| 著者 | Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2014-12-19 |
| 出版物タイトル | Molecular Therapy |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/53340 |
|---|---|
| フルテキストURL | 69_2_113.pdf |
| 著者 | Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi| |
| 抄録 | A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control. |
| キーワード | colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 113 |
| 終了ページ | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899633 |
| Web of Science KeyUT | 000353181700006 |
| JaLCDOI | 10.18926/AMO/53524 |
|---|---|
| フルテキストURL | 69_3_173.pdf |
| 著者 | Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position. |
| キーワード | chyle leak thoracic duct thoracoscopy prone position |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-06 |
| 巻 | 69巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 173 |
| 終了ページ | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26101193 |
| Web of Science KeyUT | 000356903000006 |
| タイトル（別表記） | Successful laparoscopic resection of a cecal tumor in a 95-year-old man |
|---|---|
| フルテキストURL | 127_117.pdf |
| 著者 | 渡邉 彩子| 稲田 涼| 永坂 岳司| 八木 朝彦| 松本 聖| 戸嶋 俊明| 菊池 覚次| 黒田 新士| 近藤 喜太| 母里 淑子| 岸本 浩行| 藤原 俊義| |
| 抄録 | We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials （RCTs） revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients. |
| キーワード | 超高齢者（extremely elderly patient） 大腸癌（colorectal cancer） 腹腔鏡手術（laparoscopic surgery） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 117 |
| 終了ページ | 121 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.117 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.117 |
| NAID | 130005096253 |
| JaLCDOI | 10.18926/AMO/53672 |
|---|---|
| フルテキストURL | 69_5_267.pdf |
| 著者 | Inada, Ryo| Nagasaka, Takeshi| Kondo, Yoshitaka| Watanabe, Ayako| Toshima, Toshiaki| Kubota, Nobuhito| Kikuchi, Satoru| Ishida, Michihiro| Kuroda, Shinji| Mori, Yoshiko| Kishimoto, Hiroyuki| Fujiwara, Toshiyoshi| |
| 抄録 | The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time. |
| キーワード | laparoscopic surgery total proctocolectomy open proctocolectomy ulcerative colitis case-matched study |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-10 |
| 巻 | 69巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 273 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26490023 |
| Web of Science KeyUT | 000365519600002 |
| JaLCDOI | 10.18926/AMO/53675 |
|---|---|
| フルテキストURL | 69_5_291.pdf |
| 著者 | Sugiu, Kumi| Iwamoto, Takayuki| Kelly, Catherine M.| Watanabe, Naoki| Motoki, Takayuki| Itoh, Mitsuya| Ohtani, Shoichiro| Higaki, Kenji| Imada, Takako| Yuasa, Takeshi| Omori, Masako| Sonobe, Hiroshi| Fujiwara, Toshiyoshi| Matsuoka, Junji| |
| 抄録 | Although in the neoadjuvant setting for estrogen receptor (ER)-positive breast cancers, chemotherapy or hormone therapy alone does not result in satisfactory tumor response, it is unknown whether concurrent chemo-endocrine therapy is superior to chemotherapy alone in clinical outcomes. We conducted a randomized phase II trial to test the responses of ER-positive patients to concurrent administration of chemo-endocrine therapy in the neoadjuvant setting. Women with stage II-III, ER-positive, invasive breast cancer (n=28) received paclitaxel followed by fluorouracil, epirubicin, cyclophosphamide (T-FEC) and were randomized to receive concurrent chemo-endocrine therapy consisting of goserelin administered subcutaneously for premenopausal women or an aromatase inhibitor for postmenopausal women. The primary endpoint was the pathological complete response (pCR) rate after neoadjuvant therapy. Twenty-eight patients were randomized. There were no significant differences in pCR rate between the concurrent group (12.5%;2/16) and the chemotherapy alone group (8.3%;1/12). Tumor size after therapy was significantly reduced in the concurrent therapy group (p=0.035), but not in the chemotherapy-alone group (p=0.622). Neoadjuvant chemotherapy with concurrent hormone therapy provided no significant improvement in pCR rate in ER-positive breast cancers. These preliminary results should be followed up by further studies. |
| キーワード | breast cancer neoadjuvant chemotherapy concurrent hormone therapy estrogen receptor positive tumor response |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-10 |
| 巻 | 69巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26490026 |
| Web of Science KeyUT | 000365519600005 |
| 著者 | 藤原 俊義| |
|---|---|
| 発行日 | 2014-07 |
| 出版物タイトル | Okayama University Medical Research Updates |
| 巻 | 1巻 |
| 資料タイプ | その他 |
| 著者 | 藤原 俊義| |
|---|---|
| 発行日 | 2015-02 |
| 出版物タイトル | Okayama University Medical Research Updates |
| 巻 | 7巻 |
| 資料タイプ | その他 |
| JaLCDOI | 10.18926/AMO/54419 |
|---|---|
| フルテキストURL | 70_3_197.pdf |
| 著者 | Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Sui, Kenta| Fuji, Tomokazu| Fujiwara, Toshiyoshi| |
| 抄録 | The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p＜0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p＜0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes. |
| キーワード | pancreaticoduodenectomy surgical outcome mortality major complication length of stay |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 197 |
| 終了ページ | 203 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339209 |
| Web of Science KeyUT | 000379406100007 |
| JaLCDOI | 10.18926/AMO/54421 |
|---|---|
| フルテキストURL | 70_3_213.pdf |
| 著者 | Kikuchi, Satoru| Kagawa, Shunsuke| Ohara, Toshiaki| Kubota, Tetsushi| Kuwada, Kazuya| Kagawa, Tetsuya| Kuroda, Shinji| Shirakawa, Yasuhiro| Nishizaki, Masahiko| Fujiwara, Toshiyoshi| |
| 抄録 | A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence. |
| キーワード | dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-06 |
| 巻 | 70巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 213 |
| 終了ページ | 216 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27339211 |
| Web of Science KeyUT | 000379406100009 |
| タイトル（別表記） | Incisional hernia repair after wide excision of the iliac bone |
|---|---|
| フルテキストURL | 128_117.pdf |
| 著者 | 佃 和憲| 浅野 博昭| 万代 康弘| 藤原 俊義| |
| 抄録 | The patient was a 46-year old Japanese female who had undergone wide excision of the iliac bone and hip transposition at our institute's orthopedics department 2 years earlier. She presented with a growing incisional hernia and was transferred to our gastroenterological surgery department for surgical treatment. We planned a mesh repair for the incisional hernia, which protruded over the right iliac bone. The dimensions of the abdominal defect were 15×9 cm, and we used prolene mesh to repair the defect. The mesh was fixed at the inner part of the iliac bone, folded back at the iliac horn and fixed to the abdominal oblique muscles. The postoperative course was smooth, and recurrence was not seen at 3.5 years after the operation. An incisional hernia as seen in this patient's case is very rare, but we found that the underlay technique and prolene mesh were very useful for the three-dimensional hernia repair. |
| キーワード | 腹壁瘢痕ヘルニア（incisional hernia） 腸骨軟骨肉腫（chondrosarcoma of the iliac bone） 腸骨広範囲切除術（wide excision of the iliac bone） プロリーンメッシュ（prolene mesh） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2016-08-01 |
| 巻 | 128巻 |
| 号 | 2号 |
| 開始ページ | 117 |
| 終了ページ | 120 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.128.117 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2016 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.128.117 |
| NAID | 130005262528 |
| JaLCDOI | 10.18926/AMO/54514 |
|---|---|
| フルテキストURL | 70_4_327.pdf |
| 著者 | Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi| |
| 抄録 | A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines. |
| キーワード | metformin CD8＋ T cells cancer immunology |
| Amo Type | Clinical Study Protocols |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-08 |
| 巻 | 70巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 327 |
| 終了ページ | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27549683 |
| Web of Science KeyUT | 000384748600018 |
| JaLCDOI | 10.18926/AMO/54594 |
|---|---|
| フルテキストURL | 70_5_363.pdf |
| 著者 | Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi| |
| 抄録 | Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p＝0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]＝2.28, p＝0.002) and poor ASA status (HR＝3.17, p＝0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility. |
| キーワード | sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor |
| Amo Type | Original Articles |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-10 |
| 巻 | 70巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 363 |
| 終了ページ | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27777428 |
| Web of Science KeyUT | 000388098700005 |
| JaLCDOI | 10.18926/AMO/54601 |
|---|---|
| フルテキストURL | 70_5_401.pdf |
| 著者 | Kuroda, Shinji| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi| |
| 抄録 | Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common. |
| キーワード | venous thromboembolism enoxaparin short-term use gastric cancer surgery |
| Amo Type | Clinical Study Protocols |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-10 |
| 巻 | 70巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 401 |
| 終了ページ | 404 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27777435 |
| Web of Science KeyUT | 000388098700012 |
| 著者 | Takagi, Kosei| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Watanabe, Nobuyuki| Kuise, Takashi| Fuji, Tomokazu| Araki, Hiroyuki| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2017-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 71巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/54830 |
| タイトル（別表記） | Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously |
|---|---|
| フルテキストURL | 129_41.pdf |
| 著者 | 桂 佑貴| 白川 靖博| 田邊 俊介| 前田 直見| 野間 和広| 藤原 俊義| |
| 抄録 | When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery. |
| キーワード | 食道アカラシア (achalasia) 再手術 (reoperation) 食道亜全摘 (esophagectomy) |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2017-04-03 |
| 巻 | 129巻 |
| 号 | 1号 |
| 開始ページ | 41 |
| 終了ページ | 44 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2017 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.129.41 |
| NAID | 130005632071 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| フルテキストURL | 71_2_127.pdf |
| 著者 | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| 抄録 | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| キーワード | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 127 |
| 終了ページ | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420894 |
| フルテキストURL | AnnGastroenterolSurg_3_4_396.pdf |
|---|---|
| 著者 | Fujiwara, Toshiyoshi| |
| キーワード | adenovirus clinical trial esophageal cancer radiotherapy telomerase |
| 発行日 | 2019-07-05 |
| 出版物タイトル | Annals of gastroenterological surgery |
| 巻 | 3巻 |
| 号 | 4号 |
| 出版者 | John Wiley & Sons |
| 開始ページ | 396 |
| 終了ページ | 404 |
| ISSN | 24750328 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 The Authors |
| 論文のバージョン | publisher |
| PubMed ID | 31346579 |
| DOI | 10.1002/ags3.12270 |
| Web of Science KeyUT | 000475745100009 |
| 関連URL | isVersionOf https://doi.org/10.1002/ags3.12270 |
| フルテキストURL | OncoImmunol_8_12_1671760.pdf |
|---|---|
| 著者 | Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| キーワード | Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination |
| 発行日 | 2019-10-22 |
| 出版物タイトル | OncoImmunology |
| 巻 | 8巻 |
| 号 | 12号 |
| 出版者 | TAYLOR & FRANCIS |
| 開始ページ | e1671760 |
| ISSN | 2162402X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 The Author(s). |
| 論文のバージョン | publisher |
| DOI | 10.1080/2162402X.2019.1671760 |
| Web of Science KeyUT | 000494085400001 |
| 関連URL | isVersionOf https://doi.org/10.1080/2162402X.2019.1671760 |
| フルテキストURL | cancers_11_2_177.pdf |
|---|---|
| 著者 | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
| キーワード | cancer stem cells combination therapy iron stemness |
| 発行日 | 2019-02-03 |
| 出版物タイトル | Cancers |
| 巻 | 11巻 |
| 号 | 2号 |
| 出版者 | MDPI |
| 開始ページ | 177 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 by the authors |
| 論文のバージョン | publisher |
| PubMed ID | 30717462 |
| DOI | 10.3390/cancers11020177 |
| Web of Science KeyUT | 000460747200051 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers11020177 |