JaLCDOI |
10.18926/AMO/48267
|
フルテキストURL |
66_2_171.pdf.pdf
|
著者 |
Masuyama, Hisashi|
Nobumoto, Etsuko|
Segawa, Tomonori|
Hiramatsu, Yuji|
|
抄録 |
Preeclampsia may be due to an excess of circulating anti-angiogenic growth factors derived from the placenta, but metabolic syndrome-like disorders may also set off a cascade of placental and systemic inflammation and oxidative stress. We present a case of severe superimposed preeclampsia with obesity,
diabetes and a mild imbalance of angiogenic factors, in which diet therapy ameliorated the preeclamptic signs while improving the adiponectin level. A 41-year-old pregnant woman with obesity and diabetes was referred to our hospital because of severe proteinuria and hypertension at 22 weeks of gestation. After administration of insulin and hydralazine with diet therapy, her hypertension and proteinuria were ameliorated with a 15-kg weight loss. Her adiponectin level was low and her leptin level was high, but her angiogenic factor levels were within the normal ranges for pregnant women at admission. The diet therapy ameliorated her hypertension and proteinuria while improving her adiponectin
level as she achieved weight loss. This case suggests that diet therapy for obese preeclampsia patients with a mild imbalance of anti-and pro-angiogenic factors may play an important role in managing
preeclampsia. Measurements of maternal adipocytokines and angiogenic factors may be important
to distinguish the main cause of preeclampsia, i.e., poor placentation or maternal constitutional factors, for managing preeclampsia in patients with obesity.
|
キーワード |
adipocytokine
angiogenic factor
diet therapy
obesity
preeclampsia
|
Amo Type |
Case Report
|
出版物タイトル |
Acta Medica Okayama
|
発行日 |
2012-04
|
巻 |
66巻
|
号 |
2号
|
出版者 |
Okayama University Medical School
|
開始ページ |
171
|
終了ページ |
175
|
ISSN |
0386-300X
|
NCID |
AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
著作権者 |
CopyrightⒸ 2012 by Okayama University Medical School
|
論文のバージョン |
publisher
|
査読 |
有り
|
PubMed ID |
22525475
|
Web of Science KeyUT |
000303175300010
|