著者 | 柳井 広之| |
---|---|
発行日 | 2013-08-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 125巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 田辺 俊介| 白川 靖博| 前田 直見| 大原 利章| 野間 和広| 櫻間 教文| 柳井 広之| 山辻 知樹| 猶本 良夫| 藤原 俊義| |
---|---|
発行日 | 2012-08-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 124巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 松岡 順治| 田渕 陽子| 小野 亮子| 今田 孝子| 梅岡 達生| 渡辺 直樹| 元木 崇之| 松川 啓義| 猶本 良夫| 田中 紀章| 柳井 広之| 大森 昌子| |
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発行日 | 2006-09-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 118巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 松岡 順治| 田渕 陽子| 伊藤 充矢| 小野 亮子| 今田 孝子| 元木 崇之| 松川 啓義| 大森 昌子| 柳井 広之| 猶本 良夫| 田中 紀章| |
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発行日 | 2006-09-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 118巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Okada, Yoshiki| Abe, Nobuhiro| Hisamori, Noriyuki| Kaneeda, Toshiaki| Moriyama, Shigeaki| Ohmori, Hitoshi| Mizutani, Masayoshi| Yanai, Hiroyuki| Nakashima, Yoshio| Yokoyama, Yusuke| Ozaki, Toshifumi| |
---|---|
発行日 | 2017-02 |
出版物タイトル | Acta Medica Okayama |
巻 | 71巻 |
号 | 1号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/54825 |
JaLCDOI | 10.18926/AMO/65502 |
---|---|
フルテキストURL | 77_3_323.pdf |
著者 | Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao| |
抄録 | In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases. |
キーワード | comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-06 |
巻 | 77巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 323 |
終了ページ | 330 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37357634 |
Web of Science KeyUT | 001025850000001 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Abe, Makoto| Sakae, Hiroyuki| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Tanaka, Takehiro| Kawano, Seiji| Otsuka, Fumio| Kawahara, Yoshiro| Yanai, Hiroyuki| Okada, Hiroyuki| |
キーワード | eradication flow cytometry Helicobacter pylori T lymphocytes |
発行日 | 2022-08-26 |
出版物タイトル | Medicine |
巻 | 101巻 |
号 | 34号 |
出版者 | Lippincott Williams & Wilkins |
開始ページ | e30241 |
ISSN | 0025-7974 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022 the Author(s). |
論文のバージョン | publisher |
PubMed ID | 36042652 |
DOI | 10.1097/MD.0000000000030241 |
Web of Science KeyUT | 000847532100050 |
関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000030241 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Obayashi, Yuka| Kawano, Seiji| Sakae, Hiroyuki| Abe, Makoto| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Tanaka, Takehiro| Yanai, Hiroyuki| Okada, Hiroyuki| |
キーワード | background gastric mucosa gastric cancer inflammation Helicobacter pylori propensity score matching |
発行日 | 2021-04-01 |
出版物タイトル | Internal Medicine |
巻 | 60巻 |
号 | 7号 |
出版者 | Japanese Society of Internal Medicine |
開始ページ | 969 |
終了ページ | 976 |
ISSN | 0918-2918 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 The Japanese Society of Internal Medicine |
論文のバージョン | publisher |
PubMed ID | 33162475 |
NAID | 130008014372 |
DOI | 10.2169/internalmedicine.5486-20 |
Web of Science KeyUT | 000637009100001 |
関連URL | isVersionOf https://doi.org/10.2169/internalmedicine.5486-20 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Futagawa, Mashu| Yamamoto, Hideki| Kochi, Mariko| Urakawa, Yusaku| Sogawa, Reimi| Kato, Fumino| Okazawa-Sakai, Mika| Ennishi, Daisuke| Shinozaki, Katsunori| Inoue, Hirofumi| Yanai, Hiroyuki| Hirasawa, Akira| |
キーワード | RAD51D Splice variant Leiomyosarcoma Homologous recombination (HR) Cancer susceptibility Presumed germline pathogenic variant (PGPV) |
発行日 | 2021-11-27 |
出版物タイトル | Hereditary Cancer In Clinical Practice |
巻 | 19巻 |
号 | 1号 |
出版者 | BMC |
開始ページ | 48 |
ISSN | 1731-2302 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s). |
論文のバージョン | publisher |
PubMed ID | 34838098 |
DOI | 10.1186/s13053-021-00205-x |
Web of Science KeyUT | 000722986000001 |
関連URL | isVersionOf https://doi.org/10.1186/s13053-021-00205-x |
著者 | 柳井 広之| |
---|---|
発行日 | 1996-03-31 |
出版物タイトル | |
資料タイプ | 学位論文 |
JaLCDOI | 10.18926/AMO/30509 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Yanai, Hiroyuki| Yoshino, Tadashi| Takahashi, Kiyoshi| Ninomiya, Yoshifumi| Akagi, Tadaatsu| |
抄録 | Circulating hepatitis C virus (HCV) particles can be fractionated by means of differential flotation centrifugation. It is reported that in the bottom fraction HCV is in the form immune complexes, whereas in the top, it is free of antibodies. We evaluated the significance of circulating complex and free HCV in chronic hepatitis C, and assessed the relationship in terms of the response to interferon (IFN) therapy. We examined sera before, just after, and 1 year after administering IFN to 18 patients with chronic hepatitis C, 10 of whom responded (group CR), and 8 did not (group NR). The amounts of virus were similar between both groups before therapy. After differential flotation centrifugation with 1.063 g/ml of NaCl, the top and bottom fractions were assayed for HCV RNA. Before therapy, HCV RNA was detected in the top fraction in 1 of 10 in group CR, and in 6 of 8 in group NR (P < 0.05, chi-square test). HCV RNA was positive in the bottom fraction of all samples. In a follow-up study of group NR, HCV RNA was detected in the top fraction in 3 of 8 just after IFN therapy, and in 7 of 8 after 1 year. This study suggests that the presence of HCV in the top fraction can predict a poor response to IFN therapy. |
キーワード | IL-2R ??chain phorbol ester monocyte differentiation protein kinase |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1996-06 |
巻 | 50巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 145 |
終了ページ | 150 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 8805853 |
Web of Science KeyUT | A1996UU60400005 |
JaLCDOI | 10.18926/AMO/31108 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Miyatani, Katsuya| Takahashi, Kiyoshi| Yanai, Hiroyuki| Yoshino, Tadashi| Akagi, Tadaatsu| |
抄録 | Previously, we reported that interleukin-2 (IL-2)-stimulated helper T cells produced an unknown soluble factor which induced dendritic cell-like differentiation in primary cultures of monocytic leukemia cells and we referred to this factor as dendritic cell differentiation factor (DCDF). In this study, we attempted to purify and characterize DCDF and investigated its biological effect on normal human monocytes. Gel filtration chromatography indicated that the molecular weight of DCDF is approximately 30-35 kDa. Chromatofocusing indicated that the isoelectric point of DCDF is approximately 5.0. DCDF, partially purified by subsequent gel filtration, chromatofocusing, and hydrophobic chromatography, significantly enhanced the HLA-DR expression of normal human monocytes and a human monocytic leukemia cell line, THP-1. This biological activity was not neutralized by any known antibodies to human cytokines. DCDF significantly amplified the T-cell stimulatory activity of monocytes in the allogeneic mixed leukocyte reaction (MLR). Moreover, DCDF significantly enhanced IL-1 beta and IL-6 production by monocytes in a dose-dependent manner. These results suggest that DCDF is a novel human cytokine which stimulates the accessory cell function of monocytes. |
キーワード | dendritic cell differentiation protein purification cytokine |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1994-04 |
巻 | 48巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 67 |
終了ページ | 72 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 8042536 |
Web of Science KeyUT | A1994NJ77500001 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Ono, Sawako| Marunaka, Hidenori| Yanai, Hiroyuki| Kawai, Hotaka| Takabatake, Kiyofumi| Nishida, Kenji| Toji, Tomohiro| Nakano, Keisuke| Nagatsuka, Hitoshi| Yoshino, Tadashi| |
キーワード | Lymphoepithelial carcinoma oral cavity lateral tongue |
発行日 | 2021-08-12 |
出版物タイトル | reports |
巻 | 4巻 |
号 | 3号 |
出版者 | MDPI |
開始ページ | 24 |
ISSN | 2571-841X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 by the authors. |
論文のバージョン | publisher |
DOI | 10.3390/reports4030024 |
Web of Science KeyUT | 000701728000001 |
関連URL | isVersionOf https://doi.org/10.3390/reports4030024 |
JaLCDOI | 10.18926/AMO/45273 |
---|---|
フルテキストURL | 65_2_135.pdf |
著者 | Matsuo, Toshihiko| Himei, Kengo| Ishii, Keita| Ichimura, Kouichi| Yanai, Hiroyuki| Nose, Soichiro| Mimura, Tetsushige| |
抄録 | An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma. |
キーワード | retinal (papillary, optic disc) hemangioma von Hippel-Lindau disease pheochromocytoma pancreatic neuroendocrine tumor external beam radiation (radiotherapy) |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-04 |
巻 | 65巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 135 |
終了ページ | 141 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21519372 |
Web of Science KeyUT | 000289818800010 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Fujiwara, Tomohiro| Yanai, Hiroyuki| Hagiya, Hideharu| |
キーワード | manubrium sternal infection tuberculosis |
発行日 | 2023-05-01 |
出版物タイトル | Clinical Case Reports |
巻 | 11巻 |
号 | 5号 |
出版者 | Wiley |
開始ページ | e7119 |
ISSN | 2050-0904 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 The Authors. |
論文のバージョン | publisher |
PubMed ID | 37143459 |
DOI | 10.1002/ccr3.7119 |
Web of Science KeyUT | 000978608200001 |
関連URL | isVersionOf https://doi.org/10.1002/ccr3.7119 |
JaLCDOI | 10.18926/AMO/31848 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Iishi, Tatsuhiko| Hiraki, Takao| Mimura, Hidefumi| Gobara, Hideo| Kurose, Taichi| Fujiwara, Hiroyasu| Sakurai, Jun| Yanai, Hiroyuki| Yoshino, Tadashi| Kanazawa, Susumu| |
抄録 | The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion;group 2 (n5) zones were created by applying greater RF power without saline infusion;and group 3 (n9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1ml before RFA, followed by continuous administration at a rate of 1ml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p0.059) and group 2 (p0.053). Group 3 showed significantly longer RF application time than group 2 (p0.004) and significantly greater maximum RF power than group 1 (p0.001) and group 2 (p0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858mm3, p0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878mm3, p0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma. |
キーワード | radiofrequency ablation lung experimental study |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2009-06 |
巻 | 63巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 144 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 19571900 |
Web of Science KeyUT | 000267388200003 |
JaLCDOI | 10.18926/AMO/66676 |
---|---|
フルテキストURL | 78_1_089.pdf |
著者 | Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki| |
抄録 | We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis. |
キーワード | breast cancer ectopic breast cancer axillary lymph node |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-02 |
巻 | 78巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 89 |
終了ページ | 93 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38419320 |
Web of Science KeyUT | 001204421300001 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Egusa, Yuria| Nishimura, Midori Filiz| Baba, Satoko| Takeuchi, Kengo| Makino, Takuma| Tachibana, Tomoyasu| Nishikori, Asami| Fujita, Azusa| Yanai, Hiroyuki| Sato, Yasuharu| |
キーワード | secretory carcinoma salivary gland mammary analogue secretory carcinoma Giemsa staining cytopathology fine-needle aspiration ETV6-NTRK3 fusion |
発行日 | 2021-12-07 |
出版物タイトル | Diagnostics |
巻 | 11巻 |
号 | 12号 |
出版者 | MDPI |
開始ページ | 2284 |
ISSN | 2075-4418 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 by the authors. |
論文のバージョン | publisher |
PubMed ID | 34943521 |
DOI | 10.3390/diagnostics11122284 |
Web of Science KeyUT | 000737113900001 |
関連URL | isVersionOf https://doi.org/10.3390/diagnostics11122284 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Inoue, Hirofumi| Tomida, Shuta| Horiguchi, Shigeru| Kato, Hironari| Matsuoka, Hiromi| Sanehira, Etsuko| Matsuoka, Masashi| Yanai, Hiroyuki| Hirasawa, Akira| Toyooka, Shinichi| |
キーワード | cancer genomic profiling tests formalin‐fixed paraffin‐embedded (FFPE) tumor tissue genomic DNA extraction |
備考 | This is the peer reviewed version of the following article: Hirofumi Inoue et. al. Best practices for the extraction of genomic DNA from formalin‐fixed paraffin‐embedded tumor tissue for cancer genomic profiling tests. Pathology International (2021), which has been published in final form at https://doi.org/10.1111/pin.13086. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This fulltext is available in March 2022.| |
発行日 | 2021-03-03 |
出版物タイトル | Pathology International |
巻 | 71巻 |
出版者 | Wiley |
開始ページ | 360 |
終了ページ | 364 |
ISSN | 1320-5463 |
NCID | AA10984364 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
PubMed ID | 33657250 |
DOI | 10.1111/pin.13086 |
Web of Science KeyUT | 000624843200001 |
関連URL | isVersionOf https://doi.org/10.1111/pin.13086 |
JaLCDOI | 10.18926/AMO/30764 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ino, Hideo| Hayashi, Kazuhiko| Yanai, Hiroyuki| Teramoto, Norihiro| Koirala, Tirtha Raj| Chen, Hong-Li| Oka, Takashi| Yoshino, Tadashi| Takahashi, Kiyoshi| Akagi, Tadaastu| |
抄録 | A simian cell line, Si-IIA, harboring Epstein-Barr-virus (EBV) -related herpesvirus (Si-IIA-EBV), produces malignant lymphoma in rabbits when administered by intravenous inoculation. In this study, we analyzed the Si-IIA-EBV genome and compared it with human EBV and herpesvirus macaca fascicularis 1 (HVMF 1 ), which is associated with B-cell lymphoma developing in SIV-infected immunosuppressed monkeys. DNA from Si-IIA-EBV was amplified by the polymerase chain reaction using three different primer pairs complementary to human EBV (B95-8) DNA; two of the primer pairs covered part of the long internal repeat 1 region (IR 1) and the third covered part of the BRRF 1 region. Direct sequencing of the three PCR products revealed that Si-IIA-EBV DNA had about 82% nucleotide homology to the human EBV DNA in all three regions and 92.4% homology to HVMF1 in the IR1 region. The blotting pattern by Southern blot analysis was different between Si-IIA-EBV and human EBV. |
キーワード | Epstein-Barr virus HVMF 1 lymphoma ?monkey cell line PCR |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1997-08 |
巻 | 51巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 207 |
終了ページ | 212 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 9284968 |
Web of Science KeyUT | A1997XU03200004 |