高木章乃夫

原発性胆汁性胆管炎

タイトル（別表記）	Primary biliary cholangitis : PBC
著者	高木章乃夫\| 竹内康人\| 安中哲也\|
キーワード	原発性胆汁性胆管炎原発性胆汁性肝硬変ウルソデオキシコール酸ベザフィブラート
出版物タイトル	岡山医学会雑誌
発行日	2022-12-01
巻	134巻
号	3号
開始ページ	180
終了ページ	184
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.134.180
言語	日本語
著作権者	Copyright (c) 2022 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.134.180

Twist expression promotes migration and invasion in hepatocellular carcinoma

著者	Matsuo, Noriyuki\| Shiraha, Hidenori\| Fujikawa, Tatsuya\| Takaoka, Nobuyuki\| Ueda, Naoki\| Tanaka, Shigetomi\| Nishina, Shinichi\| Nakanishi, Yutaka\| Uemura, Masayuki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2009-07-18
出版物タイトル	BMC Cancer
巻	9巻
資料タイプ	学術雑誌論文

The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer

フルテキストURL	JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
著者	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Tanaka, Noriyuki\| Kato, Hironari\| Horiguchi, Shigeru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Fushimi, Soichiro\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
キーワード	Immunohistochemistry PD-L1 Pancreatic cancer
備考	This fulltext will be available in Apr 2020\|
発行日	2019-04-29
出版物タイトル	Journal of Gastroenterology
巻	54巻
号	11号
開始ページ	1019
終了ページ	1028
ISSN	09441174
NCID	AA10988015
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31032528
DOI	10.1007/s00535-019-01586-6
Web of Science KeyUT	000492169400008
関連URL	isVersionOf https://doi.org/10.1007/s00535-019-01586-6

The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis

著者	Takeuchi, Yasuto\| Ikeda, Fusao\| Moritou, Yuki\| Hagihara, Hiroaki\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Miyake, Yasuhiro\| Ohnishi, Hideki\| Nakamura, Shinichiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2013-03
出版物タイトル	Journal of Gastroenterology
巻	48巻
号	3号
資料タイプ	学術雑誌論文

The Early Decline of alpha-Fetoprotein and Des-gamma-Carboxy Prothrombin Predicts the Response of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shumpei\| Onishi, Hideki\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Sakata, Masahiro\| Yasunaka, Tetsuya\| Shiraha, Hidenori\| Okada, Hiroyuki\|
キーワード	Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin
発行日	2020-04-21
出版物タイトル	Gastrointestinal Tumors
巻	7巻
号	3号
出版者	Karger
開始ページ	83
終了ページ	92
ISSN	2296-3774
NCID	AA12665877
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s)
論文のバージョン	publisher
DOI	10.1159/000506941
Web of Science KeyUT	000551254300003
関連URL	isVersionOf https://doi.org/10.1159/000506941

Study Protocol for a Trial: A Single-Arm, Open-Labeled Study Evaluating Transcatheter Arterial Embolization Plus Everolimus Combination Therapy for Patients With Liver Metastasis of Gastroenteropancreatic Neuroendocrine Tumors

フルテキストURL	fulltext.pdf
著者	Takeuchi, Yasuto\| Kato, Hironari\| Horiguchi, Shigeru\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Onishi, Hideki\| Shiraha, Hidenori\| Takaki, Akinobu\|
キーワード	NETs TAE clinical trial
発行日	2022
出版物タイトル	Clinical Medicine Insights－Oncology
巻	16巻
出版者	Sage Publications Ltd.
開始ページ	1
終了ページ	5
ISSN	1179-5549
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	36387610
DOI	10.1177/11795549221127750
Web of Science KeyUT	000888437000001
関連URL	isVersionOf https://doi.org/10.1177/11795549221127750

Specificities and clinical significance oh anti-cytoskeleton antibodies in anti-smooth muscle antibody positive patients with chronic liver disease C

著者	高木章乃夫\|
発行日	1994-03-31
出版物タイトル
資料タイプ	学位論文

Specificities and Clinical Significance of Anti-Cytoskeleton Antibodies in Anti-Smooth Muscle Antibody-Positive Patients with Chronic Liver Disease C

JaLCDOI	10.18926/AMO/31129
フルテキストURL	fulltext.pdf
著者	Takaki, Akinobu\| Sakaguchi, Kohsaku\| Ogawa, Shin\| Kawamoto, Hirofumi\| Tsuji, Takao\|
抄録	We investigated the specificities and characteristics of anti-cytoskeleton antibodies in 13 anti-smooth muscle antibody (ASMA)-positive patients with chronic liver disease C (CLD-C), and compared them with those in 7 ASMA-positive patients with autoimmune hepatitis (AIH), and 6 ASMA-positive patients with chronic liver disease B (CLD-B). Anti-microfilaments (anti-MF) were found not only in 6/7 AIH patients (85.7%), but also in 8/13 CLD-C patients (61.5%) with a relatively high incidence, when compared with 1/6 CLD-B patients (16.7%), while, there was no significant difference in the incidence of anti-intermediate filaments (anti-IMF), especially anti-IMF IgM, among these patient groups. Among the patients with CLD-C, the mean levels of serum gammaglobulin and IgG in the anti-MF-positive patients were 2.46 +/- 1.03 g/dl and 3277 +/- 1089 mg/dl, respectively, which were higher than those in the anti-MF-negative patients (1.60 +/- 0.53 g/dl, 2245 +/- 610 mg/dl) and those in the patients with CLD-B (1.60 +/- 0.57 g/dl, 2192 +/- 339 mg/dl). Furthermore, 4 of the 8 anti-MF-positive patients with CLD-C satisfied the serological criteria for the diagnosis of AIH. These findings suggest that autoimmune mechanisms might be involved in the pathogenesis of anti-MF-positive CLD-C, and that anti-MF might be used as a marker.
キーワード	chronic liver disease C autoimmune hepatitis anti-smooth muscle antibodies anti-cytoskeleton antibodies anti-microfilament antibodies
Amo Type	Article
出版物タイトル	Acta Medica Okayama
発行日	1994-06
巻	48巻
号	3号
出版者	Okayama University Medical School
開始ページ	143
終了ページ	149
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright© 1999 Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	7942072
Web of Science KeyUT	A1994NV04300005
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/3090

Severe Colitis Caused by Hepatic Arterial Infusion Chemotherapy with Cisplatin for Hepatocellular Carcinoma

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shumpei\| Onishi, Hideki\| Oyama, Atsushi\| Takaki, Akinobu\| Okada, Hiroyuki\|
キーワード	colitis hepatic arterial infusion chemotherapy cisplatin
発行日	2020-01-01
出版物タイトル	Internal Medicine
巻	59巻
号	1号
出版者	The Japanese Society of Internal Medicine
開始ページ	69
終了ページ	75
ISSN	0918-2918
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	32611959
DOI	10.2169/internalmedicine.3340-19
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.3340-19

Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma

著者	Nishimura, Mamoru\| Takaki, Akinobu\| Tamaki, Naofumi\| Maruyama, Takayuki\| Onishi, Hideki\| Kobayashi, Sayo\| Nouso, Kazuhiro\| Yasunaka, Tetsuya\| Koike, Kazuko\| Hagihara, Hiroaki\| Kuwaki, Kenji\| Nakamura, Shinichiro\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Tomofuji, Takaaki\| Morita, Manabu\| Yamamoto, Kazuhide\|
発行日	2013-01-30
出版物タイトル	Hepatology Research
巻	43巻
号	10号
資料タイプ	学術雑誌論文

Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure

著者	Takayama, Hiroki\| Miyake, Yasuhiro\| Nouso, Kazuhiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Kobashi, Haruhiko\| Yamamoto, Kazuhide\|
発行日	2011-01
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	26巻
号	1号
資料タイプ	学術雑誌論文

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

著者	Ohnishi, Atsuyuki\| Miyake, Yasuhiro\| Matsushita, Hiroshi\| Matsumoto, Kazuyuki\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Koike, Kazuko\| Ikeda, Fusao\| Shiraha, Hidenori\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012
出版物タイトル	Digestion
巻	86巻
号	2号
資料タイプ	学術雑誌論文

著者	Tanaka, Shigetomi\| Shiraha, Hidenori\| Nakanishi, Yutaka\| Nishina, Shin-Ichi\| Matsubara, Minoru\| Horiguchi, Shigeru\| Takaoka, Nobuyuki\| Iwamuro, Masaya\| Kataoka, Junro\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Toshimori, Junichi\| Ohnishi, Hideki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2012-12-01
出版物タイトル	International Journal of Cancer
巻	131巻
号	11号
資料タイプ	学術雑誌論文

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

著者	Kinugasa, Hideaki\| Nouso, Kazuhiro\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Nakamura, Shin-ichiro\| Shiraha, Hidenori\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Ikeda, Fusao\| Miyake, Yasuhiro\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-04
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	4号
資料タイプ	学術雑誌論文

Prognostic Model for Hepatocellular Carcinoma with Time-Dependent Factors

JaLCDOI	10.18926/AMO/43825
フルテキストURL	65_1_11.pdf
著者	Kuwaki, Kenji\| Nouso, Kazuhiro\| Kobayashi, Yoshiyuki\| Nakamura, Shinichiro\| Ito, Yoichi M.\| Iwadou, Shouta\| Hagihara, Hiroaki\| Yasunaka, Tetsuya\| Toshimori, Junichi\| Miyatake, Hirokazu\| Miyoshi, Kenji\| Onishi, Hideki\| Miyake, Yasuhiro\| Shoji, Bon\| Takaki, Akinobu\| Shiraha, Hidenori\| Iwasaki, Yoshiaki\| Kobashi, Haruhiko\| Yamamoto, Kazuhide\|
抄録	The purpose of this study was to build a prognostic model of hepatocellular carcinoma (HCC) using time-dependent covariates to re-evaluate the prognosis at any stage of the disease. The subjects were consecutive HCC patients who were treated at our institute between 1995 and 2007. We constructed time-fixed and time-dependent prognostic models with a training group (n＝336) and compared the prognostic abilities between conventional Cancer of the Liver Italian Program (CLIP) scores, Japan Integrated Staging (JIS) scores, an Okuda classification, and our prognostic models in the testing group (n＝227) with the c-index. The time-dependent prognostic model consisted of main tumor size, tumor number, portal vein invasion, distant metastasis, alpha-fetoprotein, des-gamma-carboxy prothrombin (DCP), bilirubin, and albumin and the weighted scores were set for each factor depending on the hazard ratio for the prognosis. The prognostic index was determined by summing the scores. The c-index values for the CLIP scores, JIS scores, Okuda classification, and our time-dependent model were 0.741, 0.727, 0.609, and 0.870, respectively. These results indicate that our time-dependent model can estimate the prognosis of HCC more precisely than traditional time-fixed models and can be used to re-predict the prognosis of HCC.
キーワード	hepatocellular carcinoma humans prognosis proportional hazards models time factors
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-02
巻	65巻
号	1号
出版者	Okayama University Medical School
開始ページ	11
終了ページ	19
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21339791
Web of Science KeyUT	000287620500002

Prevalence and Outcomes of Acute Hepatitis B in Okayama, Japan, 2006-2010

JaLCDOI	10.18926/AMO/52790
フルテキストURL	68_4_243.pdf
著者	Wada, Nozomu\| Yasunaka, Tetsuya\| Ikeda, Fusao\| Nishina, Sohji\| Korenaga, Masaaki\| Hino, Keisuke\| Fujioka, Shin-ichi\| Osawa, Toshiya\| Itoshima, Tatsuya\| Kawanaka, Miwa\| Yamada, Gotaro\| Kariyama, Kazuya\| Takayama, Hiroki\| Kubota, Junichi\| Morimoto, Yoichi\| Mizushima, Takaaki\| Yamashita, Haruhiko\| Tanioka, Hiroaki\| Negoro, Yuji\| Toshimori, Junichi\| Kobashi, Haruhiko\| Hirano, Atsushi\| Itano, Yasuo\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
抄録	Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p＜0.01), among men who had sex with men (100%, p＜0.005), and among patients having sex with unspecified partners (44.8%, p＜0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.
キーワード	acute hepatitis hepatitis B virus
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	243
終了ページ	247
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145410
Web of Science KeyUT	000340687500006

Prediction of the prognosis of advanced hepatocellular carcinoma by TERT promoter mutations in circulating tumor DNA

フルテキストURL	fulltext.pdf
著者	Hirai, Mami\| Kinugasa, Hideaki\| Nouso, Kazuhiro\| Yamamoto, Shumpei\| Terasawa, Hiroyuki\| Onishi, Yuma\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Sakata, Masahiro\| Yasunaka, Tetsuya\| Onishi, Hideki\| Shiraha, Hidenori\| Takaki, Akinobu\| Okada, Hiroyuki\|
キーワード	ctDNA hepatocellular carcinoma liquid biopsy prediction prognosis TERT promoter mutation
発行日	2020-08-24
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	36巻
出版者	Wiley
開始ページ	1118
終了ページ	1125
ISSN	0815-9319
NCID	AA10727383
資料タイプ	学術雑誌論文
論文のバージョン	author
PubMed ID	32830343
DOI	10.1111/jgh.15227
Web of Science KeyUT	000568136400001
関連URL	isVersionOf https://doi.org/10.1111/jgh.15227

Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer

著者	Uchida, Daisuke\| Shiraha, Hidenori\| Kato, Hironari\| Nagahara, Teruya\| Iwamuro, Masaya\| Kataoka, Junro\| Horiguchi, Shigeru\| Watanabe, Masami\| Takaki, Akinobu\| Nouso, Kazuhiro\| Nasu, Yasutomo\| Yagi, Takahito\| Kumon, Hiromi\| Yamamoto, Kazuhide\|
発行日	2014-05
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	29巻
号	5号
資料タイプ	学術雑誌論文

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

フルテキストURL	fulltext.pdf
著者	Uchida, Daisuke\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Onishi, Hideki\| Okada, Hiroyuki\|
キーワード	oxidative stress chronic hepatitis hepatocellular carcinoma
発行日	2020-05-28
出版物タイトル	Nutrients
巻	12巻
号	6号
出版者	MDPI
開始ページ	1576
ISSN	2072-6643
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32481552
DOI	10.3390/nu12061576
Web of Science KeyUT	000554005200001
関連URL	isVersionOf https://doi.org/10.3390/nu12061576

Nursing Support Increases the Efficacy of Interferon Therapy in Patients with Chronic Hepatitis C

JaLCDOI	10.18926/AMO/52894
フルテキストURL	68_5_263.pdf
著者	Namba, Shihoko\| Miyake, Kayoko\| Ikeda, Fusao\| Hazama, Tomoko\| Hitobe, Yu\| Yamasaki, Noriko\| Shiraha, Hidenori\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
抄録	Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence.
キーワード	chronic hepatitis C nursing support interferon therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-10
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	263
終了ページ	268
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338482
Web of Science KeyUT	000343269300002

高木 章乃夫