能祖一裕

Prognostic Efficacy of the Albumin Grade in Patients with Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/67662
フルテキストURL	78_5_377.pdf
著者	Hirano, Yuichi\| Nouso, Kazuhiro\| Kariyama, Kazuya\| Hiraoka, Atsushi\| Shiota, Shohei\| Wakuta, Akiko\| Yasuda, Satoshi\| Toyoda, Hidenori\| Tsuji, Kunihiko\| Hatanaka, Takeshi\| Kakizaki, Satoru\| Naganuma, Atsushi\| Tada, Toshifumi\| Itobayashi, Ei\| Ishikawa, Toru\| Shimada, Noritomo\| Takaguchi, Koichi\| Tsutsui, Akemi\| Nagano, Takuya\| Imai, Michitaka\| Nakamura, Shinichiro\| Kumada, Takashi\| Real-Life Practice Experts for HCC (RELPEC) Study Group in Japan\|
抄録	We previously found that “albumin grade”, formerly called the “ALBS grade,” demonstrated significant capability for prognostic stratification in hepatocellular carcinoma (HCC) patients treated with lenvatinib. The purpose of the present study was to compare the performance of the albumin grade with that of the modified albumin-bilirubin (mALBI) grade in predicting overall survival of HCC patients with different BCLC stages and treatment types. We enrolled 7,645 Japanese patients newly diagnosed with HCC using the Akaike information criteria (AIC), likelihood ratio, and C-index in different Barcelona Clinic Liver Cancer (BCLC) stages and treatments. The albumin grade showed similar and slightly better performance than the mALBI grade for BCLC stage 0 and A and especially for patients who underwent curative surgery and ablation. In patients treated with transcatheter arterial chemoembolization, molecular targeted agents, and the best supportive care, the mALBI grade had better performance than the albumin grade. However, the differences of the indices were very small in all scenarios. Overall, the albumin grade was comparable in efficacy to the mALBI grade, showing particular benefit for patients with early-stage HCC.
キーワード	albumin grade hepatocellular carcinoma modified albumin-bilirubin grade
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-10
巻	78巻
号	5号
出版者	Okayama University Medical School
開始ページ	377
終了ページ	386
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	39467656
Web of Science KeyUT	001343346400004

Fever and electrocoagulation syndrome after colorectal endoscopic submucosal dissection for patients with immunosuppressants and steroids

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shumpei\| Kinugasa, Hideaki\| Yamasaki, Yasushi\| Hirai, Mami\| Ako, Soichiro\| Takei, Kensuke\| Igawa, Shoko\| Yasutomi, Eriko\| Oka, Shohei\| Ohmori, Masayasu\| Inokuchi, Toshihiro\| Harada, Keita\| Hiraoka, Sakiko\| Nouso, Kazuhiro\| Tanaka, Takehiro\| Okada, Hiroyuki\|
キーワード	colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever
発行日	2021-12-09
出版物タイトル	DEN Open
巻	2巻
号	1号
出版者	Wiley
開始ページ	e83
ISSN	2692-4609
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	35310725
DOI	10.1002/deo2.83
Web of Science KeyUT	001047024900091
関連URL	isVersionOf https://doi.org/10.1002/deo2.83

Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma

フルテキストURL	fulltext.pdf
著者	Terasawa, Hiroyuki\| Kinugasa, Hideaki\| Nouso, Kazuhiro\| Yamamoto, Shumpei\| Hirai, Mami\| Tanaka, Takehiro\| Takaki, Akinobu\| Okada, Hiroyuki\|
キーワード	Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA
発行日	2021-11-07
出版物タイトル	World Journal Of Gastroenterology
巻	27巻
号	41号
出版者	Baishideng Publishing Group Inc
開始ページ	7134
終了ページ	7143
ISSN	1007-9327
NCID	AA12048247
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
PubMed ID	34887633
DOI	10.3748/wjg.v27.i41.7134
Web of Science KeyUT	000728118700010
関連URL	isVersionOf https://doi.org/10.3748/wjg.v27.i41.7134

The Impact of KRAS Mutation in Patients With Sporadic Nonampullary Duodenal Epithelial Tumors

フルテキストURL	fulltext.pdf
著者	Kinugasa, Hideaki\| Kanzaki, Hiromitsu\| Tanaka, Takehiro\| Yamamoto, Shumpei\| Yamasaki, Yasushi\| Nouso, Kazuhiro\| Ichimura, Kouichi\| Nakagawa, Masahiro\| Mitsuhashi, Toshiharu\| Okada, Hiroyuki\|
発行日	2021-11
出版物タイトル	Clinical and Translational Gastroenterology
巻	12巻
号	11号
出版者	Lippincott Williams & Wilkins
開始ページ	e00424
ISSN	2155-384X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s).
論文のバージョン	publisher
PubMed ID	34797780
DOI	10.14309/ctg.0000000000000424
Web of Science KeyUT	000720492100001
関連URL	isVersionOf https://doi.org/10.14309/ctg.0000000000000424

Liquid biopsy for patients with IBD-associated neoplasia

フルテキストURL	fulltext.pdf
著者	Kinugasa, Hideaki\| Hiraoka, Sakiko\| Nouso, Kazuhiro\| Yamamoto, Shumpei\| Hirai, Mami\| Terasawa, Hiroyuki\| Yasutomi, Eriko\| Oka, Shohei\| Ohmori, Masayasu\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Takahara, Masahiro\| Harada, Keita\| Tanaka, Takehiro\| Okada, Hiroyuki\|
キーワード	IBD-associated neoplasia IBD-associated cancer Liquid biopsy ctDNA
発行日	2020-12-03
出版物タイトル	BMC Cancer
巻	20巻
号	1号
出版者	BMC
開始ページ	1188
ISSN	1471-2407
NCID	AA12034763
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	33272240
DOI	10.1186/s12885-020-07699-z
Web of Science KeyUT	000597268700004
関連URL	isVersionOf https://doi.org/10.1186/s12885-020-07699-z

Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis

JaLCDOI	10.18926/AMO/53520
フルテキストURL	69_3_137.pdf
著者	Seki, Hiroyuki\| Ikeda, Fusao\| Nanba, Shintaro\| Moritou, Yuki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Nakamura, Minoru\| Yamamoto, Kazuhide\|
抄録	A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis.
キーワード	primary biliary cirrhosis keratin 7 hepatic failure
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-06
巻	69巻
号	3号
出版者	Okayama University Medical School
開始ページ	137
終了ページ	144
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26101189
Web of Science KeyUT	000356903000002

Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer

著者	Uchida, Daisuke\| Shiraha, Hidenori\| Kato, Hironari\| Nagahara, Teruya\| Iwamuro, Masaya\| Kataoka, Junro\| Horiguchi, Shigeru\| Watanabe, Masami\| Takaki, Akinobu\| Nouso, Kazuhiro\| Nasu, Yasutomo\| Yagi, Takahito\| Kumon, Hiromi\| Yamamoto, Kazuhide\|
発行日	2014-05
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	29巻
号	5号
資料タイプ	学術雑誌論文

Nursing Support Increases the Efficacy of Interferon Therapy in Patients with Chronic Hepatitis C

JaLCDOI	10.18926/AMO/52894
フルテキストURL	68_5_263.pdf
著者	Namba, Shihoko\| Miyake, Kayoko\| Ikeda, Fusao\| Hazama, Tomoko\| Hitobe, Yu\| Yamasaki, Noriko\| Shiraha, Hidenori\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
抄録	Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence.
キーワード	chronic hepatitis C nursing support interferon therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-10
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	263
終了ページ	268
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338482
Web of Science KeyUT	000343269300002

Assessment of health-related quality of life and how it predicts the outcome of pegylated interferon and ribavirin therapy for chronic hepatitis C

著者	Matsushita, Hiroshi\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Seki, Hiroyuki\| Nanba, Shintaro\| Takeuchi, Yasuto\| Moritou, Yuki\| Yasunaka, Tetsuya\| Onishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2014-02
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	29巻
号	2号
資料タイプ	学術雑誌論文

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

著者	Ohnishi, Atsuyuki\| Miyake, Yasuhiro\| Matsushita, Hiroshi\| Matsumoto, Kazuyuki\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Koike, Kazuko\| Ikeda, Fusao\| Shiraha, Hidenori\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012
出版物タイトル	Digestion
巻	86巻
号	2号
資料タイプ	学術雑誌論文

Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure

著者	Takayama, Hiroki\| Miyake, Yasuhiro\| Nouso, Kazuhiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Kobashi, Haruhiko\| Yamamoto, Kazuhide\|
発行日	2011-01
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	26巻
号	1号
資料タイプ	学術雑誌論文

Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor

JaLCDOI	10.18926/AMO/52139
フルテキストURL	68_1_17.pdf
著者	Moritou, Yuki\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Baba, Nobuyuki\| Takaguchi, Kouichi\| Senoh, Tomonori\| Nagano, Takuya\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Ohnishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
抄録	The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy.
キーワード	hepatic steatosis genetic polymorphism interferon HCV
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	17
終了ページ	22
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553484
Web of Science KeyUT	000331592800003

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

著者	Kinugasa, Hideaki\| Nouso, Kazuhiro\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Nakamura, Shin-ichiro\| Shiraha, Hidenori\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Ikeda, Fusao\| Miyake, Yasuhiro\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-04
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	4号
資料タイプ	学術雑誌論文

Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma

著者	Matsubara, Minoru\| Shiraha, Hidenori\| Kataoka, Jyunro\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Nishina, Shin-ichi\| Takaoka, Nobuyuki\| Uemura, Masayuki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012-10
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	27巻
号	10号
資料タイプ	学術雑誌論文

Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma

著者	Nishimura, Mamoru\| Takaki, Akinobu\| Tamaki, Naofumi\| Maruyama, Takayuki\| Onishi, Hideki\| Kobayashi, Sayo\| Nouso, Kazuhiro\| Yasunaka, Tetsuya\| Koike, Kazuko\| Hagihara, Hiroaki\| Kuwaki, Kenji\| Nakamura, Shinichiro\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Tomofuji, Takaaki\| Morita, Manabu\| Yamamoto, Kazuhide\|
発行日	2013-01-30
出版物タイトル	Hepatology Research
巻	43巻
号	10号
資料タイプ	学術雑誌論文

Monitoring of CA19-9 and SPan-1 can facilitate the earlier confirmation of progressing pancreatic cancer during chemotherapy

著者	Tsutsumi, Koichiro\| Kawamoto, Hirofumi\| Hirao, Ken\| Sakakihara, Ichiro\| Yamamoto, Naoki\| Noma, Yasuhiro\| Fujii, Masakuni\| Kato, Hironari\| Ogawa, Tsuneyoshi\| Ishida, Etsuji\| Kuwaki, Kenji\| Nouso, Kazuhiro\| Okada, Hiroyuki\| Yamamoto, Kazuhide\|
発行日	2012-09
出版物タイトル	Pancreatology
巻	12巻
号	5号
資料タイプ	学術雑誌論文

Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma

著者	Kobayashi, Sayo\| Nouso, Kazuhiro\| Kinugasa, Hideaki\| Takeuchi, Yasuto\| Tomoda, Takeshi\| Miyahara, Koji\| Hagihara, Hiroaki\| Kuwaki, Kenji\| Onishi, Hideki\| Nakamura, Shinichiro\| Ikeda, Fusao\| Miyake, Yasuhiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-12
出版物タイトル	Hepatology Research
巻	42巻
号	12号
資料タイプ	学術雑誌論文

著者	Tanaka, Shigetomi\| Shiraha, Hidenori\| Nakanishi, Yutaka\| Nishina, Shin-Ichi\| Matsubara, Minoru\| Horiguchi, Shigeru\| Takaoka, Nobuyuki\| Iwamuro, Masaya\| Kataoka, Junro\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Toshimori, Junichi\| Ohnishi, Hideki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2012-12-01
出版物タイトル	International Journal of Cancer
巻	131巻
号	11号
資料タイプ	学術雑誌論文

32P-Postlabeling analysis of IQ, MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx- and PhIP-treated monkeys

著者	Snyderwine, Elizabeth G.\| Davis, Cindy D.\| Nouso, Kazuhiro\| RoIler, Peter P.\| Schut, Herman A.J.\|
発行日	1993-07
出版物タイトル	Carcinogenesis
巻	14巻
号	7号
資料タイプ	学術雑誌論文

A case of hepatocellular carcinoma with skin injury of the upper abdominal wall after transcatheter arterial chemoembolization: a case report

著者	Kanzaki, Hiromitsu\| Nouso, Kazuhiro\| Miyahara, Koji\| Kajikawa, Naoko\| Kobayashi, Sayo\| Sakakihara, Ichiro\| Iwadow, Shota\| Uematsu, Shuji\| Okamoto, Ryoichi\| Shiraga, Kunihiro\| Mizuno, Motowo\| Araki, Yasuyuki\|
発行日	2009-09-01
出版物タイトル	Cases Journal
巻	2巻
資料タイプ	学術雑誌論文

能祖 一裕