JaLCDOI 10.18926/AMO/66676
フルテキストURL 78_1_089.pdf
著者 Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki|
抄録 We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis.
キーワード breast cancer ectopic breast cancer axillary lymph node
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 89
終了ページ 93
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
JaLCDOI 10.18926/AMO/66666
フルテキストURL 78_1_015.pdf
著者 Maeda, Reina| Shien, Tadahiko| Takahashi, Mina| Kawada, Kengo| Kajiwara, Yukiko| Kubo, Shinichiro| Takabatake, Daisuke| Ohtani, Shoichiro| Matsuoka, Kinya| Hikino, Hajime| Ogasawara, Yutaka| Taira, Naruto| Osumi, Shozo| Ikeda, Masahiko| Doihara, Hiroyoshi|
抄録 While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients.
キーワード oligometastasis breast cancer lung metastasectomy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-02
78巻
1号
出版者 Okayama University Medical School
開始ページ 15
終了ページ 20
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
フルテキストURL fulltext.pdf
著者 Tsukioki, Takahiro| Khan, Seema A.| Shien, Tadahiko|
キーワード Breast cancer Prevention Risk reduction mastectomy Chemoprevention Methylation
備考 The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00287-0|
発行日 2023-12-12
出版物タイトル Genes and Environment
45巻
1号
出版者 BMC
開始ページ 35
ISSN 1880-7046
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2023.
論文のバージョン publisher
PubMed ID 38082340
DOI 10.1186/s41021-023-00287-0
Web of Science KeyUT 001121724100001
関連URL isVersionOf https://doi.org/10.1186/s41021-023-00287-0
JaLCDOI 10.18926/AMO/64356
フルテキストURL 77_1_11.pdf
著者 Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro|
抄録 The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction.
キーワード breast reconstruction mastectomy brassiere professional bra fitter
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-02
77巻
1号
出版者 Okayama University Medical School
開始ページ 11
終了ページ 19
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36849141
Web of Science KeyUT 000953663800002
フルテキストURL fulltext.pdf
著者 Ochi, Kosuke| Suzawa, Ken| Thu, Yin Min| Takatsu, Fumiaki| Tsudaka, Shimpei| Zhu, Yidan| Nakata, Kentaro| Takeda, Tatsuaki| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Okamoto, Yoshiharu| Tomida, Shuta| Toyooka, Shinichi|
キーワード cancer-associated fibroblast drug resistance tranilast
発行日 2022-07-24
出版物タイトル Cancer Science
2022巻
出版者 Wiley
ISSN 1347-9032
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors.
論文のバージョン publisher
PubMed ID 35871750
DOI 10.1111/cas.15502
Web of Science KeyUT 000840374000001
関連URL isVersionOf https://doi.org/10.1111/cas.15502
フルテキストURL fulltext.pdf
著者 Fujihara, Miwa| Shien, Tadahiko| Shien, Kazuhiko| Suzawa, Ken| Takeda, Tatsuaki| Zhu, Yidan| Mamori, Tomoka| Otani, Yusuke| Yoshioka, Ryo| Uno, Maya| Suzuki, Yoko| Abe, Yuko| Hatono, Minami| Tsukioki, Takahiro| Takahashi, Yuko| Kochi, Mariko| Iwamoto, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
キーワード breast cancer YES1 T-DM1 dasatinib drug resistance
発行日 2021-11-26
出版物タイトル International Journal Of Molecular Sciences
22巻
23号
出版者 MDPI
開始ページ 12809
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34884609
DOI 10.3390/ijms222312809
Web of Science KeyUT 000735641400001
関連URL isVersionOf https://doi.org/10.3390/ijms222312809
JaLCDOI 10.18926/AMO/60799
フルテキストURL 74_5_401.pdf
著者 Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi|
抄録 Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC.
キーワード differentiated thyroid carcinoma juvenile children
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-10
74巻
5号
出版者 Okayama University Medical School
開始ページ 401
終了ページ 406
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33106695
Web of Science KeyUT 000581970100004
NAID 120006892925
フルテキストURL fulltext.pdf
著者 Tsukioki, Takahiro| Shien, Tadahiko| Doihara, Hiroyoshi|
キーワード Breast cancer metastatic stage IV local therapy locoregional therapy surgery survival
発行日 2020-08
出版物タイトル Translational Cancer Research
9巻
8号
出版者 AME Publishing Co.
開始ページ 5102
終了ページ 5107
ISSN 2218-676X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Translational Cancer Research. All rights reserved.
論文のバージョン publisher
DOI 10.21037/tcr.2020.01.60
Web of Science KeyUT 000562138400067
関連URL isVersionOf https://doi.org/10.21037/tcr.2020.01.60
フルテキストURL fulltext.pdf figure1.tif figure2.tif figure3.tif spfigure1.tif spfigure2.tif SupTable1.xlsx
著者 Ochi, Kosuke| Suzawa, Ken| Tomida, Shuta| Shien, Kazuhiko| Takano, Jui| Miyauchi, Shunsaku| Takeda, Tatsuaki| Miura, Akihiro| Araki, Kota| Nakata, Kentaro| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Yamane, Masaomi| Azuma, Kazuo| Okamoto, Yoshiharu| Toyooka, Shinichi|
キーワード Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance
備考 This fulltext is available in Jul. 2021.|
発行日 2020-08-27
出版物タイトル Biochemical and Biophysical Research Communications
529巻
3号
出版者 Academic Press
開始ページ 760
終了ページ 765
ISSN 0006-291X
NCID AA00564395
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32736704
DOI 10.1016/j.bbrc.2020.06.077
Web of Science KeyUT 000555780500037
関連URL iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077
フルテキストURL CCP_fulltext.pdf
著者 Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
キーワード Breast cancer Metformin Preoperative Tils CD8 PD-L1
発行日 2020-06-12
出版物タイトル Cancer Chemotherapy and Pharmacology
86巻 86巻
1号 1号
出版者 Springer
開始ページ 55 55
終了ページ 63 63
ISSN 0344-5704
NCID AA00598397
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©Author(s)
論文のバージョン publisher
PubMed ID 32533334
DOI 10.1007/s00280-020-04092-2
Web of Science KeyUT 000539841500002
関連URL isVersionOf https://doi.org/10.1007/s00280-020-04092-2
フルテキストURL fulltext.pdf
著者 Shien, Tadahiko|
発行日 2019-03
出版物タイトル Translational Cancer Research
8巻
Suppl. 2号
出版者 AME Publishing
開始ページ S118
終了ページ S119
ISSN 2218-676X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
DOI 10.21037/tcr.2018.11.19
関連URL isVersionOf https://doi.org/10.21037/tcr.2018.11.19
フルテキストURL fulltext.pdf
著者 Shien, Tadahiko| Iwata, Hiroji|
キーワード breast cancer adjuvant neoadjuvant
備考 This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record TTadahiko Shien, Hiroji Iwata, Adjuvant and neoadjuvant therapy for breast cancer, Japanese Journal of Clinical Oncology, Volume 50, Issue 3, March 2020, Pages 225–229 is available online at: https://doi.org/10.1093/jjco/hyz213.|
発行日 2020-01-28
出版物タイトル Japanese Journal of Clinical Oncology
50巻
3号
出版者 Oxford University Press
開始ページ 225
終了ページ 229
ISSN 0368-2811
NCID AA00690866
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2020 Oxford University Press
論文のバージョン author
PubMed ID 32147701
DOI 10.1093/jjco/hyz213
Web of Science KeyUT 000536439500001
関連URL isVersionOf https://doi.org/10.1093/jjco/hyz213
フルテキストURL fulltext.pdf
著者 Iwamoto, Takayuki| Fujisawa, Tomomi| Shien, Tadahiko| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Takao, Shintaro| Nishimura, Reiki| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| aira, Naruto|
キーワード Metastatic breast cancer Endocrine therapies Estrogen receptor-positive HER2-negative Resistance
発行日 2020-05-11
出版物タイトル Breast Cancer
27巻
5号
出版者 Springer
開始ページ 973
終了ページ 981
ISSN 13406868
NCID AA1103354X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32394413
DOI 10.1007/s12282-020-01095-y
Web of Science KeyUT 000531780600002
関連URL isVersionOf https://doi.org/10.1007/s12282-020-01095-y
フルテキストURL fulltext.pdf
著者 Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi|
キーワード breast cancer drug resistance lung cancer neratinib YES1
発行日 2019-12-19
出版物タイトル Cancer Science
111巻
3号
出版者 Wiley
開始ページ 849
終了ページ 856
ISSN 1347-9032
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors.
論文のバージョン publisher
PubMed ID 31856375
DOI 10.1111/cas.14289
Web of Science KeyUT 000507433400001
関連URL isVersionOf https://doi.org/10.1111/cas.14289
フルテキストURL fulltext.pdf
著者 Suzuki, Yoko| Taniguchi, Kohei| Hatono, Minami| Kajiwara, Yukiko| Abe, Yuko| Kawada, Kengo| Tsukioki, Takahiro| Kochi, Mariko| Nishiyama, Keiko| Iwamoto, Takayuki| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Tabata, Masahiro| Yanai, Hiroyuki| Doihara, Hiroyoshi|
キーワード Radiation-induced angiosarcoma Radiotherapy Breast-conserving surgery Breast cancer Paclitaxel therapy Adjuvant therapy of angiosarcoma
発行日 2020-01-16
出版物タイトル Surgical Case Reports
6巻
1号
出版者 SpringerOpen
開始ページ 25
ISSN 2198-7793
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2020
論文のバージョン publisher
PubMed ID 31950295
DOI 10.1186/s40792-020-0790-7
Web of Science KeyUT 000513920900001
関連URL isVersionOf https://doi.org/10.1186/s40792-020-0790-7
フルテキストURL OL17_2_2177.pdf
著者 Miyoshi, Yuichiro| Shien, Tadahiko| Ogiya, Akiko| Ishida, Naoko| Yamazaki, Kieko| Horii, Rie| Horimoto, Yoshiya| Masuda, Norikazu| Yasojima, Hiroyuki| Inao, Touko| Osako, Tomofumi| Takahashi, Masato| Tomioka, Nobumoto| Wanifuchi‑Endo, Yumi| Hosoda, Mitsuchika| Doihara, Hiroyoshi| Yamashita, Hiroko|
キーワード breast cancer estrogen receptor positive human epidermal growth factor receptor type 2 negative prognosis tumor infiltrating lymphocytes
発行日 2018-12-19
出版物タイトル Oncology Letters
17巻
2号
出版者 Spandidos Publications
開始ページ 2177
終了ページ 2186
ISSN 1792-1074
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 30675282
DOI 10.3892/ol.2018.9853
Web of Science KeyUT 000459551800096
関連URL isVersionOf https://doi.org/10.3892/ol.2018.9853
フルテキストURL fulltext.pdf
著者 Takahashi, Yuko| Iwamoto, Takayuki| Suzuki, Yoko| Kajiwara, Yukiko| Hatono, Minami| Tsukioki, Takahiro| Kawada, Kengo| Kochi, Mariko| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| Toyooka, Shinichi|
キーワード Gene expression Hormone receptor positive Residual tumor burden Targeted therapy Triple negative
発行日 2020-04
出版物タイトル Clinical Breast Cancer
20巻
2号
出版者 Elsevier
開始ページ 117
終了ページ 124
ISSN 1526-8209
NCID AA11694891
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31570267
DOI 10.1016/j.clbc.2019.07.001
Web of Science KeyUT 000529805200021
関連URL isVersionOf https://doi.org/10.1016/j.clbc.2019.07.001
フルテキストURL BreastCancer_24_4_593.pdf BreastCancer_24_4_593_tbl_fig.pdf
著者 Saiga, Miho| Taira, Naruto| Kimata, Yoshihiro| Watanabe, Satoko| Mukai, Yuko| Shimozuma, Kojiro| Mizoo, Taeko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi|
キーワード BREAST-Q Breast cancer Breast reconstruction Health-related quality of life Satisfaction
発行日 2017-03
出版物タイトル Breast Cancer
24巻
2号
出版者 Japanese Breast Cancer Society
開始ページ 288
終了ページ 298
ISSN 1340-6868
NCID AA1103354X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27179527
DOI 10.1007/s12282-016-0703-6
Web of Science KeyUT 000395524900012
関連URL isVerionOf https://doi.org/10.1007/s12282-016-0703-6
JaLCDOI 10.18926/AMO/54607
フルテキストURL 70_5_425.pdf
著者 Tamura, Tomoki| Hirata, Taizo| Tabata, Masahiro| Hinotsu, Shiro| Hamada, Akinobu| Motoki, Takayuki| Iwamoto, Takayuki| Mizoo, Taeko| Nogami, Tomohiro| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi|
抄録 Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer.
キーワード breast cancer phase I trial docetaxel
Amo Type Clinical Study Protocols
出版物タイトル Acta Medica Okayama
発行日 2016-10
70巻
5号
出版者 Okayama University Medical School
開始ページ 425
終了ページ 427
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27777441
Web of Science KeyUT 000388098700018
JaLCDOI 10.18926/AMO/54514
フルテキストURL 70_4_327.pdf
著者 Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi|
抄録 A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.
キーワード metformin CD8+ T cells cancer immunology
Amo Type Clinical Study Protocols
出版物タイトル Acta Medica Okayama
発行日 2016-08
70巻
4号
出版者 Okayama University Medical School
開始ページ 327
終了ページ 330
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27549683
Web of Science KeyUT 000384748600018