JaLCDOI | 10.18926/AMO/31686 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ohya, Shogen| Mizuno, Motowo| Kawada, Mikihiro| Nasu, Junichirou| Okada, Hiroyuki| Shimomura, Hiroyuki| Yamamoto, Kazuhide| Fujita, Teizou| Tsuji, Takao| |
抄録 | We have previously developed an enzyme-linked immunosorbent assay (ELISA) to measure stool decay-accelerating factor (DAF) and found that stool DAF concentrations were significantly elevated in patients with colorectal cancer, suggesting that the measurement of stool DAF may be valuable for the detection of colorectal cancer. In order to refine the assay for the measurement of stool DAF, we investigated 1) effects of centrifugation of stool samples, 2) effects of detergents, and 3) adequate combination of various anti-DAF monoclonal antibodies for the ELISA system using only monoclonal antibodies. We found that high-speed centrifugation could be omitted and that only the removal of large undigested food residues by centrifugation of short duration in a low-speed benchtop microcentrifuge sufficed to adequately prepare the stool samples. Addition of 2 detergents, octyl beta-glucoside and sodium deoxycholate, known to solubilize glycosyl-phosphatidylinositol-anchored proteins such as DAF, did not influence stool DAF values. By using 2 mouse anti-DAF monoclonal antibodies (clone 4F11 and 1C6), we were able to achieve a stable ELISA for the measurement of stool DAF using a uniform source of antibodies. The results should allow us to consistently apply the DAF assay for routine use in the detection of colorectal cancer. |
キーワード | decay-accelerating factor (DAF) colorectal cancer enzyme-linked immunosorbent assay (ELISA). monoclonal sntibodies |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2002-08 |
巻 | 56巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 171 |
終了ページ | 176 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 12199521 |
Web of Science KeyUT | 000177382600001 |
JaLCDOI | 10.18926/AMO/51864 |
---|---|
フルテキストURL | 67_5_285.pdf |
著者 | Akita, Mitsuhiro| Hiraoka, Sakiko| Kaji, Eisuke| Takemoto, Koji| Nagahara, Yasuhiro| Yamamoto, Hiroshi| Yamamoto, Kazuhide| Kato, Jun| |
抄録 | Whether presence or history of extracolonic primary malignancy is a risk for colorectal neoplasia is not fully known. In this study, 26,452 first-time colonoscopy cases were examined using a colonoscopy database. Among the analyzed subjects, 3,026 (11%) subjects had history or concomitance of extracolonic primary malignancy, while the remaining 23,426 subjects did not. Colorectal neoplasia was observed in 39% of all the subjects. A crude comparison showed that the prevalence of any type of colorectal neoplasia was higher in subjects with extracolonic malignancy than in those without (42% vs. 39%, p=0.0012). However, after adjusting for confounding factors, the odds ratios (ORs) of subjects with extracolonic malignancy for having colorectal neoplasia, advanced neoplasia, and cancer were all less than 1.0, and all significantly different from those of subjects without extracolonic malignancy. Analysis according to the type of extracolonic malignancy revealed that gastric cancer cases had a significantly lower risk for colorectal advanced neoplasia (OR:0.81;95% CI:0.67-0.99). Among major malignancies, only esophageal squamous cell cancer cases had increased risk for colorectal neoplasia (OR:1.66;95% CI:1.20-2.29). Patients with presence or history of extracolonic malignancy did not carry a higher risk of occurrence of colorectal neoplasia. |
キーワード | colorectal cancer colonoscopy risk factor database |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2013-10 |
巻 | 67巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 285 |
終了ページ | 292 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24145728 |
Web of Science KeyUT | 000325836100002 |
著者 | Ishikawa, Hisashi| Takaki, Akinobu| Tsuzaki, Ryuichiro| Yasunaka, Tetsuya| Koike, Kazuko| Shimomura, Yasuyuki| Seki, Hiroyuki| Matsushita, Hiroshi| Miyake, Yasuhiro| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
---|---|
発行日 | 2014-07-01 |
出版物タイトル | PLoS ONE |
巻 | 9巻 |
号 | 7号 |
資料タイプ | 学術雑誌論文 |
著者 | Shoji, Bon| Ikeda, Fusao| Fujioka, Shin-ichi| Kobashi, Haruhiko| Yasunaka, Tetsuya| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
---|---|
発行日 | 2010-11 |
出版物タイトル | Journal of Gastroenterology |
巻 | 45巻 |
号 | 11号 |
資料タイプ | 学術雑誌論文 |
著者 | 平岡 佐規子| 加藤 順| 藤木 茂篤| 加地 英輔| 森川 民也| 村上 貴俊| 名和 徹| 栗山 宗彰| 浦岡 俊夫| 大原 信哉| 山本 和秀| |
---|---|
発行日 | 2011-08-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 123巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Nakanishi, Yutaka| Shiraha, Hidenori| Nishina, Shin-ichi| Tanaka, Shigetomi| Matsubara, Minoru| Horiguchi, Shigeru| Iwamuro, Masaya| Takaoka, Nobuyuki| Uemura, Masayuki| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
---|---|
発行日 | 2011-01-04 |
出版物タイトル | BMC Cancer |
巻 | 11巻 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/53120 |
---|---|
フルテキストURL | 69_1_37.pdf |
著者 | Iwamuro, Masaya| Okada, Hiroyuki| Takata, Katsuyoshi| Kawai, Yoshinari| Kawano, Seiji| Nasu, Junichiro| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Yamamoto, Kazuhide| |
抄録 | The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n=9), lymphangiectasia (n=7), adenoma (n=10), duodenitis (n=4), erosion (n=1), lymphangioma (n=1), and hyperplastic polyp (n=1). The magnified features of the nine follicular lymphomas included enlarged villi (n=8), dilated microvessels (n=5), and opaque white spots of various sizes (n=9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions. |
キーワード | duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-02 |
巻 | 69巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 37 |
終了ページ | 44 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25703169 |
Web of Science KeyUT | 000349740300004 |
著者 | Fujii, Masakuni| Kawamoto, Hirofumi| Tsutsumi, Koichiro| Kato, Hironari| Hirao, Ken| Kurihara, Naoko| Mizuno, Osamu| Ishida, Etsuji| Ogawa, Tsuneyoshi| Fukatsu, Hirotoshi| Yamamoto, Kazuhide| |
---|---|
発行日 | 2013-05 |
出版物タイトル | Hepato-Gastroenterology |
巻 | 60巻 |
号 | 123号 |
資料タイプ | 学術雑誌論文 |
著者 | Tsutsumi, Koichiro| Kawamoto, Hirofumi| Hirao, Ken| Sakakihara, Ichiro| Yamamoto, Naoki| Noma, Yasuhiro| Fujii, Masakuni| Kato, Hironari| Ogawa, Tsuneyoshi| Ishida, Etsuji| Kuwaki, Kenji| Nouso, Kazuhiro| Okada, Hiroyuki| Yamamoto, Kazuhide| |
---|---|
発行日 | 2012-09 |
出版物タイトル | Pancreatology |
巻 | 12巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
著者 | Kubota, Junichi| Ikeda, Fusao| Terada, Ryo| Kobashi, Haruhiko| Fujioka, Shin-ichi| Okamoto, Ryoichi| Baba, Shinsuke| Morimoto, Youichi| Ando, Masaharu| Makino, Yasuhiro| Taniguchi, Hideaki| Yasunaka, Tetsuya| Miyake, Yasuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
---|---|
発行日 | 2009-09 |
出版物タイトル | Journal of Gastroenterology |
巻 | 44巻 |
号 | 9号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/31685 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Kondo, Junichi| Shimomura, Hiroyuki| Fujioka, Shin-ichi| Iwasaki, Yoshiaki| Takagi, Shinjiro| Ohnishi, Yasuhiro| Tsuji, Hideyuki| Sakaguchi, Kosaku| Yamamoto, Kazuhide| Tsuji, Takao| |
抄録 | The preS2 region of the hepatitis B virus (HBV) has been reported to have human polymerized albumin receptor (PAR) activity, which correlates with viral replication. Here, we studied the genomic sequence of the preS region from rare patients lacking PAR activity, despite active viral replication. PAR and DNA polymerase activity was identified in 178 HBe antigen-positive HBV carriers, and a significant correlation between 2 markers was shown, except in 2 hepatitis patients lacking PAR activity. Nucleotide sequences of the preS region of HBV from both patients were examined by direct sequencing of PCR products. In one patient, a 45-base deletion was found to overlap half of the putative polymerized human albumin binding site in the preS2 region. In the other patient, a point mutation at the first nucleotide of the start codon of the preS2 region of HBV was found. There was no such genomic change in the 3 control HBV sequences. These results indicate that the preS2 region is necessary for binding of polymerized human albumin, and this is the first report of naturally existing mutant virus with no or low PAR activity. |
キーワード | hepatitis B virus preS region polymerized albumin receptor genetic mutation genetic deletion |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2002-08 |
巻 | 56巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 193 |
終了ページ | 198 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 12199524 |
Web of Science KeyUT | 000177382600004 |
著者 | 河合 大介| 高木 章乃夫| 山本 和秀| |
---|---|
発行日 | 2013-12-02 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 125巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
著者 | Moritou, Yuki| Ikeda, Fusao| Takeuchi, Yasuto| Seki, Hiroyuki| Nanba, Shintaro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
---|---|
発行日 | 2014-02 |
出版物タイトル | Journal of Clinical Microbiology |
巻 | 52巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52894 |
---|---|
フルテキストURL | 68_5_263.pdf |
著者 | Namba, Shihoko| Miyake, Kayoko| Ikeda, Fusao| Hazama, Tomoko| Hitobe, Yu| Yamasaki, Noriko| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
抄録 | Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p=0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence. |
キーワード | chronic hepatitis C nursing support interferon therapy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-10 |
巻 | 68巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 263 |
終了ページ | 268 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25338482 |
Web of Science KeyUT | 000343269300002 |
JaLCDOI | 10.18926/AMO/30997 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Yamamoto, Kazuhide| Makino, Yasuhiro| Itoshima, Tatsuya| Kobayashi, Toshinari| Tsuji, Takao| |
抄録 | Phalloidin, a toxin from the plant Amanita phalloides, irreversibly polymerizes actin filaments and causes cholestasis. Three-dimensional structural changes induced by phalloidin in the bile canaliculi and the intra-acinar localization of these changes were studied in the rat liver by scanning and transmission electron microscopy. After 3 days of treatment, canalicular changes appeared mainly in zones 2 and 3 of Rappaport's acinus, but after 7 days of treatment changes occurred in bile canaliculi of the whole acinus. The changes in the bile canaliculi included tortuosity, saccular dilatation, loss of microvilli, bleb formation and elongation of canalicular side branches. Some side branches extended near to Disse's space, leaving only a thin cytoplasmic rim between the canalicular lumen and Disse's space. Kupffer cells were occasionally situated near such extended bile canaliculi and protruded their processes into the hepatic cord. These results suggest that bile canaliculi in zone 3 are more susceptible to phalloidin toxicity than those in zone 1 and that biliary constituents may leak from such altered bile canaliculi. |
キーワード | phalloidin bile canaliculi choletasis |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1988-08 |
巻 | 42巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 207 |
終了ページ | 213 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 3177006 |
Web of Science KeyUT | A1988P884600004 |
著者 | Uchida, Daisuke| Shiraha, Hidenori| Kato, Hironari| Nagahara, Teruya| Iwamuro, Masaya| Kataoka, Junro| Horiguchi, Shigeru| Watanabe, Masami| Takaki, Akinobu| Nouso, Kazuhiro| Nasu, Yasutomo| Yagi, Takahito| Kumon, Hiromi| Yamamoto, Kazuhide| |
---|---|
発行日 | 2014-05 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 29巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52790 |
---|---|
フルテキストURL | 68_4_243.pdf |
著者 | Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Nishina, Sohji| Korenaga, Masaaki| Hino, Keisuke| Fujioka, Shin-ichi| Osawa, Toshiya| Itoshima, Tatsuya| Kawanaka, Miwa| Yamada, Gotaro| Kariyama, Kazuya| Takayama, Hiroki| Kubota, Junichi| Morimoto, Yoichi| Mizushima, Takaaki| Yamashita, Haruhiko| Tanioka, Hiroaki| Negoro, Yuji| Toshimori, Junichi| Kobashi, Haruhiko| Hirano, Atsushi| Itano, Yasuo| Takaki, Akinobu| Yamamoto, Kazuhide| |
抄録 | Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A. |
キーワード | acute hepatitis hepatitis B virus |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-08 |
巻 | 68巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 243 |
終了ページ | 247 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25145410 |
Web of Science KeyUT | 000340687500006 |
JaLCDOI | 10.18926/AMO/30499 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Okada, Hiroyuki| Mizuno, Motowo| Yamamoto, Kazuhide| Tsuji, Takao| |
抄録 | To characterize primary sclerosing cholangitis (PSC) in Japanese patients and its association with inflammatory bowel disease (IBD), 155 reported cases of PSC, including 6 cases of our own, were reviewed. The prevalence of IBD was less in Japanese PSC patients than in Western patients (23% versus 62-100%). Japanese PSC patients with IBD were younger (mean age, 33.1 versus 51.8 years) and were more often women (51% versus 36%) than those without IBD. Seventy-four percent of PSC patients with IBD had extensive colonic lesions, and 89% of those developed IBD simultaneously, with or prior to PSC. There were 3 cases of neutrophilic cholangitis among the PSC patients with IBD but none in those without IBD. Based on these observations, we speculate that there may be subtypes of PSC which differ pathophysiologically. |
キーワード | primary sclerosing cholangitis inflammatory bowel disease |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1996-10 |
巻 | 50巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 227 |
終了ページ | 235 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 8914675 |
Web of Science KeyUT | A1996VQ20600001 |
JaLCDOI | 10.18926/AMO/43825 |
---|---|
フルテキストURL | 65_1_11.pdf |
著者 | Kuwaki, Kenji| Nouso, Kazuhiro| Kobayashi, Yoshiyuki| Nakamura, Shinichiro| Ito, Yoichi M.| Iwadou, Shouta| Hagihara, Hiroaki| Yasunaka, Tetsuya| Toshimori, Junichi| Miyatake, Hirokazu| Miyoshi, Kenji| Onishi, Hideki| Miyake, Yasuhiro| Shoji, Bon| Takaki, Akinobu| Shiraha, Hidenori| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
抄録 | The purpose of this study was to build a prognostic model of hepatocellular carcinoma (HCC) using time-dependent covariates to re-evaluate the prognosis at any stage of the disease. The subjects were consecutive HCC patients who were treated at our institute between 1995 and 2007. We constructed time-fixed and time-dependent prognostic models with a training group (n=336) and compared the prognostic abilities between conventional Cancer of the Liver Italian Program (CLIP) scores, Japan Integrated Staging (JIS) scores, an Okuda classification, and our prognostic models in the testing group (n=227) with the c-index. The time-dependent prognostic model consisted of main tumor size, tumor number, portal vein invasion, distant metastasis, alpha-fetoprotein, des-gamma-carboxy prothrombin (DCP), bilirubin, and albumin and the weighted scores were set for each factor depending on the hazard ratio for the prognosis. The prognostic index was determined by summing the scores. The c-index values for the CLIP scores, JIS scores, Okuda classification, and our time-dependent model were 0.741, 0.727, 0.609, and 0.870, respectively. These results indicate that our time-dependent model can estimate the prognosis of HCC more precisely than traditional time-fixed models and can be used to re-predict the prognosis of HCC. |
キーワード | hepatocellular carcinoma humans prognosis proportional hazards models time factors |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-02 |
巻 | 65巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 11 |
終了ページ | 19 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21339791 |
Web of Science KeyUT | 000287620500002 |
JaLCDOI | 10.18926/AMO/52900 |
---|---|
フルテキストURL | 68_5_307.pdf |
著者 | Muro, Shinichiro| Nasu, Junichiro| Harada, Ryo| Matsubara, Minoru| Nakarai, Asuka| Kanzaki, Hiromitsu| Tsutsumi, Kouichiro| Kato, Hironari| Tanaka, Takehiro| Fujiwara, Hiroyasu| Uno, Masatoshi| Okada, Hiroyuki| Yamamoto, Kazuhide| |
抄録 | A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and serum tumor markers. Fine needle aspiration revealed Grade 3 small-cell type primary pancreatic neuroendocrine carcinoma. Consequently, the diagnosis of malignant insulinoma was made. Transarterial embolization (TAE) for hepatic metastases resulted in the reduction of tumor volume and prompt resolution of hypoglycemic attacks, whereas diazoxide and systemic chemotherapy had been ineffective for controlling blood glucose levels, and octreotide was unavailable due to the allergic effect. This case report highlights the potential usefulness of TAE for malignant insulinomas in the management of hypoglycemia. |
キーワード | malignant insulinoma hypoglycemia liver metastases transarterial embolization neuroendocrinetumor |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-10 |
巻 | 68巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 307 |
終了ページ | 311 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25338488 |
Web of Science KeyUT | 000343269300008 |