| JaLCDOI | 10.18926/AMO/40133 |
|---|---|
| フルテキストURL | 64_4_249.pdf |
| 著者 | Masumoto, Akio| Masuyama, Hisashi| Takamoto, Norio| Akahori, Yoichiro| Hiramatsu, Yuji| |
| 抄録 | It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties. The aim of this study was to investigate the relationship between pregnancy induced hypertension (PIH) and the placental expression of antiangiogenic PRL fragments and cathepsin D. Placental expression of PRL fragments and cathepsin D was evaluated by Western blot analysis in a group of 9 pregnant women consisting of 5 normal pregnancies and 4 severe PIH cases. Antiangiogenic PRL fragments were detected in 4 placental samples from all PIH cases but not detected in those from normal pregnancies (p0.05). The expression of cathepsin D in PIH placentas was significantly lower than that in those without PIH (p0.05), while the placental expression of procathepsin D was significantly greater in PIH cases than in the normal pregnancies (p0.05). These data suggest that antiangiogenic PRL fragments in the placenta may be present only in PIH cases, and that PRL fragments in the placenta might be implicated in the pathophysiology of PIH. |
| キーワード | pregnancy induced hypertension preeclampsia prolactin prolactin fragment cathepsin-D |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 255 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802542 |
| Web of Science KeyUT | 000281384400006 |
| JaLCDOI | 10.18926/AMO/40134 |
|---|---|
| フルテキストURL | 64_4_257.pdf |
| 著者 | Moritani, Norifumi| Yamada, Tomohiro| Mizobuchi, Koichi| Wakimoto, Mari| Ikeya, Yoko| Matsumura, Tatsushi| Mishima, Katsuaki| Iida, Seiji| |
| 抄録 | The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites. Here, we report a case of an ALT of the tongue, with a review of the literature. A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue. Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless. We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia. Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia. Three years after the operation, the tongue demonstrated good healing without paresthesia or dysfunction, and to date there has been no evidence of recurrence. |
| キーワード | atypical lipomatous tumor well-differentiated liposarcoma tongue |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 257 |
| 終了ページ | 261 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802543 |
| Web of Science KeyUT | 000281384400007 |
| JaLCDOI | 10.18926/AMO/40135 |
|---|---|
| フルテキストURL | 64_4_263.pdf |
| 著者 | Pavelić, Jasminka| Čulić, Srdjana| Čulić, Vida| |
| 抄録 | The occurrence of Langerhans cell histiocytosis (LCH) and another malignancy in the same patient is infrequent but has been recognized. The genetic changes that could be responsible for LCH and/or concomitant leukemia development are obscure. To the best of our knowledge, this is the first description of constitutional maternally derived inv (9) (p12;q13) in an LCH patient, and also of the development of common ALL Ph after LCH diagnosis and therapy. The potential significance of these findings [inv (9)LCHALL Ph] and their mutual relationship are unknown. Therefore, cooperative studies of large numbers of patients are needed to identify the common risk factors, if any. |
| キーワード | acute lymphoblastic leukemia genetic changes langerhans cell histiocytosis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 263 |
| 終了ページ | 265 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802544 |
| Web of Science KeyUT | 000281384400008 |
| JaLCDOI | 10.18926/AMO/40501 |
|---|---|
| フルテキストURL | 64_5_267.pdf |
| 著者 | Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka| |
| 抄録 | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation. |
| キーワード | intracranial self-stimulation behavior motivational effect methamphetamine nicotine |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 275 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975759 |
| Web of Science KeyUT | 000283563300001 |
| JaLCDOI | 10.18926/AMO/40502 |
|---|---|
| フルテキストURL | 64_5_277.pdf |
| 著者 | Kumase, Fumiaki| Morizane, Yuki| Mohri, Satoshi| Takasu, Ippei| Ohtsuka, Aiji| Ohtsuki, Hiroshi| |
| 抄録 | Endothelial glycocalyx (GCX) has been reported as a protective factor for vascular endothelial cells (VEC) in diabetes and hypertension. However, the involvement of GCX impairment in ocular vasculopathy remains unclear. We evaluated the changes in the GCX thicknesses of the retinal and choroidal capillaries in rats with diabetes and hypertension by cationic colloidal iron staining using a transmission electron microscope. In the control group, the mean (standard error of the mean) thicknesses of retinal and choroidal GCX were 60.2 (1.5) nm and 84.3 (3.1) nm, respectively. The diabetic rats showed a significant decrease of GCX thickness in the retina, but not in the choroid, compared to controls (28.3 (0.3) nm, p＜0.01 and 77.8 (1.4) nm, respectively). In the hypertensive rats, both retinal and choroidal GCX were significantly decreased compared to the control values (10.9 (0.4) nm and 13.2 (1.0) nm, respectively, both p＜0.01). Moreover, we could visualize the adhesion of leukocytes and platelets on the luminal surface of VEC, at the site where the GCX was markedly degraded. These findings suggest that the GCX prevents adhesion of leukocytes and platelets to the VEC surface, and this impairment may lead to ocular vasculopathy in diabetes and hypertension. |
| キーワード | glycocalyx retina choroid diabetes hypertension |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 277 |
| 終了ページ | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975760 |
| Web of Science KeyUT | 000283563300002 |
| JaLCDOI | 10.18926/AMO/40503 |
|---|---|
| フルテキストURL | 64_5_285.pdf |
| 著者 | Nishimori, Hisakazu| Takahashi, Shunji| Kiura, Katsuyuki| Ennishi, Daisuke| Kobayashi, Takayuki| Sano, Koji| Shinozaki, Eiji| Yokoyama, Masahiro| Mishima, Yuko| Terui, Yasuhito| Chin, Keisho| Mizunuma, Nobuyuki| Ito, Yoshinori| Nishimura, Seiichiro| Takeuchi, Kengo| Ishikawa, Yuichi| Oguchi, Masahiko| Tanimoto, Mitsune| Hatake, Kiyohiko| |
| 抄録 | We evaluated the efficacy and toxicity of cisplatin/docetaxel (CDDP/TXT) chemotherapy and identified prognostic factors in Japanese patients with cancer of unknown primary site (CUP). Twenty-eight consecutive patients seen at a single institute were reviewed retrospectively. Sixteen patients were treated with TXT 80mg/m2, followed by CDDP 75mg/m2. The overall response rate to CDDP/TXT treatment was 62.5%, with a median survival time (MST) of 22.7 months. Common adverse reactions were myelosuppression and hyponatremia. The MST of all 28 patients with CUP was 8.3 months, and the 1-year overall survival rate was 45.6%. Univariate analysis identified 5 prognostic factors:performance status, liver involvement, bone involvement, pleural involvement, and lymph node involvement. In conclusion, CDDP/TXT chemotherapy is effective with tolerable toxicity in patients with CUP. Japanese patients with CUP might be chemosensitive and may survive longer. |
| キーワード | cancer of unknown primary site (CUP) cisplatin docetaxel prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 291 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975761 |
| Web of Science KeyUT | 000283563300003 |
| JaLCDOI | 10.18926/AMO/40504 |
|---|---|
| フルテキストURL | 64_5_293.pdf |
| 著者 | Sugimoto, Yoshihisa| Ito, Yasuo| Tomioka, Masao| Shimokawa, Tetsuya| Shiozaki, Yasuyuki| Mazaki, Tetsuro| Tanaka, Masato| |
| 抄録 | We used a navigation system to insert 128 pedicle screws into 69 vertebrae (L1 to L3) of 49 consecutive patients. We assessed the pedicle isthmic width and the permission angle for pedicle screw insertion. The permission angle is the angle defined by the greatest medial and lateral trajectories allowable when placing the screw through the center of the pedicle. The rate of narrow-width pedicles (isthmic width less than 5mm) was 5 of 60 pedicles (8%) at L1, 4 of 60 pedicles (7%) at L2, and none (0%) at L3, L4 and L5. The rate of narrow-angle pedicles (a permission angle less than 15 degrees) was 21 of 60 pedicles (35%) at L1, 7 of 60 (12%) at L2, 3 of 60 (5%) at L3, and none (0%) at L4 and L5. Of 128 pedicle screws inserted into 69 vertebrae from L1 to L3, 125 (97.7%) were classified as Grade 1 (no pedicle perforation). In general, the upper lumbar vertebrae have more narrow-width and -angle pedicles. However, we could reduce the rate of pedicle screw misplacement in upper lumbar vertebra using a three-dimensional fluoroscopy and navigation system. |
| キーワード | upper lumbar navigation pedicle screw anatomy misplacement |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 293 |
| 終了ページ | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975762 |
| Web of Science KeyUT | 000283563300004 |
| JaLCDOI | 10.18926/AMO/40505 |
|---|---|
| フルテキストURL | 64_5_299.pdf |
| 著者 | Sanomura, Takayuki| Ikeda, Fusao| Katoh, Tsutomu| Hosokawa, Kazue| Suzuki, Seiyuu| Nishiyama, Yoshihiro| |
| 抄録 | Tumor protrusion in hepatocellular carcinoma (HCC) is one of the risk signs of tumor rupture. Despite curative tumor treatments, HCC recurrences sometimes occur with rapidly growing humped or ruptured HCC in small sized tumors. The aim of this study was to clarify the characteristics of humped HCC clinically and radiologically associated with tumor progression, liver damage, and treatment. The subjects were 179 consecutive HCC patients who underwent angiographic examination. Dynamic studies, using helical computed tomography and magnetic resonance imaging were assessed, and the HCC area were measured. The tumor-node-metastasis (TNM) stage differed significantly between the humped and non-humped HCC groups. Humped HCC was more frequently observed in the right lobe (29.3% of right-lobe HCCs) than in the left (10.1%;p＝0.003). Analysis of recurrent HCC revealed that patients with multiple treatments of >4 sessions had more humped HCC (33.8%) than those with 1-3 sessions (16.7%;p＝0.042). Multivariate regression analysis revealed that tumor invasion in the portal vein, rather than large tumor size, was significantly associated with tumor protrusion. HCC recurrence with humped HCC occurs often in patients with multiple treatments. Tumor factors of the TNM classification, especially tumor invasion in the portal vein, might be associated with the mechanisms of tumor protrusion. |
| キーワード | humped HCC tumor protrusion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 299 |
| 終了ページ | 305 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975763 |
| Web of Science KeyUT | 000283563300005 |
| JaLCDOI | 10.18926/AMO/40506 |
|---|---|
| フルテキストURL | 64_5_307.pdf |
| 著者 | Kang, Hyun| Cha, Su-Man| Park, Sun-Gyoo| Jung, Yong-Hun| Woo, Young-Cheol| Kim, Jin-Yun| Koo, Gill-Hoi| Kim, Seong-Deok| Baek, Chong-Wha| |
| 抄録 | It is not known whether changing from isoflurane to desflurane during the latter part of anesthesia shows early emergence and recovery in long surgery. We therefore evaluated the effects of changing isoflurane to desflurane on emergence and recovery. Eighty-two patients were randomly assigned to receive isoflurane (Group I) or desflurane (Group D) or to change from isoflurane to desflurane anesthesia (Group X). At the point when there was an hour until the operation would end, isoflurane was replaced with 1 MAC of desflurane in Group X, and isoflurane and desflurane were maintained at 1 MAC in Groups I and D. When the operation ended, we compared the emergence and recovery characteristics among the 3 groups. Compared with Group I, Group X showed faster emergence and recovery. Group X and Group D showed similar emergence and recovery. In conclusion, changing isoflurane to desflurane during the latter part of anesthesia improves emergence and recovery. |
| キーワード | desflurane isoflurane laparotomy recovery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 316 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975764 |
| Web of Science KeyUT | 000283563300006 |
| JaLCDOI | 10.18926/AMO/40507 |
|---|---|
| フルテキストURL | 64_5_317.pdf |
| 著者 | Myo-Khin| San-San-Oo| Khin, May Oo| Shimono, Kunio| Koide, Norio| Okada, Shigeru| |
| 抄録 | We studied the prevalence of hepatitis C virus infection among blood donors from 3 hospitals of Central Myanmar and 7 hospitals of Lower Myanmar in the Yangon area, and analyzed the factors associated with the infection. The study period was from November, 2005 to June, 2007. A pre-tested questionnaire was used to obtain information on age, ethnic group, marital status, tattooing, body piercing, history of receiving transfusions, and liver diseases in self and in sexual partners. Data on seropositivity to hepatitis C, hepatitis B and human immunodeficiency virus infections were recorded. A total of 65,240 blood donors participated in the study. Their ages ranged from 18 years to 60 years (mean±SD＝29.5±9.3). The male-to-female ratio was 6：1. The prevalence of the antibody to hepatitis C was found to be 0.95% with varying rates (0.34 to 2.03) among hospitals. Females had a slightly higher rate (1.06%) than males (0.93%) (p＝0.237). Multivariate analyses revealed the following factors to be related to HCV infection:HIV infection, odds ratio (OR)＝3.0 (p＝0.003);history of liver disease, OR＝8.9 (p＝0.001);and age 30 years and above, OR＝2.6 (p＝0.001). We discuss the varying prevalences of HCV around the world. |
| キーワード | Myanmar hepatitis C prevalence blood donors associated factors |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 317 |
| 終了ページ | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975765 |
| Web of Science KeyUT | 000283563300007 |
| JaLCDOI | 10.18926/AMO/40508 |
|---|---|
| フルテキストURL | 64_5_323.pdf |
| 著者 | Kanaoka, Yuji| Inagaki, Ei-ichirou| Hamanaka, Souhei| Masaki, Hisao| Tanemoto, Kazuo| |
| 抄録 | The transient systemic low perfusion that occurs during cardiovascular surgery leads to oxidative stress and the production of free radicals. A systemic increase of various markers of oxidative stress has been shown to occur during cardiopulmonary bypass (CPB). However, these markers have not been adequately evaluated because they seem to be reactive and short-lived. Here, oxidative stress was measured using the free radical analytical system (FRAS 4) assessing the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). Blood samples were taken from 21 patients undergoing elective cardiovascular surgery. CPB was used in 15 patients, and abdominal aortic aneurysm (AAA) surgery without CPB was performed in 6. Measurements of d-ROMs and BAP were taken before surgery, 1 day, 1 week, and 2 weeks after surgery, and oxidative stress was evaluated. The d-ROM level increased gradually after cardiovascular surgery up to 2 weeks. Over time, the d-ROM level after surgery involving CPB became higher than that after AAA surgery. This difference reached statistical significance at 1 week and lasted to 2 weeks. The prolongation of CPB was prone to elevate the d-ROM level whereas the duration of the aortic clamp in AAA surgery had no relation to the d-ROM level. The BAP was also elevated after surgery, and was positively correlated with the level of d-ROMs. In this study, patients who underwent cardiovascular surgery involving CPB had significant oxidative damage. The production of ROMs was shown to depend on the duration of CPB. Damage can be reduced if CPB is avoided. When CPB must be used, shortening the CPB time may be effective in reducing oxidative stress. |
| キーワード | oxidative stress reactive oxygen metabolites (ROM) extracorporeal circulation (ECC) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 323 |
| 終了ページ | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975766 |
| Web of Science KeyUT | 000283563300008 |
| JaLCDOI | 10.18926/AMO/40509 |
|---|---|
| フルテキストURL | 64_5_331.pdf |
| 著者 | Park, Se-Jin| Jung, Young-Bok| Jeong, Hwa Jae| Shin, Hun-Kyu| Jung, Ho-Joong| Lim, Jong-Jun| Yoon, Ji-Woong| Kim, Eugene| |
| 抄録 | Among patients that underwent total knee arthroplasty from June, 1990 to January, 1999, 61 cases (44 patients) that could be followed for more than 10 years were included in this study. The patients were divided into a patellar retention group and a patellar resurfacing group, and were compared with regard to their clinical and radiological outcomes. In patients undergoing primary TKA, a selective patellar resurfacing protocol was used. The indications for patellar retention were a small patella, nearly normal articular cartilage, minimal preoperative patellofemoral pain, poor patellar bone quality, and young patient age. When patellar retention was performed, osteophytes of the patella were removed and marginal electrocauterization was carried out. There were 25 cases (20 patients) in the patellar retention group and 36 cases (29 patients) in the patellar resurfacing group. The mean follow-up period was 140.7 months in the patellar retention group and 149.0 months in the patellar resurfacing group. The selective patellar resurfacing with total knee arthroplasty had a favorable outcome;there were a significant difference noted between the 2 groups in the functional scores, which showed better outcomes in the patellar resurfacing group than in the patellar retention group. |
| キーワード | total knee arthroplasty (TKA) selective patellar resurfacing patellar retention patellar resurfacing |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 331 |
| 終了ページ | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975767 |
| Web of Science KeyUT | 000283563300009 |
| JaLCDOI | 10.18926/AMO/40510 |
|---|---|
| フルテキストURL | 64_5_339.pdf |
| 著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r＝－0.306, p＝0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women. |
| キーワード | systolic blood pressure estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 339 |
| 終了ページ | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975768 |
| Web of Science KeyUT | 000283563300010 |
| JaLCDOI | 10.18926/AMO/40511 |
|---|---|
| フルテキストURL | 64_5_345.pdf |
| 著者 | Ishihara, Yoshihito| Kuroda, Shingo| Kawanabe, Noriaki| Takano-Yamamoto, Teruko| Yamashiro, Takashi| |
| 抄録 | This article reports the successful surgical-orthodontic treatment of an elderly patient with dentofacial deformity and signs and symptoms of temporomandibular disorder (TMD). The patient was a 63-year-old woman with a concave profile due to mandibular protrusion. To correct skeletal deformities, the mandible was posteriorly repositioned by employing intraoral vertical ramus osteotomy (IVRO) following presurgical orthodontic treatment. After active treatment for 31 months, the facial profile was significantly improved and satisfactory occlusion was achieved. In addition, TMD symptoms of clicking sounds on the left side and difficulty in mouth opening were resolved. Regarding the findings of magnetic resonance imaging, anterior disc displacement in the opening phase was improved in the temporomandibular joint on the left side. Furthermore, stomatognathic functions were also improved without any aggravation of age-related problems. In conclusion, surgical repositioning of the mandible using IVRO leads to both morphological and functional improvements even in elderly patients. |
| キーワード | elderly patient orthodontics temporomandibular disorder intraoral vertical ramus osteotomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 345 |
| 終了ページ | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975769 |
| Web of Science KeyUT | 000283563300011 |
| JaLCDOI | 10.18926/AMO/41320 |
|---|---|
| フルテキストURL | 64_6_351.pdf |
| 著者 | Furumatsu, Takayuki| Asahara, Hiroshi| |
| 抄録 | Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis. |
| キーワード | Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 351 |
| 終了ページ | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173804 |
| Web of Science KeyUT | 000285664200001 |
| JaLCDOI | 10.18926/AMO/41321 |
|---|---|
| フルテキストURL | 64_6_359.pdf |
| 著者 | Yada, Yoshihiko| Sakate, Yoji| Kawamura, Yoshihiro| |
| 抄録 | The results of submucosal electrocoagulation (SEC), a new radical operation for prolapsed hemorrhoids, in 403 patients with third- or fourth-degree hemorrhoids are reported. After resecting the anal skin tags that coexisted with prolapsed hemorrhoids, the hemorrhoidal varices could be resected and electrically coagulated through the wound without cutting the anal canal epithelium by using a fine needle-type electric knife. The results of this series indicated that SEC could dramatically reduce the incidence of the postoperative complications that sometimes occur after conventional hemorrhoid-ectomy, such as severe anal pain, massive anal bleeding and anal stenosis. Moreover, SEC could ensure that operated patients make an early return to social activities and have a satisfactory quality of life. Relapse of prolapsed hemorrhoids after SEC was rare. |
| キーワード | submucosal electrocoagulation method (SEC) hemorrhoids hemorrhoidectomy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 365 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173805 |
| Web of Science KeyUT | 000285664200002 |
| JaLCDOI | 10.18926/AMO/41322 |
|---|---|
| フルテキストURL | 64_6_367.pdf |
| 著者 | Tantular, Indah S.| Matsuoka, Hiroyuki| Kasahara, Yuichi| Pusarawati, Suhintam| Kanbe, Toshio| Tuda, Josef S. B.| Kido, Yasutoshi| Dachlan, Yoes P.| Kawamoto, Fumihiko| |
| 抄録 | We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383T＞C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka. |
| キーワード | Glucose-6-phosphate dehydrogenase deficiency rapid G6PD test eastern Indonesian population molecular analysis G6PD Vanua Lava |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 367 |
| 終了ページ | 373 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173806 |
| Web of Science KeyUT | 000285664200003 |
| JaLCDOI | 10.18926/AMO/41323 |
|---|---|
| フルテキストURL | 64_6_375.pdf |
| 著者 | Kariya, Shin| Cureoglu, Sebahattin| Fukushima, Hisaki| Morita, Norimasa| Baylan, Muzeyyen Y.| Maeda, Yukihide| Nishizaki, Kazunori| Paparella, Michael M.| |
| 抄録 | This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls. |
| キーワード | diabetes mellitus temporal bone cochlear spiral modiolar artery hearing loss |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 375 |
| 終了ページ | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173807 |
| Web of Science KeyUT | 000285664200004 |
| JaLCDOI | 10.18926/AMO/41324 |
|---|---|
| フルテキストURL | 64_6_385.pdf |
| 著者 | Miyatake, Nobuyuki| Moriyasu, Hideyuki| Sakano, Noriko| Tada, Shinya| Suzue, Takeshi| Hirao, Tomohiro| |
| 抄録 | The link between changes in estimated glomerular filtration rate (eGFR) and cigarette smoking was evaluated in Japanese male workers with a 5-year follow-up. We examined the data of 456 Japanese male workers, aged 22-70 years, who were taking no medications, and from this group, 286 men (43.5±8.2 years) were followed for 5-years. Habits of cigarette smoking were obtained during interviews by well-trained staff. The influence of cigarette smoking on eGFR was evaluated. In the first analysis, there was no significant difference in eGFR between subjects with and without cigarette smoking. In the second analysis, eGFR was significantly reduced after 5 years in all subjects. Changes in eGFR in subjects with cigarette smoking (－1.90±12.31ml/min/1.73m2) were significantly smaller than those in subjects without cigarette smoking (－4.97±12.05ml/min/1.73m2). At follow-up, we found that eGFR was weakly and negatively correlated with the number of cigarettes smoked (/day). The present study indicated that cigarette smoking may be an important modifiable factor for eGFR in Japanese male workers who are not taking any medications. |
| キーワード | cigarette smoking estimated glomerular filtration rate (eGFR) male worker |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 385 |
| 終了ページ | 390 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173808 |
| Web of Science KeyUT | 000285664200005 |
| JaLCDOI | 10.18926/AMO/41325 |
|---|---|
| フルテキストURL | 64_6_391.pdf |
| 著者 | Suezawa, Takanori| Ishino, Kozo| Honjo, Osami| Osaki, Satoru| Kotani, Yasuhiro| Sano, Shunji| |
| 抄録 | We developed a new cardiopulmonary bypass (CPB) method to minimize myocardial damage during aortic arch reconstruction. In this method, coronary flow and heartbeat were stabilized by maintaining the aortic root pressure with an adjusted preload of the ventricle during aortic cross-clamping. This study was performed to determine the appropriate root pressure to maintain the heartbeat without causing deterioration of ventricular function. Study 1. Under partial CPB, the ascending aorta was cross-clamped in 6 pigs (group 1). Experimental data at various systolic aortic root pressures was analysed to determine the appropriate root pressure. Study 2. In group 2 (control, n＝6), the aorta was not clamped, while in group 3 (n＝6), the aorta was cross-clamped for 60 min and the systolic aortic root pressure was maintained at the pressure determined in study 1. Study 1. The diastolic coronary flow was stabilized at values comparable to that before initiation of CPB (6.6±1.4ml/beat) when the systolic aortic root pressure was above 80mmHg. Intracardiac pressure and the myocardial oxygen consumption (MvO2) seemed to be acceptable when the systolic aortic root pressure was below 100mmHg. Therefore, 90mmHg was selected for study 2. Study 2. Perioperative cardiac function did not differ between the groups. We concluded that 90mmHg was the systolic aortic root pressure appropriate for this method. |
| キーワード | aortic cross-clamp coronary flow root pressure cardiopulmonary bypass arch repair |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 391 |
| 終了ページ | 397 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173809 |
| Web of Science KeyUT | 000285664200006 |