前田嘉信

Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition

フルテキストURL	fulltext20221223-3.pdf NA_Itano_Fig.pdf supl20221223-3.pdf NA_Itano_Supl.pdf
著者	Itano, Junko\| Taniguchi, Akihiko\| Senoo, Satoru\| Asada, Noboru\| Gion, Yuka\| Egusa, Yuria\| Guo, Lili\| Oda, Naohiro\| Araki, Kota\| Sato, Yasuharu\| Toyooka, Shinichi\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Miyahara, Nobuaki\|
キーワード	idiopathic pulmonary fibrosis NPY IL-1 beta; bleomycin bronchial epithelial cells
備考	Originally Published in:Itano J, Taniguchi A, Senoo S, Asada N, Gion Y, Egusa Y, Guo L, Oda N, Araki K, Sato Y, Toyooka S, Kiura K, Maeda Y, Miyahara N. Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition. Am J Respir Cell Mol Biol. 2022 Dec;67(6):654-665. DOI: 10.1165/rcmb.2021-0542OC Copyright © 2022 by the American Thoracic Society The final publication is available at https://doi.org/10.1165/rcmb.2021-0542OC \| This full-text will be available in Dec. 2023.\|
発行日	2022-12
出版物タイトル	American Journal of Respiratory Cell and Molecular Biology
巻	67巻
号	6号
出版者	American Thoracic Society
開始ページ	654
終了ページ	665
ISSN	1044-1549
NCID	AA10707251
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the American Thoracic Society
論文のバージョン	author
PubMed ID	36122332
DOI	10.1165/rcmb.2021-0542oc
Web of Science KeyUT	000891796900010
関連URL	isVersionOf https://doi.org/10.1165/rcmb.2021-0542oc

Nintedanib can be used safely and effectively for idiopathic pulmonary fibrosis with predicted forced vital capacity <= 50%: A multi-center retrospective analysis

フルテキストURL	fulltext.pdf
著者	Senoo, Satoru\| Miyahara, Nobuaki\| Taniguchi, Akihiko\| Oda, Naohiro\| Itano, Junko\| Higo, Hisao\| Hara, Naofumi\| Watanabe, Hiromi\| Kano, Hirohisa\| Suwaki, Toshimitsu\| Fuchimoto, Yasuko\| Kajimoto, Kazuhiro\| Ichikawa, Hirohisa\| Kudo, Kenichiro\| Shibayama, Takuo\| Tanimoto, Yasushi\| Kuyama, Shoichi\| Kanehiro, Arihiko\| Maeda, Yoshinobu\| Kiura, Katsuyuki\| Okayama Respiratory Disease Study Group (ORDSG)\|
発行日	2020-08-27
出版物タイトル	PLoS ONE
巻	15巻
号	8号
出版者	Public Library of Science
開始ページ	e0236935
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Senoo et al.
論文のバージョン	publisher
PubMed ID	32853277
DOI	10.1371/journal.pone.0236935
Web of Science KeyUT	000566948800009
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0236935

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea During Treatment: A Case Report and Literature Review

フルテキストURL	fulltext.pdf
著者	Kitamura, Wataru\| Ennishi, Daisuke\| Yukawa, Ryoya\| Sasaki, Ryo\| Yoshida, Chikamasa\| Takasuka, Hiroki\| Fujiwara, Hideaki\| Asada, Noboru\| Nishimori, Hisakazu\| Fujii, Keiko\| Fujii, Nobuharu\| Matsuoka, Ken-Ichi\| Abe, Koji\| Yoshino, Tadashi\| Maeda, Yoshinobu\|
キーワード	peripheral T-cell lymphoma chorea single photon-emission computed tomography
発行日	2021-10-01
出版物タイトル	Internal Medicine
巻	60巻
号	19号
出版者	The Japanese Society of Internal Medicine
開始ページ	3155
終了ページ	3160
ISSN	0918-2918
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	33814503
DOI	10.2169/internalmedicine.7180-21
Web of Science KeyUT	000706487700015
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.7180-21

Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen

著者	Takahashi, Kanayo\| Soga, Yoshihiko\| Murayama, Yumeno\| Udagawa, Mika\| Nishimoto, Hitomi\| Sugiura, Yuko\| Maeda, Yoshinobu\| Tanimoto, Mitsune\| Takashiba, Shogo\|
発行日	2010-01
出版物タイトル	Supportive Care in Cancer
巻	18巻
号	1号
資料タイプ	学術雑誌論文

PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer

フルテキストURL	fulltext20230421-01.pdf figure20230421-01.pdf
著者	Nakasuka, Takamasa\| Ohashi, Kadoaki\| Nishii, Kazuya\| Hirabae, Atsuko\| Okawa, Sachi\| Tomonobu, Nahoko\| Takada, Kenji\| Ando, Chihiro\| Watanabe, Hiromi\| Makimoto, Go\| Ninomiya, Kiichiro\| Fujii, Masanori\| Kubo, Toshio\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Kumon, Hiromi\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
キーワード	EGFR mutation Non-small cell lung cancer Antitumor immunity Non-inflamed tumor Ad-SGE-REIC Gene therapy PD-1
備考	©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.lungcan.2023.01.018.\| This fulltext file will be available in Apr. 2024.\|
発行日	2023-04
出版物タイトル	Lung Cancer
巻	178巻
出版者	Elsevier BV
開始ページ	1
終了ページ	10
ISSN	0169-5002
NCID	AA10785743
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Elsevier B.V.
論文のバージョン	author
PubMed ID	36753780
DOI	10.1016/j.lungcan.2023.01.018
Web of Science KeyUT	000931976300001
関連URL	isVersionOf https://doi.org/10.1016/j.lungcan.2023.01.018

Particle and Heavy Ion Transport Code System‐Based Microdosimetry for the Development of Boron Agents for Boron Neutron Capture Therapy

フルテキストURL	fulltext20230530-01.pdf
著者	Shigehira, Takafumi\| Hanafusa, Tadashi\| Igawa, Kazuyo\| Kasai, Tomonari\| Furuya, Shuichi\| Nishimori, Hisakazu\| Maeda, Yoshinobu\| Michiue, Hiroyuki\| Fujimura, Atsushi\|
キーワード	boron agents boron neutron capture therapy simulation study
備考	This is the peer reviewed version of the following article: T. Shigehira, T. Hanafusa, K. Igawa, T. Kasai, S. Furuya, H. Nishimori, Y. Maeda, H. Michiue, A. Fujimura, Particle and Heavy Ion Transport Code System-Based Microdosimetry for the Development of Boron Agents for Boron Neutron Capture Therapy. Adv. Theory Simul. 2023, 6, 2300163. https://doi.org/10.1002/adts.202300163, which has been published in final form at https://doi.org/10.1002/adts.202300163. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext file will be available in Apr. 2024.\|
発行日	2023-04-28
出版物タイトル	Advanced Theory and Simulations
巻	6巻
号	7号
出版者	Wiley
開始ページ	2300163
ISSN	2513-0390
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Wiley-VCH GmbH
論文のバージョン	author
DOI	10.1002/adts.202300163
Web of Science KeyUT	000978086700001
関連URL	isVersionOf https://doi.org/10.1002/adts.202300163

Preparation of Enteric-coated Capsules of Beclomethasone Dipropionate for Patients with Intestinal Graft-versus-Host Disease and a Case Study

JaLCDOI	10.18926/AMO/51868
フルテキストURL	67_5_319.pdf
著者	Murakawa, Kiminaka\| Sato, Tomoaki\| Maeda, Yoshinobu\| Kitamura, Yoshihisa\| Tanimoto, Mitsune\| Sendo, Toshiaki\|
抄録	Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
キーワード	beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-10
巻	67巻
号	5号
出版者	Okayama University Medical School
開始ページ	319
終了ページ	324
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24145732
Web of Science KeyUT	000325836100006

Prevention of non-infectious pulmonary complications after intra-bone marrow stem cell transplantation in mice

フルテキストURL	fulltext.pdf
著者	Yamasuji-Maeda, Yoshiko\| Nishimori, Hisakazu\| Seike, Keisuke\| Yamamoto, Akira\| Fujiwara, Hideaki\| Kuroi, Taiga\| Saeki, Kyosuke\| Fujinaga, Haruko\| Okamoto, Sachiyo\| Matsuoka, Ken-Ichi\| Fujii, Nobuharu\| Tanaka, Takehiro\| Fujii, Masahiro\| Mominoki, Katsumi\| Kanekura, Takuro\| Maeda, Yoshinobu\|
発行日	2022-09-09
出版物タイトル	PLOS One
巻	17巻
号	9号
出版者	Public Library Science
開始ページ	e0273749
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Yamasuji-Maeda et al.
論文のバージョン	publisher
PubMed ID	36084023
DOI	10.1371/journal.pone.0273749
Web of Science KeyUT	000892051000058
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0273749

Progress of oral care and reduction of oral mucositis-a pilot study in a hematopoietic stem cell transplantation ward

著者	Soga, Yoshihiko\| Sugiura, Yuko\| Takahashi, Kanayo\| Nishimoto, Hitomi\| Maeda, Yoshinobu\| Tanimoto, Mitsune\| Takashiba, Shogo\|
発行日	2011-02
出版物タイトル	Supportive Care in Cancer
巻	19巻
号	2号
資料タイプ	学術雑誌論文

Pulmonary Aspergilloma and Allergic Bronchopulmonary Aspergillosis Following the 2018 Heavy Rain Event in Western Japan

フルテキストURL	fulltext.pdf
著者	Ando, Eri\| Nakasuka, Takamasa\| Kubo, Toshio\| Taniguchi, Akihiko\| Ninomiya, Kiichiro\| Kato, Yuka\| Ichihara, Eiki\| Ohashi, Kadoaki\| Rai, Kammei\| Hotta, Katsuyuki\| Yamane, Masaomi\| Miyahara, Nobuaki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
キーワード	pulmonary aspergilloma allergic bronchopulmonary aspergillosis disaster
発行日	2022-02-01
出版物タイトル	Internal Medicine
巻	61巻
号	3号
出版者	JAPAN SOC INTERNAL MEDICINE
開始ページ	379
終了ページ	383
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	34373373
DOI	10.2169/internalmedicine.7124-21
Web of Science KeyUT	000752787300015
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.7124-21

Radiation pneumonitis after definitive concurrent chemoradiotherapy with cisplatin/docetaxel for non-small cell lung cancer: Analysis of dose-volume parameters

フルテキストURL	fulltext.pdf
著者	Katsui, Kuniaki\| Ogata, Takeshi\| Watanabe, Kenta\| Katayama, Norihisa\| Kuroda, Masahiro\| Kiura, Katsuyuki\| Hiraki, Takao\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
キーワード	cisplatin docetaxel dose-volume histogram non-small cell lung cancer PACIFIC trial radiation pneumonitis
発行日	2020-05-04
出版物タイトル	Cancer Medicine
出版者	Wiley
ISSN	2045-7634
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	32364685
DOI	10.1002/cam4.3093
Web of Science KeyUT	000530411600001
関連URL	isVersionOf https://doi.org/10.1002/cam4.3093

Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden

フルテキストURL	J_Thorac_Oncol_201907017.pdf
著者	Makimoto, Go\| Ohashi, Kadoaki\| Tomida, Shuta\| Nishii, Kazuya\| Matsubara, Takehiro\| Kayatani, Hiroe\| Higo, Hisao\| Ninomiya, Kiichiro\| Sato, Akiko\| Watanabe, Hiromi\| Kano, Hirohisa\| Ninomiya, Takashi\| Kubo, Toshio\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Toyooka, Shinichi\| Takata, Minoru\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
キーワード	ALK G1202R Alectinib Amphiregulin MET NSCLC
発行日	2019-07-30
出版物タイトル	Journal of Thoracic Oncology
巻	14巻
号	11号
出版者	Elsevier
開始ページ	2009
終了ページ	2018
ISSN	15560864
NCID	AA12058455
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
論文のバージョン	author
PubMed ID	31374369
DOI	10.1016/j.jtho.2019.07.017
Web of Science KeyUT	000492678300025
関連URL	isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017

Rapid Disease Progression of Advanced Non-small Cell Lung Cancer Five Months after Cessation of Pembrolizumab

JaLCDOI	10.18926/AMO/60802
フルテキストURL	74_5_423.pdf
著者	Hirabae, Atsuko\| Ichihara, Eiki\| Sunami, Ryota\| Ota, Moeko\| Iwamoto, Yoshitaka\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
抄録	We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks.
キーワード	lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-10
巻	74巻
号	5号
出版者	Okayama University Medical School
開始ページ	423
終了ページ	425
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33106698
Web of Science KeyUT	000581970100007
NAID	120006892928

Reduced dose of PTCy followed by adjuvant alpha-galactosylceramide enhances GVL effect without sacrificing GVHD suppression

フルテキストURL	fulltext.pdf
著者	Nakamura, Makoto\| Meguri, Yusuke\| Ikegawa, Shuntaro\| Kondo, Takumi\| Sumii, Yuichi\| Fukumi, Takuya\| Iwamoto, Miki\| Sando, Yasuhisa\| Sugiura, Hiroyuki\| Asada, Noboru\| Ennishi, Daisuke\| Tomida, Shuta\| Fukuda-Kawaguchi, Emi\| Ishii, Yasuyuki\| Maeda, Yoshinobu\| Matsuoka, Ken-Ichi\|
発行日	2021-06-23
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	13125
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34162921
DOI	10.1038/s41598-021-92526-z
Web of Science KeyUT	000669995600012
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-92526-z

Responses of regulatory and effector T-cells to low-dose interleukin-2 differ depending on the immune environment after allogeneic stem cell transplantation

フルテキストURL	fulltext.pdf
著者	Meguri, Yusuke\| Asano, Takeru\| Yoshioka, Takanori\| Iwamoto, Miki\| Ikegawa, Shuntaro\| Sugiura, Hiroyuki\| Kishi, Yuriko\| Nakamura, Makoto\| Sando, Yasuhisa\| Kondo, Takumi\| Sumii, Yuichi\| Maeda, Yoshinobu\| Matsuoka, Ken-Ichi\|
キーワード	regulatory T cell low-dose interleukin-2 therapy graft-versus-host disease graft-versus-leukemia effect transplantation tolerance
発行日	2022-08-02
出版物タイトル	Frontiers In Immunology
巻	13巻
出版者	Frontiers Media
開始ページ	891925
ISSN	1664-3224
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka.
論文のバージョン	publisher
PubMed ID	35983059
DOI	10.3389/fimmu.2022.891925
Web of Science KeyUT	000844642000001
関連URL	isVersionOf https://doi.org/10.3389/fimmu.2022.891925

Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis

フルテキストURL	fulltext.pdf
著者	Katsui, Kuniaki\| Ogata, Takeshi\| Sugiyama, Soichi\| Yoshio, Kotaro\| Kuroda, Masahiro\| Hiraki, Takao\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
発行日	2021-06-04
出版物タイトル	scientific reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	11882
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34088965
DOI	10.1038/s41598-021-91449-z
Web of Science KeyUT	000678611200010
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-91449-z

Secondary Pulmonary Alveolar Proteinosis Associated with Primary Myelofibrosis and Ruxolitinib Treatment: An Autopsy Case

フルテキストURL	fulltext.pdf
著者	Sugiura, Hiroyuki\| Nishimori, Hisakazu\| Nishii, Kazuya\| Toji, Tomohiro\| Fujii, Keiko\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Nakata, Koh\| Kiura, Katsuyuki\| Maeda, Yoshinobu\|
キーワード	pulmonary alveolar proteinosis primary myelofibrosis autopsy ruxolitinib
発行日	2020-08-15
出版物タイトル	Internal Medicine
巻	59巻
号	16号
開始ページ	2023
終了ページ	2028
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	32448830
DOI	10.2169/internalmedicine.4082-19
Web of Science KeyUT	000563078400014
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.4082-19

Sequential Combination of FLAM and Venetoclax plus Azacitidine to Bridge to Cord Blood Transplantation in a Patient with Primary Induction Failure Acute Myeloid Leukemia

フルテキストURL	fulltext.pdf
著者	Murakami, Hiroyuki\| Matsuoka, Ken-Ichi\| Asano, Takeru\| Moriyama, Takashi\| Matsumura, Akifumi\| Fujiwara, Hideaki\| Asada, Noboru\| Ennishi, Daisuke\| Nishimori, Hisakazu\| Fujii, Keiko\| Fujii, Nobuharu\| Toji, Tomohiro\| Yoshino, Tadashi\| Maeda, Yoshinobu\|
キーワード	Refractory acute myeloid leukemia Transplant B-cell lymphoma-2 Azacitidine Venetoclax
発行日	2022-11-08
出版物タイトル	Case Reports In Oncology
巻	15巻
号	3号
出版者	Karger
開始ページ	974
終了ページ	979
ISSN	1662-6575
NCID	AA12780955
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Author(s).
論文のバージョン	publisher
PubMed ID	36636684
DOI	10.1159/000526697
Web of Science KeyUT	000905485600025
関連URL	isVersionOf https://doi.org/10.1159/000526697

Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD

JaLCDOI	10.18926/AMO/66915
フルテキストURL	78_2_123.pdf
著者	Saeki, Kyosuke\| Fujiwara, Hideaki\| Seike, Keisuke\| Kuroi, Taiga\| Nishimori, Hisakazu\| Tanaka, Takehiro\| Matsuoka, Ken-ichi\| Fujii, Nobuharu\| Maeda, Yoshinobu\|
抄録	Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT.
キーワード	GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	134
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688830

Spontaneous regression of multiple solitary plasmacytoma harboring Epstein–Barr virus: a case report and literature review

著者	Kitamura, Wataru\| Kobayashi, Hiroki\| Noda, Minori\| Iseki, Akiko\| Sato, Yumi\| Maeda, Yoshinobu\| Kuyama, Shoichi\|
キーワード	Plasmacytoma Epstein–Barr virus Spontaneous regression
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12185-024-03765-5\| This fulltext file will be available in Apr. 2025.\|
発行日	2024-04-15
出版物タイトル	International Journal of Hematology
出版者	Springer Science and Business Media LLC
ISSN	0925-5710
NCID	AA10797094
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Japanese Society of Hematology 2024
論文のバージョン	author
PubMed ID	38619657
DOI	10.1007/s12185-024-03765-5
Web of Science KeyUT	001204755500002
関連URL	isVersionOf https://doi.org/10.1007/s12185-024-03765-5

前田 嘉信