白羽英則

Oxidative stress-related markers as prognostic factors for patients with primary sclerosing cholangitis in Japan

フルテキストURL	fulltext.pdf
著者	Oyama, Atsushi\| Takaki, Akinobu\| Adachi, Takuya\| Wada, Nozomu\| Takeuchi, Yasuto\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\| Otsuka, Motoyuki\|
キーワード	Primary sclerosing cholangitis Oxidative stress marker Prognosis Serum reactive oxygen metabolite Total serum antioxidant capacity Revised Mayo risk score Child–Pugh score MELD score FIB-4 index Serum dROM Serum OXY-adsorbent test Immunoglobulin A
備考	The version of record of this article, first published in Hepatology International, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12072-023-10557-2\|
発行日	2023-07-26
出版物タイトル	Hepatology International
巻	17巻
号	5号
出版者	Springer Science and Business Media LLC
開始ページ	1215
終了ページ	1224
ISSN	1936-0533
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37493884
DOI	10.1007/s12072-023-10557-2
Web of Science KeyUT	001034200900001
関連URL	isVersionOf https://doi.org/10.1007/s12072-023-10557-2

Disease Progression-Related Markers for Aged Non-Alcoholic Fatty Liver Disease Patients

JaLCDOI	10.18926/AMO/65748
フルテキストURL	77_4_377.pdf
著者	Morimoto, Kosaku\| Takeuchi, Yasuto\| Takaki, Akinobu\| Wada, Nozomu\| Oyama, Atsushi\| Adachi, Takuya\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
キーワード	NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	377
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635138
Web of Science KeyUT	001163659800009

Study Protocol for a Trial: A Single-Arm, Open-Labeled Study Evaluating Transcatheter Arterial Embolization Plus Everolimus Combination Therapy for Patients With Liver Metastasis of Gastroenteropancreatic Neuroendocrine Tumors

フルテキストURL	fulltext.pdf
著者	Takeuchi, Yasuto\| Kato, Hironari\| Horiguchi, Shigeru\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Onishi, Hideki\| Shiraha, Hidenori\| Takaki, Akinobu\|
キーワード	NETs TAE clinical trial
発行日	2022
出版物タイトル	Clinical Medicine Insights－Oncology
巻	16巻
出版者	Sage Publications Ltd.
開始ページ	1
終了ページ	5
ISSN	1179-5549
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	36387610
DOI	10.1177/11795549221127750
Web of Science KeyUT	000888437000001
関連URL	isVersionOf https://doi.org/10.1177/11795549221127750

Laminin 511-E8 Fragment Offers Superior Adhesion Properties for Gastric Cancer Cells Compared with Full-Length Laminin 511

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Shiraha, Hidenori\| Kobashi, Mayu\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
キーワード	cancer progression extracellular matrix gastric cancer cells laminin 511-E8 fragment laminin isoforms
発行日	2022-04-05
出版物タイトル	Current Issues In Molecular Biology
巻	44巻
号	4号
出版者	MDPI
開始ページ	1539
終了ページ	1551
ISSN	1467-3037
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
DOI	10.3390/cimb44040105
Web of Science KeyUT	000785101600001
関連URL	isVersionOf https://doi.org/10.3390/cimb44040105

Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients

フルテキストURL	fulltext.pdf
著者	Ueta, Eijiro\| Tsutsumi, Koichiro\| Kato, Hironari\| Matsushita, Hiroshi\| Shiraha, Hidenori\| Fujii, Masakuni\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
発行日	2021-06-10
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	12298
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34112884
DOI	10.1038/s41598-021-91804-0
Web of Science KeyUT	000663785600048
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-91804-0

Management of Cirrhotic Ascites under the Add-on Administration of Tolvaptan

フルテキストURL	fulltext.pdf
著者	Adachi, Takuya\| Takeuchi, Yasuto\| Takaki, Akinobu\| Oyama, Atsushi\| Wada, Nozomu\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\|
キーワード	tolvaptan liver cirrhosis ascites
発行日	2021-05-25
出版物タイトル	International Journal of Molecular Sciences
巻	22巻
号	11号
出版者	MDPI
開始ページ	5582
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34070416
NAID	120007089839
DOI	10.3390/ijms22115582
Web of Science KeyUT	000660134900001
関連URL	isVersionOf https://doi.org/10.3390/ijms22115582

Local Recurrence and Complications after Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma : A Retrospective Cohort Study Focused on Tumor Location

JaLCDOI	10.18926/AMO/53558
フルテキストURL	69_4_219.pdf
著者	Toshimori, Junichi\| Nouso, Kazuhiro\| Nakamura, Shinichiro\| Wada, Nozomu\| Morimoto, Yuki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Ohnishi, Hideki\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
抄録	We conducted a retrospective cohort study to investigate the predisposing factors for local recurrence and complications after percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). HCC patients (n＝397) consecutively treated with RFA (256 males, 141 females, median age 69 years) were enrolled. In these patients, 1,455 nodules (median size 17mm) were ablated. Predisposing factors for overall recurrence and local recurrence in the context of tumor location and complications were examined. Local recurrence was observed for 113 of the 1,455 nodules. The 1-, 3- and 5-year local recurrence rates were 2.2ｵ, 7.4ｵ and 9.5ｵ, respectively. A multivariate Cox proportional hazard analysis revealed that large tumor size (＞2cm), tumor location (adjacent to the major portal branch or hepatic vein), and small ablated margin (＜3mm) were independent predisposing factors for local recurrence after RFA (HR＝1.70-2.81). Tumor location (adjacent to the major portal branch, hepatic vein, or diaphragm) was also revealed as a risk factor for liver damage due to RFA. HCC adjacent to the major portal vein or hepatic vein was associated with a higher risk for local recurrence and for complications;therefore, special precautions are necessary when applying RFA to HCC near vessels even when the tumors are located at an easy-to-puncture site.
キーワード	hepatocellular carcinoma radiofrequency ablation ablated margin tumor location
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-08
巻	69巻
号	4号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	226
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26289913
Web of Science KeyUT	000365519100005

Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease

著者	Shoji, Bon\| Ikeda, Fusao\| Fujioka, Shin-ichi\| Kobashi, Haruhiko\| Yasunaka, Tetsuya\| Miyake, Yasuhiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
発行日	2010-11
出版物タイトル	Journal of Gastroenterology
巻	45巻
号	11号
資料タイプ	学術雑誌論文

L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway

著者	Ishikawa, Hisashi\| Takaki, Akinobu\| Tsuzaki, Ryuichiro\| Yasunaka, Tetsuya\| Koike, Kazuko\| Shimomura, Yasuyuki\| Seki, Hiroyuki\| Matsushita, Hiroshi\| Miyake, Yasuhiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2014-07-01
出版物タイトル	PLoS ONE
巻	9巻
号	7号
資料タイプ	学術雑誌論文

Ultrastructural Analysis of an Enterolith Composed of Deoxycholic Acid

JaLCDOI	10.18926/AMO/53026
フルテキストURL	68_6_369.pdf
著者	Iwamuro, Masaya\| Miyashima, Yuichi\| Yoshioka, Takahiro\| Murata, Toshihiro\| Miyabe, Yoshio\| Kawai, Yoshinari\| Urata, Haruo\| Shiraha, Hidenori\| Okada, Hiroyuki\| Yamamoto, Kazuhide\|
抄録	A 67-year-old Japanese man underwent enterotomy because of enterolith ileus. Component analysis by infrared spectroscopy revealed that the enterolith was composed of a high concentration of deoxycholic acid. We further analyzed and compared the ultrastructure of the enterolith and a commercially available powdered form of deoxycholic acid by means of scanning electron microscopy and energy dispersive X-ray spectroscopy. Energy dispersive X-ray spectroscopy analysis revealed that the ratios of carbon and oxygen in the enterolith were equal to those in the deoxycholic acid powder. Scanning electron microscopy analysis showed rectangular prism-shaped particles on the surface of the enterolith. This structure was similar to that of the deoxycholic acid powder. The surgically removed enterolith had a twisted and coiled appearance. Possible mechanisms underlying the formation of this unique form are discussed.
キーワード	enterolith deoxycholic acid scanning electron microscopy infrared spectroscopy energy dispersive X-ray spectroscopy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2014-12
巻	68巻
号	6号
出版者	Okayama University Medical School
開始ページ	369
終了ページ	374
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25519031
Web of Science KeyUT	000346882200007

Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer

著者	Uchida, Daisuke\| Shiraha, Hidenori\| Kato, Hironari\| Nagahara, Teruya\| Iwamuro, Masaya\| Kataoka, Junro\| Horiguchi, Shigeru\| Watanabe, Masami\| Takaki, Akinobu\| Nouso, Kazuhiro\| Nasu, Yasutomo\| Yagi, Takahito\| Kumon, Hiromi\| Yamamoto, Kazuhide\|
発行日	2014-05
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	29巻
号	5号
資料タイプ	学術雑誌論文

The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis

著者	Takeuchi, Yasuto\| Ikeda, Fusao\| Moritou, Yuki\| Hagihara, Hiroaki\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Miyake, Yasuhiro\| Ohnishi, Hideki\| Nakamura, Shinichiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2013-03
出版物タイトル	Journal of Gastroenterology
巻	48巻
号	3号
資料タイプ	学術雑誌論文

Hepatitis C Virus-specific T-cell Response Correlates with Hepatitis Activity and Donor IL28B Genotype Early after Liver Transplantation

JaLCDOI	10.18926/AMO/52898
フルテキストURL	68_5_291.pdf
著者	Tsuzaki, Ryuichiro\| Takaki, Akinobu\| Yagi, Takahito\| Ikeda, Fusao\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Shiraha, Hidenori\| Miyake, Yasuhiro\| Sadamori, Hiroshi\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Utsumi, Masashi\| Nakayama, Eiichi\| Fujiwara, Toshiyoshi\| Yamamoto, Kazuhide\|
抄録	It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
キーワード	interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-10
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	302
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338486
Web of Science KeyUT	000343269300006
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/53129

Nursing Support Increases the Efficacy of Interferon Therapy in Patients with Chronic Hepatitis C

JaLCDOI	10.18926/AMO/52894
フルテキストURL	68_5_263.pdf
著者	Namba, Shihoko\| Miyake, Kayoko\| Ikeda, Fusao\| Hazama, Tomoko\| Hitobe, Yu\| Yamasaki, Noriko\| Shiraha, Hidenori\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
抄録	Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence.
キーワード	chronic hepatitis C nursing support interferon therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-10
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	263
終了ページ	268
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338482
Web of Science KeyUT	000343269300002

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

著者	Ohnishi, Atsuyuki\| Miyake, Yasuhiro\| Matsushita, Hiroshi\| Matsumoto, Kazuyuki\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Koike, Kazuko\| Ikeda, Fusao\| Shiraha, Hidenori\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012
出版物タイトル	Digestion
巻	86巻
号	2号
資料タイプ	学術雑誌論文

Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure

著者	Takayama, Hiroki\| Miyake, Yasuhiro\| Nouso, Kazuhiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Kobashi, Haruhiko\| Yamamoto, Kazuhide\|
発行日	2011-01
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	26巻
号	1号
資料タイプ	学術雑誌論文

柿胃石の成分分析における標準物質としての柿渋の有用性

タイトル（別表記）	Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars
フルテキストURL	126_127.pdf
著者	岩室雅也\| 岡本裕子\| 村田年弘\| 河合良成\| 白羽英則\| 岡田裕之\| 山本和秀\|
抄録	The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm－1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars.
キーワード	柿胃石（gastric phytobezoar）タンニン酸（tannic acid）消化管異物（gastrointestinal foreign body）成分分析（component analysis）
出版物タイトル	岡山医学会雑誌
発行日	2014-08-01
巻	126巻
号	2号
開始ページ	127
終了ページ	131
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.127
NAID	130004685263

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

著者	Tatsukawa, Masashi\| Takaki, Akinobu\| Shiraha, Hidenori\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Kobashi, Haruhiko\| Fujioka, Shin-Ichi\| Sakaguchi, Kohsaku\| Yamamoto, Kazuhide\|
発行日	2011-10-21
出版物タイトル	BMC Cancer
巻	11巻
資料タイプ	学術雑誌論文

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

著者	Kinugasa, Hideaki\| Nouso, Kazuhiro\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Nakamura, Shin-ichiro\| Shiraha, Hidenori\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Ikeda, Fusao\| Miyake, Yasuhiro\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-04
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	4号
資料タイプ	学術雑誌論文

Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma

著者	Matsubara, Minoru\| Shiraha, Hidenori\| Kataoka, Jyunro\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Nishina, Shin-ichi\| Takaoka, Nobuyuki\| Uemura, Masayuki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012-10
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	27巻
号	10号
資料タイプ	学術雑誌論文

白羽 英則