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Waseda, Koichi Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ocho, Kazuki Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hasegawa, Kou Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kimura, Kosuke Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Iwamuro, Masaya Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Hanayama, Yoshihisa Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kondo, Eisei Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyahara, Nobuaki Departments of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Otsuka, Fumio Departments of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Abstract
KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.
Keywords
KL-6
mycobacterium avium complex
pulmonary nontuberculous mycobacterium infection
rheumatoid arthritis-associated interstitial lung disease
bronchial alveolar lavage
Amo Type
Case Report
Published Date
2016-06
Publication Title
Acta Medica Okayama
Volume
volume70
Issue
issue3
Publisher
Okayama University Medical School
Start Page
217
End Page
221
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2016 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT