生体内水銀の体外排泄に関する研究

Extracorporeal excretion of mercury by two molybdenum complexes was investigated using mice after injection of metallic mercury or mercuric ion. After injection of metallic mercury into mice, the mice that received the incomplete cubane-type sulfur-bridged nitrilotriacetato molybdenum (IV) complex ([Mo3S4(Hnta)3]2-, referred to as the NTA complex) had the highest mercury content in their urine on the first day, followed by L-cysteine solution and then water. On the other hand, after injection of mercuric ion, the urinary mercury excretion from the mice that received various concentrations of the incomplete cubane-type sulfur-bridged cysteinato molybdenum (V) complex ([Mo2O2S2(cys)2]2-, referred to as the CYS complex) showed a higher level than that of mice that received water (control group). The mercury content in the heart and lungs of the group that received the CYS complex solution decreased in comparison with that of the group that received the water. At the same time, the mercury level in the kidneys for the CYS complex solution group showed the tendency to increase relative to the group that received water.

記念講演要旨（Summary of Commemorational Lecture）