JaLCDOI | 10.18926/AMO/32914 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Miyake, Yasuhiro| Iwasaki, Yoshiaki| Ishikawa, Shin| Tatsukawa, Masashi| Nawa, Toru| Kato, Jun| Takaki, Akinobu| Kobashi, Haruhiko| Sakaguchi, Kohsaku| Shiratori, Yasushi| |
抄録 | We report herein a case with acute hepatitis due to hepatitis B virus genotype Ae, concurrent with amebic colitis. A 39-year-old homosexual Japanese man was admitted to our hospital with jaundice. Laboratory tests showed an elevation of transaminase and positivity for hepatitis B surface antigen and IgM-type antibody to hepatitis B core antigen. The hepatitis B virus genotype was determined to be Ae. Furthermore, a mud-like stool with blood and mucous had sometimes been noted during the past 3 years, and amebic colitis was shown by colonofi berscopy during hospitalization. The patient was diagnosed with acute hepatitis B, concurrent with amebic colitis, and was successfully treated with lamivudine and metronidazole. In Japanese patients with acute hepatitis B virus genotype A infection, homosexual activity tends to be high. Furthermore, in Japanese homosexual men, amebiasis has been increasing. Thus, in Japanese patients with acute hepatitis B, a determination of genotype should be performed in order to investigate the route of transmission of hepatitis B virus, and a search for amebiasis should be performed in patients with acute hepatitis due to hepatitis B virus genotype A. Furthermore, education of homosexual men regarding hepatitis B virus, hepatitis B virus vaccination, and amebiasis is urgently required. |
キーワード | hepatitis B virus genotype homosexual amebic colitis lamivudine |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-02 |
巻 | 61巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 35 |
終了ページ | 39 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17332840 |
Web of Science KeyUT | 000244432400005 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Afify, Said M.| Calle, Anna Sanchez| Hassan, Ghmkin| Kumon, Kazuki| Nawara, Hend M.| Zahra, Maram H.| Mansour, Hager M.| Khayrani, Apriliana Cahya| Alam, Md Jahangir| Du, Juan| Seno, Akimasa| Iwasaki, Yoshiaki| Seno, Masaharu| |
キーワード | Cancer models Cancer stem cells |
発行日 | 2020-03-17 |
出版物タイトル | British Journal of Cancer |
巻 | 122巻 |
号 | 9号 |
出版者 | Springer Nature |
開始ページ | 1378 |
終了ページ | 1390 |
ISSN | 0007-0920 |
NCID | AA00574355 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Authors |
論文のバージョン | publisher |
PubMed ID | 32203212 |
DOI | 10.1038/s41416-020-0792-z |
Web of Science KeyUT | 000519841900001 |
関連URL | isVersionOf https://doi.org/10.1038/s41416-020-0792-z |
JaLCDOI | 10.18926/AMO/53520 |
---|---|
フルテキストURL | 69_3_137.pdf |
著者 | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
抄録 | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
キーワード | primary biliary cirrhosis keratin 7 hepatic failure |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-06 |
巻 | 69巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 144 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26101189 |
Web of Science KeyUT | 000356903000002 |
JaLCDOI | 10.18926/AMO/32825 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Nakajima, Hirofumi| Shimomura, Hiroyuki| Iwasaki, Yoshiaki| Ikeda, Fusao| Umeoka, Fumi| Chengyu, Piao| Taniguchi, Hideaki| Ohnishi, Yasuhiro| Takagi, Shin-jiro| Fujioka, Shin-ichi| Shiratori, Yasushi| |
抄録 | To improve the efficacy of interferon (IFN) treatment for chronic hepatitis C, we have proposed the twice-daily administration of IFN-beta as a promising induction therapy. In this study, we demonstrated differences between the clearance of circulating HCV-RNA and the induction of anti-viral actions during the first 2 weeks of treatment. Nine patients with a high viral load and genotype 1b were randomly assigned to 3 groups: group A received 3MU of IFN-beta twice a day at intervals of 5 and 19 h; group B received 3MU of IFN-beta twice a day at intervals of 10 and 14 h; group C received 6MU of IFN-alpha once a day with ribavirin. The expression of OAS2, PKR, and MxA in peripheral blood mononuclear cells (PBMCs) were quantified by real-time polymerase chain reaction method. The viral clearance showed a bi-phasic pattern, and those in the second phase of groups A and B were significantly steeper than that of group C. The peak level of OAS2 during the first phase was correlated with the first phase decay. The MxA expression tended to be higher in group A and B than in group C. The expression of these 3 proteins tended to decrease at day 6 in group C, but increase in groups A and B. These might make differences in the viral decay during the second phase |
キーワード | chronic hepatitis C(CHC) interferon(IFN)beta hepatitis C virus(HCV)dynamics antiviral actions real time PCR |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2003-10 |
巻 | 57巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 217 |
終了ページ | 225 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 14679399 |
Web of Science KeyUT | 000186186000002 |
著者 | Matsushita, Hiroshi| Ikeda, Fusao| Iwasaki, Yoshiaki| Seki, Hiroyuki| Nanba, Shintaro| Takeuchi, Yasuto| Moritou, Yuki| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
---|---|
発行日 | 2014-02 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 29巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Saho, Hikari| Taniguchi-Tabata, Ayano| Ekuni, Daisuke| Yokoi, Aya| Kataoka, Kouta| Fukuhara, Daiki| Toyama, Naoki | Islam, Md Monirul| Sawada, Nanami| Nakashima, Yukiho| Nakahara, Momoko| Deguchi, Junya| Uchida-Fukuhara, Yoko| Yoneda, Toshiki| Iwasaki, Yoshiaki| Morita, Manabu| |
キーワード | secondhand smoke dental caries permanent dentition young adult |
発行日 | 2020-11-20 |
出版物タイトル | International Journal of Environmental Research and Public Health |
巻 | 17巻 |
号 | 22号 |
出版者 | MDPI |
開始ページ | 8623 |
ISSN | 1660-4601 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by the authors. |
論文のバージョン | publisher |
PubMed ID | 33233610 |
DOI | 10.3390/ijerph17228623 |
Web of Science KeyUT | 000594343500001 |
関連URL | isVersionOf https://doi.org/10.3390/ijerph17228623 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Islam, Md Monirul| Ekuni, Daisuke| Toyama, Naoki | Taniguchi-Tabata, Ayano| Kataoka, Kota| Uchida-Fukuhara, Yoko| Fukuhara, Daiki| Saho, Hikari| Sawada, Nanami| Nakashima, Yukiho| Iwasaki, Yoshiaki| Morita, Manabu| |
キーワード | sleep quality sleep duration periodontal disease university students |
発行日 | 2020-04-27 |
出版物タイトル | International Journal of Environmental Research and Public Health |
巻 | 17巻 |
号 | 9号 |
出版者 | MDPI |
ISSN | 1660-4601 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by the authors. |
論文のバージョン | publisher |
PubMed ID | 32349308 |
DOI | 10.3390/ijerph17093034 |
Web of Science KeyUT | 000535745400058 |
関連URL | isVersionOf https://doi.org/10.3390/ijerph17093034 |
フルテキストURL | ijerph16_5_00690.pdf |
---|---|
著者 | Toyama, Naoki| Ekuni, Daisuke| Taniguchi-Tabata, Ayano| Kataoka, Kota| Yamane-Takeuchi, Mayu| Fujimori, Kohei| Kobayashi, Terumasa| Fukuhara, Daiki| Irie, Koichiro| Azuma, Tetsuji| Iwasaki, Yoshiaki| Morita, Manabu| |
キーワード | bruxism cohort study malocclusion underweight young adults |
発行日 | 2019-02-26 |
出版物タイトル | International Journal of Environmental Research and Public Health |
巻 | 16巻 |
号 | 5号 |
出版者 | MDPI |
開始ページ | 690 |
ISSN | 1660-4601 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2019 by the authors |
論文のバージョン | publisher |
PubMed ID | 30813621 |
DOI | 10.3390/ijerph16050690 |
Web of Science KeyUT | 000462664200015 |
関連URL | isVersionOf https://doi.org/10.3390/ijerph16050690 |
フルテキストURL | OL18_3_2756.pdf |
---|---|
著者 | Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu| |
キーワード | cancer stem cell conditioned medium mouse embryonic stem cells |
発行日 | 2019-09 |
出版物タイトル | Oncology Letters |
巻 | 18巻 |
号 | 3号 |
出版者 | Spandidos Publications |
開始ページ | 2756 |
終了ページ | 2762 |
ISSN | 1792-1074 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Seno et al. |
論文のバージョン | publisher |
PubMed ID | 31452753 |
DOI | 10.3892/ol.2019.10614 |
Web of Science KeyUT | 000487675500075 |
関連URL | isVersionOf https://doi.org/10.3892/ol.2019.10614 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Uchida-Fukuhara, Yoko| Ekuni, Daisuke| Islam, Md Monirul| Kataoka, Kota| Taniguchi-Tabata, Ayano| Fukuhara, Daiki| Toyama, Naoki | Kobayashi, Terumasa| Fujimori, Kohei| Sawada, Nanami| Iwasaki, Yoshiaki| Morita, Manabu| |
キーワード | salivary microbiome sequence analysis young adult dental caries saliva oral health |
発行日 | 2020-05-25 |
出版物タイトル | International Journal of Environmental Research and Public Health |
巻 | 17巻 |
号 | 10号 |
出版者 | MDPI |
開始ページ | 3713 |
ISSN | 1660-4601 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 by the authors. |
論文のバージョン | publisher |
PubMed ID | 32466124 |
DOI | 10.3390/ijerph17103713 |
Web of Science KeyUT | 000539300900370 |
関連URL | isVersionOf https://doi.org/10.3390/ijerph17103713 |
JaLCDOI | 10.18926/AMO/31989 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ishii, Yasushi| Shimomura, Hiroyuki| Ito, Mamoru| Miyake, Masanobu| Ikeda, Fusao| Miyake, Jiro| Fujioka, Shin-ichi| Iwasaki, Yoshiaki| Tsuji, Hideyuki| Tsuji, Takao| |
抄録 | It has been documented that the serum complement activities measured by hemolytic assay (CH50) are decreased after storage of sera at a low temperature in some patients with chronic hepatitis C. However, the mechanism of this phenomenon has not been identified yet. Here, we tried to elucidate factors involved in the cold activation of complement (CAC). To clarify what pathway is activated in CAC, we measured complement cleavage products after cold storage of sera. C4d increased significantly after 12 h-storage at cold temperatures in 5 CAC (+) sera compared with 5 CAC (-) (P < 0.01) and 3 control sera (P < 0.05), while Bb did not increase in any of the groups. In order to determine whether IgG or IgG complex is necessary for CAC, 8 CAC (+) sera were incubated with Protein G Sepharose gel beads, and all of them retained hemolytic activities to some extent after cold storage. Column chromatography through Superose 6HR of CAC-positive serum identified the fractions containing molecules that induced CAC in normal serum, which were depleted by treatment with protein G Sepharose. In conclusion, CAC in hepatitis C seems to occur via a classical or lectin pathway, and the IgG complex produced in hepatitis C virus infection may be an important factor in inducing CAC, a common extrahepatic manifestation of hepatitis C. |
キーワード | hepatitis C virus chronic hepatitis complement activation |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2001-08 |
巻 | 55巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 229 |
終了ページ | 235 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 11512565 |
Web of Science KeyUT | 000170367200005 |
JaLCDOI | 10.18926/AMO/53560 |
---|---|
フルテキストURL | 69_4_237.pdf |
著者 | Nanba, Shintarou| Ikeda, Fusao| Fujioka, Shin-ichi| Araki, Yasuyuki| Takaguchi, Kouichi| Hashimoto, Noriaki| Seki, Hiroyuki| Takaki, Akinobu| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
抄録 | The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51オ), and 89オ of them obtained sustained virological response (SVR), while 69オ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence<80オ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2. |
キーワード | hepatitis C virus interferon genotype 2 response-guided therapy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-08 |
巻 | 69巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 237 |
終了ページ | 244 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26289915 |
Web of Science KeyUT | 000365519100007 |
著者 | Mizutani, Shinsuke| Ekuni, Daisuke| Furuta, Michiko| Tomofuji, Takaaki| Irie, Koichiro| Azuma, Tetsuji| Kojima, Azusa| Nagase, Jun| Iwasaki, Yoshiaki| Morita, Manabu| |
---|---|
発行日 | 2012-09 |
出版物タイトル | Journal of Clinical Periodontology |
巻 | 39巻 |
号 | 9号 |
資料タイプ | 学術雑誌論文 |
著者 | Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio| |
---|---|
発行日 | 2005-01-20 |
出版物タイトル | BMC Cancer |
巻 | 5巻 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Hassan, Ghmkin| Afify, Said M.| Zahra, Maram H.| Nawara, Hend M.| Kumon, Kazuki| Iwasaki, Yoshiaki| Salomon, David S.| Seno, Akimasa| Seno, Masaharu| |
キーワード | Cancer stem cells Human iPSCs Signal pathway inhibitors Tumor initiation |
備考 | The version of record of this article, first published in Cytotechnology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10616-023-00575-1| |
発行日 | 2023-04-01 |
出版物タイトル | Cytotechnology |
巻 | 75巻 |
号 | 3号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 243 |
終了ページ | 253 |
ISSN | 0920-9069 |
NCID | AA10678299 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37181678 |
DOI | 10.1007/s10616-023-00575-1 |
Web of Science KeyUT | 000961388400001 |
関連URL | isVersionOf https://doi.org/10.1007/s10616-023-00575-1 |
著者 | Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide| |
---|---|
発行日 | 2011-10-21 |
出版物タイトル | BMC Cancer |
巻 | 11巻 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52898 |
---|---|
フルテキストURL | 68_5_291.pdf |
著者 | Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide| |
抄録 | It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. |
キーワード | interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-10 |
巻 | 68巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 291 |
終了ページ | 302 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25338486 |
Web of Science KeyUT | 000343269300006 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53129 |
JaLCDOI | 10.18926/AMO/52139 |
---|---|
フルテキストURL | 68_1_17.pdf |
著者 | Moritou, Yuki| Ikeda, Fusao| Iwasaki, Yoshiaki| Baba, Nobuyuki| Takaguchi, Kouichi| Senoh, Tomonori| Nagano, Takuya| Takeuchi, Yasuto| Yasunaka, Tetsuya| Ohnishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
抄録 | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p=0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p=0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p=0.049, and <0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. |
キーワード | hepatic steatosis genetic polymorphism interferon HCV |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-02 |
巻 | 68巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 17 |
終了ページ | 22 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24553484 |
Web of Science KeyUT | 000331592800003 |
JaLCDOI | 10.18926/AMO/64370 |
---|---|
フルテキストURL | 77_1_105.pdf |
著者 | Iwasaki, Yoshiaki| Higuchi, Chigusa| |
抄録 | The inactivated coronavirus disease 2019 vaccine CoronaVac has not been approved in Japan. Little information is available on cases in Japan in which an approved mRNA vaccine was administered as the initial (first or second) dose after two doses of CoronaVac. Furthermore, the safety and efficacy of this combination are not established. We here evaluated the safety and efficacy in a patient who showed an antibody response to an approved vaccine, mRNA-1273, after a previous vaccination with CoronaVac. The adverse events consisted of only mild local and systemic common reactions and were transient. In addition, a strong and persistent antibody response was observed. |
キーワード | coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 vaccine adverse events antibody response |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-02 |
巻 | 77巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 105 |
終了ページ | 109 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 36849154 |
Web of Science KeyUT | 000953005500001 |
JaLCDOI | 10.18926/AMO/31969 |
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フルテキストURL | fulltext.pdf |
著者 | Piao, Cheng-Yu| Fujioka, Shin-ichi| Iwasaki, Yoshiaki| Fujio, Kozo| Kaneyoshi, Toshihiko| Araki, Yasuyuki| Hashimoto, Kuniaki| Senoh, Tomonori| Terada, Ryo| Nishida, Tomohiro| Kobashi, Haruhiko| Sakaguchi, Kohsaku| Shiratori, Yasushi| |
抄録 | Lamivudine is widely used to treat patients with hepatitis B. However, the outcomes in patients with hepatocellular carcinoma (HCC) treated with lamivudine have not been established. This study was conducted to evaluate the outcomes of lamivudine treatment for patients with HCC using an untreated, matched control group. Thirty patients with controlled HCC orally received lamivudine. As controls, 40 patients with HCC who were not treated with lamivudine and matched for clinical features were selected. The lamivudine-treated and untreated groups were compared with respect to changes in liver function, HCC recurrence, survival, and cause of death. In the lamivudine-treated group, there was significant improvement in the Child-Pugh score at 24 months after starting treatment, while no improvement was observed in the untreated group. There was no significant difference in the cumulative incidence of HCC recurrence and survival between the groups. However, there was a significant difference in the cumulative incidence of death due to liver failure (P= 0.043). A significant improvement in liver function was achieved by lamivudine treatment, even in patients with HCC. These results suggest that lamivudine treatment for patients with HCC may prevent death due to liver failure. Further prospective randomized studies using a larger number of patients are required. |
キーワード | liver failure Child-Pughscore recurrence survival resistant mutant |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2005-10 |
巻 | 59巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 217 |
終了ページ | 224 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 16286955 |
Web of Science KeyUT | 000232835600006 |