ID | 32712 |
JaLCDOI | |
フルテキストURL | |
著者 |
Yamamoto, Goki
Okayama University
Tanabe, Masatada
Okayama University
Wakabayashi, Hiroshi
Okayama University
publons
Hashimoto, Gonosuke
Okayama University
Yamamoto, Michio
Okayama University
|
抄録 | Effect of inorganic phosphate on ferrous ion- and ascorbate-induced lipid. peroxidations of isolated rat liver mitochondria was investigated. As a result it has been shown that phosphate accelerates the ferrous ion.induced lipid peroxidation; namely, phos. phate shortens the induction lag period of the lipid peroxidation reaction but the malondialdehyde after onset of its production is yielded at the same rate in various concentrations of phosphate. On the other hand, phosphate inhibits ascorbate.induced lipid peroxidation. There are stoichiometric interactions between the concentration of phos. phate and the induction period. Oxygen uptake by mitochondria was observed in the presence of both ferrous ion and phosphate at initial step of the reaction without being accompanied by malondialdehyde production, and afterwards there occurred malondialdehyde production with rapid rate of the oxygen uptake. Possible mechanisms and interactions among ferrous ion, ascorbate and phosphate were discussed. |
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1974-10
|
巻 | 28巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 299
|
終了ページ | 310
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
NAID |