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JaLCDOI 10.18926/AMO/57374
フルテキストURL 73_5_433.pdf
著者 Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi|
抄録 An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia.
キーワード preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 433
終了ページ 440
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649370
Web of Science KeyUT 000491886600009
JaLCDOI 10.18926/AMO/57373
フルテキストURL 73_5_427.pdf
著者 Owari, Yutaka| Suzuki, Hiromi| Miyatake, Nobuyuki|
抄録 The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan.
キーワード Active Guide sedentary behavior elderly people randomized controlled trial health promotion
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 427
終了ページ 432
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649369
Web of Science KeyUT 000491886600008
JaLCDOI 10.18926/AMO/57372
フルテキストURL 73_5_419.pdf
著者 Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo|
抄録 We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis.
キーワード sedentary behavior hemodialysis mortality physical activity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 419
終了ページ 425
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649368
Web of Science KeyUT 000491886600007
JaLCDOI 10.18926/AMO/57369
フルテキストURL 73_5_393.pdf
著者 Yi Yi Cho Thein| Win, Myitzu| Thuzara, Moe| Matsumoto, Hiroshi| Yamada, Kiyoshi| Kimata, Yoshihiro| Leung, Michael|
抄録 Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation.
キーワード microsurgery educational programs challenges of microsurgical free flaps reoperation flap salvageable rate
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 393
終了ページ 401
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649365
Web of Science KeyUT 000491886600004
JaLCDOI 10.18926/AMO/57367
フルテキストURL 73_5_383.pdf
著者 Fu, Li| Nishibori, Masahiro|
抄録 High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.
キーワード HMGB1 epileptogenesis inflammation blood-brain barrier
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 383
終了ページ 386
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649363
Web of Science KeyUT 000491886600002
JaLCDOI 10.18926/AMO/57366
フルテキストURL 73_5_379.pdf
著者 Wake, Hidenori|
抄録 Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
キーワード htidine-rich glycoprotein septic pathogenesis immunothrombosis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 379
終了ページ 382
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649362
Web of Science KeyUT 000491886600001
フルテキストURL SciRep_9_1_14001_p.pdf
著者 Uchiyama, Hironobu| Sasaki, Ken| Hinosawa, Shogo| Tanaka, Keisuke| Matsumura, Kentarou| Yajima, Shunsuke| Miyatake, Takahisa|
発行日 2019-09-30
出版物タイトル Scientific reports
9巻
1号
出版者 Springer Nature
開始ページ 14001
ISSN 20452322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019
論文のバージョン publisher
PubMed ID 31570743
DOI 10.1038/s41598-019-50440-5
Web of Science KeyUT 000488223900004
関連URL isVersionOf https://doi.org/10.1038/s41598-019-50440-5
フルテキストURL fulltext.pdf
著者 Takahashi, Yuko| Iwamoto, Takayuki| Suzuki, Yoko| Kajiwara, Yukiko| Hatono, Minami| Tsukioki, Takahiro| Kawada, Kengo| Kochi, Mariko| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| Toyooka, Shinichi|
キーワード Gene expression Hormone receptor positive Residual tumor burden Targeted therapy Triple negative
発行日 2020-04
出版物タイトル Clinical Breast Cancer
20巻
2号
出版者 Elsevier
開始ページ 117
終了ページ 124
ISSN 1526-8209
NCID AA11694891
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31570267
DOI 10.1016/j.clbc.2019.07.001
Web of Science KeyUT 000529805200021
関連URL isVersionOf https://doi.org/10.1016/j.clbc.2019.07.001
フルテキストURL Allergol_Int_201908007.pdf
著者 Matsumoto, Naomi| Yorifuji, Takashi| Nakamura, Kazue| Ikeda, Masanori| Tsukahara, Hirokazu| Doi, Hiroyuki|
キーワード Breastfeeding Cohort Colostrum Eczema Food allergy
発行日 2019-09-17
出版物タイトル Allergology International
出版者 Elsevier
ISSN 13238930
NCID AA11091750
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン publisher
PubMed ID 31540813
DOI 10.1016/j.alit.2019.08.007
関連URL isVersionOf https://doi.org/10.1016/j.alit.2019.08.007
フルテキストURL TL60_43_151189.pdf
著者 Wang, Lei| Fujii, Mayu| Namba, Misa| Yamaji, Minoru| Okamoto, Hideki|
キーワード Fluorescence ESIPT Naphthalimide Ca2+ probe
備考 © 2019 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.tetlet.2019.151189].|
発行日 2019-09-20
出版物タイトル Tetrahedron Letters
60巻
43号
出版者 PERGAMON-ELSEVIER SCIENCE
開始ページ 151189
ISSN 00404039
NCID AA00861801
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 Elsevier Ltd.
論文のバージョン author
DOI 10.1016/j.tetlet.2019.151189
Web of Science KeyUT 000491626500018
関連URL isVersionOf https://doi.org/10.1016/j.tetlet.2019.151189
フルテキストURL Biomed_Pharmacother_2019109038.pdf
著者 Ueno, Hiroshi| Suemitsu, Shunsuke| Murakami, Shinji| Kitamura, Naoya| Wani, Kenta| Takahashi, Yu| Matsumoto, Yosuke| Okamoto, Motoi| Ishihara, Takeshi|
キーワード Inhalation Dizocilpine MK-801 Mouse Drug Schizophrenia
発行日 2019-09-30
出版物タイトル Biomedicine & Pharmacotherapy
117巻
出版者 Elsevier
開始ページ 109038
ISSN 07533322
NCID AA10506249
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier Masson SAS.
論文のバージョン publisher
PubMed ID 31177060
DOI 10.1016/j.biopha.2019.109038
Web of Science KeyUT 000477804500018
関連URL isVersionOf https://doi.org/10.1016/j.biopha.2019.109038
フルテキストURL BiochemBiophysRep_19_100665.pdf
著者 Kato, Mutsuko| Sato, Keita| Habuta, Munenori| Fujita, Hirofumi| Bando, Tetsuya| Morizane, Yuki| Shiraga, Fumio| Miyaishi, Satoru| Ohuchi, Hideyo|
キーワード Opsin 5 UV-Absorbing pigment Fibroblasts Chicken Egr1 Mmp2
発行日 2019-09-30
出版物タイトル Biochemistry and Biophysics Reports
19巻
出版者 Elsevier B.V
開始ページ 100665
ISSN 24055808
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier B.V.
論文のバージョン publisher
PubMed ID 31463372
DOI 10.1016/j.bbrep.2019.100665
関連URL isVersionOf https://doi.org/10.1016/j.bbrep.2019.100665
フルテキストURL eNeurologicalSci_16_100204.pdf
著者 Takamiya, Motonori| Takahashi, Yoshiaki| Morimoto, Mizuki| Morimoto, Nobutoshi| Yamashita, Satoshi| Abe, Koji|
キーワード Anti-skeletal muscle protein 5′-nucleotidase 1A antibody Chronic hepatitis C Dysphagia Inclusion body myositis Intravenous immunoglobulin therapy
備考 Case Report|
発行日 2019-09-30
出版物タイトル eNeurologicalSci
16巻
出版者 Elsevier B.V.
開始ページ 100204
ISSN 24056502
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier B.V.
論文のバージョン publisher
PubMed ID 31517073
DOI 10.1016/j.ensci.2019.100204
関連URL isVersionOf https://doi.org/10.1016/j.ensci.2019.100204
フルテキストURL DevBiol_452_104.pdf
著者 Saito, Nanami| Nishimura, Koki| Makanae, Aki| Satoh, Akira|
キーワード Blastema induction Bmp Fgf Gill regeneration Nerve Organ regeneration
発行日 2019-08-15
出版物タイトル Developmental Biology
452巻
出版者 Elsevier
開始ページ 104
終了ページ 113
ISSN 00121606
NCID AA00627848
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier Inc.
論文のバージョン publisher
PubMed ID 31034835
DOI 10.1016/j.ydbio.2019.04.011
Web of Science KeyUT 000473375100005
関連URL isVersionOf https://doi.org/10.1016/j.ydbio.2019.04.011
フルテキストURL JAllergyClin Immunol_144_5_1336.pdf
著者 Gupta, Atul| Ikeda, Masanori| Geng, Bob| Azmi, Jay| Price, Robert G.| Bradford, Eric S.| Yancey, Steven W.| Steinfeld, Jonathan|
キーワード Pediatric asthma eosinophilia mepolizumab
発行日 2019-08-16
出版物タイトル Journal of Allergy and Clinical Immunology
144巻
5号
開始ページ 1336
終了ページ 1342
ISSN 00916749
NCID AA00692442
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
論文のバージョン publisher
PubMed ID 31425781
DOI 10.1016/j.jaci.2019.08.005
関連URL isVersionOf https://doi.org/10.1016/j.jaci.2019.08.005
フルテキストURL JDS96_1_26.pdf Fig.pdf
著者 Sugihara, Satoru| Sugimoto, Saeko| Tachibana, Kota| Kobashi, Mina| Nomura, Hayato| Miyake, Tomoko| Hirai, Yoji| Yamasaki, Osamu| Morizane, Shin|
キーワード Epidermal keratinocyte IL-17A Lympho-epithelial Kazal-type inhibitor Serine protease inhibitor TNF-α
発行日 2019-08-21
出版物タイトル Journal of Dermatological Science
96巻
1号
出版者 Elsevier
開始ページ 26
終了ページ 32
ISSN 09231811
NCID AA1075636X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31501002
DOI 10.1016/j.jdermsci.2019.08.007
Web of Science KeyUT 000497889600004
関連URL isVersionOf https://doi.org/10.1016/j.jdermsci.2019.08.007
フルテキストURL J_TradComplMed_2019.pdf
著者 Abouelela, Mohamed E.| Orabi, Mohamed A.A.| Abdelhamid, Reda A.| Abdelkader, Mohamed S.| Madkor, Hafez R.| Darwish, Faten M.M.| Hatano, Tsutomu| Elsadek, Bakheet E.M.|
キーワード Ceiba pentandra(L.) Gaertn. Methotrexate Nephrotoxicity Antioxidant
発行日 2019-08-28
出版物タイトル Journal of Traditional and Complementary Medicine
出版者 Elsevier
ISSN 22254110
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.
論文のバージョン publisher
DOI 10.1016/j.jtcme.2019.08.006
関連URL isVersionOf https://doi.org/10.1016/j.jtcme.2019.08.006
フルテキストURL Heliyon_5_8_02306.pdf
著者 Okubo, Keisuke| Ito, Takashi| Shiota, Yasuyoshi| Kawata, Yusuke| Yamamoto, Tadashi| Takashiba, Shogo|
キーワード Biofilm Dental chair unit water line (DUWL) Heterotrophic bacteria Low-concentration Materials science Ozonized water
発行日 2019-08-31
出版物タイトル Heliyon
5巻
8号
出版者 Elsevier Science
開始ページ e02306
ISSN 24058440
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier Ltd.
論文のバージョン publisher
PubMed ID 31463403
DOI 10.1016/j.heliyon.2019.e02306
Web of Science KeyUT 000484391200055
関連URL isVersionOf https://doi.org/10.1016/j.heliyon.2019.e02306
フルテキストURL fulltext.pdf
著者 Yu, Jiabin| Yang, Jiajia| Yu, Yinghua| Wu, Qiong| Takahashi, Satoshi| Ejima, Yoshimichi| Wu, Jinglong|
キーワード Affective tactile CT afferents; Neuroscience Physical factors Pleasantness ratings Stroking hardness.
発行日 2019-08-31
出版物タイトル Heliyon
5巻
8号
出版者 Elsevier
開始ページ e02141
ISSN 24058440
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier Ltd.
論文のバージョン publisher
PubMed ID 31453390
DOI 10.1016/j.heliyon.2019.e02141
Web of Science KeyUT 000484391200175
関連URL isVersionOf https://doi.org/10.1016/j.heliyon.2019.e02141
フルテキストURL fulltext.pdf
著者 Nomura, Kaoru| Yamaguchi, Toshiyuki| Mori, Shoko| Fujikawa, Kohki| Nishiyama, Ken-ichi| Shimanouchi, Toshinori| Tanimoto, Yasushi| Morigaki, Kenichi| Shimamoto, Keiko|
発行日 2019-07-09
出版物タイトル Biophysical Journal
117巻
1号
出版者 elsevier
開始ページ 99
終了ページ 110
ISSN 00063495
NCID AA00566095
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 Biophysical Society.
論文のバージョン publisher
PubMed ID 31164197
DOI 10.1016/j.bpj.2019.05.014
Web of Science KeyUT 000474550400012
関連URL isVersionOf https://doi.org/10.1016/j.bpj.2019.05.014