ID | 31631 |
JaLCDOI | |
フルテキストURL | |
著者 |
Iwagaki, Hiromi
Okayama University
Urushihara, Naoto
Okayama University
Kobashi, Kenta
Okayama University
Morimoto, Yoshinori
Okayama University
Isozaki, Hiroshi
Okayama University
Takakura, Norihisa
Okayama University
Tanaka, Noriaki
Okayama University
|
抄録 | The relationship between endogenous cytokine antagonists and surgical stress is poorly understood. Surgical stress induces immunosuppression, and the reversed therapy of postoperative immunosuppression has been expected. The aim of the present study was to assess the effect of a serine protease inhibitor on postoperative immune reactivity. Twenty patients with colorectal cancer were randomly separated into experimental and control groups of 10 patients each. The experimental group received perioperative administration of a serine protease inhibitor while the control group did not. Plasma levels of cytokine antagonists, which suppress cell-mediated immunity, such as cortisol, interleukin-1 receptor antagonist, soluble interleukin-2 receptor (sIL-2R) and soluble tumor necrosis factors p55, p75 (sTNF-R55, -R75) were simultaneously measured. Significant reductions of plasma concentration of sIL-2R and sTNF-R55 were observed. Perioperative administration of a serine protease inhibitor may contribute to ameliorating immunosuppression after major surgery. |
キーワード | surgical stress
cytokine antagonist
protease inhibitor
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1999-10
|
巻 | 53巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 239
|
終了ページ | 244
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |