JaLCDOI | 10.18926/AMO/32636 |
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フルテキストURL | fulltext.pdf |
著者 | Kondo, Eisaku| Yoshino, Tadashi| Akagi, Tadaatsu| Hayashi, Kazuhiko| Takahashi, Kiyoshi| |
抄録 | Southern blot hybridization was used to detect the rearrangement and amplification of five proto-oncogenes (bcl-2, bcl-1, c-myc, c-myb and c-Ha-ras) and one tumor suppressor gene (RB-1) in 55 Japanese patients with non-Hodgkin's lymphoma; 16 with T-cell lymphomas and 39 with B-cell lymphomas (7 follicular and 32 diffuse lymphomas). Genetic abnormalities of the proto-oncogenes were detected in 7 of the 55 (13%). Genetic abnormalities of bcl-2 plus other genes were detected in 5 of 7 cases of follicular lymphoma (71%), rearrangements of bcl-2 and c-myc, rearrangement of bcl-2 and amplification of c-myb. Genetic abnormalities were observed in only three cases of diffuse lymphoma. In each of 3 cases of B-cell lymphoma, one of the genes, blc-2 mbr, bcl-2 mcr and c-myc, was rearranged respectively. The incidence of genetic abnormalities in diffuse lymphomas (6.3%) was lower than that in follicular lymphomas. None of diffuse lymphomas had double oncogene abnormality. No abnormalities were found in RB-1, bcl-1, and Ha-ras. These findings suggest that follicular lymphomas are associated with some abnormalities of oncogenes not restricted to bcl-2 that facilitate growth which may be associated with their clinical features. |
キーワード | malignant lymphoma cellular oncogenes |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1992-12 |
巻 | 46巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 407 |
終了ページ | 415 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1485535 |
Web of Science KeyUT | A1992KE49600002 |
フルテキストURL | fulltext.pdf |
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著者 | Nasu, Atsuko| Gion, Yuka| Nishimura, Yoshito| Nishikori, Asami| Sakamoto, Misa| Egusa, Yuria| Fujita, Azusa| Yoshino, Tadashi| Sato, Yasuharu| |
キーワード | SOX4 p16 adult T-cell leukemia/lymphoma peripheral T-cell lymphoma not otherwise specified |
発行日 | 2021-04-24 |
出版物タイトル | Diagnostics |
巻 | 11巻 |
号 | 5号 |
出版者 | MDPI |
開始ページ | 766 |
ISSN | 2075-4418 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 by the authors. |
論文のバージョン | publisher |
PubMed ID | 33923245 |
NAID | 120007042395 |
DOI | 10.3390/diagnostics11050766 |
Web of Science KeyUT | 000653793000001 |
関連URL | isVersionOf https://doi.org/10.3390/diagnostics11050766 |
JaLCDOI | 10.18926/AMO/54978 |
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フルテキストURL | 71_2_105.pdf |
著者 | Shinya, Takayoshi| Tanaka, Takashi| Soh, Junichi| Matsushita, Toshi| Sato, Shuhei| Toyooka, Shinichi| Yoshino, Tadashi| Miyoshi, Shinichiro| Kanazawa, Susumu| |
抄録 | We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy. |
キーワード | thymic epithelial neoplasm thymic carcinoma thymoma dual-time-point PET/CT chest CT |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2017-04 |
巻 | 71巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 105 |
終了ページ | 112 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 28420891 |
フルテキストURL | fulltext.pdf |
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著者 | Yoshino, Tadashi| Tanaka, Takehiro| Sato, Yasuharu| |
キーワード | chronic lymphocytic leukemia/small lymphocytic lymphoma differential diagnosis indolent lymphoma |
発行日 | 2020 |
出版物タイトル | Journal of Clinical and Experimental Hematopathology |
巻 | 60巻 |
号 | 4号 |
出版者 | Japanese Society for Lymphoreticular Tissue Research |
開始ページ | 124 |
終了ページ | 129 |
ISSN | 1346-4280 |
NCID | AA11556796 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by The Japanese Society for Lymphoreticular Tissue Research |
論文のバージョン | publisher |
PubMed ID | 32249238 |
DOI | 10.3960/jslrt.19041 |
Web of Science KeyUT | 000599137300002 |
関連URL | isVersionOf https://doi.org/10.3960/jslrt.19041 |
著者 | Hayashi, Eiko| Takata, Katsuyoshi| Sato, Yasuharu| Tashiro, Yukie| Tachiyama, Yoshiro| Sawada-Kitamura, Seiko| Hiramatsu, Yasushi| Sugiguchi, Shun| Nose, Soichiro| Hirokawa, Mitsuyoshi| Ando, Midori| Abd Mader, Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Yoshino, Tadashi| |
---|---|
発行日 | 2013-09 |
出版物タイトル | Human Pathology |
巻 | 44巻 |
号 | 9号 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext20240213-01.pdf |
---|---|
著者 | Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke| |
発行日 | 2023-12-14 |
出版物タイトル | Blood Advances |
巻 | 7巻 |
号 | 24号 |
出版者 | American Society of Hematology |
開始ページ | 7459 |
終了ページ | 7470 |
ISSN | 2473-9529 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 by The American Society of Hematology. |
論文のバージョン | publisher |
PubMed ID | 37552496 |
DOI | 10.1182/bloodadvances.2023010402 |
Web of Science KeyUT | 001141306600001 |
関連URL | isVersionOf https://doi.org/10.1182/bloodadvances.2023010402 |
JaLCDOI | 10.18926/AMO/31606 |
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フルテキストURL | fulltext.pdf |
著者 | Sarker, Ashit Baran| Akagi, Tadaatsu| Yoshino, Tadashi| Fujiwara, Kotaro| Nose, Soichiro| |
抄録 | The distribution of lectin receptors in the human tonsil was studied using 16 biotinylated lectins. The avidin-biotin-peroxidase complex (ABC) method was used on frozen and paraffin-embedded tissue sections. Cell suspensions were also analysed by dual flow cytometry using respective fluorescein isothiocyanate-conjugated lectins and phycoerythrin-labeled anti-CD3 and anti-human immunoglobulin. Frozen sections fixed with acetone and paraffin-embedded materials fixed in three solutions were compared for lectin affinity; ethanol-fixed sections gave best results followed by frozen and buffered formalin-fixed ones, then nonbuffered formalin. Con-A, RCA-1, LcH, WGA, MPA, PHA, PSA, PNA, SJA and GSA-1 reacted with all tissue components of the tonsil in immunohistochemical studies, but binding intensity was fixative dependent. Binding of Lotus and BPA to lymphocytes was limited to germinal center lymphocytes. Other tissue components were also reactive but staining intensity was weaker in Lotus compared with BPA. SBA and DBA did not react with lymphocytes, but reacted with macrophages/histiocytes, vascular endothelia, and epithelial cells. LBA and LPA were constantly negative with all tissue components irrespective of fixatives. Flow cytometric analyses showed that all but three (DBA, LBA and LPA) partially or totally stained lymphocyte surfaces. Lotus receptors were expressed exclusively on B-lymphocytes. |
キーワード | lectins ?histochemistry flow cytometry human tonsil |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1993-02 |
巻 | 47巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 13 |
終了ページ | 19 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 8460551 |
Web of Science KeyUT | A1993KP18500003 |
JaLCDOI | 10.18926/AMO/64363 |
---|---|
フルテキストURL | 77_1_65.pdf |
著者 | Sato, Ken| Takigawa, Nagio| Kubo, Toshio| Katayama, Hideki| Kishino, Daizo| Okada, Toshiaki| Hisamoto, Akiko| Mimoto, Junko| Ochi, Nobuaki| Yoshino, Tadashi| Ueoka, Hiroshi| Tanimoto, Mitsune| Maeda, Yoshionobu| Kiura, Katsuyuki| |
抄録 | We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors. |
キーワード | celecoxib cisplatin EGCG lung tumor polyphenon E |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-02 |
巻 | 77巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 65 |
終了ページ | 70 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 36849147 |
Web of Science KeyUT | 000952992100004 |
JaLCDOI | 10.18926/AMO/32184 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Hirasawa, Ryoto| Hashimoto, Hozo| Makino, Shinya| Suemaru, Shuso| Takao, Toshihiro| Ota, Zensuke| Hoshida, Yoshihiko| Yoshino, Tadashi| Akagi, Tadaatsu| |
抄録 | A 46-year-old woman with acromegaly and hyperthyroidism due to a pituitary adenoma. She had high serum thyroid-stimulating hormone (TSH) levels and very high serum growth hormone (GH) levels. Transsphenoidal removal of the tumor, post-operative irradiation, frontal craniotomy for removal of residual tumor and large-dose bromocriptine therapy were carried out consecutively. After therapy, serum GH levels gradually decreased, but not to the normal range, and serum TSH levels remained at inappropriately normal levels. Using immunoperoxidase techniques, GH-, TSH- and follicle-stimulating hormone (FSH)-containing cells were demonstrated in the adenoma. A long-acting somatostatin analogue (SMS 201-995, 600 micrograms/day) suppressed the serum GH level to the normal range with a concomitant suppression of TSH. Furthermore, the paradoxical serum GH responses to TRH and LH-RH were slightly improved. No important subjective side-effects were noted. Therefore, SMS 201-995 appeared to be a very effective drug in this patient with a GH- and TSH-producing pituitary tumor.</P> |
キーワード | TSH- and GH - producing pituitary adenoma acromegaly heperthyroidism somatostatin analogue (SMS 201-995) |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1991-04 |
巻 | 45巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 107 |
終了ページ | 115 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1867112 |
Web of Science KeyUT | A1991FL60800007 |
JaLCDOI | 10.18926/AMO/31124 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ariki, Norifumi| Iwagaki, Hiromi| Yoshino, Tadashi| Nonaka, Yasuyuki| Fujiki, Shigeatsu| Perdomo, Jose Antonio| Hizuta, Akio| Tomoda, Jun| Tanaka, Noriaki| Tsuji, Takao| Orita, Kunzo| |
抄録 | Endoscopical segmental piecemeal tumorectomy (ESPT) for nodular elevation of colorectal tumor is advantageous in terms of minimizing both surgical invasion and postoperative burden to the patients. Nodular elevation of colorectal tumors is said to occur when the body of the tumor is adenomatous and the surface of the focal cancer grows more horizontally into the lumen than vertically. We report here four cases of nodular elevation of colorectal tumors which were each treated by different surgical procedures. |
キーワード | nodular elevation coloretal tumors endoscopical segmental piecemeal tumorectomy |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1994-06 |
巻 | 48巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 169 |
終了ページ | 171 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 7942075 |
Web of Science KeyUT | A1994NV04300009 |
フルテキストURL | fulltext.pdf |
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著者 | Ikeda, Tomoka| Gion, Yuka| Nishimura, Yoshito| Nishimura, Midori Filiz| Yoshino, Tadashi| Sato, Yasuharu| |
キーワード | EBV-positive mucocutaneous ulcer clinical features pathological features immunosuppression |
発行日 | 2021-01-21 |
出版物タイトル | International Journal of Molecular Sciences |
巻 | 22巻 |
号 | 3号 |
出版者 | MDPI |
開始ページ | 1053 |
ISSN | 1422-0067 |
NCID | AA12038549 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 by the authors. |
論文のバージョン | publisher |
PubMed ID | 33494358 |
DOI | 10.3390/ijms22031053 |
Web of Science KeyUT | 000615330100001 |
関連URL | isVersionOf https://doi.org/10.3390/ijms22031053 |
JaLCDOI | 10.18926/AMO/32620 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Takata, Hiroshi| Yoshino, Tadashi| Hoshida, Yoshihiko| Takata, Ikuko| Akagi, Tadaatsu| |
抄録 | A cell line of human lung large cell carcinoma (LCC) was established directly from the metastatic skin tumor tissue. The clinical course of the patient who carried this carcinoma was peculiar; generalized lymphadenopathy, histologically resembling Hodgkin's disease, was found as the first clinical symptom. The lung tumor was not discovered until the time of autopsy. This cell line (KaMi) grew adherent to culture vessels with the population doubling time of 20.6h, formed colonies in soft agars with efficiency of 22.6%, and formed tumors in athymic nude mice. The authenticity of KaMi was confirmed by chromosomal analysis and isoenzyme patterns. KaMi cells bore a strong resemblance to the original tumor cells which were composed of small spindle cells, large polygonal cells, and multinucleated giant cells. Immunohistochemically, KaMi cells showed a weak tendency to differentiate to squamous cells, and these immunohistochemical reactivities were almost compatible to those of the original tumor cells, but ultrastructurally, KaMi cells were more immature than the original ones. Treatment with several reagents could not augment a differentiation of KaMi cells. Cytokeratin profiles showed a tendency of squamous cell differentiation. KaMi cells may aid in elucidating the pathogenesis and biology of LCC and its relationship to other lung tumors. |
キーワード | Large cell lung carcinoma cell line cytokeratin |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1992-08 |
巻 | 46巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 257 |
終了ページ | 264 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1279943 |
Web of Science KeyUT | A1992JL44200005 |
フルテキストURL | fulltext.pdf |
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著者 | Chen, Mengxi| Tanaka, Takehiro| Igawa, Takuro| Han, Yanyan| Peng, Fangli| Jin, Zaishun| Yoshino, Tadashi| |
キーワード | PDX1 PTF1A SALL4 Ectopic pancreas Gastro-duodenum Jejunum |
発行日 | 2023-07 |
出版物タイトル | Heliyon |
巻 | 9巻 |
号 | 7号 |
出版者 | Cell Press |
開始ページ | e18241 |
ISSN | 2405-8440 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 The Authors. |
論文のバージョン | publisher |
PubMed ID | 37519669 |
DOI | 10.1016/j.heliyon.2023.e18241 |
Web of Science KeyUT | 001043928200001 |
関連URL | isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241 |
JaLCDOI | 10.18926/AMO/32088 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Jin, Gui-Shan| Kondo, Eisaku| Miyake, Takayoshi| Shibata, Masao| Takashima, Takako| Liu, Yi-Xuan| Hayashi, Kazuhiko| Akagi, Tadaatsu| Yoshino, Tadashi| |
抄録 | FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear. We immunohistochemically demonstrated the expression and intracellular localization of FKHRL1 in human breast tumors by the novel anti-FKHRL1 antibody which is available for formalin-fixed paraffin-embedded specimens. In a total of 51 cases of benign tumors, FKHRL1 was diffusely expressed in all cases, and its intracellular localization was revealed to be cytoplasmic (inactive form) in 94% of cases of intraductal papillomas (16/17) and 91% cases of fibroadenomas (31/34), with a similar pattern to normal glandular epithelium. In invasive ductal carcinomas, 83% of the cases (93/112) diffusely expressed FKHRL1; however, unlike benign tumors, 71% of the cases (66/93) showed the nuclear-targeted, active form of FKHRL1. Moreover, activated FKHRL1 was predominantly observed in scirrhous (29/36, 81% of the cases) and papillotubular (30/38, 79% of the cases) subtypes, compared to the solid-tubular subtype (7/19, 37% of the cases). Furthermore, the cases with nuclear-targeted FKHRL1 showed a tendency to have lymph nodal metastasis with statistical significance (P < 0.0001). Thus, the activation of FKHRL1 seems to be recognized as one of the specific features of invasive ductal carcinoma of the breast. |
キーワード | FKHRL1 intracellular localization breast tumors |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2004-08 |
巻 | 58巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 197 |
終了ページ | 205 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 15551757 |
Web of Science KeyUT | 000223559700004 |
JaLCDOI | 10.18926/AMO/31588 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Fujiwara, Kotaro| Yoshino, Tadashi| Miyake, Kenji| Ohara, Nobuya| Akagi, Tadaatsu| |
抄録 | Lymphocyte adhesion molecules defined by anti-CD44 antibody (Hermes-3) may be involved in lymphocyte binding to high endothelial venules at sites where lymphocytes exist the blood. CD44 expression was immunohistochemically examined in 167 well characterized cases of malignant lymphomas (MLs). None of 12 nodal follicular lymphomas (FLs) were CD44+, whereas 3 of 4 extranodal ones showed distinct CD44 expression. In contrast to nodal FLs, 28 of the 38 (74%) nodal diffuse B-cell lymphomas were CD44+ (p < 0.0001). T-cell lymphomas showed a significantly higher expression of CD44 antigen than diffuse B-cell lymphomas in the nodal cases (p < 0.04), but not in the extranodal ones. In nodal diffuse lymphomas, 3 of 5 stage I lymphomas (60%) were CD44+ in contrast to 53 of 63 stage II-IV lymphomas (84%), but the difference was not statistically significant. Of 14 Hodgkin's diseases, 9 cases were CD44+ with no significant correlation with clinical stage. The data of flow cytometric analysis confirmed the results of immunohistochemical analysis. In conclusion, CD44 expression is relevant to primary sites of distinctive MLs originating in the mucosal regions (MALToma) and some histological subtypes, but the relation with clinical stage was not defined. Some other adhesion molecules or different mechanisms must also be taken into account concerning the genesis and the expansion of MLs. |
キーワード | malignant lymphomas adhesion molecules CD44 clinical staging histological classification |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1993-06 |
巻 | 47巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 215 |
終了ページ | 222 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 8379348 |
Web of Science KeyUT | A1993LL12400011 |
JaLCDOI | 10.18926/AMO/31834 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Munemasa, Mitsuru| Yoshino, Tadashi| Kobayashi, Keita| Miyake, Takayoshi| Sakugawa, Sumie Takase| Mannami, Tomohiko| Shinagawa, Katsuji| Tanimoto, Mitsune| Akagi, Tadaatsu| |
抄録 | Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma. We examined whether B cell response to thyroglobulin (Tg), which is a common thyroid-specific autoantigen, is related etiologically to the pathogenesis of thyroid MALT lymphoma. Expression of human Tg antigens and Cluster of differentiation (CD) 35 was examined immunohistochemically in 15 cases of thyroid MALT lymphoma using paraffin-embedded, formalin-fixed tissue specimens. In all cases of thyroid MALT lymphoma, human Tg was detected immunohistochemically in the follicular epithelial cells and follicular dendritic cells (FDCs). These FDCs were positive by double immunostaining for anti-human Tg rabbit polyclonal antibody (Ab) and for CD35. Results showed that the Tg, a thyroid autoantigen, had immunostained the germinal center of the thyroid MALT lymphoma. The Tg was present in the FDCs, as revealed by the staining pattern of the germinal center;this fact was confirmed by double immunostaining of anti-human Tg mouse monoclonal Ab and anti-CD35 mouse monoclonal Ab. The results of our study suggest that Tg is an autoantigen that is recognized by thyroid MALT lymphoma cells. |
キーワード | thyroglobulin follicular dendritic cells mucosa-associated lymphoid tissue lymphoma |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2009-04 |
巻 | 63巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 71 |
終了ページ | 78 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 19404338 |
Web of Science KeyUT | 000265457600001 |
フルテキストURL | fulltext.pdf |
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著者 | Han, Yanyan| Igawa, Takuro| Ogino, Kyohei| Nishikori, Asami| Gion, Yuka| Yoshino, Tadashi| Sato, Yasuharu| |
キーワード | hemosiderin deposition plasma cell-type Castleman disease IgG4-related disease serum IL-6 serum C-reactive protein |
発行日 | 2020 |
出版物タイトル | Journal of Clinical and Experimental Hematopathology |
巻 | 60巻 |
号 | 1号 |
出版者 | The Japanese Society for Lymphoreticular Tissue Research |
開始ページ | 1 |
終了ページ | 6 |
ISSN | 1346-4280 |
NCID | AA11556796 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by The Japanese Society for Lymphoreticular Tissue Research |
論文のバージョン | publisher |
PubMed ID | 32037354 |
NAID | 130007821430 |
DOI | 10.3960/jslrt.19037 |
Web of Science KeyUT | 000522556200001 |
関連URL | isVersionOf https://doi.org/10.3960/jslrt.19037 |
著者 | Sonoi, Norihiro| Soga, Yoshihiko| Maeda, Hiroshi| Ichimura, Koichi| Yoshino, Tadashi| Aoyama, Kazutoshi| Fujii, Nobuharu| Maeda, Yoshinobu| Tanimoto, Mitsune| Logan, Richard| Raber-Durlacher, Judith| Takashiba, Shogo| |
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発行日 | 2012-07 |
出版物タイトル | Odontology |
巻 | 100巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext.pdf |
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著者 | Nishimura, Midori Filiz| Nishimura, Yoshito| Nishikori, Asami| Yoshino, Tadashi| Sato, Yasuharu| |
キーワード | Castleman disease idiopathic multicentric Castleman disease TAFRO syndrome idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia |
発行日 | 2022-04-27 |
出版物タイトル | Journal Of Clinical And Experimental Hematopathology |
出版者 | The Japanese Society for Lymphoreticular Tissue Research |
開始ページ | 21036 |
ISSN | 1346-4280 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022 The Japanese Society for Lymphoreticular Tissue Research |
論文のバージョン | publisher |
PubMed ID | 35474035 |
DOI | 10.3960/jslrt.21036 |
Web of Science KeyUT | 000796525400001 |
関連URL | isVersionOf https://doi.org/10.3960/jslrt.21036 |
JaLCDOI | 10.18926/AMO/31646 |
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フルテキストURL | fulltext.pdf |
著者 | Kohka, Hideo| Iwagaki, Hiromi| Yoshino, Tadashi| Kobashi, Kenta| Saito, Shinnya| Isozaki, Hiroshi| Takakura, Norihisa| Tanaka, Noriaki| |
抄録 | Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 microg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states |
キーワード | steroid interleukin-10 cancer-burden state |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1999-02 |
巻 | 53巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 55 |
終了ページ | 59 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
Web of Science KeyUT | 000078897700009 |