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The cause of the death due to the atomic-bomb radiation is yet unknown definitely and the same can be said of shock brought about by the atomic-bomb. It cannot be said with certainity that infection of pathogenic bacteria concerns in the mortality, for even minor injuries did not often escape bacterial invasion from any part of the whole body. In this case the progress was same to a symptom of agranulocytosis, namely collapse, chill, fever, red throat or ulcerative stomatitis and from the reason of the heavily infected tonsils, although cultures were not made, there are reasons to consider it as agranulocytosis angina. The interpretation of the histologic changes observed in this patient, is rendered difficult not only by the factor of infection, but by the possible influence of one damaged organ upon another. From the histological changes there were the destruction of the epithelium of the gastro-intestinal organs, the atrophy of the testis and the necrosis of the tonsils, but the most noteworthy was the changes in the bone-marrow. The hyperplasia of the reticulum cells, the disappearance of the hematopoetic foci, and the great quantity of mitotic figures in the myeloid cells observecl in this case are found in many of the atomic-bomb victims died approximately one month after the exposure. This is a case of the death caused by aplastic anemia with infective complication or in orther words symptomatic agranulocytosis caused by the atomic-bomb radiation with sepsis.

1. When hemolysed blood is administered orally to rabbits, in cases of healthy and those with blocked reticulo-endothelial systems, a transient increase in the verdohemoglobin (M. Engel) is seen in circulating blood, while in that of rabbits with impaired parenchymal liver cells, no such increase occurs. 2. On irrigation of hemolysed blood through rabbit livers, in healthy rabbits production of indirect bilirubin may be demonstrated while in that with blockage of the reticulo-endothelial system or with impaired liver parenchymal cells, this may not be seen. Moreover, in this case of blockade of the reticulo-endothelial system. production of verdohemoglobin may be demonstrated. while none whatsoever may be demonstrated in cases of impaired liver parenchmal. On the other hand on irrigation of verdohemoglobin and biliverdin solutions, in healthy and in impaired liver parenchymal cell cases, production of bilirubin may be observed while absolutely none was detected in cases of blocked reticulo-endothelial systems, 3. Concluding from the results stated above and those of clinical experiments stated elsewhere, the following process is assumed: when blood is imposed on the organism it is primarily phagocytosed by the reticulo-endothelial system, next dissolved to verdohemoglobin {M. Engel) in the parenchymal cells of the liver, and then dissolved into globin, iron, and biliverdin in the reticulo-endothelial system, of which biliverdin is further reduced to bilirubin. A portion of this remains in the circulating blood as indirect bilirubin, while the majority of it is esterized in the parenchymal cells of the liver, and proceeds to the bile ducts as direct bilirubin.

While I was on duty with the Naval Institute of Tropical Hygiene at Macassar, Celebes, during World War Ⅱ, I had the opportunity to examine various wild and domestic animals for parasites, these animals being taken mainly from Celebes. Since the parasitic worms of this island had not yet been worked out at any length, an opportunity for collecting in this part of the world yielded much interesting material. I collected a fairly large amount of material from monkeys, buffaloes, birds, lizards, snakes and fishes, the latter being examined very carefully from the stand-point of prevention of parasitic infections transmitted from fish to man. Domestic fowl and small wild birds were also examined for intestinal parasites during my study on avian malaria carried out at the institute. Unfortunately I managed to bring back to Japan by air only a part of the collection before the termination of the war. The greater part of the collection shipped to me subsequently by air mail suffered serious damage in transit, and for this reason description and illustrations are based almost exclusively on mounted slides.

1. The proteolytic action of papayotin is activated by X-ray irradiation with 60 r and 1000 r, and inhibited with 200 r and 400 r. 2. The influences of X-rays upon papayotin are direct and remain unchanged for definite periods of time. 3. The proteolytic action of papayotin show wavy phenomena which correspond to the time and dose of the X-ray irradiation. 4. The proteolytic action of papayotin is considered to be inhibited by the decomposition products (polypeptides) of substrate only in the presence of some other factors.

1. In the bile of rabbits, the metabolisms of biliverdin and bilirubin are in a solucible state, and which have a ratio of 2: 1 in normal animals. 2. In the production of biliverdin, the liver, especially the parenchyma of the liver has a very important role, while that of the reticulo-endothelial system is rather minor. However, in the case of glucose administration, the reduction of bilirubin from biliverdin is performed in the reticulo-endothelial system, thus conferring an important part of this system. 3. The production of bilirubin is performed primarily extrahepatically, and the participation of the extrahepatical reticuloendothelial system is of a conservative nature, thus denying us any willingness to agree to the theory of bilirubin production in the reticulo-endothelial system. 4. On administration of hemolysed blood, bile pigments in bile demonstrate a remarkable increase, while as compared when injected into the auricle veins in cases of administration through the portal vein a decline in the functions of the liver reticulo-endothelial system is seen, causing a decrease in biliverdin amount. In the former modus of administration, an occasional stimulation of the liver reticulo- endothelial system is seen, causing reduction of biliverdin to bilirubin. 5. Concluding from these facts, biliverdin in rabbit bile occupies the role of an intermediate product in the production and metabolism of bilirubin.

I. Nematodes of fishes 1. Rhabdochona amago Yamaguti, 1935 II. Nematodes of frogs 2. Cosmocerca japonica Yamaguti, 1938 3. Cosmocercoides pulcher Wilkie, 1930 4. Oswaldocruzia bialata (Molin, 1860) 5. Rhabdias montana n. sp. III. Nematodes of mammals 6. Protospirura muris (Gmelin, 1890) 7. Heterakis spumosa Schneider, 1866 8. Longistriata wolgaensis Schulz, 1926 IV. Acanthocephala of frogs 9. Acanthocephalus lucidus van Cleave, 1925

In 1951 the junior author reported two unnamed species of the genus Aedes from Mt. Hakusan, Ishikawa Prefecture, suggesting the first species to be related to Aedes (Ochlerotatus) punctor. An examination made by the senior author on large numbers of additional specimens collected at the same locality in 1952 and 1953 has revealed that each of the two represents a new species, so that Aedes (Ochlerotatus) hakusanensis is proposed for the first species, and Aedes (Aedes) pseudoesoensis for the second species.

I. Trematodes of reptiles 1. Cyathocotyle crocodili n. sp. 2. Pseudoneodiplostomum (Pseudoneodiplostomoides) crocodili n. subg. n. sp. 3. Acanthostomum crocodili n. sp. II. Trematodes of birds 4. Plagiorchis maculosus (Rud., 1ε02) 5. Echinochasmus bagulai Verma, 1935

Anoplocephalidae Kholodk., 1902 1. Oochoristica celebesensis n. sp. Dilepididae Fuhrmann, 1907 2. Ophiovalipora micracantha n. sp. Proteocephalidae La Rue, 1911 3. Acanthotaenia shipleyi von Linstow, 1903

Onchobothriidae Braun, 1900 1. Balanobothrium tenax Hornell, 1912 2. Balanobothrium stegostomatis n. sp. 3. Phoreiobothrium sp. Hornelliellidae n. fam. 4. Hornelliella annandalei (Hornell, 1912) n. g. Austramphilinidae Johnston, 1931 5. Gyrometra albotaenia n. g., n. sp.

In such animals not having any organic changes in their brains during the initial stage showed a descendence of convulsive threshold. abnormal findings in their electroencephalogram and ascending activity of ChE. But what is the cause of these functional changes? First, from the fact that though there was no organic changes, they were sensitized and reiniected by a known antigen, which is obviously an antigen-antibody reaction. Second, from the fact that we got a histological.change, which was acknowledged as C.L.A. changes by increasing the concentration of these solution and the number of injections, it could be thought that these functional changes were caused by what I called latent C.L.A.. That is, it seems it could be thought that it would give functionally a permanent hypersensitivity, which is called convulsive arrangement. Furthermore, a similar histological findings as seen in old epileptics were made experimentally after prolonged and repeated injections of very diluted antigens. I believe it can be said, also from this histological point that they are experimental epileptics. But I am not trying to say that idiopathic epilepsy is the same allergic disease as asthma. If it was so, it should offer clinically a problem of eosinophilia in the blood of epileptics. But actually there is no eosinophilia in epileptics. Also, in adult epileptics, convulsive attacks is not often seen soon after introduction of antigens. Consequently, my theory that epilepsy is allergic, does not mean that allergy is the direct cause of epileptic attacks. What I mean is, the causal genesis of idiopathic epilepsy is hypersensitivity of nerve cells in the brain. This hypersensitivity was attained as a tissue reaction by some allergic mechanism without any organic changes. This functional change gives the nerve cell a hypersensitive state, which becomes the base of the beginnihg of convulsion. Its inducement of attack could be water stagnation in the body, anemic state of the brain, alkalosis, or introduction of allergens. In short, the cause of attack does not always come from allergic reactions.

Lecithodendriidae Odhner, 1910 1. Phaneropsolus simiae n. sp. Heterophyidae Odhner, 1914 2. Galactosomum canis n. sp. Paramphistomidae Fischoeder, 1901 3. Explanatum explanatum (Creplin, 1857) 4. Paramphistomum cervi (Schrank, 1790) 5. Calicophoron cauliorchis (Stiles et Goldberger, 1900) 6. Ceylonocotyle εcoliocoelium (Fischoeder, 1901) 7. Fischoederius elongatus (Poirier, 1883) Fasciolidae Railliet, 1895 8. Fasciola hepatica Linne, 1758

Echinorhynchidae Cobbold, 1879 1. Acanthocephalus bufonis (Shipley, 1903) Rhadinorhynchidae Travassos, 1923 2. Rhadinorhynchus celebesensis n. sp. 3. Filisoma indicum van Cleave, 1928 Quadrigyridae van Cleave, 1920 4. Pallisentis gaboes (MacCallum, 1918) van Cleave. 1928 Gigantorhynchidae Hamann, 1892 5. Empodius sp. Neoechinorhynchidae Hamann, 1892 6. Neoechinorhynchus longilemniscus n. sp.

I. Trematodes of mammals 1. Brachylaemus tokudai n. sp. 2. Acanthatrium ovatum Yamaguti, 1939 II. Cestodes of frogs 3. Baerietta montana n. sp. 4. Baerietta claviformis n. sp. III. Cestodes of· birds 5. Choanotaenia barbara Meggitt, 1926 IV. Cestodes of mammals 6. Hymenolepis apodemi n. sp.

We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon antibodies. The percent areas of beta-cells, alpha-cells and non-alpha-non-beta-cells were compared among groups. In untreated OLETF rats, the fasting plasma glucose (FPG) level was elevated at the 18th week and remained elevated until the 35th week. On the other hand, no significant elevation in FPG levels was observed in olmesartan- or temocapril-treated rats. Pancreatic islets from olmesartan-treated rats were significantly smaller in size as compared with those from untreated OLETF rats. Furthermore, the average area occupied by beta-cells as a fraction of the total area of an individual islet was significantly higher in olmesartan- or temocapril-treated rats than that in untreated OLETF rats. Olmesartan and temocapril both prevented the development of hyperglycemia, possibly through the prevention of islet beta-cell loss in spontaneously diabetic OLETF rats.

Angiotensin I-converting enzyme (ACE) inhibitory and hypotensive effects of 7 peptide fractions (Frs) of royal jelly protein hydrolysate (RJPH) were studied in comparison with those of RJPH alone. Fr 4 and Fr 5 were the highest in ACE inhibitory activity and yield, respectively. Molecular weights (MWs) of RJPH and Fr 1-Fr 7 were distributed from 100 to 5,000 and those of Fr 1-Fr 7 increased in order from Fr 1 to Fr 7. RJPH, Fr 3 and Fr 4 at doses of 10, 30 and 100mg/kg i.v. and Fr 5 and Fr 6 at doses of 30 and 100mg/kg i.v. caused transiently significant hypotensive effects in spontaneously hypertensive rats (SHR). Fr 3, Fr 4, Fr 5 and Fr 6 at a dose of 1,000mg/kg also caused significant hypotensive effects 3h, 4-5h, 7-8h and 8h after oral administration in SHR, respectively. RJPH caused a long-lasting hypotensive effect in proportion to the magnitude of the MWs of RJPH fractions. The hypotensive pattern of RJPH was similar to the combined pattern of Fr 3-Fr 6. From these results, it can be concluded that the long-lasting hypotensive effect of oral administration of RJPH is dependent on the MWs of its ACE inhibitory peptides and the time required to digest them.

Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this "11R", all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV).

There is little information available concerning the influence of right bundle branch block (RBBB) on the prognosis of patients with inferior myocardial infarction (MI). In this study we evaluated the influence of RBBB on the short-term prognosis of patients with inferior MI. Our study subjects were 1,265 hospitalized patients with Q wave MI. Patients were divided into 4 groups based on the presence or absence of RBBB and on the location of the infarction. RBBB was classified into 4 categories according to the timing of its appearance and its duration as new permanent, transient, old and age indeterminate. In-hospital death and pulmonary congestion were observed more frequently in patients with RBBB than in those without RBBB. Moreover, in inferior MI as in anterior MI, in-hospital death and pulmonary congestion occurred more frequently in new permanent RBBB patients than in patients with other types of RBBB. Multivariate regression analysis reveals that new permanent RBBB was a strong independent predictor for an adverse short-term prognosis in patients with inferior MI, as well as in patients with anterior MI. New permanent RBBB during inferior MI is a strong independent predictor for increased in-hospital mortality, regardless of the infarction location.

In this study we investigated the attitudes of Japanese medical students toward being informed of a diagnosis of life-threatening illness. Fourth-year medical students from 20 randomly sampled universities were administered questionnaires that examined their opinion about whether they would welcome disclosure of medical information if they were diagnosed as having an ultimately fatal disease. Data from 1,619 students (male 1,074, female 545, effective collection rate 90.6%) were analyzed. With regard to attitudes about disclosure of a diagnosis of life-threatening illness, 87.7% of the students stated that they would wish to be informed even if there was little chance of recovery, and 11.6% expressed a wish to be informed of their condition only if there was a chance of recovery. Students who did not wish to be informed even if there was a chance of recovery accounted for 0.7% of those surveyed. Our study reveals that medical students are more positive than are members of the general population with regard to being informed of the truth. The proportion of those who wished to be informed even if there was little chance of recovery was higher among students from national and public universities than among those from private universities, and the inter-group difference was statistically significant. Among male students, answers to the survey were significantly correlated with 12-item General Health Questionnaire scores and mental health status, suggesting that mental health status may have affected how this study population viewed being informed of their diagnosis.