ID | 66012 |
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著者 |
Morizane, Shin
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
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publons
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Mukai, Tomoyuki
Department of Immunology and Molecular Genetics, Kawasaki Medical School
Sunagawa, Ko
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tachibana, Kota
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kawakami, Yoshio
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ouchida, Mamoru
Department of Molecular Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
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抄録 | Considering the role of epidermal keratinocytes, they occupy more than 90% of the epidermis, form a physical barrier, and also function as innate immune barrier. For example, epidermal keratinocytes are capable of recognizing various cytokines and pathogen-associated molecular pattern, and producing a wide variety of inflammatory cytokines, chemokines, and antimicrobial peptides. Previous basic studies have shown that the immune response of epidermal keratinocytes has a significant impact on inflammatory skin diseases. The purpose of this review is to provide foundation of knowledge on the cytokines which are recognized or produced by epidermal keratinocytes. Since a number of biologics for skin diseases have appeared, it is necessary to fully understand the relationship between epidermal keratinocytes and the cytokines. In this review, the cytokines recognized by epidermal keratinocytes are specifically introduced as "input cytokines", and the produced cytokines as "output cytokines". Furthermore, we also refer to the existence of biologics against those input and output cytokines, and the target skin diseases. These use results demonstrate how important targeted cytokines are in real skin diseases, and enhance our understanding of the cytokines.
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キーワード | epidermal keratinocytes
input cytokines
output cytokines
biologics
inflammatory skin diseases
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発行日 | 2023-10-10
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出版物タイトル |
Frontiers in Immunology
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巻 | 14巻
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出版者 | Frontiers Media
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開始ページ | 1239598
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ISSN | 1664-3224
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2023 Morizane, Mukai, Sunagawa, Tachibana, Kawakami and Ouchida.
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論文のバージョン | publisher
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関連URL | isVersionOf https://doi.org/10.3389/fimmu.2023.1239598
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ライセンス | https://creativecommons.org/licenses/by/4.0/
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Citation | Morizane S, Mukai T, Sunagawa K, Tachibana K, Kawakami Y and Ouchida M (2023) “Input/output cytokines” in epidermal keratinocytes and the involvement in inflammatory skin diseases. Front. Immunol. 14:1239598. doi: 10.3389/fimmu.2023.1239598
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助成機関名 |
Japan Society for the Promotion of Science
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助成番号 | 20K08672
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