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JaLCDOI 10.18926/AMO/63738
フルテキストURL 76_3_291.pdf
著者 Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
抄録 Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
キーワード total hip arthroplasty bacterial contamination periprosthetic joint infection
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 295
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790359
Web of Science KeyUT 000823568300008
フルテキストURL fulltext.pdf
著者 Tamura, Nayu| Obara, Takafumi| Yamada, Taihei| Nojima, Tsuyoshi| Nakamura, Shunsuke| Koide, Yasuhiro| Takaoka, Makoto| Naito, Hiromichi| Nakao, Atsunori|
キーワード vitamin C malnutrition malabsorption peliosis anemia
発行日 2022
出版物タイトル Internal Medicine
61巻
12号
出版者 The Japanese Society of Internal Medicine
開始ページ 1913
終了ページ 1916
ISSN 0918-2918
NCID AA12022491
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Japanese Society of Internal Medicine
論文のバージョン publisher
PubMed ID 34776490
DOI 10.2169/internalmedicine.8409-21
Web of Science KeyUT 000813840600001
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.8409-21
フルテキストURL fulltext20220630-11.pdf Tables20220630-11.pdf SI20220630-11.pdf
著者 Uchida, Tetsuya| Nishioka, Ryohei| Yanai, Risa|
キーワード cellulose nanocrystals composite dispersibility mechanical properties surface treatment
備考 This is the peer reviewed version of the following article: [Uchida, T, Nishioka, R, Yanai, R. Preparation of cellulose nanocrystals coated with polymer crystals and their application in composite films. Polym Adv Technol. 2022; 1- 8.], which has been published in final form at [https://doi.org/10.1002/pat.5705]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext is available in April 2023.|
発行日 2022-04-26
出版物タイトル Polymers for Advanced Technologies
33巻
8号
出版者 Wiley
開始ページ 2511
終了ページ 2518
ISSN 1042-7147
NCID AA10838191
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 John Wiley & Sons Ltd.
論文のバージョン author
DOI 10.1002/pat.5705
Web of Science KeyUT 000787505800001
関連URL isVersionOf https://doi.org/10.1002/pat.5705
フルテキストURL fulltext20220630-10.pdf
著者 Sumi, Nanako| Nagahiro, Shota| Nakata, Eiji| Watanabe, Kazunori| Ohtsuki, Takashi|
キーワード Ultrasound Sonosensitizer Rose Bengal RNAi RNA delivery
備考 © 2022 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.bmcl.2022.128767.
This fulltext is available in May 2024. |
発行日 2022-07
出版物タイトル Bioorganic & Medicinal Chemistry Letters
68巻
出版者 Elsevier BV
開始ページ 128767
ISSN 0960-894X
NCID AA1079577X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Elsevier Ltd.
論文のバージョン author
PubMed ID 35513220
DOI 10.1016/j.bmcl.2022.128767
Web of Science KeyUT 000800009100005
関連URL isVersionOf https://doi.org/10.1016/j.bmcl.2022.128767
フルテキストURL fulltext20220630-9.pdf
著者 Naito, Hiromichi| Nojima, Tsuyoshi| Yorifuji, Takashi| Fujisaki, Noritomo| Nakao, Atsunori|
キーワード Post cardiac arrest syndrome Hypoxic ischemic brain injury Cardiopulmonary resuscitation Prognosis
発行日 2022-8
出版物タイトル The American Journal of Emergency Medicine
58巻
出版者 Elsevier BV
開始ページ 27
終了ページ 32
ISSN 0735-6757
NCID AA10642870
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors.
論文のバージョン publisher
PubMed ID 35623180
DOI 10.1016/j.ajem.2022.05.017
Web of Science KeyUT 000808614800006
フルテキストURL fulltext20220630-8.pdf
著者 Nishimura, Takeshi| Nojima, Tsuyoshi| Naito, Hiromichi| Ishihara, Satoshi| Nakayama, Shinichi| Nakao, Atsunori|
キーワード JTDB Prehospital Emergency life-saving technician Trauma
発行日 2022-06
出版物タイトル The American Journal of Emergency Medicine
56巻
出版者 Elsevier BV
開始ページ 218
終了ページ 222
ISSN 0735-6757
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors.
論文のバージョン publisher
PubMed ID 35447563
DOI 10.1016/j.ajem.2022.04.004
Web of Science KeyUT 000799775900035
関連URL isVersionOf https://doi.org/10.1016/j.ajem.2022.04.004
フルテキストURL fulltext20220630-1.pdf
著者 Udono, Heiichiro| Nishida, Mikako|
キーワード Mitochondrial ROS Oxidative stress Apoptosis Ageing Nrf2
備考 © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbagen.2022.130171] .
This fulltext is available in Aug. 2023.|
発行日 2022-08
出版物タイトル Biochimica et Biophysica Acta (BBA) - General Subjects
1866巻
8号
出版者 Elsevier BV
開始ページ 130171
ISSN 0304-4165
NCID AA00564679
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Elsevier B.V.
論文のバージョン author
PubMed ID 35588955
DOI 10.1016/j.bbagen.2022.130171
Web of Science KeyUT 000806942900004
関連URL isVersionOf https://doi.org/10.1016/j.bbagen.2022.130171
フルテキストURL fulltext20220630-7.pdf figure20220630-7.pdf
著者 Nagasaki, Joji| Togashi, Yosuke|
キーワード CD4(+) T cell cytotoxic CD4(+ )T cell regulatory T cell T-cell exhaustion
備考 This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Joji Nagasaki, Yosuke Togashi, A variety of ‘exhausted’ T cells in the tumor microenvironment, International Immunology, Volume 34, Issue 11, November 2022, Pages 563–570, https://doi.org/10.1093/intimm/dxac013] is available online at: [https://doi.org/10.1093/intimm/dxac013]
This fulltext is available in April 2023.|
発行日 2022-4-23
出版物タイトル International Immunology
34巻
11号
出版者 Oxford University Press
開始ページ 563
終了ページ 570
ISSN 1460-2377
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン author
PubMed ID 35460561
DOI 10.1093/intimm/dxac013
Web of Science KeyUT 000805278200001
関連URL isVersionOf https://doi.org/10.1093/intimm/dxac013
フルテキストURL fulltext20220630-6.pdf
著者 Tsunata, Ren| Takemoto, Masatsugu| Ogasawara, Satoshi| Saito, Tatsuya| Ueno, Tomoyuki|
備考 © 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
発行日 2022-5
出版物タイトル IEEE Transactions on Industry Applications
58巻
3号
出版者 Institute of Electrical and Electronics Engineers (IEEE)
開始ページ 3470
終了ページ 3485
ISSN 0093-9994
NCID AA00667900
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2022, IEEE
論文のバージョン author
DOI 10.1109/tia.2022.3154336
Web of Science KeyUT 000799279300052
関連URL isVersionOf https://doi.org/10.1109/tia.2022.3154336
フルテキストURL fulltext20220630-5.pdf figure20220630-5.pdf
著者 Okazaki, Yuki| Furumatsu, Takayuki| Kodama, Yuya| Hiranaka, Takaaki| Kintaka, Keisuke| Kamatsuki, Yusuke| Ozaki, Toshifumi|
キーワード Anterior cruciate ligament Coronal inclination Knee kinematics Magnetic resonance imaging Medial meniscus Posterior root tear
備考 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00590-022-03285-0
This fulltext is available in May 2023.|
発行日 2022-05-20
出版物タイトル European Journal of Orthopaedic Surgery and Traumatology
33巻
4号
出版者 Springer Science and Business Media LLC
開始ページ 1255
終了ページ 1262
ISSN 1432-1068
NCID AA11622799
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2022
論文のバージョン author
PubMed ID 35593940
DOI 10.1007/s00590-022-03285-0
Web of Science KeyUT 000800795900002
関連URL isVersionOf https://doi.org/10.1007/s00590-022-03285-0
フルテキストURL fulltext20220630-4.pdf
著者 Kato, Kosaku| Uemura, Yohei| Asakura, Kiyotaka| Yamakata, Akira|
備考 This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry C, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcc.2c01662
This fulltext is available in May 2023.|
発行日 2022-05-25
出版物タイトル The Journal of Physical Chemistry C
126巻
22号
出版者 American Chemical Society
開始ページ 9257
終了ページ 9263
ISSN 1932-7447
NCID AA1217589X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 American Chemical Society
論文のバージョン author
DOI 10.1021/acs.jpcc.2c01662
Web of Science KeyUT 000810253900001
関連URL isVersionOf https://doi.org/10.1021/acs.jpcc.2c01662
フルテキストURL fulltext20220630-3.pdf
著者 Maki, Yuta| Kawata, Kazuki| Liu, Yanbo| Goo, Kang‐Ying| Okamoto, Ryo| Kajihara, Yasuhiro| Satoh, Ayano|
キーワード glycoprotein N-glycan cholera toxin native chemical ligation live imaging
備考 This is the peer reviewed version of the following article: [Y. Maki, K. Kawata, Y. Liu, K.-Y. Goo, R. Okamoto, Y. Kajihara, A. Satoh, Chem. Eur. J. 2022, 28, e202201253], which has been published in final form at [https://doi.org/10.1002/chem.202201253]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext is available in May 2023.|
発行日 2022-05-23
出版物タイトル Chemistry - A European Journal
28巻
37号
出版者 Wiley
開始ページ e202201253
ISSN 0947-6539
NCID AA11076269
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Wiley-VCH GmbH
論文のバージョン author
PubMed ID 35604098
DOI 10.1002/chem.202201253
Web of Science KeyUT 000798823300001
関連URL isVersionOf https://doi.org/10.1002/chem.202201253
フルテキストURL fulltext20220620-4.pdf
著者 Ren, Jianchao| Kaneta, Takashi|
備考 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00078-7
This fulltext is available in Feb. 2023.|
発行日 2022-02-25
出版物タイトル Analytical Sciences
38巻
4号
出版者 Springer Science and Business Media LLC
開始ページ 651
終了ページ 655
ISSN 0910-6340
NCID AA10500785
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.
論文のバージョン author
PubMed ID 35286641
DOI 10.1007/s44211-022-00078-7
Web of Science KeyUT 000808551700004
関連URL isVersionOf https://doi.org/10.1007/s44211-022-00078-7
フルテキストURL fulltext20220630-2.pdf
著者 Takahashi, Misa| Hagiya, Hideharu| Tanaka, Shuichi| Yamamoto, Koichiro| Honda, Hiroyuki| Hasegawa, Kou| Otsuka, Fumio|
備考 © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.02.021] .
This fulltext is available in March 2023.|
発行日 2022-7
出版物タイトル Journal of Infection and Chemotherapy
28巻
7号
出版者 Elsevier BV
開始ページ 978
終了ページ 981
ISSN 1341-321X
NCID AA11057978
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Elsevier B.V.
論文のバージョン author
PubMed ID 35277342
DOI 10.1016/j.jiac.2022.02.021
Web of Science KeyUT 000808081000003
関連URL isVersionOf https://doi.org/10.1016/j.jiac.2022.02.021
フルテキストURL fulltext.pdf
著者 Tamura, Katsunori| Oshima, Yuri| Fuse, Yuta| Nagaoka, Noriyuki| Kunoh, Tatsuki| Nakanishi, Makoto| Fujii, Tatsuo| Nanba, Tokuro| Takada, Jun|
発行日 2022-04-10
出版物タイトル ACS Omega
7巻
15号
出版者 American Chemical Society
開始ページ 12795
終了ページ 12802
ISSN 2470-1343
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors.
論文のバージョン publisher
PubMed ID 35474768
DOI 10.1021/acsomega.1c07390
Web of Science KeyUT 000812569200001
関連URL isVersionOf https://doi.org/10.1021/acsomega.1c07390
フルテキストURL fulltext.pdf
著者 Yamada, Yuto| Fujiwara, Masaki| Shimazu, Taichi| Etoh, Tsuyoshi| Kodama, Masafumi| So, Ryuhei| Matsushita, Takanori| Yoshimura, Yusaku| Horii, Shigeo| Fujimori, Maiko| Takahashi, Hirokazu| Nakaya, Naoki| Miyaji, Tempei| Hinotsu, Shiro| Harada, Keita| Okada, Hiroyuki| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi|
発行日 2022-06
出版物タイトル BMJ Open
12巻
6号
出版者 BMJ Publishing Group
開始ページ e060621
ISSN 2044-6055
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Author(s) (or their employer(s)) 2022.
論文のバージョン publisher
PubMed ID 35701062
DOI 10.1136/bmjopen-2021-060621
Web of Science KeyUT 000811702800009
関連URL isVersionOf https://doi.org/10.1136/bmjopen-2021-060621
JaLCDOI 10.18926/AMO/63722
フルテキストURL 76_3_281.pdf
著者 Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong|
抄録 Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
キーワード periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 281
終了ページ 290
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790358
Web of Science KeyUT 000823568300007
JaLCDOI 10.18926/AMO/63721
フルテキストURL 76_3_273.pdf
著者 Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro|
抄録 Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination.
キーワード hip total hip arthroplasty arthroplasty radiography lordosis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 273
終了ページ 280
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790357
Web of Science KeyUT 000823568300006
JaLCDOI 10.18926/AMO/63720
フルテキストURL 76_3_265.pdf
著者 Kosaki, Yoshinori| Naito, Hiromichi| Iida, Atsuyoshi| Ihoriya, Hiromi| Nojima, Tsuyoshi| Yamada, Taihei| Yamamoto, Hirotsugu| Nakamura, Shunsuke| Mandai, Yasuhiro| Nakao, Atsunori|
抄録 Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons.
キーワード BLS medical education emergency medicine resuscitation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 265
終了ページ 271
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790356
Web of Science KeyUT 000823568300005
JaLCDOI 10.18926/AMO/63719
フルテキストURL 76_3_255.pdf
著者 Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi|
抄録 Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
キーワード alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 255
終了ページ 263
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790355
Web of Science KeyUT 000823568300004