JaLCDOI | 10.18926/AMO/30473 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Tamada, Toshinori| Inoue, Hajime| Mori, Akitane| |
抄録 | In the pathophysiology of lumbosacral radiculopathy, inflammation of the nerve root is of critical importance. Additionally, free radicals have been shown to be associated with some inflammatory process. This study was designed to investigate whether free radicals participate in the pathophysiology of nerve root involvement. We measured superoxide dismutase (SOD) activity in cerebrospinal fluid (CSF) of 31 patients with unilateral lumbosacral radiculopathy caused by a herniated disc using electron spin resonance (ESR) spectrometry. Then SOD activity was compared with the type of nerve root compression as seen on preoperative myelography. SOD activity in the normal control group was 7U/ml, while that in the hernia group remarkably decreased. The concentration gradient of SOD activity was different between central herniation and centrolateral herniation. Our findings indicate that free radicals are generated after nerve root compression. Under severe deficiency of SOD activity in CSF, serum SOD penetrates into CSF after further compression. In addition, SOD in CSF may play an important role in protecting against nerve root involvement. |
キーワード | superoxide dismutase(SOD) cerebrospinal fluid(CSF) nerve root compression inflammation free radicals |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1996-08 |
巻 | 50巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 197 |
終了ページ | 201 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 8874581 |
Web of Science KeyUT | A1996VE60800003 |
JaLCDOI | 10.18926/AMO/32429 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Takahashi, Isao| Kohi, Fumikazu| Inagaki, Noritoshi| Ohmoto, Eijiro| Fukumoto, Mitsuhiro| Watanabe, Seiichiro| Takaoka, Kazuko| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi| |
抄録 | The O2- production by neutrophils was examined in 4 cases of refractory anemia with excess of blasts (RAEB) in order to evaluate the possible causes of enhanced susceptibility to infection and to gain some informations on the differentiation of neutrophils in this hematological disorder. In three of the four RAEB cases there was little O2- production by neutrophils, in addition to there being morphological anomalies of the neutrophils such as a Pelger-Huet-like anomaly, granular deficiency and binucleated cells. These results suggest that the impairment of O2- production by neutrophils in RAEB is one of the possible causes of susceptibility to infection and also suggest that the differentiation of neutrophils in this hematological disorder is faulty. The estimation of O2- production by neutrophils may be a useful diagnostic method for preleukemia. |
キーワード | superoxide anion refractory anemia with excess of blasts (RAEB) preleukemia |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1983-10 |
巻 | 37巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 417 |
終了ページ | 421 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 6316758 |
Web of Science KeyUT | A1983RN98400005 |
JaLCDOI | 10.18926/AMO/31037 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Takahashi, Isao| Inagaki, Noritoshi| Nakada, Hiroshi| Ohmoto, Eijiro| Takeuchi, Makoto| Osada, Ken| Matsuzaki, Toshiaki| Fukuda, Shunichi| Uchida, Kozaburo| Kohi, Fumikazu| Yorimitsu, Seiichi| Kimura, Ikuro| Kitajima, Koichi| Sanada, Hiroshi| |
抄録 | Superoxide anion (O2-) production by neutrophils from 14 untreated patients with acute nonlymphocytic leukemia (ANLL) was significantly less than that of healthy controls (4.93 +/- 1.99 vx 6.20 +/- 1.53 nmol/min/10(6) neutrophils, p less than 0.05). In 10 patients with myelodysplastic syndrome (MDS), however, it was not significantly different from the control level although 6 of the 10 patients had low levels, when individual patients were compared with the lower limit of the control range. An inverse correlation between the O2- production of neutrophils and the percentage of leukemic cells in the marrow existed in ANLL (r = -0.55, p less than 0.01), but not in MDS. Three of 4 MDS patients who died of pneumonia prior to leukemic conversion showed a low level of O2- production. The impaired O2- production by neutrophils from some MDS patients, probably due to the faulty differentiation from leukemic clones, may be one of the causes of enhanced susceptibility to infection. |
キーワード | superoxide anion production myelodysplastic syndrome preleukemia |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1988-02 |
巻 | 42巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 15 |
終了ページ | 19 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 2834918 |
Web of Science KeyUT | A1988M237800003 |
JaLCDOI | 10.18926/AMO/31830 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Hareva, David H.| Okada, Hiroki| Kitawaki, Tomoki| Oka, Hisao| |
抄録 | The authors previously developed a mobile ecological momentary assessment (EMA) system as a real-time data collection device using a mobile phone. In this study, a real-time advice function and real-time reporting function were added to the previous system as a supportive intervention. The improved system was found to work effectively and was applied to several clinical cases, including patients with depressive disorder, dizziness, smoking habit, and bronchial asthma. The average patient compliance rate was high (89%) without the real-time advice and higher (93%) with the advice. The trends in clinical data for patients using a mobile EMA with/without the new function were analyzed for up to several months. In the case of dizziness, an improving trend in its clinical data was observed after applying the real-time advice, and in the case of depressive disorder, a stabilizing trend was observed. The mobile EMA system with the real-time advice function could be useful as a supportive intervention in behavior modification and for motivating patients in self-management of their disease. |
キーワード | ecological momentary assessment intervention mobile phone real-time advice |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2009-04 |
巻 | 63巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 113 |
終了ページ | 120 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 19404343 |
Web of Science KeyUT | 000265457600006 |
JaLCDOI | 10.18926/AMO/30738 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ohtani, Yuu| Aoe, Motoi| Hara, Fumikata| Tao, Hiroyuki| Koshimune, Ryuichiro| Hirami, Yuuji| Hanabata, Tetsuro| Shimizu, Nobuyoshi| |
抄録 | To investigate the suppressive effect of human recombinant TIMP-1 (rh-TIMP-1) on tumor proliferation using an in vivo xenograft system, HT29 was suspended in 0.1 ml phosphate buffered saline (PBS) and then subcutaneously injected in the back of female mice (BALB/C nu/nu). The mice were divided into 2 groups an and the tumor diameter was measured after rh-TIMP-1 (2 mg/kg) (rh-TIMP-1 group) or PBS (control group) was administered injections according to the following schedules. Schedule 1 : Beginning 2 weeks after the subcutaneous injection of HT29, an intraperitoneal injection of rh-TIMP-1 or PBS were performed twice a day (every 12 h) for 14 consecutive days. Schedule 2 : Beginning 1 week after the subcutaneous injection of HT29, an intraperitoneal injection was performed twice a day for 14 consecutive days. Schedule 3 : Intraperitoneal injections were started simultaneously with the subcutaneous injection of HT29, and then performed twice a day for 21 consecutive days. The mice were sacrificed and the tumors extirpated for immunohistochemical investigation. In addition, gelatin zymography and a cell proliferation assay were performed. With Schedule 1, the changes in the tumor diameter in the rh-TIMP-1 group followed the same course as those in the control group, and no suppressive effect on tumor proliferation was observed. However, with Schedule 3, a remarkable suppressive effect was observed throughout the treatment period. In immunostaining, more cases negative for MMP-9 were observed in the rh-TIMP-1 group than in the control group. Cases negative for CD34 were significantly more observed in the rh-TIMP-1 group than in the control group with Schedule 3. All of the results were obtained through the suppressive effect of rh-TIMP-1 on angiogenesis. |
キーワード | MMP-2 MMP-9 TIMP-1 molecular targeting therapy angiogenesis |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2006-10 |
巻 | 60巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 257 |
終了ページ | 266 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17072372 |
Web of Science KeyUT | 000241509000002 |
JaLCDOI | 10.18926/AMO/32588 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ohbuchi, Shinji| |
抄録 | For the purpose of revealing the role of the reticuloendothelial system (RES) for the antibody formation, the rats which received the repeated intraperitoneal and subcutaneous injections of a vast amount of PVP were challenged by bovine serum albumin (BSA) introducing through 2 routes of intramuscular and intravenous, and then antibody formation was observed. Blood cell count and clearance rate of radiogold were observed for the purpose of obtaining the information of blockade grade of the RES by PVP. Phagocytic activity of macrophages ingesting PVP against iron colloid were also observed in vitro. 1. A severe anemia was induced by the administration of a vast amount of PVP, 15 ml of 3% solution daily or every other day for 63 days. Histological picture indicated the suppressed erythropoiesis probably by iron deficiency or the lowered iron transporting activity of the RES, as the anemia recovered after intraperitoneal iron injections. 2. With the generalized and marked swelling of the RES, the cells in germinal center of spleen and lymph nodes were extremely swollen and lymphocytes disappeared completely, suggesting that the macrophages in germinal center play an important role in reproduction and differentiation of lymphocytes. 3. The phagocytic activity of the RES as understood from the clearance rate of radiogold was suppressed only slightly even by a heavy deposition of PVP after the repeated injections. The state of blockade or the suppressed phagocytic activity persisted for 48 hours or more after the several PVP injections. However, complete blockade of the RES or inactivation of the phagocytic activity by PVP injection was not attained. 4. A prolonged treatment of animals with PVP caused delay in the appearance of circulating antibody but the final titration reached the same level as that of control. The data suggest that the blockade of the RES by PVP induces the delay in the transmittance of the information for the antibody formation from the macrophages to the immunologically competent cells but no delay in the ingesting antigen by the macrophages. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1968-02 |
巻 | 22巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 37 |
終了ページ | 49 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4238236 |
NAID | 120002312244 |
JaLCDOI | 10.18926/AMO/32582 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ohbuchi, Shinji| |
抄録 | The rats which received the repeated intra peritoneal or intravenous injections of methyl palmitate showed a marked depressed phagocytic activity of the RES as shown by the clearance test with radioactive iron as well as by histological observations and a significantly suppressed antibody formation against the challenge by BSA. Differing from the cases of the blockade of the RES made by PVP or radiogold, the injection of methyl palmitate did not result in any injurious effect on the lymph follicles of lymph nodes and spleen and the plasma cells proliferation as revealed by the histological observation. Histochemical observations of iron phagocytosis of the RES done by Perls stain revealed that methyl palmitate suppressed the phagocytic activity of the Kupffer cells of the liver dramatically and also suppressed the phagocytic activity of the sinus-lining cells in spleen to a lesser degree. The result indicates that the injection of methyl palmitate attacks the phagocytic function of the RES selectively and induces the reduced immune response of the organism without giving any damages to the proliferation of immunologically com petent cells. The fact suggests that the RES lowered in their phagocytic activity fails to produce the informational substance for immune response, showing a lower level in the antibody formation even in the presence of antigen and proliferating immunologically competent cells. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1968-06 |
巻 | 22巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 146 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4239072 |
NAID | 120002312296 |
JaLCDOI | 10.18926/AMO/32574 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ohbuchi, Shinji| |
抄録 | For the purpose of revealing the interaction between macrophages and plasma cells in relation to antibody formation and information for cell specialization, the proliferation of plasma cell by antigenic stimulation was observed in the rats whose RES had been previously injured by radiogold. The production of the circulating antibody was markedly suppressed by the pretreatment with radiogold. Histological observation revealed that the plasma cells and lymphocytes were completely obliterated and the tissues were replaced by the basophilic cells and fibroblastic cells. Lymph nodes which contained less radiogold and expected to be less in cell injury had also lost their lymphocytes, but showed a marked proliferation of plasma cells in the medullary cord and large basophilic cells in the area of lymph follicles. The data suggest that the impaired immune response will be due to the failure of the macrophages in releasing the informational substance for plasma cell specialization and for antibody formation on account of possible inability in metabolizing the ingested antigen by the injured macrophages. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1968-04 |
巻 | 22巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 113 |
終了ページ | 122 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4239068 |
NAID | 120002311513 |
JaLCDOI | 10.18926/AMO/32554 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Okada, Shigeru| |
抄録 | For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data indicated that the erythropoiesis of ra bbit is sensitive to AMD, as much as that of mice, while the rat is resistant to AMD, and its erythropoiesis is not affected by the similar dose of AMD as in the case of mouse and rabbit. 2. The morphologic observations on the eradication process of erythroblasts in the bone marrow of mice and rabbits indicates that AMD acts as to inhibit the transformation of the stem cell to the proerythroblast but not on the erythroblast in the course of specialization. The time required for the eradication coincided with the time of the proerythroblast to the mature red cell. 3. Discussion has been made on the possibility of the common stem cell to erythroid and granulocytic cells in relation to the lymphoid cells in bone marrow and their blast form. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1969-06 |
巻 | 23巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 165 |
終了ページ | 176 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4242841 |
NAID | 120002311439 |
JaLCDOI | 10.18926/AMO/32545 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Okada, Shigeru| |
抄録 | For the purpose of revealing whether or not hemoglobin synthesis is inhibited by the AMD, the author estimated the hemoglobin level of AMD treated anilmals by microspectrophotometer, and found that the hemoglobin levels of all the developmental stages of erythroid cells were not inhibited by the AMD. The data indicated that about one half of mRNA for hemoglobin is synthesized in the early stage of specialization with the supplementary synthesis at the later stages and all these mRNA is stable and insensitive to AMD. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1969-10 |
巻 | 23巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 387 |
終了ページ | 392 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4244047 |
NAID | 120002312271 |
JaLCDOI | 10.18926/AMO/32515 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Okada, Shigeru| |
抄録 | For the purpose of revealing whether AMD inhibits the RNA synthesis of erythroblasts in an effective dose in vivo to eradicate erythroid cells in rabbit bone marrow, the author observed the RNA synthesis by H3-uridine incorporation in vitro and RNA level on the cells from the anemic animals taken at a certain period after a single injection of AMD in a small dose of 50 and 100μg/kg body weight. The data revealed that by such a small dose of injection of AMD the RNA synthesis of erythroid precursors, early basophilic and proerythroblast stages, was successfully suppressed without any suppressing effect on the RNA synthesis of erythroblasts in the later stages of specialization, indicating that there are at least two kinds of RNA synthesis: one seen mainly in the earlier stages of specialization and the other one seen mainly in the later stages, and they can be distinguished from each other by the AMD sensitivity. |
Amo Type | Article |
出版物タイトル | Acta Medicinae Okayama |
発行日 | 1969-08 |
巻 | 23巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 265 |
終了ページ | 271 |
NCID | AA00041342 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 4243559 |
NAID | 120002311801 |
JaLCDOI | 10.18926/AMO/31113 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Suo, Jian| Tanaka, Noriaki| Hizuta, Akio| Yunoki, Shigeru| Orita, Kunzo| |
抄録 | PSK (Krestin) is a protein-bound polysaccharide with antitumor and immunomodulatory activity. In this study, the effects of the oral administration of PSK were investigated on the natural killer (NK) activity of liver-associated lymphocytes and their subfractions separated by density gradient centrifugation, in WKAH rats with liver metastasis of KDA hepatoma. PSK was administered orally, at a dose of 500 mg/kg once a day for 3 weeks. The NK activity of nonparenchymal liver cells (NPLC) and their subfractions, including large granular lymphocytes (LGL), was markedly augmented by this treatment. The effects of oral PSK were also examined in CDF1 mice with liver metastases of Colon 26 adenocarcinoma; the survival of tumor-bearing mice was prolonged and both metastatic foci and liver weight were decreased. These results suggest that PSK may be effective for the suppression of liver metastasis through activation of liver-associated NK cells. |
キーワード | PSK NK activity liver metastasis cancer |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1994-10 |
巻 | 48巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 237 |
終了ページ | 242 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 7863794 |
Web of Science KeyUT | A1994PP23600002 |
JaLCDOI | 10.18926/AMO/31919 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Yoshihara, Hisashi| Tanaka, Noriaki| Orita, Kunzo| |
抄録 | The influence of surgical stress on the natural killer (NK) activity of peripheral blood lymphocytes in patients with carcinoma of the lung or gastrointestinal system was studied. The peripheral blood lymphocytes of the patients showed a marked decrease in NK activity against K-562 cells as target cells 1-2 days after surgery. The activity remained lowered for 2 weeks after thoractomy and for 1 week after laparotomy. No appreciable suppression of NK activity was observed with normal human peripheral blood lymphocytes preincubated with postoperative patient sera. Peripheral blood mononuclear cells obtained postoperatively from patients lost NK activity after ultraviolet irradiation, without any detectable loss of viability. Such irradiated mononuclear cells showed inhibition of NK activity after a 24-hour preincubation with peripheral blood lymphocytes from normal subjects. Similar suppressive activity was demonstrable in a fraction of mononuclear cells with adhesiveness to plastic petri dishes, while non-adherent cells had no such activity. When added immediately to the cytotoxicity assay system without the 24-hour preincubation, patient mononuclear cells caused no inhibition of NK activity, whereas adherent cells from normal subjects enhanced NK activity. The findings seems to indicate that, following surgical stress, plastic dish-adherent peripheral blood mononuclear cells become deprived of NK helper activity and exert suppression, thus causing postoperative depression of NK activity. |
キーワード | natural killing suppressor cell surgical stress |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1986-04 |
巻 | 40巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 113 |
終了ページ | 119 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 2940814 |
Web of Science KeyUT | A1986C034800007 |
JaLCDOI | 10.18926/AMO/31688 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Mouri, Hirokazu| Sakaguchi, Kohsaku| Sawayama, Tomoyuki| Senoh, Tomonori| Ohta, Takeyuki| Nishimura, Mamoru| Fujiwara, Akiko| Terao, Masako| Shiratori, Yasushi| Tsuji, Takao| |
抄録 | Transforming growth factor-beta1 (TGF-beta1) exerts potent immunosuppressive effects. In this study, we investigated the potential role of TGF-beta1 produced by hepatocellular carcinoma (HCC) cell lines in immunosuppression mechanisms. Using the Mv1Lu cell-growth inhibition assay and an enzyme-linked immunosorbent assay (ELISA), we detected optimal levels of TGF-beta1 in the culture supernatants conditioned by the HCC cell lines PLC/PRF/5, Hep3B, and HepG2. To determine the biological activity of TGF-beta1 in the supernatants, we examined the effects of the culture supernatants on the production of interferon (IFN)-gamma induced during the culture of peripheral blood mononuclear cells (PBMCs) stimulated with interleukin (IL)-12. IFN-gamma production of IL-12-stimulated PBMCs in the 1:1 dilution of the acid-activated conditioned medium of PLC/PRF/5, Hep3B, and HepG2 reduced to 14.7 +/- 0.8, 17.3 +/- 9.0, and 35.9 +/- 14.6%, respectively, compared with the value in the culture with control medium (complete culture medium). These results suggest that HCC cells producing TGF-beta1 may reduce the generation or activation of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, and thus could enhance their ability to escape immune-mediated surveillance. |
キーワード | hepatocellular carcinoma immunosuppression transforming growth factor-?1 (TGF-?1) interleukin-12 interferon-? (IFN-?) |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2002-12 |
巻 | 56巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 309 |
終了ページ | 315 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 12685860 |
Web of Science KeyUT | 000179959000006 |
JaLCDOI | 10.18926/AMO/30342 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Fujiwara, Ryoichi| Tanaka, Noriaki| Orita, Kunzo| |
抄録 | The influence of surgical stress on the local graft-versus-host reaction (GVHR) in F1 mice was studied. Skin incision 1 day prior to injection of parental spleen cells produced impairment of popliteal lymph node enlargement; however, this effect was not observed when GVHR was induced 3 and 5 days after operation. Strong GVHR suppressive activity of spleen cells was observed three hours after leg amputation before a decrease in thymus weight became evident. The GVHR suppressive activity declined by six hours later, but a second peak of 60% inhibition was observed after 24 h. This suppressive activity completely disappeared by treatment with anti-Thy 1.2 and complement. This shows that the GVHR is suppressed by surgical stress, and that this suppression is due to suppressor T lymphocytes. |
キーワード | surgical stress graft-versus-host reaction suppressor T cells |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1984-10 |
巻 | 38巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 439 |
終了ページ | 446 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 6240191 |
Web of Science KeyUT | A1984TQ61100003 |
JaLCDOI | 10.18926/AMO/31010 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Fukuda, Tomio| Aji, Toshiki| Tongu, Yasumasa| |
抄録 | The surface ultrastructure of larval Anisakis type I, Anisakis type II, Raphidascaris, Contracaecum type A, Thynnascaris type A and Thynnascaris type B was examined by scanning electron microscopy. These species were identified clearly by the presence of a boring tooth, a mucron, and other morphological features. The means of the distances between transverse striations (DBTS) of larval Anisakis type I (5.45 +/- 0.125 micron), larval Raphidascaris (2.92 +/- 0.051 micron), and larval Contracaecum type A (1.68 +/- 0.056 micron) are significantly different (p less than 0.05). There was a correlation between the diameter of worm trunk (DOWT) and DBTS among these three larval types. In most cases a larva could be identified from the mean value of DBTS and DOWT even if obtained as a fragment from a patient. |
キーワード | Anisakidae ultrastructure surface striation scanning ekectron microscopy |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1988-04 |
巻 | 42巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 105 |
終了ページ | 116 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 3389198 |
Web of Science KeyUT | A1988N237200007 |
JaLCDOI | 10.18926/AMO/64040 |
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フルテキストURL | 76_5_585.pdf |
著者 | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
抄録 | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
キーワード | renal cell carcinoma pulmonary metastasis complete resection |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2022-10 |
巻 | 76巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 585 |
終了ページ | 591 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 36352806 |
Web of Science KeyUT | 000884907100012 |
JaLCDOI | 10.18926/AMO/54813 |
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フルテキストURL | 70_6_493.pdf |
著者 | Yasuhara, Takao| Kuwahara, Ken| Sasada, Susumu| Toyoshima, Atsuhiko| Morimoto, Jun| Kin, Kyohei| Manabe, Hiroaki| Miyoshi, Yasuyuki| Kusumegi, Akira| Takahashi, Yuichiro| Ito, Kiyoshi| Date, Isao| |
抄録 | Unexpected injuries can have a profound effect on a surgeonʼs performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a ʻSurgical Body Supportʼ device. Similarly injured surgeons may benefit from such support. |
キーワード | Achilles tendon rupture electromyogram genuflection injured leg standing position |
Amo Type | Short Communication |
出版物タイトル | Acta Medica Okayama |
発行日 | 2016-12 |
巻 | 70巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 493 |
終了ページ | 496 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 28003675 |
JaLCDOI | 10.18926/AMO/30800 |
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フルテキストURL | fulltext.pdf |
著者 | Uemura, Tadahiro| Otani, Jun| Kawasaki, Seiji| Kawai, Hiroshi| Suga, Masando| Maruyama, Shuichiro| Murakami, Masakazu| Morisue, Shinpachi| Yoshizane, Ken| Morokoshi, Yoshiro| Yamamoto, Masahiko| Soda, Mitsuhiro| |
抄録 | A retrospective study on postoperative complications and factors affecting prognosis was performed on elderly patients with gastric cancer. We studied the correlation of age, pathological depth, preoperative laboratory data, physical status, duration of surgery, volume of blood loss, blood transfusion, curability, and extent of lymph node dissection to postoperative complications and prognosis in 47 patients with gastric cancer over 80 years old. Preoperative function of lung and liver frequently showed abnormal data. Postoperative complications were noted in 47% of patients, especially in the pulmonary system, liver and heart. Curability and extent of lymph node dissection were the significant factor affecting survival. Some mortalities caused by initial malignancy were recognized in the conservative lymph node dissection in the stage I . The incidence of postoperative complications was not significantly different according to extent of lymph node dissection. Blood transfusion was the only significant factor for the incidence of postoperative complication. The most frequent cause of death was the initial malignancy. We recommend that a low grade lymph node dissection should not be readily chosen for elderly patients in early cases. |
キーワード | gastric cancer elderly patients postoperative complications preoperative evaluation blood transfusion |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1997-06 |
巻 | 51巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 159 |
終了ページ | 165 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 9227796 |
Web of Science KeyUT | A1997XJ12700008 |
JaLCDOI | 10.18926/AMO/54419 |
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フルテキストURL | 70_3_197.pdf |
著者 | Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Sui, Kenta| Fuji, Tomokazu| Fujiwara, Toshiyoshi| |
抄録 | The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p<0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p<0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes. |
キーワード | pancreaticoduodenectomy surgical outcome mortality major complication length of stay |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2016-06 |
巻 | 70巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 197 |
終了ページ | 203 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 27339209 |
Web of Science KeyUT | 000379406100007 |