ID | 31995 |
JaLCDOI | |
フルテキストURL | |
著者 |
Takeuchi, Mamoru
Okayama University
Morita, Kiyoshi
Okayama University
Oe, Katsunori
Okayama University
Taga, Naoyuki
Okayama University
Hirakawa, Masahisa
Okayama University
|
抄録 | To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P < 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis. |
キーワード | adrenomedullin
cardiopulmonary bypass
vasopressin
pediatric cardiac surgery
brain natriuretic peptide
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2001-08
|
巻 | 55巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 245
|
終了ページ | 252
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |