| 著者 | 大塚 文男| |
|---|---|
| 発行日 | 2013-12-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishimura, Yoshito| Miyoshi, Tomoko| Sato, Asuka| Hasegawa, Kou| Hagiya, Hideharu| Kosaki, Yoshinori| Otsuka, Fumio| |
| キーワード | coronavirus disease 2019 (COVID-19) pandemic burnout prevention intention to leave |
| 発行日 | 2021-11-04 |
| 出版物タイトル | International Journal of Environmental Research and Public Health |
| 巻 | 18巻 |
| 号 | 21号 |
| 出版者 | MDPI |
| 開始ページ | 11581 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34770095 |
| DOI | 10.3390/ijerph182111581 |
| Web of Science KeyUT | 000719055900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph182111581 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishimura, Yoshito| Miyoshi, Tomoko| Hagiya, Hideharu| Kosaki, Yoshinori| Otsuka, Fumio| |
| キーワード | coronavirus disease 2019 (COVID-19) pandemic burnout prevention healthcare delivery system intention to leave |
| 発行日 | 2021-03-02 |
| 出版物タイトル | International Journal of Environmental Research and Public Health |
| 巻 | 18巻 |
| 号 | 5号 |
| 出版者 | MDPI |
| 開始ページ | 2434 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/ijerph18052434 |
| Web of Science KeyUT | 000628102900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph18052434 |
| 著者 | Fujimori, Takumi| Hagiya, Hideharu| Iio, Koji| Yamasaki, Osamu| Miyamoto, Yuji| Hoshino, Yoshihiko| Kakehi, Ayaka| Okura, Mami| Minabe, Hiroshi| Yokoyama, Yukika| Otsuka, Fumio| Higashikage, Akihito| |
|---|---|
| キーワード | Buruli ulcer Mycobacterium ulcerans Mycobacterium ulcerans subsp shinshuense 16S rRNA sequencing analysis |
| 備考 | © 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2023.02.009. | This fulltext file will be available in May 2024.| |
| 発行日 | 2023-05 |
| 出版物タイトル | Journal of Infection and Chemotherapy |
| 巻 | 29巻 |
| 号 | 5号 |
| 出版者 | Elsevier BV |
| 開始ページ | 523 |
| 終了ページ | 526 |
| ISSN | 1341-321X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
| 論文のバージョン | author |
| PubMed ID | 36813163 |
| DOI | 10.1016/j.jiac.2023.02.009 |
| Web of Science KeyUT | 000972082300001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jiac.2023.02.009 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fukushima, Shinnosuke| Hagiya, Hideharu| Honda, Hiroyuki| Ishida, Tomoharu| Shoji, Ryohei| Hasegawa, Kou| Otsuka, Fumio| |
| キーワード | Bacteremia Calcium polystyrene sulfonate Escherichia coli Infective endocarditis Rectal ulcer |
| 備考 | The version of record of this article, first published in Clinical Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12328-024-01949-4| |
| 発行日 | 2024-03-25 |
| 出版物タイトル | Clinical Journal of Gastroenterology |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 1865-7257 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38528197 |
| DOI | 10.1007/s12328-024-01949-4 |
| Web of Science KeyUT | 001190477300001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s12328-024-01949-4 |
| フルテキストURL | fulltext20230508-04.pdf |
|---|---|
| 著者 | Hagiya, Hideharu| Otsuka, Yuki| Otsuka, Fumio| |
| 備考 | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jns.2022.120232.| This fulltext file will be available in May 2023.| |
| 発行日 | 2022-05-15 |
| 出版物タイトル | Journal of the Neurological Sciences |
| 巻 | 436巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 120232 |
| ISSN | 0022-510X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 35339066 |
| DOI | 10.1016/j.jns.2022.120232 |
| Web of Science KeyUT | 000795473800002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jns.2022.120232 |
| フルテキストURL | fulltext20220906-1.pdf |
|---|---|
| 著者 | Kakehi, Ayaka| Hagiya, Hideharu| Iio, Koji| Nakano, Yasuhiro| Ihoriya, Hiromi| Taira, Yuki| Nakamoto, Kenta| Hasegawa, Kou| Higashikage, Akihito| Otsuka, Fumio| |
| キーワード | Candida dubliniensis Candidemia COVID-19 Sequencing analysis |
| 備考 | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.07.007] . | |
| 発行日 | 2022-10 |
| 出版物タイトル | Journal of Infection and Chemotherapy |
| 巻 | 28巻 |
| 号 | 10号 |
| 出版者 | Elsevier BV |
| 開始ページ | 1433 |
| 終了ページ | 1435 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
| 論文のバージョン | author |
| PubMed ID | 35863730 |
| DOI | 10.1016/j.jiac.2022.07.007 |
| Web of Science KeyUT | 000843880400016 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jiac.2022.07.007 |
| JaLCDOI | 10.18926/AMO/65151 |
|---|---|
| フルテキストURL | 77_2_203.pdf |
| 著者 | Fukushima, Shinnosuke| Hagiya, Hideharu| Iio, Koji| Honda, Hiroyuki| Ishida, Tomoharu| Nagaoka, Hirokazu| Hasegawa, Kou| Otsuka, Fumio| |
| 抄録 | Granulicatella species are rare, nutritionally variant streptococci that cause infective endocarditis. Their clinical and microbiological characteristics remain unknown. We reviewed five years of Granulicatella cases in our hospital database (Jan 2017-Jun 2022), finding 6 Granulicatella adiacens cases and 1 Granulicatella elegans case. Clinical backgrounds and bacteremia sources were diverse; 3 cases developed polymicrobial bacteremia. Antimicrobial testing showed non-susceptibility to penicillin G in 4 of 7 cases (57.1%), and high susceptibility to carbapenems and vancomycin in all cases. Determining optimal antibiotic therapy for Granulicatella infections is vital in this era of antimicrobial resistance. |
| キーワード | antimicrobial resistance bacteremia Granulicatella species nutritionally variant streptococci |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 207 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094959 |
| Web of Science KeyUT | 000982563800002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oka, Kosuke| Takagi, Yume| Hagiya, Hideharu| Otsuka, Fumio| |
| キーワード | cat scratch disease lymphadenopathy and subcutaneous abscess |
| 発行日 | 2022-04-14 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 10巻 |
| 号 | 4号 |
| 出版者 | Wiley |
| 開始ページ | e04816 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35441012 |
| DOI | 10.1002/ccr3.4816 |
| Web of Science KeyUT | 000782511000001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ccr3.4816 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Koichiro| Hasegawa, Kou| Oka, Kosuke| Otsuka, Fumio| |
| キーワード | autosomal-dominant polycystic kidney disease hypertension and mesenteric artery dissection |
| 発行日 | 2021-10-06 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 9巻 |
| 号 | 10号 |
| 出版者 | Wiley |
| 開始ページ | e04922 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34631096 |
| DOI | 10.1002/ccr3.4922 |
| Web of Science KeyUT | 000724731500122 |
| 関連URL | isVersionOf https://doi.org/10.1002/ccr3.4922 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oka, Kosuke| Tokumasu, Kazuki| Hagiya, Hideharu| Otsuka, Fumio| |
| キーワード | C-reactive protein (CRP) fever of unknown origin (FUO) functional hyperthermia (FH) psychiatric disorder psychogenic fever |
| 発行日 | 2024-02-03 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 13巻 |
| 号 | 3号 |
| 出版者 | MDPI |
| 開始ページ | 889 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 38337583 |
| DOI | 10.3390/jcm13030889 |
| Web of Science KeyUT | 001159108700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm13030889 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tokumasu, Kazuki| Fujita-Yamashita, Manami| Sunada, Naruhiko| Sakurada, Yasue| Yamamoto, Koichiro| Nakano, Yasuhiro| Matsuda, Yui| Otsuka, Yuki| Hasegawa, Toru| Hagiya, Hideharu| Honda, Hiroyuki| Otsuka, Fumio| |
| キーワード | adverse events COVID-19 SARS-CoV-2 vaccination mRNA vaccine |
| 発行日 | 2023-10-30 |
| 出版物タイトル | Vaccines |
| 巻 | 11巻 |
| 号 | 11号 |
| 出版者 | MDPI |
| 開始ページ | 1661 |
| ISSN | 2076-393X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 38005993 |
| DOI | 10.3390/vaccines11111661 |
| Web of Science KeyUT | 001113977600001 |
| 関連URL | isVersionOf https://doi.org/10.3390/vaccines11111661 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sunada, Naruhiko| Nakano, Yasuhiro| Otsuka, Yuki| Tokumasu, Kazuki| Honda, Hiroyuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Omura, Daisuke| Ochi, Kanako| Hagiya, Hideharu| Ueda, Keigo| Kataoka, Hitomi| Otsuka, Fumio| |
| キーワード | insomnia myalgic encephalomyelitis chronic fatigue long COVID Omicron variant post COVID-19 condition |
| 発行日 | 2022-12-09 |
| 出版物タイトル | Journal Of Clinical Medicine |
| 巻 | 11巻 |
| 号 | 24号 |
| 出版者 | MDPI |
| 開始ページ | 7332 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36555948 |
| DOI | 10.3390/jcm11247332 |
| Web of Science KeyUT | 000901154300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm11247332 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kametaka, Daisuke| Iwamuro, Masaya| Takahashi, Takahide| Hirabata, Araki| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Otsuka, Fumio| Kawahara, Yoshiro| Okada, Hiroyuki| |
| キーワード | flow cytometry autoimmune gastritis atrophic gastritis Helicobacter pylori |
| 発行日 | 2022-05-25 |
| 出版物タイトル | Current Issues In Molecular Biology |
| 巻 | 44巻 |
| 号 | 6号 |
| 出版者 | MDPI |
| 開始ページ | 2443 |
| 終了ページ | 2452 |
| ISSN | 1467-3037 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35735608 |
| DOI | 10.3390/cimb44060167 |
| Web of Science KeyUT | 000816477400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cimb44060167 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Otsuka, Yuki| Tokumasu, Kazuki| Nakano, Yasuhiro| Honda, Hiroyuki| Sakurada, Yasue| Sunada, Naruhiko| Omura, Daisuke| Hasegawa, Kou| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kataoka, Hitomi| Otsuka, Fumio| |
| キーワード | long covid covid-19 aftercare clinic general fatigue general physician post-acute sequelae of covid-19 |
| 発行日 | 2021-10-07 |
| 出版物タイトル | Cureus |
| 巻 | 13巻 |
| 号 | 10号 |
| 出版者 | Cureus Inc. |
| 開始ページ | e18568 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Otsuka et al. |
| 論文のバージョン | publisher |
| DOI | 10.7759/cureus.18568 |
| Web of Science KeyUT | 000709721800008 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.18568 |
| JaLCDOI | 10.18926/AMO/61424 |
|---|---|
| フルテキストURL | 75_1_1.pdf |
| 著者 | Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| 抄録 | To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. |
| キーワード | androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-02 |
| 巻 | 75巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33649607 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tokumasu, Kazuki| Honda, Hiroyuki| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Yamamoto, Koichiro| Nakano, Yasuhiro| Hasegawa, Toru| Yamamoto, Yukichika| Otsuka, Yuki| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio| |
| キーワード | general fatigue post-exertional malaise long COVID myalgic encephalomyelitis chronic fatigue syndrome post COVID-19 condition |
| 発行日 | 2022-06-25 |
| 出版物タイトル | Medicina |
| 巻 | 58巻 |
| 号 | 7号 |
| 出版者 | MDPI |
| 開始ページ | 850 |
| ISSN | 1010-660X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35888568 |
| DOI | 10.3390/medicina58070850 |
| Web of Science KeyUT | 000834490500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/medicina58070850 |
| JaLCDOI | 10.18926/AMO/57950 |
|---|---|
| フルテキストURL | 74_1_33.pdf |
| 著者 | Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio| |
| 抄録 | A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful |
| キーワード | blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 33 |
| 終了ページ | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099246 |
| Web of Science KeyUT | 000516606200005 |
| NAID | 120006795617 |
| JaLCDOI | 10.18926/AMO/60797 |
|---|---|
| フルテキストURL | 74_5_381.pdf |
| 著者 | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
| 抄録 | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
| キーワード | hormones hyperprolactinemia inflammation pituitary prolactin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-10 |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 381 |
| 終了ページ | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106693 |
| Web of Science KeyUT | 000581970100002 |
| NAID | 120006892923 |
| JaLCDOI | 10.18926/bgeou/47111 |
|---|---|
| フルテキストURL | bgeou_147_135_144.pdf |
| 著者 | Mimura, Yukari| Ogura, Toshio| Otsuka, Fumio| |
| 抄録 | Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects. |
| キーワード | Graves' disease human-TRAb TSAb |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2011-06-25 |
| 巻 | 147巻 |
| 開始ページ | 135 |
| 終了ページ | 144 |
| ISSN | 1883-2423 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120003551002 |