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ID 30741
JaLCDOI
フルテキストURL
著者
Nagasaka, Takeshi Okayama University ORCID Kaken ID publons researchmap
Goel, Ajay Baylor University Medical Center
Matsubara, Nagahide Okayama University
Tanaka, Noriaki Okayama University
抄録
Aberrant promoter methylation, an 'epigenetic' form of genomic instability that leads to transcriptional silencing of tumor suppressor genes, is increasingly being recognized as a crucial component in the evolution of human cancers. With our limited knowledge of the molecular basis and timing of the initiation of altered methylation events in the stepwise progression of cancers, the biggest challenge we currently face is to identify novel biomarkers and technologies for the timely screening of patients carrying such alterations. One such strategy would be to develop tests for the detection of fecal DNA methylation patterns that will improve the sensitivity of noninvasive screening tests for colorectal neoplasia, and moreover, will decrease both mortality and the incremental costs of treating colorectal cancers.
キーワード
fecal DNA
colorectal cancer
methylation
epigenetics
Amo Type
Review
発行日
2006-10
出版物タイトル
Acta Medica Okayama
60巻
5号
出版者
Okayama University Medical School
開始ページ
249
終了ページ
256
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT