タイトル(別表記) Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis
著者 杉原 雄策| 川野 誠司| 原田 馨太| 高嶋 志保| 竹井 大介| 井口 俊博| 高原 政宏| 平岡 佐規子| 母里 淑子| 岸本 浩行| 永坂 岳司| 岡田 裕之|
抄録 A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs.
キーワード 家族性大腸腺腫症 (familial adenomatous polyposis) 小腸癌 (jejunal cancer) 小腸内視鏡検査 (small intestine endoscope)
備考 症例報告 (Case Reports)
出版物タイトル 岡山医学会雑誌
発行日 2017-08-01
129巻
2号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 111
終了ページ 114
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL https://doi.org/10.4044/joma.129.111
言語 Japanese
著作権者 Copyright (c) 2017 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.129.111
Sort Key 8
Eprints Journal Name joma
参考文献 1 ) 中川一彦, 権藤延久, 藤原由規 : 家族性大腸腺腫症. 外科治療 (2000) 82, 838-845. 2 ) Jagelman DG, DeCosse JJ, Bussey HJR : Upper Gastrointestinal cancer in familial adenomatous polyposis. Lancet (1988) 21, 1149-1151. 3 ) 八重樫寛治, 岩間毅夫, 三島好雄 : 家族性大腸ポリポーシス. 日臨 (1991) 49, 2910-2916. 4 ) Vasen H, Moslein G, Alonso A, Aretz S, Bernstein I, et al. : Guidelines for the clinical management of familial adenomatous polyposis (FAP) . Gut (2008) 57, 704-713. 5 ) 澤田 傑, 上坂克彦, 加藤知行, 森本剛史, 小寺泰弘, 他 : 多発性十二指腸癌と腹腔内デスモイド腫瘍を併発した大腸腺腫症の1例. 日消外会誌 (1996) 29, 122-126. 6 ) 塩田摂成, 星野和義, 梶谷慎司, 万木英一, 阿部重郎, 他 : 大腸全摘術施行後, 胃全摘術後に多発性十二指腸腺腫内癌を生じた家族性腺腫性ポリポーシスの1例. 癌の臨床 (1999) 45, 237-241. 7 ) 秋山典夫, 石﨑正壽, 田中司玄文, 藤田耕一郎 : 家族性大腸選手用に大腸癌, 胃癌, 十二指腸乳頭部癌を合併した1例. 日消外会誌 (2000) 61, 1613-1617. 8 ) Kashiwagi H, Kanazawa K, Koizumi M, Shibusawa H, Spigelman A : Development of duodenal cancer in a patient with familial adenomatous polyposis. J Gastroenterol (2000) 35, 856-860. 9 ) 吉田 信, 河島秀昭, 原 隆志, 石後岡正弘, 樫山基矢, 他 : 家族性大腸腺腫症の術後回腸瘻閉鎖部に発症した小腸癌の1例. 日消外会誌 (2002) 35, 1438-1442. 10) Iizuka T, Sawada T, Hayakawa K, Hashimoto M, Udagawa H, et al. : Successful Local Excision of Ileostomy Adenocarcinoma After Colectomy for Familial Adenomatous Polyposis : Report of a Case. Surg Today (2002) 32, 638-641. 11) 永橋昌幸, 土屋嘉昭, 野村達也, 梨本 篤, 藪崎 裕, 他 : 十二指腸癌に対して膵頭温存十二指腸全摘術を施行した家族性大腸腺腫症の1例. 日消外会誌 (2000) 61, 28-33. 12) 木村 理, 平井一郎, 渡邊利広, 森谷敏幸, 高須直樹, 他 : 家族性大腸腺腫症術後に発生したVater 乳頭部癌に対して乳頭切除術を施行した1例. 胆道 (2008) 22, 732-735. 13) 星野伸晃, 加藤岳人, 平松和洋 : 胃全摘23年後に十二指腸球部盲端に腺癌が発症したGardner 症候群の1例. 日消外会誌 (2013) 46, 85-90. 14) 鈴木秀幸, 柴田 近, 三浦 康 : FAP に対する大腸全摘後の永久回腸ストーマに発生した回腸癌の2例. 日消外会誌 (2012) 45, 451-458. 15) 星野伸晃, 加藤岳人, 平松和洋 : 胃全摘後23年目に十二指腸球部盲端に腺癌が発症したGardner 症候群の1例. 日消外会誌 (2013) 46, 85-90. 16) 村木 愛, 堀 明洋, 森岡 淳 : 家族性大腸腺腫症に対する大腸全摘術後の回腸人工肛門部癌の1例. 日臨外会誌 (2013) 74, 2841-2845. 17) Ishida H, Kumamoto K, Amano K : Identification of APC Gene Mutations in Jejunal Carcinomas from a Patient with Familial Adenomatous Polyposis. Jpn J Clin Oncol (2013) 43, 929-934. 18) 石橋敬一郎, 渡辺雄一郎, 近範 泰 : 家族性大腸腺腫症に発生した子宮内膜癌, 卵巣癌, 十二指腸癌の1例. Jpn J Cancer Chemother (2015) 42, 1715-1717. 19) Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, et al. : Genetic alterations suring colorectal tumor development. N Engl J Med (1988) 319, 525-532. 20) 牛尾恭輔, 石堂達也, 中嶋秀麿, 宮川邦久, 石川 勉, 他 : 臨床研究から明らかなにしえた家族性大腸腺腫症の病態. 胃と腸 (1993) 28, 1305-1321. 21) Spigelman AD, Talbot IC, Penna C, Nugent KP, Phillip RK, et al. : Evidence for adenoma-carcinoma sequence in the duodenum of patients with familial adenomatous polyposis. J Clin Pathol (1994) 47, 709-710. 22) 新井賢一郎, 船橋公彦, 小池淳一, 栗原聰元, 塩川洋之, 他 : 早期診断と治療において腹腔鏡補助下手術が有用であった原発性早期小腸癌の1例の本邦報告41例の文献的考察. 臨床と研究 (2013) 88, 108-113. 23) Matsumoto M, Nakajima T, Kakugawa Y, Sakamoto T, Kuribayashi S, et al. : Surveillance using capsule endoscopy is safe in postcolectomy patients with familial adenomatous polyposis : a prospective Japanese study. Fam Cancer (2016) 15, 75-83.
JaLCDOI 10.18926/AMO/54817
フルテキストURL 70_6_511.pdf
著者 Gobara, Hideo| Hiraki, Takao| Iguchi, Toshihiro| Fujiwara, Hiroyasu| Nagasaka, Takeshi| Kishimoto, Hiroyuki| Tanaka, Takehiro| Kanazawa, Susumu|
抄録 An 87-year-old Japanese man underwent percutaneous cryoablation (PCA) therapy for his renal cell tumor. We displaced the colon from the tumor using hydrodissection. Computed tomography (CT) immediately after PCA was indicative of iceball extension to the colon wall, and a discontinuous enhancement of the colon wall was observed. We therefore performed an emergency surgery. On laparotomy, we observed a dark-purple area on the affected area of the colon, and the resected specimen showed focal, deep ulceration on the mucosal surface. Photomicrography revealed mucosal necrosis, submucosal hemorrhage, and necrotic foci in the muscularis propria, corresponding to the discontinuous colon wall enhancement on CT and the deep ulceration and dark-purple area on laparotomy. He recovered from surgery and was discharged without any complications.
キーワード bowel injury complication cryoablation renal cell carcinoma thermal ablation
Amo Type Case Report
発行日 2016-12
出版物タイトル Acta Medica Okayama
70巻
6号
出版者 Okayama University Medical School
開始ページ 511
終了ページ 514
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28003679
JaLCDOI 10.18926/AMO/54512
フルテキストURL 70_4_317.pdf
著者 Sakurai, Jun| Matsui, Yusuke| Hiraki, Takao| Iguchi, Toshihiro| Fujiwara, Hiroyasu| Gobara, Hideo| Mitsuhashi, Toshiharu| Nagasaka, Takeshi| Susumu Kanazawa, Susumu Kanazawa|
抄録 The present single center prospective phase II clinical trial is designed to evaluate the efficacy and safety of percutaneous radiofrequency (RF) ablation for colorectal lung metastases. Patients who have colorectal lung metastases without extrapulmonary metastases are included in this study. The primary endpoint is 3-year overall survival (OS) after RF ablation. The secondary endpoints are the prevalence of adverse events within 4 weeks, local tumor progression rate, 1- and 5-year OS, cause-specific survival, and relapse-free survival. The recruitment of patients commenced in July 2014, and the enrolment of 45 patients is intended over the 3 years of study period.
キーワード radiofrequency ablation colorectal cancer lung metastasis
Amo Type Clinical Study Protocols
発行日 2016-08
出版物タイトル Acta Medica Okayama
70巻
4号
出版者 Okayama University Medical School
開始ページ 317
終了ページ 321
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27549681
Web of Sience KeyUT 000384748600016
JaLCDOI 10.18926/AMO/53672
フルテキストURL 69_5_267.pdf
著者 Inada, Ryo| Nagasaka, Takeshi| Kondo, Yoshitaka| Watanabe, Ayako| Toshima, Toshiaki| Kubota, Nobuhito| Kikuchi, Satoru| Ishida, Michihiro| Kuroda, Shinji| Mori, Yoshiko| Kishimoto, Hiroyuki| Fujiwara, Toshiyoshi|
抄録 The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time.
キーワード laparoscopic surgery total proctocolectomy open proctocolectomy ulcerative colitis case-matched study
Amo Type Original Article
発行日 2015-10
出版物タイトル Acta Medica Okayama
69巻
5号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 273
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26490023
Web of Sience KeyUT 000365519600002
タイトル(別表記) Successful laparoscopic resection of a cecal tumor in a 95-year-old man
フルテキストURL 127_117.pdf
著者 渡邉 彩子| 稲田 涼| 永坂 岳司| 八木 朝彦| 松本 聖| 戸嶋 俊明| 菊池 覚次| 黒田 新士| 近藤 喜太| 母里 淑子| 岸本 浩行| 藤原 俊義|
抄録 We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials (RCTs) revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients.
キーワード 超高齢者(extremely elderly patient) 大腸癌(colorectal cancer) 腹腔鏡手術(laparoscopic surgery)
備考 症例報告(Case Reports)
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
127巻
2号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 117
終了ページ 121
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL isVersionOf https://doi.org/10.4044/joma.127.117
言語 Japanese
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.127.117
NAID 130005096253
Sort Key 7
Eprints Journal Name joma
参考文献 1) 大腸癌治療ガイドライン 医師用 2014年版, 大腸癌研究会編, 金原出版, 東京(2014). 2) Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W, Nelson H, Clinical Outcomes of Surgical Therapy Study Group : Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg (2007) 246, 655-662. 3) Colon Cancer Laparoscopic or Open Resection Study Group, Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy A, Bonjer HJ : Survival after laparoscopic surgery versus open surgery for colon cancer : long-term outcome of a randomised clinical trial. Lancet Oncol (2009) 10, 44-52. 4) Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ : Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg (2010) 97, 1638-1645. 5) Kitano S, Inomata M, Sato A, Yoshimura K, Moriya Y, Japan Clinical Oncology Group Study : Randomized controlled trial to evaluate laparoscopic surgery for colorectal cancer : Japan Clinical Oncology Group Study JCOG 0404. Jpn J Clin Oncol (2005) 35, 475-477. 6) Lujan J, Valero G, Hernandez Q, Sanchez A, Frutos MD, Parrilla P : Randomized clinical trial comparing laparoscopic and open surgery in patients with rectal cancer. Br J Surg (2009) 96, 982-989. 7) 永坂岳司, 稲田 涼, 藤原俊義 : 腸管損傷の修復法 : OGS NOW16合併症対策&知っておきたい他科の手術手技, メジカルビュー社, 東京(2013)pp74-81. 8) 大腸癌取り扱い規約 第8版, 大腸癌研究会編, 金原出版, 東京(2013). 9) 小澤平太, 固武健二郎 : 我が国の大腸癌 最新の基本統計(2) ―大腸癌全国登録1974~1999年症例のデータから―. 大腸癌Frontier(2010)3, 293-297. 10) Grailey K, Markar SR, Karthikesalingam A, Aboud R, Ziprin P, Faiz O : Laparoscopic versus open colorectal resection in the elderly population. Surg Endosc (2013) 27, 19-30. 11) 藤井正一, 石部敦士, 大田貢由, 渡辺一輝, 渡邉 純, 辰巳健志, 山岸 茂, 市川靖史, 大木繁男, 國崎主税, 嶋田 紘, 遠藤 格 : 高齢者(80歳以上)大腸癌に対する手術成績の検討. 日本大腸肛門病会誌(2013)66, 221-228. 12) 須藤 剛, 佐藤敏彦 : 高齢者大腸癌患者における腹腔鏡補助下手術の検討. 日老医誌(2011)48, 665-671. 13) Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santibañes E, Pekolj J, Slankamenac K, Bassi C, Graf R, Vonlanthen R, et al. : The Clavien-Dindo classification of surgical complications : five-year experience. Ann Surg (2009) 96, 187-196.
JaLCDOI 10.18926/AMO/53340
フルテキストURL 69_2_113.pdf
著者 Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi|
抄録 A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control.
キーワード colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy
Amo Type Case Report
発行日 2015-04
出版物タイトル Acta Medica Okayama
69巻
2号
出版者 Okayama University Medical School
開始ページ 113
終了ページ 118
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25899633
Web of Sience KeyUT 000353181700006
著者 Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi|
発行日 2014-12-19
出版物タイトル Molecular Therapy
資料タイプ 学術雑誌論文
著者 Kondo, Yoshitaka| Nagasaka, Takeshi| Kobayashi, Satoru| Kobayashi, Naoya| Fujiwara, Toshiyoshi|
発行日 2014-03
出版物タイトル Hepato-Gastroenterology
61巻
130号
資料タイプ 学術雑誌論文
著者 Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
発行日 2014-05-28
出版物タイトル Gut
資料タイプ 学術雑誌論文
著者 Yamada, Eiji| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Sakuma, Leon| Takaoka, Munenori| Yamada, Takako| Noma, Kazuhiro| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Tanabe, Shunsuke| Nagasaka, Takeshi| Fujiwara, Toshiyoshi| Naomoto, Yoshio|
発行日 2012-12
出版物タイトル Journal of Surgical Research
178巻
2号
資料タイプ 学術雑誌論文
著者 Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi|
発行日 2013-12-01
出版物タイトル Clinical Cancer Research
19巻
23号
資料タイプ 学術雑誌論文
著者 Satoh, Daisuke| Yagi, Takahito| Nagasaka, Takeshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Utsumi, Masashi| Tanaka, Takehiro| Sadamori, Hiroshi| Fujiwara, Toshiyoshi|
発行日 2013-04-27
出版物タイトル World Journal of Hepatology
5巻
4号
資料タイプ 学術雑誌論文
著者 永坂 岳司| 藤原 俊義|
発行日 2013-08-01
出版物タイトル 岡山医学会雑誌
125巻
2号
資料タイプ 学術雑誌論文
著者 稲田 涼| 永坂 岳司| 母里 淑子| 楳田 祐三| 久保田 暢人| 森川 達也| 近藤 喜太| 宇野 太| 貞森 裕| 八木 孝仁| 藤原 俊義|
発行日 2013-04-01
出版物タイトル 岡山医学会雑誌
125巻
1号
資料タイプ 学術雑誌論文
著者 稲田 涼| 永坂 岳司| 竹原 清人| 杉原 正大| 母里 淑子| 楳田 祐三| 久保田 暢人| 森川 達也| 近藤 喜太| 宇野 太| 貞森 裕| 八木 孝仁| 藤原 俊義|
発行日 2013-04-01
出版物タイトル 岡山医学会雑誌
125巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/46628
フルテキストURL 65_3_169.pdf
著者 Takeda, Masanori| Nagasaka, Takeshi| Dong-Sheng, Sun| Nishie, Hiroyuki| Oka, Tetsuhiro| Yamada, Eiji| Mori, Yoshiko| Shigeyasu, Kunitoshi| Morikawa, Tatsuya| Mizobuchi, Satoshi| Fujiwara, Toshiyoshi|
抄録 Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p<.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors.
キーワード BRAF/KRAS mutations promoter methylation colorectal cancer
Amo Type Original Article
発行日 2011-06
出版物タイトル Acta Medica Okayama
65巻
3号
出版者 Okayama University Medical School
開始ページ 169
終了ページ 177
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21709714
Web of Sience KeyUT 000292017500003
著者 永坂 岳司| 田中 紀章| 孫 冬生| 猶本 良夫| 松原 長秀| 八木 孝仁| 藤原 俊義|
発行日 2010-08-02
出版物タイトル 岡山医学会雑誌
122巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30741
フルテキストURL fulltext.pdf
著者 Nagasaka, Takeshi| Goel, Ajay| Matsubara, Nagahide| Tanaka, Noriaki|
抄録 Aberrant promoter methylation, an 'epigenetic' form of genomic instability that leads to transcriptional silencing of tumor suppressor genes, is increasingly being recognized as a crucial component in the evolution of human cancers. With our limited knowledge of the molecular basis and timing of the initiation of altered methylation events in the stepwise progression of cancers, the biggest challenge we currently face is to identify novel biomarkers and technologies for the timely screening of patients carrying such alterations. One such strategy would be to develop tests for the detection of fecal DNA methylation patterns that will improve the sensitivity of noninvasive screening tests for colorectal neoplasia, and moreover, will decrease both mortality and the incremental costs of treating colorectal cancers.
キーワード fecal DNA colorectal cancer methylation epigenetics
Amo Type Review
発行日 2006-10
出版物タイトル Acta Medica Okayama
60巻
5号
出版者 Okayama University Medical School
開始ページ 249
終了ページ 256
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17072371
Web of Sience KeyUT 000241509000001
著者 永坂 岳司| 松原 長秀| 笹本 博美| 高畑 隆臣| 竹田 正範| 木村 圭吾| 内田 卓之| 石井 龍宏| 長尾 厚樹| 小南 賢吉郎| 中川 仁志| 神原 健| 能登原 憲司| 磯崎 博司| 田中 紀章|
発行日 2005-09-01
出版物タイトル 岡山医学会雑誌
117巻
2号
資料タイプ 学術雑誌論文