Application of amorphous sugar matrix dried from alcohol to solid dispersion of hydrophobic drug and its physicochemical characteristics

岡山大学審査学位論文

Takeda K, Gotoda Y, Hirota D, Hidaka F, Sato T, Matsuura T, Imanaka H, Ishida N, Imamura K. Surfactant-Free Solid Dispersions of Hydrophobic Drugs in an Amorphous Sugar Matrix Dried from an Organic Solvent. Mol Pharm. 2017 Mar 6;14(3):791-798. doi: 10.1021/acs.molpharmaceut.6b01048.

Takeda K, Sekitoh T, Fujioka A, Yamamoto K, Okamoto T, Matsuura T, Imanaka H, Ishida N, Imamura K. Physical Stability of an Amorphous Sugar Matrix Dried From Methanol as an Amorphous Solid Dispersion Carrier and the Influence of Heat Treatment. J Pharm Sci. 2019 Jun;108(6):2056-2062. doi: 10.1016/j.xphs.2019.01.008.

Koji Takeda, Shinta Miyazaki, Takashi Okamoto, Hiroyuki Imanaka, Naoyuki Ishida, Koreyoshi Imamura. Water sorption and glass-to-rubber transition of amorphous sugar matrices, vacuum foam- and spray-dried from alcohols. Journal of Food Engineering. 2023;349:111483. doi: 10.1016/j.jfoodeng.2023.111483

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