検索結果 - 岡山大学学術成果リポジトリ

Interaction of Orexin and Bone Morphogenetic Proteins in Steroidogenesis by Human Adrenocortical Cells

フルテキストURL	fulltext.pdf
著者	Soejima, Yoshiaki\| Iwata, Nahoko\| Nishioka, Ran\| Honda, Mako\| Nakano, Yasuhiro\| Yamamoto, Koichiro\| Suyama, Atsuhito\| Otsuka, Fumio\|
キーワード	bone morphogenetic protein (BMP) orexin steroidogenesis and adrenal
発行日	2023-08-08
出版物タイトル	International Journal of Molecular Sciences
巻	24巻
号	16号
出版者	MDPI
開始ページ	12559
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	37628739
DOI	10.3390/ijms241612559
Web of Science KeyUT	001056982200001
関連URL	isVersionOf https://doi.org/10.3390/ijms241612559

Bayesian statistical modeling to predict observer-specific optimal windowing parameters in magnetic resonance imaging

フルテキストURL	fulltext.pdf
著者	Sugimoto, Kohei\| Oita, Masataka\| Kuroda, Masahiro\|
キーワード	MR image Image intensity standardization Windowing Prediction Bayesian statistical modeling
発行日	2023-08
出版物タイトル	Heliyon
巻	9巻
号	8号
出版者	Cell Press
開始ページ	e19038
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37636402
DOI	10.1016/j.heliyon.2023.e19038
Web of Science KeyUT	001056714100001
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2023.e19038

Expression of microbial rhodopsins in Escherichia coli and their extraction and purification using styrene-maleic acid copolymers

フルテキストURL	fulltext.pdf
著者	Kojima, Keiichi\| Sudo, Yuki\|
発行日	2022-03-18
出版物タイトル	STAR Protocols
巻	3巻
号	1号
出版者	Cell Press
開始ページ	101046
ISSN	2666-1667
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021
論文のバージョン	publisher
PubMed ID	34984357
DOI	10.1016/j.xpro.2021.101046
Web of Science KeyUT	001055085700004
関連URL	isVersionOf https://doi.org/10.1016/j.xpro.2021.101046

Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia

フルテキストURL	O004059.pdf
著者	矢野昭正\|
発行日	2005-09-30
資料タイプ	学位論文
学位授与番号	乙第4059号
学位授与年月日	2005-09-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Xanthine oxidase-derived free radicals directly activate rat pancreatic stellate cells

フルテキストURL	O004054.pdf
著者	谷岡洋亮\|
発行日	2005-09-30
資料タイプ	学位論文
学位授与番号	乙第4054号
学位授与年月日	2005-09-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Effects of acute moderate exercise on the phagocytosis of Kupffer cells in rats

フルテキストURL	O004053.pdf
著者	矢野博己\|
発行日	2005-09-30
資料タイプ	学位論文
学位授与番号	乙第4053号
学位授与年月日	2005-09-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B

フルテキストURL	K003017.pdf
著者	藤田洋史\|
発行日	2005-09-30
資料タイプ	学位論文
学位授与番号	甲第3017号
学位授与年月日	2005-09-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Effects of the rigid and sterically bulky structure of non-fused nonfullerene acceptors on transient photon-to-current dynamics

フルテキストURL	fulltext.pdf
著者	Jinnai, Seihou\| Murayama, Kasumi\| Nagai, Keisuke\| Mineshita, Megumi\| Kato, Kosaku\| Muraoka, Azusa\| Yamakata, Akira\| Saeki, Akinori\| Kobori, Yasuhiro\| Ie, Yutaka\|
発行日	2022-08-09
出版物タイトル	Journal of Materials Chemistry A
巻	10巻
号	37号
出版者	Royal Society of Chemistry (RSC)
開始ページ	20035
終了ページ	20047
ISSN	2050-7488
NCID	AA12603290
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Royal Society of Chemistry 2022
論文のバージョン	publisher
DOI	10.1039/d2ta02604j
Web of Science KeyUT	000837730900001
関連URL	isVersionOf https://doi.org/10.1039/d2ta02604j

A tonoplast‐localized magnesium transporter is crucial for stomatal opening in Arabidopsis under high Mg2+ conditions

フルテキストURL	fulltext.pdf
著者	Inoue, Shin‐ichiro\| Hayashi, Maki\| Huang, Sheng\| Yokosho, Kengo\| Gotoh, Eiji\| Ikematsu, Shuka\| Okumura, Masaki\| Suzuki, Takamasa\| Kamura, Takumi\| Kinoshita, Toshinori\| Ma, Jian Feng\|
キーワード	ACDP CNNM Arabidopsis thaliana magnesium transport plant growth stomatal opening
発行日	2022-08-17
出版物タイトル	New Phytologist
巻	236巻
号	3号
出版者	Wiley
開始ページ	864
終了ページ	877
ISSN	0028-646X
NCID	AA00755407
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors
論文のバージョン	publisher
PubMed ID	35976788
DOI	10.1111/nph.18410
Web of Science KeyUT	000841377100001
関連URL	isVersionOf https://doi.org/10.1111/nph.18410

Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms

フルテキストURL	O004077.pdf
著者	馬場雅子\|
発行日	2005-12-31
資料タイプ	学位論文
学位授与番号	乙第4077号
学位授与年月日	2005-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Emergence of nuclear heparanase induces differentiation of human mammary cancer cells

フルテキストURL	K003052.pdf
著者	信久徹治\|
発行日	2005-12-31
資料タイプ	学位論文
学位授与番号	甲第3052号
学位授与年月日	2005-12-31
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Demonstration of iodide-dependent UVA-triggered growth inhibition in Saccharomyces cerevisiae cells and identification of its suppressive molecules

フルテキストURL	fulltext20230828-02.pdf
著者	Ono, Ryota\| Saeki, Nozomu\| Kojima, Keiichi\| Moriya, Hisao\| Sudo, Yuki\|
キーワード	UVA Saccharomyces cerevisiae Iodide Growth inhibition Suppressive molecule
備考	© 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Oct. 2024.\|
発行日	2023-10-15
出版物タイトル	Biochemical and Biophysical Research Communications
巻	677巻
出版者	Elsevier BV
開始ページ	1
終了ページ	5
ISSN	0006-291X
NCID	AA00564395
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Elsevier Inc.
論文のバージョン	author
PubMed ID	37523893
DOI	10.1016/j.bbrc.2023.07.048
Web of Science KeyUT	001047346900001
関連URL	isVersionOf https://doi.org/10.1016/j.bbrc.2023.07.048

Evidence for Hypoxia-Induced Shift in ATP Production from Glycolysis to Mitochondrial Respiration in Pulmonary Artery Smooth Muscle Cells in Pulmonary Arterial Hypertension

フルテキストURL	fulltext.pdf
著者	Akagi, Satoshi\| Nakamura, Kazufumi\| Kondo, Megumi\| Hirohata, Satoshi\| Udono, Heiichiro\| Nishida, Mikako\| Saito, Yukihiro\| Yoshida, Masashi\| Miyoshi, Toru\| Ito, Hiroshi\|
キーワード	glycolysis mitochondrial respiration pulmonary arterial hypertension pulmonary artery smooth muscle cells Seahorse technology hypoxia ATP production
発行日	2023-07-31
出版物タイトル	Journal of Clinical Medicine
巻	12巻
号	15号
出版者	MDPI
開始ページ	5028
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	37568430
DOI	10.3390/jcm12155028
Web of Science KeyUT	001045690800001
関連URL	isVersionOf https://doi.org/10.3390/jcm12155028

A Boy Safely Treated with Tyrosine Kinase Inhibitors for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Osteolysis

JaLCDOI	10.18926/AMO/65757
フルテキストURL	77_4_439.pdf
著者	Shiwaku, Takahiro\| Ishida, Hisashi\| Tatebe, Yasuhisa\| Tamefusa, Kosuke\| Ochi, Motoharu\| Fujiwara, Kaori\| Kubo, Toshihide\| Nakata, Eiji\| Washio, Kana\| Tsukahara, Hirokazu\|
抄録	A three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This suggests that TKIs can be safely given with concomitant corticosteroids to children with Ph+ALL, even when osteolytic lesions are present.
キーワード	acute lymphoblastic leukemia children tyrosine kinase inhibitor osteolysis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	439
終了ページ	442
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635146
Web of Science KeyUT	001088434900002

Immunohistochemical Expression of Placental Vitamin D Receptors in Pregnancies Complicated by Early and Late-Onset Preeclampsia

JaLCDOI	10.18926/AMO/65752
フルテキストURL	77_4_415.pdf
著者	Jelcic, Dzenis\| Puzovic, Velibor\| Benzon, Benjamin\| Palada, Ivan\| Jerković, Jelena\| Vulic, Marko\|
抄録	The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset.
キーワード	vitamin D receptor immunohistochemistry early and late-onset preeclampsia
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	415
終了ページ	422
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635142
Web of Science KeyUT	001163659800006

Association of Tumor Necrosis Factor-Alpha with Psychopathology in Patients with Schizophrenia

JaLCDOI	10.18926/AMO/65750
フルテキストURL	77_4_395.pdf
著者	Pavlovic, Marko\| Babic, Dragan\| Rastovic, Pejana\| Arapovic, Jurica\| Martinac, Marko\| Jakovac, Sanja\| Barbaric, Romana\|
抄録	We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
キーワード	tumor necrosis factor-alpha schizophrenia psychopathology immune system
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	395
終了ページ	405
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635140
Web of Science KeyUT	001163659800010

Disease Progression-Related Markers for Aged Non-Alcoholic Fatty Liver Disease Patients

JaLCDOI	10.18926/AMO/65748
フルテキストURL	77_4_377.pdf
著者	Morimoto, Kosaku\| Takeuchi, Yasuto\| Takaki, Akinobu\| Wada, Nozomu\| Oyama, Atsushi\| Adachi, Takuya\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
キーワード	NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	377
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635138
Web of Science KeyUT	001163659800009

GATA4 rs61277615, rs73203482, and rs35813172 in Newborns with Transposition of the Great Arteries

JaLCDOI	10.18926/AMO/65745
フルテキストURL	77_4_365.pdf
著者	Moldovan, Elena\| Bănescu, Claudia\| Cucerea, Manuela\| Moldovan, Valeriu\| Gozar, Liliana\| Pușcașiu, Lucian\|
抄録	Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported.
キーワード	transposition of the great arteries ductal-dependent coarctation of the aorta GATA4 MLPA Sanger sequencing
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	365
終了ページ	370
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635136
Web of Science KeyUT	001163659800008

Effectiveness of deep learning classifiers in histopathological diagnosis of oral squamous cell carcinoma by pathologists

フルテキストURL	fulltext.pdf
著者	Sukegawa, Shintaro\| Ono, Sawako\| Tanaka, Futa\| Inoue, Yuta\| Hara, Takeshi\| Yoshii, Kazumasa\| Nakano, Keisuke\| Takabatake, Kiyofumi\| Kawai, Hotaka\| Katsumitsu, Shimada\| Nakai, Fumi\| Nakai, Yasuhiro\| Miyazaki, Ryo\| Murakami, Satoshi\| Nagatsuka, Hitoshi\| Miyake, Minoru\|
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-38343-y\|
発行日	2023-07-19
出版物タイトル	Scientific Reports
巻	13巻
号	1号
出版者	Nature Portfolio
開始ページ	11676
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37468501
DOI	10.1038/s41598-023-38343-y
Web of Science KeyUT	001033545700013
関連URL	isVersionOf https://doi.org/10.1038/s41598-023-38343-y

Expression and clinicopathological characteristics of PDX1, PTF1A, and SALL4 in large and small ducts of ectopic pancreas located in gastro-duodenum and jejunum

フルテキストURL	fulltext.pdf
著者	Chen, Mengxi\| Tanaka, Takehiro\| Igawa, Takuro\| Han, Yanyan\| Peng, Fangli\| Jin, Zaishun\| Yoshino, Tadashi\|
キーワード	PDX1 PTF1A SALL4 Ectopic pancreas Gastro-duodenum Jejunum
発行日	2023-07
出版物タイトル	Heliyon
巻	9巻
号	7号
出版者	Cell Press
開始ページ	e18241
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37519669
DOI	10.1016/j.heliyon.2023.e18241
Web of Science KeyUT	001043928200001
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241