著者 吉野 正| 赤木 忠厚|
発行日 2001-04-28
出版物タイトル 岡山医学会雑誌
113巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32620
フルテキストURL fulltext.pdf
著者 Takata, Hiroshi| Yoshino, Tadashi| Hoshida, Yoshihiko| Takata, Ikuko| Akagi, Tadaatsu|
抄録 <p>A cell line of human lung large cell carcinoma (LCC) was established directly from the metastatic skin tumor tissue. The clinical course of the patient who carried this carcinoma was peculiar; generalized lymphadenopathy, histologically resembling Hodgkin's disease, was found as the first clinical symptom. The lung tumor was not discovered until the time of autopsy. This cell line (KaMi) grew adherent to culture vessels with the population doubling time of 20.6h, formed colonies in soft agars with efficiency of 22.6%, and formed tumors in athymic nude mice. The authenticity of KaMi was confirmed by chromosomal analysis and isoenzyme patterns. KaMi cells bore a strong resemblance to the original tumor cells which were composed of small spindle cells, large polygonal cells, and multinucleated giant cells. Immunohistochemically, KaMi cells showed a weak tendency to differentiate to squamous cells, and these immunohistochemical reactivities were almost compatible to those of the original tumor cells, but ultrastructurally, KaMi cells were more immature than the original ones. Treatment with several reagents could not augment a differentiation of KaMi cells. Cytokeratin profiles showed a tendency of squamous cell differentiation. KaMi cells may aid in elucidating the pathogenesis and biology of LCC and its relationship to other lung tumors. </p>
キーワード Large cell lung carcinoma cell line cytokeratin
Amo Type Article
発行日 1992-08
出版物タイトル Acta Medica Okayama
46巻
4号
出版者 Okayama University Medical School
開始ページ 257
終了ページ 264
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1279943
Web of Science KeyUT A1992JL44200005
JaLCDOI 10.18926/AMO/32636
フルテキストURL fulltext.pdf
著者 Kondo, Eisaku| Yoshino, Tadashi| Akagi, Tadaatsu| Hayashi, Kazuhiko| Takahashi, Kiyoshi|
抄録 <p>Southern blot hybridization was used to detect the rearrangement and amplification of five proto-oncogenes (bcl-2, bcl-1, c-myc, c-myb and c-Ha-ras) and one tumor suppressor gene (RB-1) in 55 Japanese patients with non-Hodgkin's lymphoma; 16 with T-cell lymphomas and 39 with B-cell lymphomas (7 follicular and 32 diffuse lymphomas). Genetic abnormalities of the proto-oncogenes were detected in 7 of the 55 (13%). Genetic abnormalities of bcl-2 plus other genes were detected in 5 of 7 cases of follicular lymphoma (71%), rearrangements of bcl-2 and c-myc, rearrangement of bcl-2 and amplification of c-myb. Genetic abnormalities were observed in only three cases of diffuse lymphoma. In each of 3 cases of B-cell lymphoma, one of the genes, blc-2 mbr, bcl-2 mcr and c-myc, was rearranged respectively. The incidence of genetic abnormalities in diffuse lymphomas (6.3%) was lower than that in follicular lymphomas. None of diffuse lymphomas had double oncogene abnormality. No abnormalities were found in RB-1, bcl-1, and Ha-ras. These findings suggest that follicular lymphomas are associated with some abnormalities of oncogenes not restricted to bcl-2 that facilitate growth which may be associated with their clinical features.</p>
キーワード malignant lymphoma cellular oncogenes
Amo Type Article
発行日 1992-12
出版物タイトル Acta Medica Okayama
46巻
6号
出版者 Okayama University Medical School
開始ページ 407
終了ページ 415
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1485535
Web of Science KeyUT A1992KE49600002
フルテキストURL blood_119_1_285.pdf
著者 Nishimori, Hisakazu| Maeda, Yoshinobu| Teshima, Takanori| Sugiyama, Haruko| Kobayashi, Koichiro| Yamasuji, Yoshiko| Kadohisa, Sachiyo| Uryu, Hidetaka| Takeuchi, Kengo| Tanaka, Takehiro| Yoshino, Tadashi| Iwakura, Yoichiro| Tanimoto, Mitsune|
備考 This research was originally published in Blood. 2012. © the American Society of Hematology.|
発行日 2012-01-05
出版物タイトル Blood
119巻
1号
開始ページ 285
終了ページ 295
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 22077062
DOI 10.1182/blood-2011-01-332478
Web of Science KeyUT 000299012400035
関連URL https://doi.org/10.1182/blood-2011-01-332478
フルテキストURL fulltext.pdf
著者 Ikeda, Tomoka| Gion, Yuka| Sakamoto, Misa| Tachibana, Tomoyasu| Nishikori, Asami| Nishimura, Midori Filiz| Yoshino, Tadashi| Sato, Yasuharu|
キーワード Lymphoid tissues Lymphoma
発行日 2020-06-19
出版物タイトル Modern Pathology
33巻
12号
出版者 Springer Nature
開始ページ 2437
終了ページ 2448
ISSN 0893-3952
NCID AA1067307X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © Authors
論文のバージョン author
PubMed ID 32561847
DOI 10.1038/s41379-020-0599-8
Web of Science KeyUT 000541317200003
関連URL isVersionOf https://doi.org/10.1038/s41379-020-0599-8
著者 Kobayashi, Hiroki| Asada, Noboru| Igawa, Takuro| Abe, Masaya| Meguri, Yusuke| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-ichi| Yoshino, Tadashi| Maeda, Yoshinobu|
キーワード adult T-cell leukemia-lymphoma breast involvement positron emission tomography/computed tomography
発行日 2020-11-01
出版物タイトル Internal Medicine
59巻
21号
出版者 日本内科学会
開始ページ 2757
終了ページ 2761
ISSN 0918-2918
NCID AA10827774
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 by The Japanese Society of Internal Medicine
論文のバージョン publisher
DOI 10.2169/internalmedicine.5077-20
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.5077-20
フルテキストURL fulltext.pdf
著者 Nishimura, Midori Filiz| Igawa, Takuro| Gion, Yuka| Tomita, Sakura| Inoue, Dai| Izumozaki, Akira| Ubara, Yoshifumi| Nishimura, Yoshito| Yoshino, Tadashi| Sato, Yasuharu|
キーワード plasma cell type idiopathic multicentric Castleman disease IL-6 IgG4-related disease immunohistochemistry hyper IL-6 syndrome
発行日 2020-12-10
出版物タイトル Journal of Personalized Medicine
10巻
4号
出版者 MDPI
開始ページ 269
ISSN 2075-4426
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 by the authors.
論文のバージョン publisher
PubMed ID 33321725
DOI 10.3390/jpm10040269
Web of Science KeyUT 000601729100001
関連URL isVersionOf https://doi.org/10.3390/jpm10040269
フルテキストURL fulltext.pdf
著者 Sakatani, Akio| Igawa, akuro| Okatani, Takeshi| Fujihara, Megumu| Asaoku, Hideki| Sato, Yasuharu| Yoshino, Tadashi|
キーワード classic Hodgkin lymphoma CD79a prognosis immunohistochemistry
発行日 2020
出版物タイトル Journal of Clinical and Experimental Hematopathology
60巻
3号
出版者 The Japanese Society for Lymphoreticular Tissue Research
開始ページ 78
終了ページ 86
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 by The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 32641598
NAID 130007907547
DOI 10.3960/jslrt.20010
Web of Science KeyUT 000575120100003
関連URL isVersionOf https://doi.org/10.3960/jslrt.20010
フルテキストURL fulltext.pdf
著者 Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Omote, Sizuma| Matsueda, Katsunori| Tanaka, Takehiro| Ennishi, Daisuke| Otsuka, Fumio| Yoshino, Tadashi| Okada, Hiroyuki|
キーワード Flow cytometry Light chain restriction Gastrointestinal lymphoma Lymphocyte isolation
発行日 2020
出版物タイトル MethodsX
7巻
出版者 Elsevier
開始ページ 101095
ISSN 2215-0161
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 The Author(s).
論文のバージョン publisher
PubMed ID 33102158
DOI 10.1016/j.mex.2020.101095
Web of Science KeyUT 000607658800035
関連URL isVersionOf https://doi.org/10.1016/j.mex.2020.101095
フルテキストURL fulltext.pdf
著者 Ikeda, Tomoka| Gion, Yuka| Nishimura, Yoshito| Nishimura, Midori Filiz| Yoshino, Tadashi| Sato, Yasuharu|
キーワード EBV-positive mucocutaneous ulcer clinical features pathological features immunosuppression
発行日 2021-01-21
出版物タイトル International Journal of Molecular Sciences
22巻
3号
出版者 MDPI
開始ページ 1053
ISSN 1422-0067
NCID AA12038549
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 33494358
DOI 10.3390/ijms22031053
Web of Science KeyUT 000615330100001
関連URL isVersionOf https://doi.org/10.3390/ijms22031053
JaLCDOI 10.18926/AMO/54978
フルテキストURL 71_2_105.pdf
著者 Shinya, Takayoshi| Tanaka, Takashi| Soh, Junichi| Matsushita, Toshi| Sato, Shuhei| Toyooka, Shinichi| Yoshino, Tadashi| Miyoshi, Shinichiro| Kanazawa, Susumu|
抄録 We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy.
キーワード thymic epithelial neoplasm thymic carcinoma thymoma dual-time-point PET/CT chest CT
Amo Type Original Article
発行日 2017-04
出版物タイトル Acta Medica Okayama
71巻
2号
出版者 Okayama University Medical School
開始ページ 105
終了ページ 112
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28420891
タイトル(別表記) A case of paraneoplastic neurological syndrome associated with Hodgkin lymphoma
著者 池町 涼介| 近藤 歌穂 | 松村 彰文| 藤井 総一郎| 竹内 誠| 佐藤 恒太| 阿部 康二| 吉野 正|
抄録  An 86-year-old man was admitted to another hospital with ataxia and general fatigue. Brain MRI scan revealed a high-intensity area in the bilateral thalamus, and he was referred to Okayama University Hospital for detailed examination. Cerebrospinal fluid (CSF) and blood tests showed no evidence of infection or autoimmune encephalitis. An FDG-PET/CT scan revealed systemic lymphadenopathy, and cervical lymph node biopsy showed classical Hodgkin lymphoma. Neurological symptoms were suspicious of paraneoplastic neurological syndrome (PNS), but onco-neural antibodies were not detected in either serum or CSF. He was referred to our hospital, Okayama Red Cross Hospital, for treatment and administered 6 cycles of an ABVD regimen, and an FDG-PET/CT scan showed a complete remission. The brain lesion disappeared and neurological symptoms were improved, so he was diagnosed with PNS. PNS is rare complication associated with malignant lymphoma and early diagnosis is important because neurological symptoms can be improved with anti-cancer treatment.
キーワード 傍腫瘍性神経症候群 (paraneoplastic neurological syndrome) 悪性リンパ腫 (malignant lymphoma)
出版物タイトル 岡山医学会雑誌
発行日 2020-08-03
132巻
2号
開始ページ 87
終了ページ 90
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.132.87
言語 Japanese
著作権者 Copyright (c) 2020 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.132.87
NAID 130007894959
フルテキストURL fulltext.pdf
著者 Yoshino, Tadashi| Tanaka, Takehiro| Sato, Yasuharu|
キーワード chronic lymphocytic leukemia/small lymphocytic lymphoma differential diagnosis indolent lymphoma
発行日 2020
出版物タイトル Journal of Clinical and Experimental Hematopathology
60巻
4号
出版者 Japanese Society for Lymphoreticular Tissue Research
開始ページ 124
終了ページ 129
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 by The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 32249238
DOI 10.3960/jslrt.19041
Web of Science KeyUT 000599137300002
関連URL isVersionOf https://doi.org/10.3960/jslrt.19041
フルテキストURL fulltext.pdf
著者 Tanaka, Takehiro| Nishida, Kenji| Iwamuro, Masaya| Kikuchi, Satoru| Yoshino, Tadashi|
発行日 2021-02-26
出版物タイトル Case reports in gastrointestinal medicine
2021巻
出版者 HINDAWI LTD
開始ページ 6617370
ISSN 2090-6528
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2021 Takehiro Tanaka et al.
論文のバージョン publisher
PubMed ID 33728073
DOI 10.1155/2021/6617370
Web of Science KeyUT 000627132200002
関連URL isVersionOf https://doi.org/10.1155/2021/6617370
著者 後藤田 達洋| 川野 誠司| 河野 吉泰| 三浦 公| 神崎 洋光| 岩室 雅也| 河原 祥朗| 田中 健大| 吉野 正| 白川 靖博| 田端 雅弘| 谷本 光音| 岡田 裕之|
発行日 2016-12-01
出版物タイトル 岡山医学会雑誌
128巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30333
フルテキストURL fulltext.pdf
著者 Motoi, Makoto| Yoshino, Tadashi| Kawabata, Kenji| Ikehara, Ikuko| Ohsumi, Shozo| Ogawa, Katsuo|
抄録 <p>Using the peroxidase antiperoxidase (PAP) method, lysozyme (LZM) was shown to exist in normal, reactive and neoplastic cells belonging to the mononuclear phagocyte system (MPS), but was not detected in histiocytosis X cells. Immunostaining for cytoplasmic LZM by the PAP method is useful for identification of mononuclear phagocytes and for diagnosis of the diseases in which these cells participate.</p>
キーワード lysozyme PAP method mononuclear phagocyte system
Amo Type Article
発行日 1984-04
出版物タイトル Acta Medica Okayama
38巻
2号
出版者 Okayama University Medical School
開始ページ 125
終了ページ 133
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6375269
Web of Science KeyUT A1984SN81800004
JaLCDOI 10.18926/AMO/30447
フルテキストURL fulltext.pdf
著者 Yoshino, Tadashi| Hoshida, Yoshihiko| Murakami, Ichiro| Takahashi, Kiyoshi| Akagi, Tadaatsu|
抄録 <p>We have attempted to clarify the characteristics of monoclonal antibodies (MAbs) detecting lymphocyte subsets in fixed materials. We examined by means of flow cytometric technique influences of fixatives and reactivity with malignant lymphomas (MLs). Specific markers for T-cells were UCHL1 and OPD4, which reacted especially with helper/inducer T-cells. MT1 recognized almost all of T-cells from peripheral blood and tonsils, but reacted with a part of B-MLs. As for B-cell markers, L26 was the most reliable marker for B-MLs. L26 and MB1 antigens could not be detected on living cells flow cytometrically. LN1 reacted with a part of T-cells as well as B-cells, but fluorescent intensity of the former was apparently stronger than that of the latter. Although LN2 antigen was located mainly in the cytoplasm close to the nuclear membrane immunohistochemically, it could be detected on living cells flow cytometrically. LN2 positive cells belonged to B-cells in peripheral blood and tonsils. When fixed for relatively short time, B5 and buffered formalin were better for examining MAbs than non-buffered formalin and ethanol.</p>
キーワード monoclonal antibodies lymphocyte subset flow cytometry
Amo Type Article
発行日 1990-10
出版物タイトル Acta Medica Okayama
44巻
5号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 250
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1701954
Web of Science KeyUT A1990EG00700002
JaLCDOI 10.18926/AMO/30452
フルテキストURL fulltext.pdf
著者 Moreira, Luis Fernando| Iwagaki, Hiromi| Watanabe, Kazuhiko| Yoshino, Tadashi| Fuchimoto, Sadanori| Orita, Kunzo|
抄録 <p>A rare gastrointestinal tract neoplasm, primary non-Hodgkin's B-cell lymphoma in a 39-year-old, asymptomatic woman is described. The tumor was originally localized in the rectum without evidence of any other lymphoma-involved organ and treated by curative surgical procedure associated with postoperative chemotherapy.</p>
キーワード primary lymphoma rectum surgical treatment
Amo Type Article
発行日 1990-10
出版物タイトル Acta Medica Okayama
44巻
5号
出版者 Okayama University Medical School
開始ページ 279
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2260500
Web of Science KeyUT A1990EG00700008
JaLCDOI 10.18926/AMO/30484
フルテキストURL fulltext.pdf
著者 Tonoyama, Yuji| Teramoto, Norihiro| Sarker, Ashit Baran| Yoshino, Tadashi| Hayashi, Kazuhiko| Takahashi, Kiyoshi| Akagi, Tadaatsu|
抄録 <p>To elucidate the latent state and reactivation of Epstein-Barr virus (EBV) in non-neoplastic lymphoid lesions, we investigated 144 non-neoplastic lymphoid lesions by in situ hybridization (ISH) to detect the expression of EBV-encoded small RNAs (EBER)-1 and BCRF-1 and by immunostaining for latent membrane protein (LMP)-1 and ZEBRA. ISH for EBER-1 detected EBER-1-positive cells (EPC) in 31 of the 144 examined lesions (22%). EPC were detected in 4 of 49 cases of nonspecific lymphoid hyperplasia, in 16 of 20 abscess-forming granulomatous lymphadenitis (AFGL), 5 of 25 Kikuchi's disease, and in 3 of 3 infectious mononucleosis. LMP-1 was expressed in 6 of 124 non-neoplastic lymphoid lesions (4.8%). LMP-1-positive cells were observed in 6 of the 31 EBER-1-positive cases (19%). EPC were detected significantly more frequently in LMP-1- and ZEBRA-positive specimens than in the LMP-1- and ZEBRA-negative specimens. BCRF-1 was expressed in 4 of 11 cases examined: 2 of 3 AFGL, 1 of 2 Kikuchi's disease, and in the 1 case of atypical lymphoid hyperplasia. This study suggests that Epstein-Barr virus is prevalent and can be reactivated in the lymph nodes effaced by destructive inflammation, such as AFGL. Such inflammation may provide a local milieu that is conducive for EBV to enter the lytic cycle.</p>
キーワード EBER-I BCRF-l LMP-l ZEBRA lymphoid lesion
Amo Type Article
発行日 1996-04
出版物タイトル Acta Medica Okayama
50巻
2号
出版者 Okayama University Medical School
開始ページ 89
終了ページ 96
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8744934
Web of Science KeyUT A1996UJ08100005
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/5331
フルテキストURL fulltext.pdf
著者 Han, Yanyan| Igawa, Takuro| Ogino, Kyohei| Nishikori, Asami| Gion, Yuka| Yoshino, Tadashi| Sato, Yasuharu|
キーワード hemosiderin deposition plasma cell-type Castleman disease IgG4-related disease serum IL-6 serum C-reactive protein
発行日 2020
出版物タイトル Journal of Clinical and Experimental Hematopathology
60巻
1号
出版者 The Japanese Society for Lymphoreticular Tissue Research
開始ページ 1
終了ページ 6
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 by The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 32037354
NAID 130007821430
DOI 10.3960/jslrt.19037
Web of Science KeyUT 000522556200001
関連URL isVersionOf https://doi.org/10.3960/jslrt.19037