JaLCDOI | 10.18926/AMO/54416 |
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フルテキストURL | 70_3_175.pdf |
著者 | Setiawan, Heri| Nagaoka, Kenjiro| Kubo, Masayuki| Fujikura, Yoshihisa| Ogino, Keiki| |
抄録 | Oxidative stress is widely known to play a role in asthma. However, the contribution of xanthine oxidoreductase (XOR) as a source of the superoxide anion radical (O2-) in oxidative stress associated with asthma has not yet been examined in detail. Here we investigated pathophysiological changes in XOR in an experimental model of asthma induced by the house dust mite Dermatophagoides farinae (Df). In the lungs of Df-treated mice, the production of O2- from XOR increased and the nitrite concentrations decreased, whereas the protein expression of XOR remained unchanged. Moreover, the protein expression levels of XOR and the hydrogen peroxide (H2O2) concentrations in bronchoalveolar lavage fluid (BALF) were higher in the Df-treated mice than in saline-treated mice. Immunohistochemically, although XOR was highly localized in the bronchial epithelial cells of the saline-treated mice, immunostaining for XOR was absent in the bronchial epithelium of Df-treated mice. These results suggest that oxidative stress is up-regulated by increases in the conversion of the dehydrogenase form (xanthine dehydrogenase; XDH) of XOR to the oxidase form (xanthine oxidase; XOD). |
キーワード | xanthine oxidase oxidative stress asthma |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2016-06 |
巻 | 70巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 175 |
終了ページ | 182 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 27339206 |
Web of Science KeyUT | 000379406100004 |
著者 | Zou, Yu| Wang, Da-Hong| Sakano, Noriko| Sato, Yoshie| Iwanaga, Suketaka| Taketa, Kazuhisa| Kubo, Masayuki| Takemoto, Kei| Masatomi, Chie| Inoue, Kiyomi| Ogino, Keiki| |
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発行日 | 2014-02 |
出版物タイトル | International Journal of Environmental Research and Public Health |
巻 | 11巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52652 |
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フルテキストURL | 68_3_129.pdf |
著者 | Minoura, Akira| Wang, Da-Hong| Sato, Yoshie| Zou, Yu| Sakano, Noriko| Kubo, Masayuki| Takemoto, Kei| Masatomi, Chie| Ogino, Keiki| |
抄録 | We examined the relationships between dietary carbohydrate, protein, fat, and the ratio of n6/n3 fatty acid intakes with the predicted 10-year coronary heart disease (CHD) risk in a general Japanese population. We used the Framingham risk score to determine the 10-year CHD risk of the subjects, who were employees of 6 companies in a single prefecture in Japan. After excluding the subjects who reported any history of angina pectoris, myocardial infarction, diabetes, or cancer, and those with missing data resulting in the inability of estimation of 10-year CHD risk and food intakes, the final data analysis was carried out for 809 subjects. The logistic regression models revealed a significantly increased odds ratio of 10-year CHD risk in the subjects with the highest tertile of carbohydrate intake (% energy) (odds ratio 3.64, 95% CI, 2.07-6.40);after adjustment for other variables, the odds ratio for the 10-year CHD risk was also higher in the subjects with the highest tertile of carbohydrate intake (odds ratio 1.72, 95% CI, 0.70-4.25). We also found that fat intake and the ratio of n6/n3 fatty acids were inversely associated with the predicted 10-year CHD risk (p for trend<0.01). The present findings added evidence of a positive association of dietary carbohydrate and inverse associations of total fat and n6/n3 fatty acid ratio with the predicted 10-year CHD risk in a general Japanese population. |
キーワード | fat intake carbohydrate intake ratio of n6/n3 fatty acids 10-year coronary heart disease risk Japanese |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-06 |
巻 | 68巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 129 |
終了ページ | 135 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24942790 |
Web of Science KeyUT | 000337655600001 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52516 |
著者 | Iwanaga, Suketaka| Sakano, Noriko| Taketa, Kazuhisa| Takahashi, Noriko| Wang, Da-Hong| Takahashi, Hidekazu| Kubo, Masayuki| Miyatake, Nobuyuki| Ogino, Keiki| |
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発行日 | 2013-02-01 |
出版物タイトル | Obesity Research & Clinical Practice |
資料タイプ | 学術雑誌論文 |
著者 | Inoue, Kiyomi| Sakano, Noriko| Ogino, Keiki| Sato, Yoshie| Wang, Da-Hong| Kubo, Masayuki| Takahashi, Hidekazu| Kanbara, Sakiko| Miyatake, Nobuyuki| |
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発行日 | 2013-03-01 |
出版物タイトル | Journal of Clinical Biochemistry and Nutrition |
巻 | 52巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |