野間和広

食道原発悪性黒色腫の１切除例

タイトル（別表記）	A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
フルテキストURL	126_45.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
キーワード	食道（esophagus）悪性黒色腫（malignant melanoma）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	45
終了ページ	48
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.45
NAID	130004505808

術前DCF療法が著効した食道原発内分泌細胞癌の１切除例

タイトル（別表記）	Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
フルテキストURL	126_39.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
キーワード	食道癌（esophageal cancer）内分泌細胞癌（endocrine cell carcinoma） DCF療法（DCF treatment）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	39
終了ページ	43
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.39
NAID	130004505807

小細胞癌成分を含む食道癌肉腫の１切除例

著者	田辺俊介\| 白川靖博\| 前田直見\| 大原利章\| 野間和広\| 櫻間教文\| 柳井広之\| 山辻知樹\| 猶本良夫\| 藤原俊義\|
発行日	2012-08-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	2号
資料タイプ	学術雑誌論文

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

著者	Ieda, Takeshi\| Tazawa, Hiroshi\| Okabayashi, Hiroki\| Yano, Shuya\| Shigeyasu, Kunitoshi\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Kishimoto, Hiroyuki\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Saitou, Takashi\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
発行日	2019-11-8
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	16378
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	31705021
DOI	10.1038/s41598-019-52816-z
Web of Science KeyUT	000495372900001
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-52816-z

Verrucous carcinoma of the esophagus with complete response after chemoradiotherapy

フルテキストURL	fulltext.pdf
著者	Hashimoto, Masashi\| Shirakawa, Yasuhiro\| Tanabe, Shunsuke\| Tanaka, Takehiro\| Maeda, Naoaki\| Sakurama, Kazufumi\| Noma, Kazuhiro\| Fujiwara, Toshiyoshi\|
キーワード	Esophagectomy Verrucous carcinoma Esophageal squamous cell carcinoma
発行日	2022-07-04
出版物タイトル	Surgical Case Reports
巻	8巻
号	1号
出版者	Springer
開始ページ	128
ISSN	2198-7793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35781764
DOI	10.1186/s40792-022-01486-7
Web of Science KeyUT	000820644000001
関連URL	isVersionOf https://doi.org/10.1186/s40792-022-01486-7

Validity of the 30-Second Chair-Stand Test to Assess Exercise Tolerance and Clinical Outcomes in Patients with Esophageal Cancer: A Retrospective Study with Reference to 6-Minute Walk Test Results

JaLCDOI	10.18926/AMO/65149
フルテキストURL	77_2_193.pdf
著者	Ikeda, Tomohiro\| Noma, Kazuhiro\| Okura, Kazuki\| Katayama, Sho\| Takahashi, Yusuke\| Maeda, Naoaki\| Tanabe, Shunsuke\| Wakita, Akiyuki\| Hamada, Masanori\| Fujiwara, Toshiyoshi\| Senda, Masuo\|
抄録	This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk.
キーワード	esophageal cancer exercise tolerance rehabilitation
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2023-04
巻	77巻
号	2号
出版者	Okayama University Medical School
開始ページ	193
終了ページ	197
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37094957
Web of Science KeyUT	000982503800009

Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment

フルテキストURL	fulltext.pdf
著者	Tazawa, Hiroshi\| Shigeyasu, Kunitoshi\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Sakurai, Fuminori\| Mizuguchi, Hiroyuki\| Kobayashi, Hisataka\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
キーワード	adenovirus EMT survivin telomerase vimentin
発行日	2022-04-09
出版物タイトル	Cancer Science
出版者	Wiley
ISSN	1347-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35398956
DOI	10.1111/cas.15369
Web of Science KeyUT	000783300600001
関連URL	isVersionOf https://doi.org/10.1111/cas.15369

The Essential Role of Fibroblasts in Esophageal Squamous Cell Carcinoma-Induced Angiogenesis

著者	野間和広\|
発行日	2008-09-30
出版物タイトル
資料タイプ	学位論文

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

フルテキストURL	fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf
著者	Kajioka, Hiroki\| Kagawa, Shunsuke\| Ito, Atene\| Yoshimoto, Masashi\| Sakamoto, Shuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
備考	This fulltext is available in January, 2022.\|
発行日	2021-01-28
出版物タイトル	Cancer Letters
巻	497巻
出版者	Elsevier
開始ページ	1
終了ページ	3
ISSN	0304-3835
NCID	AA00598513
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33065249
DOI	10.1016/j.canlet.2020.10.015
Web of Science KeyUT	000596072900001
関連URL	isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015

Surgical technique of suprapancreatic D2 lymphadenectomy focusing on the posterior hepatic plexus for advanced gastric cancer

フルテキストURL	fulltext20220131-2.pdf
著者	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Takeda, Sho\| Kikuchi, Satoru\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Teraishi, Fuminori\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
キーワード	Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4\|
発行日	2022-1-12
出版物タイトル	Langenbeck's Archives of Surgery
巻	407巻
号	2号
出版者	Springer Science and Business Media LLC
開始ページ	871
終了ページ	877
ISSN	1435-2443
NCID	AA11211080
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
論文のバージョン	author
PubMed ID	35022835
DOI	10.1007/s00423-022-02437-4
Web of Science KeyUT	000741939500003
関連URL	isVersionOf https://doi.org/10.1007/s00423-022-02437-4

Successfully Treated Pneumatosis Cystoides Intestinalis with Pneumoperitoneum Onset in a Patient Administered α-glucosidase Inhibitor

JaLCDOI	10.18926/AMO/49672
フルテキストURL	67_2_123.pdf
著者	Tanabe, Shunsuke\| Shirakawa, Yasuhiro\| Takehara, Yuko\| Maeda, Naoaki\| Katsube, Ryoichi\| Ohara, Toshiaki\| Sakurama, Kazufumi\| Noma, Kazuhiro\| Fujiwara, Toshiyoshi\|
抄録	An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patientʼs condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital.
キーワード	pneumatosis cystoides intestinalis pneumoperitoneum α-glucosidase inhibitor
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	128
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603930
Web of Science KeyUT	000317801700008

Skeletal muscle loss in the postoperative acute phase after esophageal cancer surgery as a new prognostic factor

フルテキストURL	fulltext.pdf
著者	Maeda, Naoaki\| Shirakawa, Yasuhiro\| Tanabe, Shunsuke\| Sakurama, Kazufumi\| Noma, Kazuhiro\| Fujiwara, Toshiyoshi\|
発行日	2020-06-26
出版物タイトル	World Journal of Surgical Oncology
巻	18巻
号	1号
出版者	BMC
開始ページ	143
ISSN	1477-7819
NCID	AA12048269
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	32591002
DOI	10.1186/s12957-020-01908-6
Web of Science KeyUT	000545948700003
関連URL	isVersionOf https://doi.org/10.1186/s12957-020-01908-6

Safe and curative modified two-stage operation for T4 esophageal cancer after definitive chemoradiotherapy: a case report

フルテキストURL	fulltext.pdf
著者	Matsumoto, Tasuku\| Noma, Kazuhiro\| Maeda, Naoaki\| Kato, Takuya\| Moriwake, Kazuya\| Kawasaki, Kento\| Hashimoto, Masashi\| Tanabe, Shunsuke\| Shirakawa, Yasuhiro\| Fujiwara, Toshiyoshi\|
キーワード	T4 esophageal cancer Chemoradiotherapy Esophagectomy Two-stage operation
備考	The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-023-01692-x\|
発行日	2023-06-26
出版物タイトル	Surgical Case Reports
巻	9巻
号	1号
出版者	Springer
開始ページ	119
ISSN	2198-7793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	37358692
DOI	10.1186/s40792-023-01692-x
Web of Science KeyUT	001016770100001
関連URL	isVersionOf https://doi.org/10.1186/s40792-023-01692-x

Prone-Position Thoracoscopic Ligation of the Thoracic Duct for Chyle Leak Following Radical Neck Dissection in a Patient with a Right Aortic Arch

JaLCDOI	10.18926/AMO/53524
フルテキストURL	69_3_173.pdf
著者	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kashima, Hajime\| Maeda, Naoaki\| Tanabe, Shunsuke\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position.
キーワード	chyle leak thoracic duct thoracoscopy prone position
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2015-06
巻	69巻
号	3号
出版者	Okayama University Medical School
開始ページ	173
終了ページ	176
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26101193
Web of Science KeyUT	000356903000006

Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments

フルテキストURL	fulltext20210831-3.pdf
著者	Shirakawa, Yasuhiro\| Tazawa, Hiroshi\| Tanabe, Shunsuke\| Kanaya, Nobuhiko\| Noma, Kazuhiro\| Koujima, Takeshi\| Kashima, Hajime\| Kato, Takuya\| Kuroda, Shinji\| Kikuchi, Satoru\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Kanazawa, Susumu\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
キーワード	Telomerase adenovirus radiotherapy esophageal cancer immunotherapy
備考	© 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .\|
発行日	2021-8
出版物タイトル	European Journal of Cancer
巻	153巻
出版者	Elsevier BV
開始ページ	98
終了ページ	108
ISSN	0959-8049
NCID	AA1075407X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Elsevier Ltd.
論文のバージョン	author
PubMed ID	34153720
DOI	10.1016/j.ejca.2021.04.043
Web of Science KeyUT	000686051300013
関連URL	isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043

Perioperative and Postoperative Continuous Nutritional Counseling Improves Quality of Life of Gastric Cancer Patient Undergoing Gastrectomy

著者	Hanzawa, Shunya\| Kikuchi, Satoru\| Kuroda, Shinji\| Shoji, Ryohei\| Kashima, Hajime\| Matsumi, Yuki\| Takahashi, Ayako\| Kakiuchi, Yoshihiko\| Takagi, Kosei\| Tanabe, Shunsuke\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Shikata, Kenichi\| Fujiwara, Toshiyoshi\|
備考	This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.\| This fulltext file will be available in Apr. 2025.\|
発行日	2024-04-15
出版物タイトル	Nutrition and Cancer
出版者	Informa UK Limited
ISSN	0163-5581
NCID	AA00325612
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	38619145
DOI	10.1080/01635581.2024.2340782
Web of Science KeyUT	001202947500001
関連URL	isVersionOf https://doi.org/10.1080/01635581.2024.2340782

Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells

JaLCDOI	10.18926/AMO/63425
フルテキストURL	76_2_203.pdf
著者	Masuda, Tomoya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Ieda, Takeshi\| Kikuchi, Satoru\| Kuroda, Shinji\| Noma, Kazuhiro\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
キーワード	esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	203
終了ページ	215
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503449
Web of Science KeyUT	000792291900003

Outcomes of solitary postoperative recurrence of esophageal squamous cell carcinoma diagnosed with FDG-PET/CT and treated with definitive radiation therapy

フルテキストURL	fulltext.pdf
著者	Ihara, Hiroki\| Yoshio, Kotaro\| Tanabe, Shunsuke\| Sugiyama, Soichi\| Hashimoto, Masashi\| Maeda, Naoaki\| Akagi, Shinsuke\| Takao, Soshi\| Noma, Kazuhiro\| Hiraki, Takao\|
キーワード	Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival
備考	The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4\|
発行日	2023-04-07
出版物タイトル	Esophagus
巻	20巻
号	3号
出版者	Springer Science and Business Media LLC
開始ページ	548
終了ページ	556
ISSN	1612-9059
NCID	AA11885266
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37027045
DOI	10.1007/s10388-023-01000-4
Web of Science KeyUT	000964113700001
関連URL	isVersionOf https://doi.org/10.1007/s10388-023-01000-4

Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer

JaLCDOI	10.18926/AMO/54981
フルテキストURL	71_2_127.pdf
著者	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Maeda, Naoaki\| Tanabe, Shunsuke\| Kuroda, Shinji\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Katayama, Norihisa\| Kanazawa, Susumu\| Fujiwara, Toshiyoshi\|
抄録	Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.
キーワード	esophageal cancer radiation therapy high-risk patient
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2017-04
巻	71巻
号	2号
出版者	Okayama University Medical School
開始ページ	127
終了ページ	133
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	28420894

Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer

フルテキストURL	fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf
著者	Kajiwara, Yoshinori\| Tazawa, Hiroshi\| Yamada, Motohiko\| Kanaya, Nobuhiko\| Fushimi, Takuro\| Kikuchi, Satoru\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
キーワード	Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x\| This full-text of the article will be available in Nov. 2023.\|
発行日	2022-11-27
出版物タイトル	Cancer Immunology, Immunotherapy
巻	72巻
号	5号
出版者	Springer Science and Business Media LLC
開始ページ	1285
終了ページ	1300
ISSN	0340-7004
NCID	AA00598499
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
論文のバージョン	author
PubMed ID	36436021
DOI	10.1007/s00262-022-03334-x
Web of Science KeyUT	000889040300003
関連URL	isVersionOf https://doi.org/10.1007/s00262-022-03334-x

野間 和広