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ID 54422
JaLCDOI
フルテキストURL
Thumnail 70_3_217.pdf 2.52 MB
著者
Waseda, Koichi Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ocho, Kazuki Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hasegawa, Kou Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kimura, Kosuke Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Iwamuro, Masaya Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Hanayama, Yoshihisa Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kondo, Eisei Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Miyahara, Nobuaki Departments of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Otsuka, Fumio Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
抄録
KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.
キーワード
KL-6
mycobacterium avium complex
pulmonary nontuberculous mycobacterium infection
rheumatoid arthritis-associated interstitial lung disease
bronchial alveolar lavage
Amo Type
Case Report
発行日
2016-06
出版物タイトル
Acta Medica Okayama
70巻
3号
出版者
Okayama University Medical School
開始ページ
217
終了ページ
221
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT