検索結果 - 岡山大学学術成果リポジトリ

Primary Lacrimal Sac Diffuse Large B-cell Lymphoma Treated With Local Radiotherapy Alone: A Case With No Relapse After 21 Years of Follow-Up

フルテキストURL	fulltext.pdf
著者	Matsuo, Toshihiko\| Tanaka, Takehiro\| Takemoto, Mitsuhiro\|
キーワード	diffuse large b-cell lymphoma excisional biopsy lacrimal sac laser photocoagulation macular edema pathology radiation cataract radiation retinopathy radiotherapy vitrectomy
発行日	2025-10-25
出版物タイトル	Cureus
巻	17巻
号	10号
出版者	Springer Science and Business Media LLC
開始ページ	e95411
ISSN	2168-8184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Copyright 2025 Matsuo et al.
論文のバージョン	publisher
DOI	10.7759/cureus.95411
関連URL	isVersionOf https://doi.org/10.7759/cureus.95411

Effects of Visual Stimuli on Perceived Sound Volume in Virtual Reality Spaces

著者	Matsuda, Yuki\| Kobayashi, Toma\| Watanabe, Hiroki\| Yasumoto, Keiichi\|
キーワード	Virtual Reality Subjective sound volume Visual stimuli
備考	This is an Accepted Manuscript of a conference paper published by Springer Nature Switzerland.\| HCII 2025\| Lecture Notes in Computer Science, volume 15788\| This fulltext file will be available in Jun. 2026.\|
発行日	2025
出版物タイトル	Virtual, Augmented and Mixed Reality
出版者	Springer Nature Switzerland
開始ページ	286
終了ページ	299
ISSN	0302-9743
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s), under exclusive license to Springer Nature Switzerland AG
論文のバージョン	author
DOI	10.1007/978-3-031-93700-2_19
Web of Science KeyUT	001544376900019
関連URL	isVersionOf https://doi.org/10.1007/978-3-031-93700-2_19

Comparative analysis of interactions between five strains of Pseudomonas syringae pv. tabaci and Nicotiana benthamiana

フルテキストURL	fulltext.pdf
著者	Nakao, Yuna\| Asai, Shuta\| Matsui, Hidenori\| Ichinose, Yuki\| Katou, Shinpei\|
キーワード	Chlorosis Nicotiana benthamiana Phytohormones Pseudomonas syringae pv. tabaci
発行日	2025-10-14
出版物タイトル	Journal of General Plant Pathology
出版者	Springer Science and Business Media LLC
ISSN	1345-2630
NCID	AA11449093
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025
論文のバージョン	publisher
DOI	10.1007/s10327-025-01257-w
Web of Science KeyUT	001592749600001
関連URL	isVersionOf https://doi.org/10.1007/s10327-025-01257-w

Surrogate-assisted motion planning and layout design of robotic cellular manufacturing systems

フルテキストURL	fulltext.pdf
著者	Kawabe, Tomoya\| Nishi, Tatsushi\| Liu, Ziang\| Fujiwara, Tomofumi\|
キーワード	Robotics Cellular manufacturing Layout design Sequence-pair Motion planning Surrogate optimization Machine learning Artificial intelligence
発行日	2025-06
出版物タイトル	Engineering Applications of Artificial Intelligence
巻	150巻
出版者	Elsevier BV
開始ページ	110530
ISSN	0952-1976
NCID	AA10718939
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Authors.
論文のバージョン	publisher
DOI	10.1016/j.engappai.2025.110530
Web of Science KeyUT	001457362200001
関連URL	isVersionOf https://doi.org/10.1016/j.engappai.2025.110530

Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells

フルテキストURL	fulltext.pdf suppl.pdf
著者	Su Pwint, Nang Thee\| Li, Chunning\| Gao, Tong\| Wang, Yuze\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
キーワード	breast cancer SPRED2 neurofibromatosis type 1 neurofibromin RAS/RAF/ERK
発行日	2025-10-16
出版物タイトル	International Journal of Molecular Sciences
巻	26巻
号	20号
出版者	MDPI AG
開始ページ	10072
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 by the authors.
論文のバージョン	publisher
DOI	10.3390/ijms262010072
関連URL	isVersionOf https://doi.org/10.3390/ijms262010072

Impact of Neoadjuvant Chemotherapy with Gemcitabine Plus S-1 in Patients with Resectable Pancreatic Ductal Adenocarcinoma

フルテキストURL	fulltext.pdf
著者	Yasui, Kazuya\| Takagi, Kosei\| Fuji, Tomokazu\| Nishiyama, Takeyoshi\| Nagai, Yasuo\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Fujii, Yuki\| Otsuka, Motoyuki\| Fujiwara, Toshiyoshi\|
キーワード	neoadjuvant chemotherapy pancreatic cancer resectable textbook outcome
発行日	2025-10-10
出版物タイトル	Cancers
巻	17巻
号	20号
出版者	MDPI AG
開始ページ	3287
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 by the authors.
論文のバージョン	publisher
DOI	10.3390/cancers17203287
関連URL	isVersionOf https://doi.org/10.3390/cancers17203287

ATPase copper transporting beta contributes to cisplatin resistance as a regulatory factor of extracellular vesicles in head and neck squamous cell carcinoma

フルテキストURL	fulltext.pdf suppl1.docx suppl2.xlsx suppl3.xlsx suppl4.xlsx
著者	Ogawa, Tatsuo\| Ono, Kisho\| Ryumon, Shoji\| Kawai, Hotaka\| Sato, Kohei\| Umemori, Koki\| Yoshida, Kunihiro\| Obata, Kyoichi\| Kunisada, Yuki\| Okui, Tatsuo\| Okamoto, Kuniaki\| Nagatsuka, Hitoshi\| Momen-Heravi, Fatemeh\| Ibaragi, Soichiro\|
発行日	2025-10-17
出版物タイトル	Cancer Gene Therapy
出版者	Springer Science and Business Media LLC
ISSN	0929-1903
NCID	AA11052453
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025
論文のバージョン	publisher
PubMed ID	41107546
DOI	10.1038/s41417-025-00975-9
関連URL	isVersionOf https://doi.org/10.1038/s41417-025-00975-9

Biochar-amended Sediment Microbial Fuel Cells for Water Quality Improvement in Intensive and Extensive Pond Drainages in Central Vietnam

フルテキストURL	fulltext.pdf
著者	Nguyen, Uyen Tu \| Maeda, Morihiro\| Somura, Hiroaki\| Nakahara, Nozomi\| Perera, Gamamada Liyanage Erandi Priyangika\| Nakano, Chiyu\| Le, Huu Tien\| Nishina, Yuta\|
キーワード	biochar Central Vietnam electricity generation redox potential shrimp farming
発行日	2025
出版物タイトル	Journal of Water and Environment Technology
巻	23巻
号	5号
出版者	Japan Society on Water Environment
開始ページ	234
終了ページ	249
ISSN	1348-2165
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 Japan Society on Water Environment
論文のバージョン	publisher
DOI	10.2965/jwet.25-032
関連URL	isVersionOf https://doi.org/10.2965/jwet.25-032

On weapons allometry and the form of sexual selection

フルテキストURL	fulltext.pdf
著者	Shinohara, Hironori\| Sharma, Manmohan D.\| Pennell, Tanya M.\| Okada, Kensuke\| Hosken, David J.\|
キーワード	inbreeding selection beetle Gnatocerus
発行日	2025-09-24
出版物タイトル	Royal Society Open Science
巻	12巻
号	9号
出版者	The Royal Society
開始ページ	251152
ISSN	2054-5703
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Authors.
論文のバージョン	publisher
PubMed ID	40994570
DOI	10.1098/rsos.251152
Web of Science KeyUT	001576643100006
関連URL	isVersionOf https://doi.org/10.1098/rsos.251152

Highly efficient transgenesis mediated by Tip100 transposon system in medaka

フルテキストURL	fulltext.pdf suppl1.pdf suppl2.xlsx
著者	Tanaka, Yoshitaka\| Seki, Takahide\| Hoshino, Atsushi\| Ansai, Satoshi\|
キーワード	Fish Medaka Morning glory Transgenic Transposon
発行日	2025-10-09
出版物タイトル	Transgenic Research
巻	34巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	46
ISSN	0962-8819
NCID	AA10873487
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025
論文のバージョン	publisher
PubMed ID	41068540
DOI	10.1007/s11248-025-00466-5
Web of Science KeyUT	001590049100001
関連URL	isVersionOf https://doi.org/10.1007/s11248-025-00466-5

Rectal Swab–based Targeted Prophylactic Antibiotics Reduce Infectious Complications After Transrectal Prostate Biopsy: A Systematic Review and Meta-analysis of Randomized Controlled Trials

フルテキストURL	fulltext.pdf suppl.docx
著者	Tsuboi, Ichiro\| Kardoust Parizi, Mehdi\| Matsukawa, Akihiro\| Miszczyk, Marcin\| Fazekas, Tamás\| Cormio, Angelo\| Kawada, Tatsushi\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Wada, Koichiro\| Karakiewicz, Pierre I.\| Chlosta, Piotr\| Briganti, Alberto\| Araki, Motoo\| Shariat, Shahrokh F.\|
キーワード	Febrile urinary tract infection Targeted prophylactic antibiotics Transrectal prostate biopsy Sepsis
発行日	2025-10
出版物タイトル	European Urology Open Science
巻	80巻
出版者	Elsevier BV
開始ページ	57
終了ページ	65
ISSN	2666-1683
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s).
論文のバージョン	publisher
PubMed ID	41064532
DOI	10.1016/j.euros.2025.08.007
Web of Science KeyUT	001572715700001
関連URL	isVersionOf https://doi.org/10.1016/j.euros.2025.08.007

The safety and efficacy of finasteride for transgender men with androgenetic alopecia: a case series

フルテキストURL	fulltext.pdf suppl1.tif suppl2.tif suppl3.tif
著者	Tominaga, Yusuke\| Kobayashi, Tomoko\| Matsumoto, Yuko\| Sako, Tomoko\| Moriwake, Takatoshi\| Horii, Satoshi\| Sadahira, Takuya\| Katayama, Satoshi\| Iwata, Takehiro\| Nishimura, Shingo\| Bekku, Kensuke\| Edamura, Kohei\| Watanabe, Masami\| Araki, Motoo\|
キーワード	Finasteride Dihydrotestosterone Transgender men Androgenetic alopecia Resumption of menstruation
発行日	2025-09-29
出版物タイトル	Journal of Medical Case Reports
巻	19巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	468
ISSN	1752-1947
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	41024043
DOI	10.1186/s13256-025-05562-y
Web of Science KeyUT	001585008600008
関連URL	isVersionOf https://doi.org/10.1186/s13256-025-05562-y

Epstein-Barr Virus-Associated Early Gastric Carcinoma with Lymphoid Stroma Mimicking a Submucosal Tumor: A Typical Case Diagnosed by Endoscopic Resection and Treated by Local Resection with Sentinel Node Navigation

JaLCDOI	10.18926/AMO/69442
フルテキストURL	79_5_399.pdf
著者	Isozaki, Hiroshi\| Matsumoto, Sasau\| Takama, Takehiro\| Isozaki, Yuka\| Murakami, Shigeki\|
抄録	Gastric cancer with lymphoid stroma (GCLS) accounts for 1%-7% of gastric cancers; ~80% are Epstein-Barr virus (EBV)-positive. The rate of lymph node metastasis is relatively low, even when an early GCLS has invaded the submucosa. We report an early GCLS with massive submucosal invasion mimicking a submucosal tumor (SMT), diagnosed by endoscopic submucosal resection (ESD) and treated with local resection and sentinel node navigation surgery (SNNS). The patient was a 40-year-old Japanese man. A protruding lesion on the greater curvature of the middle part of his stomach was detected by X-ray, and an endoscopic examination revealed a 2.5-cm protruding tumor covered with a normal mucosa and small ulcers at the apex. ESD was performed for a diagnosis. The pathological diagnosis was lymphoepithelioma-like gastric cancer (GCLS), pT1b(SM2), Ly0, V0, pHM1, pVM1. EBV infection in the cancer cells was confirmed pathologically by EBV-encoded RNA. The local resection was performed using SNNS. The patient has had no recurrence or post-gastrectomy syndrome 4 years postsurgery. EBV-associated early GCLS resembling an SMT is relatively rare, and clinicians need to be aware of this disease. Local resection using SNNS may be a surgical option for GCLS cases with a low rate of lymphatic metastasis.
キーワード	gastric cancer gastric cancer with lymphoid stroma lymphoepithelioma-like carcinoma Epstein Barr virus sentinel node navigation surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	399
終了ページ	404
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Gastroduodenal Artery-Preserving Pancreatoduodenectomy after Esophagectomy with Gastric Conduit Reconstruction

JaLCDOI	10.18926/AMO/69441
フルテキストURL	79_5_393.pdf
著者	Masunaga, Akari\| Takagi, Kosei\| Nagai, Yasuo\| Yasui, Kazuya\| Fuji, Tomokazu\| Yamada, Motohiko\| Nishiyama, Takeyoshi\| Kanehira, Noriyuki\| Sota, Yumi\| Fujiwara, Toshiyoshi\|
抄録	Pancreatoduodenectomy (PD) after esophagectomy with gastric conduit reconstruction is technically challenging. Preserving the blood supply of the gastric conduit is crucial in performing PD after esophagectomy. We report the case of a 66-year-old man who underwent gastroduodenal artery-preserving PD after esophagectomy with gastric conduit reconstruction for intraductal papillary mucinous neoplasm. The patient developed pseudoaneurysm rupture postoperatively, but was successfully treated with interventional radiology. Precise assessment is important in developing a surgical strategy depending on the patient’s specific anatomy and tumor characteristics. Moreover, special attention should be paid to avoid accidental injuries of the gastric conduit and gastric vessels during surgery.
キーワード	pancreatoduodenectomy esophagectomy gastric conduit fluorescence imaging
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	393
終了ページ	398
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

The Utility of a Preoperative 3D Imaging Analysis System for Trigonal Meningioma

JaLCDOI	10.18926/AMO/69440
フルテキストURL	79_5_387.pdf
著者	Mori, Yusuke\| Otani, Yoshihiro\| Omae, Ryo\| Hirano, Shuichiro\| Ishida, Joji\| Fujii, Kentaro\| Haruma, Jun\| Hiramatsu, Masafumi\| Matsushita, Toshi\| Higaki, Fumiyo\| Sugiu, Kenji\| Tanaka, Shota\|
抄録	Trigonal meningiomas are rare and pose surgical challenges due to their deep location and proximity to critical neuroanatomical structures. We present the case of a 67-year-old woman with a growing trigonal meningioma successfully resected with guidance by a preoperative 3D imaging analysis system. Integration of CT and MRI including diffusion tensor imaging (DTI) enabled precise mapping of the optic radiation, guiding a middle temporal gyrus approach. Preoperative embolization reduced tumor vascularity, facilitating gross total resection with minimal blood loss. This case highlights the effectiveness of preoperative 3D imaging systems in optimizing surgical planning and improving outcomes in complex neurosurgical cases.
キーワード	trigonal meningioma imaging analysis diffusion tensor imaging
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	387
終了ページ	392
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Immunoglobulin G4-related Disease Mimicking Portal Vein Tumor Thrombus

JaLCDOI	10.18926/AMO/69439
フルテキストURL	79_5_381.pdf
著者	Sakurai, Atsunobu\| Yabuki, Takayuki\| Aoki, Hideki\| Iseki, Akiko\|
抄録	We report the case of a 72-year-old Japanese man with an incidental portal vein mass that was surgically resected and diagnosed as immunoglobulin G4 (IgG4)-related disease. The mass was discovered during an atrial fibrillation examination. The patient had a history of gastric cancer and was also diagnosed with rectal cancer, raising concerns about metastasis. Due to technical challenges, a biopsy was not feasible. Imaging findings suggested portal vein tumor thrombosis, complicating the diagnosis. This case highlights a rare presentation of IgG4-related disease mimicking portal vein tumor thrombus.
キーワード	immunoglobulin G4-related disease inflammatory pseudotumor mass portal vein pericarditis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	381
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Blood Pressure and Heart Rate Patterns Identified by Unsupervised Machine Learning and Their Associations with Subclinical Cerebral and Renal Damage in a Japanese Community: The Masuda Study

JaLCDOI	10.18926/AMO/69438
フルテキストURL	79_5_369.pdf
著者	Hisamatsu, Takashi\| Kinuta, Minako\| Munetomo, Sosuke\| Fukuda, Mari\| Kojima, Katsuhide\| Taniguchi, Kaori\| Nakahata, Noriko\| Kanda, Hideyuki\|
抄録	We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage.
キーワード	blood pressure heart rate subclinical disease uniform manifold approximation and projection unsupervised machine learning
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	369
終了ページ	379
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Advantages of Single-Position Surgery over Posterior Fusion for Single-Level Degenerative Lumbar Diseases

JaLCDOI	10.18926/AMO/69437
フルテキストURL	79_5_359.pdf
著者	Hirose, Tomohiko\| Ikuma, Hisanori\| Otsuka, Kazutoshi\| Kawasaki, Keisuke\|
抄録	Single-position surgery with lateral lumbar interbody fusion (LLIF) and percutaneous pedicle screws (PPSs) is gaining attention for its reduced invasiveness. We developed SPAPS, a technique allowing two surgeons to perform anterior LLIF and posterior PPS insertion simultaneously in a single lateral decubitus position. This retrospective study compared SPAPS (SPAPS-LLIF, Group SL) and minimally invasive posterior/transforaminal lumbar interbody fusion (MIS-PLIF/TLIF, Group PT) in patients treated between 2016 and 2019 with a two-year follow-up. Operative time, estimated blood loss (EBL), length of hospital stay (LOS), JOABPEQ and VAS scores, segmental lordotic angle, lumbar lordotic angle, segmental Cobb’s angle, PPS misplacement, PPS loosening, fusion status, and muscle cross-sectional areas were compared. Fifty-two patients were analyzed (Group SL: 25; Group PT: 27). SPAPS significantly reduced operative time (118.0 vs. 165.3 min, p <0.01) and estimated blood loss (8.6 vs. 164.1 mL, p<0.01). While clinical outcomes and hospital stay were comparable, Group SL had significantly lower PPS loosening (0% vs. 13%, p<0.01) and non-union rates (0% vs. 22.2%, p=0.02). Multifidus muscle atrophy was also less in Group SL (−14.3 vs. −121.5 mm2, p<0.01). SPAPS demonstrated advantages in reducing surgical invasiveness without compromising clinical efficacy, offering a promising alternative to conventional posterior fusion surgery.
キーワード	single-position surgery simultaneous lateral decubitus positioning lateral lumbar interbody fusion posterior lumbar interbody fusion
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	359
終了ページ	368
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Comparison of Extraocular Muscles in Patients with Exotropia and Healthy Participants Using Anterior Segment Optical Coherence Tomography

JaLCDOI	10.18926/AMO/69436
フルテキストURL	79_5_353.pdf
著者	Chihara, Yuki\| Hamasaki, Ichiro\| Shibata, Kiyo\| Morisawa, Shin\| Kono, Reika\| Kanenaga, Keisuke\| Morizane, Yuki\|
抄録	To analyze and characterize the medial and lateral rectus muscles in patients with exotropia using anterior segment optical coherence tomography (AS-OCT). This study included 24 patients with exotropia (48 eyes) and 25 healthy individuals (50 eyes). Anterior segment optical coherence tomography was used to construct the en face images. The anterior chamber angle to the extraocular muscle insertion distance, muscle width, and muscle fiber angle from the muscle insertion sites were compared between the exotropia and the control groups. The correlation between these parameters and age or angle of deviation was evaluated. The mean ages were 13.2±4.1 years for the exotropia group and 17.6±7.2 years for the control group. The lateral rectus angle was significantly more inwardly rotated in the exotropia group than in the control group (1.6±6.3°, −1.4±4.0°, p=0.014). With increasing angle of deviation, the width of the lateral rectus increased (p=0.002). Our results indicate that the lateral rectus angle is significantly more inwardly rotated in patients with exotropia. These findings should contribute to a deeper understanding of the extraocular muscles in patients with this condition.
キーワード	exotropia AS-OCT anterior chamber angle to extraocular muscle insertion distance muscle width muscle fiber angle
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	353
終了ページ	358
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Inhibition of Air-Exposure Stress–Induced Autolysis in Clostridium perfringens by Zn2+

JaLCDOI	10.18926/AMO/69435
フルテキストURL	79_5_345.pdf
著者	Matsunaga, Nozomu\| Egusa, Seira\| Aono, Riyo\| Tamai, Eiji\| Hitusmoto, Yasuo\| Katayama, Seiichi\|
抄録	Clostridium perfringens is a pathogenic anaerobe that causes gas gangrene and food poisoning. Although autolysin-mediated reorganization of the bacterial cell wall is crucial for cell division, excessive autolysin activity induced by stressors can lead to cell lysis. In C. perfringens, air exposure is a significant stressor that causes cell lysis, and Acp (N-acetylglucosaminidase) is known to be a major autolysin. To further facilitate C. perfringens research, a technology to prevent air-induced cell lysis must be developed. This study investigated the role of Acp in air-induced autolysis and explored potential inhibitors that would prevent cell lysis during experimental procedures. Morphological analyses confirmed that Acp functions as an autolysin in C. perfringens, as acpdeficient strains exhibited filamentous growth. The mutants exhibited negligible autolysis under air-exposure stress, confirming the involvement of Acp in the autolytic process. We also evaluated the effects of various divalent cations on Acp activity in vitro and identified Zn2+ as a potent inhibitor. Brief treatment with a Zn2+- containing buffer induced dose-dependent cell elongation and autolysis inhibition in C. perfringens. These findings demonstrate that simple Zn2+ treatment before experiments stabilizes C. perfringens cells, reducing autolysis under aerobic conditions and facilitating various biological studies, except morphological analyses.
キーワード	Clostridium perfringens autolysin zinc air-exposure autolysis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	345
終了ページ	352
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り