Yuichiro| Sugaya, Akiko| Kariya, Shin| Shimizu, Aiko| Kataoka, Yuko| Ando, Mizuo| |
| 抄録 | Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment. |
| キーワード | middle-ear salivary gland choristoma middle-ear morphological abnormalities newborn hearing screening unilateral hearing loss surgical resection |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-08 |
| 巻 | 78巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 355 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39198990 |
| Web of Science KeyUT | 001310557400004 |
| JaLCDOI | 10.18926/AMO/67549 |
|---|---|
| フルテキストURL | 78_4_331.pdf |
| 著者 | Furukawa, Chieko| Tachibana, Tomoyasu| Nobuhisa, Tetsuji| Kanie, Yuichiro| Wani, Yoji| Matsumoto, Jun-Ya| Kariya, Akifumi| Sato, Asuka| Ishikawa, Iichiro| Naoi, Yuto| Ando, Mizuo| |
| 抄録 | No previous study has published magnetic resonance imaging (MRI) findings for a subglottic pleomorphic adenoma. Here, we describe the case of a 62-year-old man with a subglottic pleomorphic adenoma. Endoscopic findings revealed a smooth-surfaced tumor arising from the subglottic posterior wall. MRI revealed the lesion as an isointense region on T1-weighted images, which was homogeneously enhanced. This lesion showed a heterogeneously hyperintense region on T2-weighted images. Diffusion-weighted imaging (DWI) showed slightly high intensity in the same area, with a normal or only slightly high apparent diffusion coefficient (ADC). Laryngomicrosurgery was performed for transoral excision of the subglottic tumor, resulting in a postsurgical diagnosis of pleomorphic adenoma. |
| キーワード | subglottis pleomorphic adenoma MRI transoral surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-08 |
| 巻 | 78巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 331 |
| 終了ページ | 335 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39198987 |
| Web of Science KeyUT | 001310557400001 |
| JaLCDOI | 10.18926/AMO/67548 |
|---|---|
| フルテキストURL | 78_4_323.pdf |
| 著者 | Katayama, Akira| Kimura, Satoshi| Matsusaki, Takashi| Morimatsu, Hiroshi| |
| 抄録 | It has not been clear how recipient age affects the incidence of serious complications after pediatric living donor liver transplantation (LDLT). We investigated the records of 42 pediatric patients receiving LDLT, dividing our sample into two groups: the infant group (aged < 1 year) and the non-infant group (aged ≥ 1 year and ≤15 years). The primary outcome was postoperative complications assessed using the Clavien-Dindo classification. Multivariate analysis using the Cox regression model was applied to adjust for confounding factors in assessing the incidence of Clavien-Dindo grade ≥ III (C-D ≥ III) complications. The incidence of C-D ≥ III complications was higher in the non-infant group (46.2%) than in the infant group (12.5%) (odds ratio 6.00, 95% confidence interval [CI] 1.13-31.88, p=0.03). In multivariate analysis using the Cox regression model, the Graft-to-Recipient Weight Ratio (GRWR) was independently associated with the incidence of C-D ≥ III complications (hazard ratio [HR] 0.62, 95%CI 0.40-0.95, p=0.03), but being an infant was not (HR 0.84, 95%CI 0.35-1.98, p=0.68). In conclusion, the incidence of C-D ≥ III complications was higher in the non-infant group than in the infant group, but this was largely a function of GRWR: multivariate analysis revealed that GRWR was independently associated with complications. |
| キーワード | pediatric liver transplantation postoperative severe complications Graft-to-Recipient Weight Ratio |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-08 |
| 巻 | 78巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 323 |
| 終了ページ | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39198986 |
| Web of Science KeyUT | 001310576400003 |
| JaLCDOI | 10.18926/AMO/67547 |
|---|---|
| フルテキストURL | 78_4_313.pdf |
| 著者 | Eto, Eriko| Maki, Jota| Yamashita, Noriyuki| Hasegawa, Toru| Suemori, Ayano| Nakato, Hikari| Oba, Hikaru| Mitoma, Tomohiro| Mishima, Sakurako| Kirino, Satoe| Ohira, Akiko| Masuyama, Hisashi| |
| 抄録 | During the coronavirus pandemic, face-to-face simulation education became impossible. Therefore, we aimed to develop remote-access simulation education with a sense of realism through Information and Communication Technology (ICT) using a perinatal whole-body management and delivery simulator. In September 2021, we administered a multi-center simultaneous remote simulation based on our developed model. Ten universities in the Chugoku–Shikoku region were connected via a web-conferencing system to a live broadcast of a virtual vaginal birth in which a fictional hospitalized pregnant woman experienced accelerated labor and gave birth through vacuum delivery for fetal distress. A Video on Demand (VOD) was made beforehand using a new simulator that allowed for a visual understanding of the process of the inter-vaginal examination. We provided a participatory program that enhanced the sense of realism by combining VOD and real-time lectures on each scenario, with two-way communication between participants and trainee doctors using a chat function. Most participants answered “satisfied” or “very satisfied” with the content, level of difficulty, and level of understanding. From November 2021, we have used the videos of all processes in face-to-face classes. Our construction of a high-flexibility education system using remote simulation in the field of obstetrics and gynecology, especially in the vaginal delivery module, is unique, creative, and sustainable. |
| キーワード | remote simulator education perinatal simulator information and communication technology high-flexibility education |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-08 |
| 巻 | 78巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 313 |
| 終了ページ | 322 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39198985 |
| Web of Science KeyUT | 001310576400002 |
| JaLCDOI | 10.18926/AMO/67546 |
|---|---|
| フルテキストURL | 78_4_307.pdf |
| 著者 | Sugihara, Naoya| Hashine, Katsuyoshi| Yamashita, Natsumi| Sakamoto, Miki| Terashita, Masato| Funaki, Keisuke| Saiki, Kaori| Sawada, Takatora| Kakuda, Toshio| Nishimura, Kenichi| Fukumoto, Tetsuya| Miura, Noriyosi| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi| |
| 抄録 | The Briganti nomogram (cut-off value 5%) is commonly used to determine the indications for pelvic lymph node dissection (PLND) in patients with prostate cancer. We retrospectively analyzed the potential oncological benefit of PLND based on the 5% cut-off value on the Briganti nomogram. We obtained the data from the Medical Investigation Cancer Network (MICAN) Study, which included 3,463 patients who underwent a radical prostatectomy (RP) at nine institutions in Japan between 2010 and 2020. We included patients with Briganti scores ≥ 5% and a follow-up period ≥6 months and excluded patients categorized in the very high-risk group (based on NCCN categories); a final total of the cases of 1,068 patients were analyzed. The biochemical recurrence (BCR)-free survival was significantly worse in the patients who underwent PLND compared to those who did not (p=0.019). A multivariate analysis showed that high prostate-specific antigen (PSA) levels (p<0.001) and an advanced T-stage (p=0.018) were significant prognostic factors for BCR, whereas PLND had no effect on BCR (p=0.059). Thus, PLND in patients with prostate cancer whose Briganti score was 5% did not provide any oncological benefit. Further research is necessary to determine the indication criteria for conducting PLND. |
| キーワード | Briganti nomogram pelvic lymph node dissection prostate cancer radical prostatectomy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-08 |
| 巻 | 78巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 312 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39198984 |
| Web of Science KeyUT | 001310576400001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yumoto, Tetsuya| Hongo, Takashi| Obara, Takafumi| Ageta, Kohei| Aokage, Toshiyuki| Tsukahara, Kohei| Nakao, Atsunori| Naito, Hiromichi| |
| キーワード | clinical conference end-of-life care ICU rounds multidisciplinary team meetings |
| 発行日 | 2024-07-24 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 13巻 |
| 号 | 15号 |
| 出版者 | MDPI |
| 開始ページ | 4324 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39124591 |
| DOI | 10.3390/jcm13154324 |
| Web of Science KeyUT | 001287177900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm13154324 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsuge, Mitsuru| Ichihara, Eiki| Hasegawa, Kou| Kudo, Kenichiro| Tanimoto, Yasushi| Nouso, Kazuhiro| Oda, Naohiro| Mitsumune, Sho| Kimura, Goro| Yamada, Haruto| Takata, Ichiro| Mitsuhashi, Toshiharu| Taniguchi, Akihiko| Tsukahara, Kohei| Aokage, Toshiyuki| Hagiya, Hideharu| Toyooka, Shinichi| Tsukahara, Hirokazu| Maeda, Yoshinobu| |
| キーワード | novel coronavirus disease 2019 pneumonia hydroperoxide nitric oxide reactive oxygen species citrulline arginine asymmetric dimethylarginine |
| 発行日 | 2024-07-31 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 25巻 |
| 号 | 15号 |
| 出版者 | MDPI |
| 開始ページ | 8370 |
| ISSN | 1661-6596 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39125944 |
| DOI | 10.3390/ijms25158370 |
| Web of Science KeyUT | 001286890700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms25158370 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishihara, Takahiro| Takaya, Yoichi| Nakayama, Rie| Yoshida, Yu| Toh, Norihisa| Miyoshi, Toru| Nakamura, Kazufumi| Yuasa, Shinsuke| |
| キーワード | echocardiography prognosis right atrial function tricuspid regurgitation |
| 発行日 | 2024-08-02 |
| 出版物タイトル | ESC Heart Failure |
| 巻 | 11巻 |
| 号 | 6号 |
| 出版者 | Wiley |
| 開始ページ | 4019 |
| 終了ページ | 4027 |
| ISSN | 2055-5822 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39092803 |
| DOI | 10.1002/ehf2.14846 |
| Web of Science KeyUT | 001283015200001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ehf2.14846 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Feng, Yue| Li, Zhenhua| Li, Xiaoyi| Shen, Lili| Liu, Xueyang| Zhou, Cuicui| Zhang, Jinyang| Sang, Min| Han, Guangye| Yang, Wenqiang| Kuang, Tingyun| Wang, Wenda| Shen, Jian-Ren| |
| 発行日 | 2023-10-25 |
| 出版物タイトル | Science Advances |
| 巻 | 9巻 |
| 号 | 43号 |
| 出版者 | American Association for the Advancement of Science |
| 開始ページ | eadi8446 |
| ISSN | 2375-2548 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 The Authors |
| 論文のバージョン | publisher |
| PubMed ID | 37878698 |
| DOI | 10.1126/sciadv.adi8446 |
| Web of Science KeyUT | 001261640600010 |
| 関連URL | isVersionOf https://doi.org/10.1126/sciadv.adi8446 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Shien, Tadahiko| Tsuda, Hitoshi| Sasaki, Keita| Mizusawa, Junki| Akiyama, Futoshi| Kurosumi, Masafumi| Sawaki, Masataka| Tamura, Nobuko| Tanaka, Kiyo| Kogawa, Takahiro| Takahashi, Mina| Hayashi, Naoki| Mukai, Hirofumi| Masuda, Norikazu| Hara, Fumikata| Iwata, Hiroji| |
| キーワード | Breast cancer Neoadjuvant chemoradiotherapy Pathological therapeutic effect Specimen sampling method |
| 備考 | The version of record of this article, first published in Breast Cancer Research and Treatment, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10549-024-07408-5| |
| 発行日 | 2024-06-27 |
| 出版物タイトル | Breast Cancer Research and Treatment |
| 巻 | 208巻 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 145- |
| 終了ページ | 154 |
| ISSN | 0167-6806 |
| NCID | AA10623184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38935214 |
| DOI | 10.1007/s10549-024-07408-5 |
| Web of Science KeyUT | 001256954600001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s10549-024-07408-5 |
| フルテキストURL | papyrus_030_12_18.pdf |
|---|---|
| 著者 | 山野 定寿| |
| 抄録 | 教科書（清水：2020）の三角形の指導計画では、頂点から底辺上に高さがない鈍角三角形は、平行四辺形の中の「高さが外にあるときの面積の求め方」で、また、１組の平行線を用いて面積が等しいことを説明する活動は、単元の後半の「面積の求め方の工夫」で指導することになっている。筆者は、この２点を「三角形の面積」に統合した新たな指導計画を作成して授業実践を行い、この効果を分析することにした。授業実践の結果、「三角形の面積」に統合した新たな指導計画は、三角形の学習を主体的なものにするばかりでなく、平行四辺形の理解を容易にすることが分かった。 |
| キーワード | 鈍角三角形 平行線 指導計画 |
| 出版物タイトル | 岡山大学算数・数学教育学会誌 : パピルス |
| 発行日 | 2024-02-14 |
| 巻 | 30巻 |
| 開始ページ | 12 |
| 終了ページ | 18 |
| ISSN | 1341-3155 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/67207 |
|---|---|
| フルテキストURL | 78_3_301.pdf |
| 著者 | Nakazaki, Kiyoshi| Hirai, Satoshi| Hishikawa, Tomohito| |
| 抄録 | We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment. |
| キーワード | vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 301 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902220 |
| Web of Science KeyUT | 001267340600001 |
| JaLCDOI | 10.18926/AMO/67205 |
|---|---|
| フルテキストURL | 78_3_291.pdf |
| 著者 | Minagi, Hitoshi| Aoki, Hideki| Doita, Susumu| Miyake, Eiki| Ogawa, Toshihiro| Taniguchi, Fumitaka| Watanabe, Megumi| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji| |
| 抄録 | In the clinical course of malignant melanoma, which can metastasize to multiple organs, gallbladder metastases are rarely detected. A 69-year-old man who underwent resection of a primary malignant melanoma was subsequently treated with nivolumab for lung metastases and achieved complete response. Seven years after surgery, multiple nodules were found in the gallbladder, and he underwent laparoscopic cholecystectomy. The postoperative diagnosis was metastases of malignant melanoma. He has been recurrence-free 8 months after surgery. If radical resection is possible, such surgery should be performed for gallbladder metastases found in patients with other controlled lesions of malignant melanoma. |
| キーワード | malignant melanoma gallbladder metastasis laparoscopic cholecystectomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 294 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902218 |
| Web of Science KeyUT | 001267351900003 |
| JaLCDOI | 10.18926/AMO/67204 |
|---|---|
| フルテキストURL | 78_3_285.pdf |
| 著者 | Hirano, Shuichiro| Otani, Yoshihiro| Fujii, Kentaro| Date, Isao| |
| 抄録 | Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease. |
| キーワード | meningioma organized chronic subdural hematoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902217 |
| Web of Science KeyUT | 001267351900002 |
| JaLCDOI | 10.18926/AMO/67202 |
|---|---|
| フルテキストURL | 78_3_271.pdf |
| 著者 | Ye, Mengjiao| Zhang, Renwei| |
| 抄録 | We investigated how humidified high-flow nasal cannula oxygen therapy (HFNC) with a pulmonary infection control (PIC) window as a ventilation switching indication in combination with atomizing inhalation of terbutaline affects the lung function of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We examined 140 hospitalized AECOPD patients randomized to control and observation groups. Conventional supportive therapy and invasive mechanical ventilation with tracheal intubation were conducted in both groups, with a PIC window as the indication for ventilation switching. Noninvasive positive pressure ventilation (NIPPV) plus atomizing inhalation of terbutaline was used in the control group. In the observation group, HFNC combined with atomizing inhalation of terbutaline was used. Compared to the control group, after 48-hr treatment and treatment completion, the observation group had significantly increased levels of lung function indicators (maximal voluntary ventilation [MVV] plus forced vital capacity [FVC], p<0.05) and oxygen metabolism indicators (arterial oxygen partial pressure [PaO2], arterial oxygen content [CaO2], and oxygenation index, p<0.05). The comparison of the groups revealed that the levels of airway remodeling indicators (matrix metalloproteinase-2 [MMP-2], tissue inhibitor of metalloproteinase 2 [TIMP-2] plus MMP-9) and inflammatory indicators (interferon gamma [IFN-γ] together with interleukin-17 [IL-17], IL-10 and IL-4) were significantly lower after 48 h of treatment as well as after treatment completion (both p<0.05). These results demonstrate that HFNC with a PIC window as the indication for ventilation switching combined with atomizing inhalation of terbutaline can relieve the disorder of oxygen metabolism and correct airway hyper-reactivity. |
| キーワード | chronic obstructive pulmonary disease inhalation oxygen therapy pulmonary function ventilation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 271 |
| 終了ページ | 279 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902215 |
| Web of Science KeyUT | 001267351000008 |
| JaLCDOI | 10.18926/AMO/67201 |
|---|---|
| フルテキストURL | 78_3_259.pdf |
| 著者 | Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan| |
| 抄録 | The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients. |
| キーワード | multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902214 |
| Web of Science KeyUT | 001267351000007 |
| JaLCDOI | 10.18926/AMO/67200 |
|---|---|
| フルテキストURL | 78_3_251.pdf |
| 著者 | Murofushi, Koji| Mitomo, Sho| Hirohata, Kenji| Furuya, Hidetaka| Katagiri, Hiroki| Kaneoka, Koji| Yagishita, Kazuyoshi| |
| 抄録 | There have been few investigations into the effectiveness of thoracic spine exercises for improving thoracic range of motion (ROM) in any plane. This study assessed the effectiveness of two thoracic spine exercises: one in the quadruped position and one in the thoracic standing position. We determined how these exercises affect thoracic spine mobility ROM over a 2-week intervention period. Thirty-nine healthy participants were enrolled and assigned to a Quadruped Thoracic Rotation group (n=17 participants: 9 females and 8 males) or Flamenco Thoracic Spine Rotation group (n=22: 14 females and 8 males). All participants were administered a KOJI AWARENESSTM screening test, and the initial thoracic spine ROM before intervention exercise was measured in a laboratory setting. Quadruped Thoracic Rotation was performed as the quadruped exercise and Flamenco Thoracic Spine Rotation as the standing exercise. The KOJI AWARENESSTM thoracic spine test and ROM were evaluated on the day after the first exercise session and again after the program. Despite their different approaches to thoracic mobility, the quadruped exercise and standing exercise achieved equivalent improvement in thoracic ROM after 2 weeks. Practitioners have a range of exercise options for enhancing thoracic mobility based on their environmental or task-specific needs. |
| キーワード | thoracic spine thoracic rotation range of motion exercise intervention |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 251 |
| 終了ページ | 258 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902213 |
| Web of Science KeyUT | 001267351000006 |
| JaLCDOI | 10.18926/AMO/67199 |
|---|---|
| フルテキストURL | 78_3_245.pdf |
| 著者 | Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa| |
| 抄録 | Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients. |
| キーワード | knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 245 |
| 終了ページ | 250 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902212 |
| Web of Science KeyUT | 001267351000005 |
| レファレンス | Akishita M, Kozaki K, Iijima K, Tanaka T, Shibasaki K, Ogawa S and Arai H: Chapter 1 Definitions and diagnosis of sarcopenia. Geriatr Gerontol Int (2018) 18 Suppl 1: 7-12.| Shimokata H, Shimada H, Satake S, Endo N, Shibasaki K, Ogawa S and Arai H: Chapter 2 Epidemiology of sarcopenia. Geriatr Gerontol Int (2018) 18 Suppl 1: 13-22.| Bennell KL, Wrigley TV, Hunt MA, Lim BW and Hinman RS: Update on the role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am (2013) 39: 145-176.| Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, Proia A, Russo A, Bernabei R and Onder G: Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Sci Med Sci (2012) 67: 48-55.| Loeser RF: Age-related changes in the musculoskeletal system and the development of osteoarthritis. 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J Am Med Dir Assoc (2020) 21: 300-307.| Kashani K, Frazee EN, Kukrálová L, Sarvottam K, Herasevich V, Young PM, Kashyap R and Lieske JC: Evaluating muscle mass by using markers of kidney function: development of the sarcopenia index. Crit Care Med (2017) 45: e23-e29.| Kashani K, Sarvottam K, Pereira NL, Barreto EF and Kennedy CC: The sarcopenia index: a novel measure of muscle mass in lung transplant candidates. Clin Transplant (2018) 32: e13182.| Kusunoki H, Tsuji S, Wada Y, Fukai M, Nagai K, Itoh M, Sano K, Tamaki K, Ohta Y, Amano M, Maeda H, Hasegawa Y, Kishimoto H, Shimomura S, Yoshikawa H and Shinmura K: Relationship between sarcopenia and the serum creatinine/cystatin C ratio in Japanese rural community-dwelling older adults. J Cachexia Sarcopenia Muscle Clinical Reports (2018) 3: 1-14.| Kusunoki H, Tsuji S, Kusukawa T, Wada Y, Tamaki K, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Sugita H, Hasegawa Y, Kishimoto H, Shimomura S and Shinmura K: Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community-dwelling older adults with sarcopenia. Clin Exp Nephrol (2021) 25: 231-239.| Kanda Y: Investigation of the freely available easy-to-use software ʻEZRʼ for medical statistics. Bone Marrow Transplant (2013) 48: 452-458.| Davis AM, King LK, Stanaitis I and Hawker GA: Fundamentals of osteoarthritis: outcome evaluation with patient-reported measures and functional tests. Osteoarthritis Cartilage (2022) 30: 775-785.| Slemenda C, Brandt KD, Heilman DK, Mazzuca S, Braunstein EM, Katz BP and Wolinsky FD: Quadriceps weakness and osteoarthritis of the knee. 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BMC Geriatr (2021) 21: 2.| Kim BS, Lee SY, Kim BR, Choi JH, Kim SR, Lee HJ and Lee SJ: Associations between obesity with low muscle mass and physical function in patients with end-stage knee osteoarthritis. Geriatr Orthop Surg Rehabil. (2021) 12: 21514593211020700.| Jin WS, Choi EJ, Lee SY, Bae EJ, Lee TH and Park J: Relationships among obesity, sarcopenia, and osteoarthritis in the elderly. J Obes Metab Syndr (2017) 26: 36-44.| Misra D, Fielding RA, Felson DT, Niu J, Brown C, Nevitt M, Lewis CE, Torner J and Neogi T; MOST study: Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia. Arthritis Rheumatol (2019) 71: 232-237.| Kim HT, Kim HJ, Ahn HY and Hong YH: An analysis of age-related loss of skeletal muscle mass and its significance on osteoarthritis in a Korean population. Korean J Intern Med (2016) 31: 585-593.| Lee SY, Ro HJ, Chung SG, Kang SH, Seo KM and Kim DK: Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis. PLoS One (2016) 11: e0166385.| Visser AW, de Mutsert R, Loef M, le Cessie S, den Heijer M, Bloem JL, Reijnierse M, Rosendaal FR and Kloppenburg M; NEO Study Group: The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study. Osteoarthritis Cartilage (2014) 22: 197-202.| Ardeljan AD, Polisetty TS, Palmer J, Vakharia RM and Roche MW: Comparative analysis on the effects of sarcopenia following primary total knee arthroplasty: a retrospective matched-control analysis. J Knee Surg (2022) 35: 128-134.| Babu JM, Kalagara S, Durand W, Antoci V, Deren ME and Cohen E: Sarcopenia as a risk factor for prosthetic infection after total hip or knee arthroplasty. J Arthroplasty (2019) 34: 116-122.| Chaiwat O, Wongyingsinn M, Muangpaisan W, Chalermsri C, Siriussawakul A, Pramyothin P, Thitisakulchai P, Limpawattana P and Thanakiattiwibun C: A simpler screening tool for sarcopenia in surgical patients. PLoS One (2021) 16: e0257672.| |
| JaLCDOI | 10.18926/AMO/67198 |
|---|---|
| フルテキストURL | 78_3_237.pdf |
| 著者 | Muraoka, Osamu| Imai, Norio| Kuraishi, Tatsuya| Imai, Makoto| Fukuhara, Takashi| Yoshimine, Toshifumi| |
| 抄録 | Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period. |
| キーワード | fracture liaison services complications after admission secondary hip fracture mortality |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 237 |
| 終了ページ | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902211 |
| Web of Science KeyUT | 001267351000004 |