フルテキストURL | fulltext.pdf |
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著者 | Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki| |
キーワード | colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever |
発行日 | 2021-12-09 |
出版物タイトル | DEN Open |
巻 | 2巻 |
号 | 1号 |
出版者 | Wiley |
開始ページ | e83 |
ISSN | 2692-4609 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 The Authors. |
論文のバージョン | publisher |
PubMed ID | 35310725 |
DOI | 10.1002/deo2.83 |
Web of Science KeyUT | 001047024900091 |
関連URL | isVersionOf https://doi.org/10.1002/deo2.83 |
フルテキストURL | fulltext.pdf |
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著者 | Terasawa, Hiroyuki| Kinugasa, Hideaki| Nouso, Kazuhiro| Yamamoto, Shumpei| Hirai, Mami| Tanaka, Takehiro| Takaki, Akinobu| Okada, Hiroyuki| |
キーワード | Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA |
発行日 | 2021-11-07 |
出版物タイトル | World Journal Of Gastroenterology |
巻 | 27巻 |
号 | 41号 |
出版者 | Baishideng Publishing Group Inc |
開始ページ | 7134 |
終了ページ | 7143 |
ISSN | 1007-9327 |
NCID | AA12048247 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2021. |
論文のバージョン | publisher |
PubMed ID | 34887633 |
DOI | 10.3748/wjg.v27.i41.7134 |
Web of Science KeyUT | 000728118700010 |
関連URL | isVersionOf https://doi.org/10.3748/wjg.v27.i41.7134 |
フルテキストURL | fulltext.pdf |
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著者 | Kinugasa, Hideaki| Kanzaki, Hiromitsu| Tanaka, Takehiro| Yamamoto, Shumpei| Yamasaki, Yasushi| Nouso, Kazuhiro| Ichimura, Kouichi| Nakagawa, Masahiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki| |
発行日 | 2021-11 |
出版物タイトル | Clinical and Translational Gastroenterology |
巻 | 12巻 |
号 | 11号 |
出版者 | Lippincott Williams & Wilkins |
開始ページ | e00424 |
ISSN | 2155-384X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 The Author(s). |
論文のバージョン | publisher |
PubMed ID | 34797780 |
DOI | 10.14309/ctg.0000000000000424 |
Web of Science KeyUT | 000720492100001 |
関連URL | isVersionOf https://doi.org/10.14309/ctg.0000000000000424 |
フルテキストURL | fulltext.pdf |
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著者 | Kinugasa, Hideaki| Hiraoka, Sakiko| Nouso, Kazuhiro| Yamamoto, Shumpei| Hirai, Mami| Terasawa, Hiroyuki| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Yamasaki, Yasushi| Inokuchi, Toshihiro| Takahara, Masahiro| Harada, Keita| Tanaka, Takehiro| Okada, Hiroyuki| |
キーワード | IBD-associated neoplasia IBD-associated cancer Liquid biopsy ctDNA |
発行日 | 2020-12-03 |
出版物タイトル | BMC Cancer |
巻 | 20巻 |
号 | 1号 |
出版者 | BMC |
開始ページ | 1188 |
ISSN | 1471-2407 |
NCID | AA12034763 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s). 2020 |
論文のバージョン | publisher |
PubMed ID | 33272240 |
DOI | 10.1186/s12885-020-07699-z |
Web of Science KeyUT | 000597268700004 |
関連URL | isVersionOf https://doi.org/10.1186/s12885-020-07699-z |
JaLCDOI | 10.18926/AMO/53520 |
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フルテキストURL | 69_3_137.pdf |
著者 | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
抄録 | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
キーワード | primary biliary cirrhosis keratin 7 hepatic failure |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-06 |
巻 | 69巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 144 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26101189 |
Web of Science KeyUT | 000356903000002 |
著者 | Uchida, Daisuke| Shiraha, Hidenori| Kato, Hironari| Nagahara, Teruya| Iwamuro, Masaya| Kataoka, Junro| Horiguchi, Shigeru| Watanabe, Masami| Takaki, Akinobu| Nouso, Kazuhiro| Nasu, Yasutomo| Yagi, Takahito| Kumon, Hiromi| Yamamoto, Kazuhide| |
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発行日 | 2014-05 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 29巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52894 |
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フルテキストURL | 68_5_263.pdf |
著者 | Namba, Shihoko| Miyake, Kayoko| Ikeda, Fusao| Hazama, Tomoko| Hitobe, Yu| Yamasaki, Noriko| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
抄録 | Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p=0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence. |
キーワード | chronic hepatitis C nursing support interferon therapy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-10 |
巻 | 68巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 263 |
終了ページ | 268 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25338482 |
Web of Science KeyUT | 000343269300002 |
著者 | Matsushita, Hiroshi| Ikeda, Fusao| Iwasaki, Yoshiaki| Seki, Hiroyuki| Nanba, Shintaro| Takeuchi, Yasuto| Moritou, Yuki| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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発行日 | 2014-02 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 29巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Ohnishi, Atsuyuki| Miyake, Yasuhiro| Matsushita, Hiroshi| Matsumoto, Kazuyuki| Takaki, Akinobu| Yasunaka, Tetsuya| Koike, Kazuko| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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発行日 | 2012 |
出版物タイトル | Digestion |
巻 | 86巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
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発行日 | 2011-01 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 26巻 |
号 | 1号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52139 |
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フルテキストURL | 68_1_17.pdf |
著者 | Moritou, Yuki| Ikeda, Fusao| Iwasaki, Yoshiaki| Baba, Nobuyuki| Takaguchi, Kouichi| Senoh, Tomonori| Nagano, Takuya| Takeuchi, Yasuto| Yasunaka, Tetsuya| Ohnishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
抄録 | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p=0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p=0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p=0.049, and <0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. |
キーワード | hepatic steatosis genetic polymorphism interferon HCV |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-02 |
巻 | 68巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 17 |
終了ページ | 22 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24553484 |
Web of Science KeyUT | 000331592800003 |
著者 | Kinugasa, Hideaki| Nouso, Kazuhiro| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Nakamura, Shin-ichiro| Shiraha, Hidenori| Kuwaki, Kenji| Hagihara, Hiroaki| Ikeda, Fusao| Miyake, Yasuhiro| Takaki, Akinobu| Yamamoto, Kazuhide| |
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発行日 | 2012-04 |
出版物タイトル | Journal of Gastroenterology |
巻 | 47巻 |
号 | 4号 |
資料タイプ | 学術雑誌論文 |
著者 | Matsubara, Minoru| Shiraha, Hidenori| Kataoka, Jyunro| Iwamuro, Masaya| Horiguchi, Shigeru| Nishina, Shin-ichi| Takaoka, Nobuyuki| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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発行日 | 2012-10 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 27巻 |
号 | 10号 |
資料タイプ | 学術雑誌論文 |
著者 | Nishimura, Mamoru| Takaki, Akinobu| Tamaki, Naofumi| Maruyama, Takayuki| Onishi, Hideki| Kobayashi, Sayo| Nouso, Kazuhiro| Yasunaka, Tetsuya| Koike, Kazuko| Hagihara, Hiroaki| Kuwaki, Kenji| Nakamura, Shinichiro| Ikeda, Fusao| Iwasaki, Yoshiaki| Tomofuji, Takaaki| Morita, Manabu| Yamamoto, Kazuhide| |
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発行日 | 2013-01-30 |
出版物タイトル | Hepatology Research |
巻 | 43巻 |
号 | 10号 |
資料タイプ | 学術雑誌論文 |
著者 | Tsutsumi, Koichiro| Kawamoto, Hirofumi| Hirao, Ken| Sakakihara, Ichiro| Yamamoto, Naoki| Noma, Yasuhiro| Fujii, Masakuni| Kato, Hironari| Ogawa, Tsuneyoshi| Ishida, Etsuji| Kuwaki, Kenji| Nouso, Kazuhiro| Okada, Hiroyuki| Yamamoto, Kazuhide| |
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発行日 | 2012-09 |
出版物タイトル | Pancreatology |
巻 | 12巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
著者 | Kobayashi, Sayo| Nouso, Kazuhiro| Kinugasa, Hideaki| Takeuchi, Yasuto| Tomoda, Takeshi| Miyahara, Koji| Hagihara, Hiroaki| Kuwaki, Kenji| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Yamamoto, Kazuhide| |
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発行日 | 2012-12 |
出版物タイトル | Hepatology Research |
巻 | 42巻 |
号 | 12号 |
資料タイプ | 学術雑誌論文 |
著者 | Tanaka, Shigetomi| Shiraha, Hidenori| Nakanishi, Yutaka| Nishina, Shin-Ichi| Matsubara, Minoru| Horiguchi, Shigeru| Takaoka, Nobuyuki| Iwamuro, Masaya| Kataoka, Junro| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
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発行日 | 2012-12-01 |
出版物タイトル | International Journal of Cancer |
巻 | 131巻 |
号 | 11号 |
資料タイプ | 学術雑誌論文 |
著者 | Snyderwine, Elizabeth G.| Davis, Cindy D.| Nouso, Kazuhiro| RoIler, Peter P.| Schut, Herman A.J.| |
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発行日 | 1993-07 |
出版物タイトル | Carcinogenesis |
巻 | 14巻 |
号 | 7号 |
資料タイプ | 学術雑誌論文 |
著者 | Kanzaki, Hiromitsu| Nouso, Kazuhiro| Miyahara, Koji| Kajikawa, Naoko| Kobayashi, Sayo| Sakakihara, Ichiro| Iwadow, Shota| Uematsu, Shuji| Okamoto, Ryoichi| Shiraga, Kunihiro| Mizuno, Motowo| Araki, Yasuyuki| |
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発行日 | 2009-09-01 |
出版物タイトル | Cases Journal |
巻 | 2巻 |
資料タイプ | 学術雑誌論文 |
著者 | Takuma, Yoshitaka| Nouso, Kazuhiro| |
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発行日 | 2010-03-28 |
出版物タイトル | World Journal of Gastroenterology |
巻 | 16巻 |
号 | 12号 |
資料タイプ | 学術雑誌論文 |