フルテキストURL | fulltext.pdf |
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著者 | Oyama, Atsushi| Takaki, Akinobu| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| Otsuka, Motoyuki| |
キーワード | Primary sclerosing cholangitis Oxidative stress marker Prognosis Serum reactive oxygen metabolite Total serum antioxidant capacity Revised Mayo risk score Child–Pugh score MELD score FIB-4 index Serum dROM Serum OXY-adsorbent test Immunoglobulin A |
備考 | The version of record of this article, first published in Hepatology International, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12072-023-10557-2| |
発行日 | 2023-07-26 |
出版物タイトル | Hepatology International |
巻 | 17巻 |
号 | 5号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 1215 |
終了ページ | 1224 |
ISSN | 1936-0533 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37493884 |
DOI | 10.1007/s12072-023-10557-2 |
Web of Science KeyUT | 001034200900001 |
関連URL | isVersionOf https://doi.org/10.1007/s12072-023-10557-2 |
フルテキストURL | fulltext.pdf |
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著者 | Kobashi, Mayu| Ishikawa, Shigenao| Inaba, Tomoki| Iwamuro, Masaya| Aoyama, Yuki| Kagawa, Tomo| Takeuchi, Yasuto| Ando, Midori| Nakamura, Satoko| Okada, Hiroyuki| |
キーワード | Frozen section Pathological diagnosis Diagnostic accuracy Early gastric cancer Endoscopic submucosal dissection Lateral margin |
備考 | The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00464-023-10100-2| |
発行日 | 2023-05-22 |
出版物タイトル | Surgical Endoscopy |
巻 | 37巻 |
号 | 9号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 6736 |
終了ページ | 6748 |
ISSN | 0930-2794 |
NCID | AA10750363 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37217685 |
DOI | 10.1007/s00464-023-10100-2 |
Web of Science KeyUT | 000993678400007 |
関連URL | isVersionOf https://doi.org/10.1007/s00464-023-10100-2 |
JaLCDOI | 10.18926/AMO/66674 |
---|---|
フルテキストURL | 78_1_079.pdf |
著者 | Takahara, Masahiro| Hiraoka, Sakiko| Ohmori, Masayasu| Takeuchi, Keiko| Takei, Kensuke| Aoyama, Yuki| Yasutomi, Eriko| Igawa, Shoko| Inokuchi, Toshihiro| Toyosawa, Junki| Yamasaki, Yasushi| Kinugasa, Hideaki| Harada, Keita| Onishi, Hideki| Okada, Hiroyuki| |
抄録 | This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful in noninvasive treatment strategies. |
キーワード | transabdominal ultrasonography fecal immunochemical test ulcerative colitis Mayo endoscopic subscore |
Amo Type | Short Communication |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-02 |
巻 | 78巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 79 |
終了ページ | 83 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38419318 |
Web of Science KeyUT | 001203658200004 |
フルテキストURL | fulltext.pdf |
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著者 | Obata, Taisuke| Tsutsumi, Koichiro| Ueta, Eijiro| Oda, Takashi| Kikuchi, Tatsuya| Ako, Soichiro| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Kato, Hironari| Okada, Hiroyuki| Otsuka, Motoyuki| |
発行日 | 2023-12-12 |
出版物タイトル | Molecular Therapy Nucleic Acids |
巻 | 34巻 |
出版者 | Cell Press |
開始ページ | 102054 |
ISSN | 2162-2531 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 The Author(s). |
論文のバージョン | publisher |
PubMed ID | 38111913 |
DOI | 10.1016/j.omtn.2023.102054 |
Web of Science KeyUT | 001146413100001 |
関連URL | isVersionOf https://doi.org/10.1016/j.omtn.2023.102054 |
フルテキストURL | fulltext.pdf |
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著者 | Kikuchi, Tatsuya| Kono, Yoshiyasu| Nakagawa, Koji| Okada, Hiroyuki| Miyamoto, Masakazu| Takaya, Yoichi| Hirata, Shoichiro| Inoo, Shoko| Kuraoka, Sakiko| Okanoue, Shotaro| Matsueda, Katsunori| Satomi, Takuya| Hamada, Kenta| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| |
キーワード | antithrombotic drugs gastrointestinal bleeding left atrial appendage closure |
発行日 | 2023-12-27 |
出版物タイトル | JGH Open |
巻 | 8巻 |
号 | 1号 |
出版者 | Wiley |
開始ページ | e13009 |
ISSN | 2397-9070 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 The Authors. |
論文のバージョン | publisher |
DOI | 10.1002/jgh3.13009 |
Web of Science KeyUT | 001131741800001 |
関連URL | isVersionOf https://doi.org/10.1002/jgh3.13009 |
フルテキストURL | fulltext.pdf |
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著者 | Toyosawa, Junki| Yamasaki, Yasushi| Fujimoto, Tsuyoshi| Tanaka, Shouichi| Tanaka, Takehiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki| |
発行日 | 2022-05-13 |
出版物タイトル | Endoscopy International Open |
巻 | 10巻 |
号 | 05号 |
出版者 | Georg Thieme Verlag KG |
開始ページ | E602 |
終了ページ | E608 |
ISSN | 2364-3722 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022. The Author(s). |
論文のバージョン | publisher |
PubMed ID | 35571476 |
DOI | 10.1055/a-1785-8616 |
Web of Science KeyUT | 000794976400009 |
関連URL | isVersionOf https://doi.org/10.1055/a-1785-8616 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Yamasaki, Yasushi| Ohmori, Masayasu| Toyosawa, Junki| Ako, Soichiro| Okada, Hiroyuki| |
発行日 | 2022-05-13 |
出版物タイトル | Endoscopy International Open |
巻 | 10巻 |
号 | 05号 |
出版者 | Georg Thieme Verlag KG |
開始ページ | E609 |
終了ページ | E615 |
ISSN | 2364-3722 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022. The Author(s). |
論文のバージョン | publisher |
PubMed ID | 35571472 |
DOI | 10.1055/a-1785-8589 |
Web of Science KeyUT | 000794976400010 |
関連URL | isVersionOf https://doi.org/10.1055/a-1785-8589 |
JaLCDOI | 10.18926/AMO/65969 |
---|---|
フルテキストURL | 77_5_471.pdf |
著者 | Oka, Shohei| Harada, Keita| Yamamoto, Shumpei| Yasutomi, Eriko| Igawa, Shoko| Ohmori, Masayasu| Hirai, Mami| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Hiraoka, Sakiko| Okada, Hiroyuki| |
抄録 | Although the clinical usefulness of colonoscopy has been established, the procedure remains painful for many patients. This study was designed to clarify the factors predicting colonoscopy-related pain. We evaluated 283 consecutive patients who completed a first-ever, total colonoscopy without sedatives or analgesics. The severity of pain symptoms was evaluated by a numeric rating scale (NRS) in a questionnaire immediately after the colonoscopy. Patient backgrounds and endoscopic findings were analyzed to evaluate their association with pain. Out of 283 patients, 53 scored their pain 0-1 on the NRS while 48 scored it 6-10. We defined the colonoscopies of the former and latter patients as painless and painful, respectively, and compared the two. Multivariate analyses revealed that low body weight (OR 4.95, 95%CI 1.89-12.99) and longer intubation time (OR 3.63, 95%CI 1.46-9.03) were significant risk factors for painful colonoscopy. To identify factors contributing to the increased intubation time, we divided subjects into short- and long-intubation-time groups based on a median insertion time of 7 min. Older age (OR 2.28, 95%CI 1.31-3.98), previous abdominal surgery (OR 1.93, 95%CI 1.13-3.32) and findings of invasive cancer (OR 10.90, 95%CI 1.34-88.90) were significant factors for longer intubation time. |
キーワード | colonoscopy colonoscopy-related pain comfortable colonoscopy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-10 |
巻 | 77巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 471 |
終了ページ | 478 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37899258 |
Web of Science KeyUT | 001108661600004 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Matsumoto, Kazuyuki| Kato, Hironari| Morimoto, Kosaku| Miyamoto, Kazuya| Saragai, Yosuke| Kawamoto, Hirofumi| Okada, Hiroyuki| |
キーワード | Bile duct obstruction Neoplasms Endoscopic biliary drainage Bilateral drainage Self-expandable metallic stents |
発行日 | 2022-07-19 |
出版物タイトル | Gut and Liver |
巻 | 17巻 |
号 | 1号 |
出版者 | The Editorial Office of Gut and Liver |
開始ページ | 170 |
終了ページ | 178 |
ISSN | 1976-2283 |
NCID | AA12329814 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Gut and Liver. |
論文のバージョン | publisher |
PubMed ID | 35851039 |
DOI | 10.5009/gnl220012 |
Web of Science KeyUT | 000830704600001 |
関連URL | isVersionOf https://doi.org/10.5009/gnl220012 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki| |
キーワード | Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry |
備考 | The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6| |
発行日 | 2022-02-08 |
出版物タイトル | Journal of Gastrointestinal Surgery |
巻 | 26巻 |
号 | 6号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 1213 |
終了ページ | 1223 |
ISSN | 1091-255X |
NCID | AA11494553 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2022 |
論文のバージョン | publisher |
PubMed ID | 35137343 |
DOI | 10.1007/s11605-021-05197-6 |
Web of Science KeyUT | 000752761400001 |
関連URL | isVersionOf https://doi.org/10.1007/s11605-021-05197-6 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki| |
キーワード | colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever |
発行日 | 2021-12-09 |
出版物タイトル | DEN Open |
巻 | 2巻 |
号 | 1号 |
出版者 | Wiley |
開始ページ | e83 |
ISSN | 2692-4609 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 The Authors. |
論文のバージョン | publisher |
PubMed ID | 35310725 |
DOI | 10.1002/deo2.83 |
Web of Science KeyUT | 001047024900091 |
関連URL | isVersionOf https://doi.org/10.1002/deo2.83 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Kato, Hironari| Matsumoto, Kazuyuki| Okada, Hiroyuki| |
キーワード | biliary drainage EUS-BD malignant hilar biliary obstruction side-by-side stent-in-stent |
発行日 | 2021-09-07 |
出版物タイトル | DEN Open |
巻 | 2巻 |
号 | 1号 |
出版者 | Wiley |
開始ページ | e33 |
ISSN | 2692-4609 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 The Authors. |
論文のバージョン | publisher |
PubMed ID | 35310763 |
DOI | 10.1002/deo2.33 |
Web of Science KeyUT | 001047024900042 |
関連URL | isVersionOf https://doi.org/10.1002/deo2.33 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Kanzaki, Hiromitsu| Horii, Joichiro| Takenaka, Ryuta| Nakagawa, Hiroyuki| Matsueda, Kazuhiro| Tsuzuki, Takao| Kita, Masahide| Yamasaki, Yasushi| Tanaka, Takehiro| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Tomoda, Jun| Okada, Hiroyuki| |
発行日 | 2022-06-10 |
出版物タイトル | Endoscopy International Open |
巻 | 10巻 |
号 | 06号 |
出版者 | Georg Thieme Verlag KG |
開始ページ | E712 |
終了ページ | E718 |
ISSN | 2364-3722 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022. The Author(s). |
論文のバージョン | publisher |
PubMed ID | 35859656 |
DOI | 10.1055/a-1793-9439 |
Web of Science KeyUT | 000826506700001 |
関連URL | isVersionOf https://doi.org/10.1055/a-1793-9439 |
JaLCDOI | 10.18926/AMO/65748 |
---|---|
フルテキストURL | 77_4_377.pdf |
著者 | Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
抄録 | Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker. |
キーワード | NAFLD NASH liver fibrosis chemokine FIB-4 |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 377 |
終了ページ | 385 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635138 |
Web of Science KeyUT | 001163659800009 |
JaLCDOI | 10.18926/AMO/65740 |
---|---|
フルテキストURL | 77_4_347.pdf |
著者 | Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki| |
抄録 | The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. |
キーワード | flow cytometry stem cell transplantation transplantation-associated microangiopathy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-08 |
巻 | 77巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 347 |
終了ページ | 357 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37635134 |
Web of Science KeyUT | 001163659800002 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Hirai, Ryosuke| Kawano, Seiji| Inoo, Shoko| Kuraoka, Sakiko| Okanoue, Shotaro| Satomi, Takuya| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Okada, Hiroyuki| |
キーワード | Fibrinolytic agents Endoscopic submucosal resection Postoperative hemorrhage Purinergic P2Y receptor antagonists |
発行日 | 2022-09-29 |
出版物タイトル | Gut and Liver |
巻 | 17巻 |
号 | 3号 |
出版者 | The Editorial Office of Gut and Liver |
開始ページ | 404 |
終了ページ | 411 |
ISSN | 1976-2283 |
NCID | AA12329814 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Gut and Liver. |
論文のバージョン | publisher |
PubMed ID | 36172713 |
DOI | 10.5009/gnl220196 |
Web of Science KeyUT | 000869939200001 |
関連URL | isVersionOf https://doi.org/10.5009/gnl220196 |
JaLCDOI | 10.18926/AMO/65494 |
---|---|
フルテキストURL | 77_3_291.pdf |
著者 | Himei, Hitomi| Kato, Hironari| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
抄録 | We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal. |
キーワード | benign biliary stricture inside stent plastic stent |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-06 |
巻 | 77巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 291 |
終了ページ | 299 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37357630 |
Web of Science KeyUT | 001026279600007 |
JaLCDOI | 10.18926/AMO/65488 |
---|---|
フルテキストURL | 77_3_235.pdf |
著者 | Kuraoka, Sakiko| Iwamuro, Masaya| Satomi, Takuya| Yamazaki, Tatsuhiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kato, Hironari| Otsuka, Fumio| Okada, Hiroyuki| |
抄録 | Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ΔIGF-1 SD score and Δthyroidstimulating hormone (TSH) and between ΔIGF-1 SD score and Δfree testosterone. ΔBody weight and ΔIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (≥ 12 weeks) users. |
キーワード | anamorelin body weight cancer cachexia endocrine system |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-06 |
巻 | 77巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 235 |
終了ページ | 241 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37357624 |
Web of Science KeyUT | 001026279600001 |
フルテキストURL | fulltext.pdf |
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著者 | Iwamuro, Masaya| Tanaka, Takehiro| Okada, Hiroyuki| |
キーワード | Diagnosis Diffuse large B-cell lymphoma Duodenal neoplasms Esoph-agogastroduodenoscopy Follicular lymphoma Gastrointestinal lymphoma |
発行日 | 2023-03-28 |
出版物タイトル | World Journal of Gastroenterology |
巻 | 29巻 |
号 | 12号 |
出版者 | Baishideng Publishing Group |
開始ページ | 1852 |
終了ページ | 1862 |
ISSN | 1007-9327 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023. |
論文のバージョン | publisher |
PubMed ID | 37032723 |
DOI | 10.3748/wjg.v29.i12.1852 |
Web of Science KeyUT | 000982154800007 |
関連URL | isVersionOf https://doi.org/10.3748/wjg.v29.i12.1852 |
タイトル(別表記) | A case of duodenal diverticulitis in a patient receiving tocilizumab for rheumatoid arthritis |
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著者 | 岩室 雅也| 馬場 雄己| 河原 祥朗| 岡田 裕之| |
抄録 | A Japanese woman was diagnosed with rheumatoid arthritis at the age of 41. At the age of 56, her rheumatoid arthritis worsened and a subcutaneous injection of tocilizumab and oral prednisolone was administered, which led to an improvement of arthritis. At the age of 57, right lower abdominal pain and vomiting suddenly appeared. Abdominal computed tomography showed a parapapillary diverticulum in the descending duodenum. The diverticulum was filled with residue, and an inflammation of the surrounding adipose tissue was observed; no free air was found. The patient was diagnosed with duodenal diverticulitis and treated with antibiotics, which resulted in an uneventful recovery. The maximum value of CRP was 1.88㎎/dL on the third day of hospitalization. Esophagogastroduodenoscopy performed on the 8th day of hospitalization revealed a parapapillary diverticulum with adhesion of pus and redness of the mucosa at the opening of the diverticulum, consistent with diverticulitis. This case highlights that diverticulitis in infrequent areas such as the duodenum may occur in patients who are treated with tocilizumab. In addition, inflammation of diverticulitis may be underestimated because abnormal laboratory values such as those induced by inflammatory reactions are less likely to occur during tocilizumab treatment. |
キーワード | トシリズマブ(tocilizumab) 十二指腸憩室(duodenal diverticulum) 憩室炎(diverticulitis) |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2022-12-01 |
巻 | 134巻 |
号 | 3号 |
開始ページ | 166 |
終了ページ | 170 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.134.166 |
言語 | 日本語 |
著作権者 | Copyright (c) 2022 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.134.166 |