著者 Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi|
発行日 2014-05-25
出版物タイトル PLOS ONE
9巻
3号
資料タイプ 学術雑誌論文
著者 Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi|
発行日 2014-01-22
出版物タイトル PLOS ONE
9巻
1号
資料タイプ 学術雑誌論文
著者 Nakatsuka, Atsuko| Matsuyama, Makoto| Yamaguchi, Satoshi| Katayama, Akihiro| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Ogawa, Daisuke| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Watanabe, Eijiro| Wada, Jun|
発行日 2016-02-17
出版物タイトル Scientific Reports
6巻
資料タイプ 学術雑誌論文
著者 Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi|
発行日 2013-10-22
出版物タイトル International Journal of Nephrology and Renovascular Disease
6巻
資料タイプ 学術雑誌論文
著者 Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi|
発行日 2013-10-15
出版物タイトル PLoS ONE
8巻
10号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52789
フルテキストURL 68_4_235.pdf
著者 Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi|
抄録 The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
キーワード microalbuminuria type 2 diabetes mellitus remission regression
Amo Type Original Article
発行日 2014-08
出版物タイトル Acta Medica Okayama
68巻
4号
出版者 Okayama University Medical School
開始ページ 235
終了ページ 241
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145409
Web of Sience KeyUT 000340687500005
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52828
タイトル(別表記) Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages
フルテキストURL 126_1.pdf
著者 宮本 聡| 四方 賢一| 宮坂 京子| 岡田 震一| 佐々木 基史| 小寺 亮| 廣田 大昌| 梶谷 展生| 高塚 哲全| 片岡 仁美| 西下 伸吾| 堀口 千景| 船越 顕博| 西森 久和| 内田 治仁| 小川 大輔| 槇野 博史|
キーワード cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果
備考 平成24年度岡山医学会賞総合研究奨励賞(結城賞)受賞論文 (The 2012 Okayama Medical Association Award)
出版物タイトル 岡山医学会雑誌
発行日 2014-04-01
126巻
1号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 1
終了ページ 6
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.1
Sort Key 1
Eprints Journal Name joma
参考文献 1) Sugimoto H, Shikata K, Hirata K, Akiyama K, Matsuda M, Kushiro M, Shikata Y, Miyatake N, Miyasaka M, Makino H : Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli : glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation. Diabetes (1997) 46, 2075-2081. 2) Okada S, Shikata K, Matsuda M, Ogawa D, Usui H, Kido Y, Nagase R, Wada J, Shikata Y, Makino H : Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes (2003) 52, 2586-2593. 3) Miyamoto S, Shikata K, Miyasaka K, Okada S, Sasaki M, Kodera R, Hirota D, Kajitani N, Takatsuka T, Kataoka HU, Nishishita S, Sato C, et al. : Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage : anti-inflammatory effect of cholecystokinin. Diabetes (2012) 61, 897-907. 4) Rehfeld JF : Clinical endocrinology and metabolism. Cholecystokinin. Best Pract Res Clin Endocrinol Metab (2004) 18, 569-586. 5) Crawley JN, Corwin RL : Biological actions of cholecystokinin. Peptides (1994) 15, 731-755. 6) Meng AH, Ling YL, Zhang XP, Zhang JL : Anti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat. World J Gastroenterol (2002) 8, 712-717. 7) Li S, Ni Z, Cong B, Gao W, Xu S, Wang C, Yao Y, Ma C, Ling Y : CCK-8 inhibits LPS-induced IL-1beta production in pulmonary interstitial macrophages by modulating PKA, p38, and NF-kappaB pathway. Shock (2007) 27, 678-686. 8) Lacourse KA, Lay JM, Swanberg LJ, Jenkins C, Samuelson LC : Molecular structure of the mouse CCK-A receptor gene. Biochem Biophys Res Commun (1997) 236, 630-635. 9) de Weerth A, Jonas L, Schade R, Schoneberg T, Wolf G, Pace A, Kirchhoff F, Schulz M, Heinig T, Greten H, von Schrenck T : Gastrin/cholecystokinin type B receptors in the kidney : molecular, pharmacological, functional characterization, and localization. Eur J Clin Invest (1998) 28, 592-601. 10) Xu SJ, Gao WJ, Cong B, Yao YX, Gu ZY : Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages. Acta Pharmacol Sin (2004) 25, 1347-1353. 11) Sanchez AP, Sharma K : Transcription factors in the pathogenesis of diabetic nephropathy. Expert Rev Mol Med (2009) 11, e13. 12) Takano Y, Yamauchi K, Hayakawa K, Hiramatsu N, Kasai A, Okamura M, Yokouchi M, Shitamura A, Yao J, Kitamura M : Transcriptional suppression of nephrin in podocytes by macrophages : roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. FEBS Lett (2007) 581, 421-426. 13) Leon-Tamariz F, Verbaeys I, Van Boven M, De Cuyper M, Buyse J, de Witte P, Verbruggen A, Cokelaere M : Biodistribution and pharmacokinetics of PEG-10kDa-cholecystokinin-10 in rats after different routes of administration. Curr Drug Deliv (2010) 7, 137-143.
著者 Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi|
発行日 2012-10
出版物タイトル Clinical and Experimental Nephrology
16巻
5号
資料タイプ 学術雑誌論文
著者 Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi|
発行日 2012-11
出版物タイトル Diabetes
61巻
11号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/45272
フルテキストURL 65_2_129.pdf
著者 Toyota, Noriko| Ogawa, Daisuke| Ishii, Keita| Hirata, Kyoji| Wada, Jun| Shikata, Kenichi| Makino, Hirofumi|
抄録 A 62-year-old woman with a history of poorly controlled type 2 diabetes mellitus was admitted to our hospital with a 3-week history of mild fever, vomiting, and anorexia. Abdominal computed tomography (CT) showed bilateral hydronephrosis and gas accumulation in the urinary bladder wall and left ureter. Laboratory tests showed leukocytosis and elevated C-reactive protein level. Urine culture showed heavy growth of Escherichia coli. The final diagnosis was emphysematous cystitis. The patient was treated with systemic antibiotics and drainage using a urethral catheter. The clinical and radiographic findings resolved rapidly, and she was discharged from the hospital on day 28. Emphysematous cystitis is a relatively rare urinary tract infection associated with gas formation, and has the potential for a serious outcome if untreated. Early detection by imaging studies such as CT is important in providing prompt treatment and favorable clinical outcome.
キーワード computed tomography diabetes mellitus emphysematous cystitis
Amo Type Case Report
発行日 2011-04
出版物タイトル Acta Medica Okayama
65巻
2号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 133
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21519371
Web of Sience KeyUT 000289818800009
JaLCDOI 10.18926/AMO/45266
フルテキストURL 65_2_81.pdf
著者 Sasaki, Motofumi| Shikata, Kenichi| Okada, Shinichi| Miyamoto, Satoshi| Nishishita, Shingo| Usui Kataoka, Hitomi| Sato, Chikage| Wada, Jun| Ogawa, Daisuke| Makino, Hirofumi|
抄録 Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease.
キーワード kidney inflammation chemokine
Amo Type Original Article
発行日 2011-04
出版物タイトル Acta Medica Okayama
65巻
2号
出版者 Okayama University Medical School
開始ページ 81
終了ページ 89
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21519365
Web of Sience KeyUT 000289818800003